Prof. MEng PhD T.H. Smit publications

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Publications Prof. MEng PhD T.H. Smit

Positions
Associate Professor, Full Professor
Main activities
Research
Specialisation
Tissue Engineering; Mechanobiology of development and disease
Focus of research

Development of the spine

Disc degeneration and osteo-arthritis

Tissue Engineering and Regenerative Medicine

Degradable polymers

Bioreactors

2020

  • Micha Dimitra, Pals Gerard, Smit Theo H., Ghazanfari Samaneh An in vitro model to evaluate the properties of matrices produced by fibroblasts from osteogenesis imperfecta and Ehlers-Danlos Syndrome patients Biochemical and biophysical research communications 2020;521 (2):310-317 [PubMed]

2019

  • Versteegden Luuk R., Sloff Marije, Hoogenkamp Henk R., Pot Michiel W., Pang Jeffrey, Hafmans Theo G., de Jong Thijs, Smit Theo H., Leeuwenburgh Sander C., Oosterwijk Egbert, Feitz Wout F., Daamen Willeke F., van Kuppevelt Toin H. A salt-based method to adapt stiffness and biodegradability of porous collagen scaffolds RSC Advances 2019;9 (63):36742-36750
  • Blom Robin P., Mol Douwe, van Ruijven Leo J., Kerkhoffs Gino M. M. J., Smit Theo H. A Single Axial Impact Load Causes Articular Damage That Is Not Visible with Micro-Computed Tomography: An Ex Vivo Study on Caprine Tibiotalar Joints Cartilage 2019 [PubMed]
  • Rustenburg Christine M. E. Degeneration of the lumbar spine: Preclinical concepts for clinical questions 2019. 233p. ISBN 9789402817935. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Smit T. H. , van Royen B. J.; Co-supervisors: Emanuel K. S., Vergroesen P. P. A.)
  • Vashaghian Mahshid, Diedrich Chantal M., Zandieh-Doulabi Behrouz, Werner Arie, Smit Theodoor H., Roovers J. P. Gentle cyclic straining of human fibroblasts on electrospun scaffolds enhances their regenerative potential Acta biomaterialia 2019;84:159-168 [PubMed]
  • Marrese Marica, Antonovaite Nelda, Nelemans Ben K. A., Smit Theodoor H., Iannuzzi Davide Micro-indentation and optical coherence tomography for the mechanical characterization of embryos: Experimental setup and measurements on chicken embryos Acta biomaterialia 2019;97:524-534 [PubMed]
  • Rustenburg Christine M E, Faraj Sayf S A, Ket Johannes C F, Emanuel Kaj S, Smit Theodoor H Prognostic factors in the progression of intervertebral disc degeneration: Which patient should be targeted with regenerative therapies? Spine 2019;2 (3):e1063 [PubMed]
  • Fazaeli Sepanta, Ghazanfari Samaneh, Mirahmadi Fereshteh, Everts Vincent, Smit Theodoor Henri, Koolstra Jan Harm The dynamic mechanical viscoelastic properties of the temporomandibular joint disc: The role of collagen and elastin fibers from a perspective of polymer dynamics Journal of the mechanical behavior of biomedical materials 2019;100 [PubMed]

2018

  • Vergroesen Pieter-Paul A., Emanuel Kaj S., Peeters Mirte, Kingma Idsart, Smit Theodoor H. Are axial intervertebral disc biomechanics determined by osmosis? Journal of biomechanics 2018;70:4-9 [PubMed]
  • Vashaghian Mahshid, Zaat Sebastianus A. J., Smit Theodoor H., Roovers Jan-Paul Biomimetic implants for pelvic floor repair Neurourology and urodynamics 2018;37 (2):566-580 [PubMed]
  • Paul Cornelis P. L., Emanuel Kaj S., Kingma Idsart, van der Veen Albert J., Holewijn Roderick M., Vergroesen Pieter-Paul A., van de Ven Peter M., Mullender Margriet G., Helder Marco N., Smit Theodoor H. Changes in intervertebral disk mechanical behavior during early degeneration Journal of biomechanical engineering 2018;140 (9) [PubMed]
  • Emanuel K. S., Mader K. T., Peeters M., Kingma I., Rustenburg C. M. E., Vergroesen P. P. A., Sammon C., Smit T. H. Early changes in the extracellular matrix of the degenerating intervertebral disc, assessed by Fourier transform infrared imaging Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2018;26 (10):1400-1408 [PubMed]
  • Beekmans Steven V., Emanuel Kaj S., Smit Theodoor H., Iannuzzi Davide Erratum: Publisher Correction: Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle (Scientific reports (2017) 7 1 (11364)) Scientific reports 2018;8 (1):4880 [PubMed]
  • Jensen Bjarke, H Smit Theodoor Examples of Weak, If Not Absent, Form-Function Relations in the Vertebrate Heart Journal of cardiovascular development and disease 2018;5 (3) [PubMed]
  • Paul Cornelis P. L. Intervertebral disc degeneration: Studies in the loaded disc culture system 2018. 245p. ISBN 9789463322935. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Smit T. H.; Co-supervisors: Helder M. N., Mullender M. G.)
  • Smit Theodoor H. Mechanobiology to repair the herniated disc EBioMedicine 2018;38:23-24 [PubMed]
  • Ghazanfari Samaneh, Werner Arie, Ghazanfari Sara, Weaver James C., Smit Theodoor H. Morphogenesis of aligned collagen fibers in the annulus fibrosus: Mammals versus avians Biochemical and biophysical research communications 2018;503 (2):1168-1173 [PubMed]
  • Emanuel Kaj S., van der Veen Albert J., Rustenburg Christine M. E., Smit Theodoor H., Kingma Idsart Osmosis and viscoelasticity both contribute to time-dependent behaviour of the intervertebral disc under compressive load: A caprine in vitro study Journal of biomechanics 2018;70:10-15 [PubMed]
  • Paul Cornelis P. L., Smit Theodoor H., de Graaf Magda, Holewijn Roderick M., Bisschop Arno, van de Ven Peter M., Mullender Margriet G., Helder Marco N., Strijkers Gustav J. Quantitative MRI in early intervertebral disc degeneration: T1rho correlates better than T2 and ADC with biomechanics, histology and matrix content PLoS ONE 2018;13 (1):e0191442 [PubMed]

2017

  • de Jong Thijs A clinically translatable concept for periodontal ligament engineering around dental implants: The characterization of patient-friendly materials with optimal biomechanical properties 2017. 146p. ISBN 9789463321365. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Smit T. H.; Co-supervisor: Bakker A. D.)
  • de Jong Thijs, Oostendorp Corien, Bakker Astrid D., van Kuppevelt Toin H., Smit Theo H. Adipose-Derived-Stem-Cell-Seeded Fibrin Matrices for Periodontal Ligament Engineering: The Need for Dynamic Strain JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING 2017;7 (12):1303-1312
  • van de Bunt Fabian, Emanuel Kaj S., Wijffels Thomas, Kooren Peter N., Kingma Idsart, Smit Theodoor H. A novel physiological testing device to study knee biomechanics in vitro Knee 2017;24 (4):718-725 [PubMed]
  • Vashaghian Mahshid Biomimetic matrices for pelvic floor repair 2017. 167p. ISBN 9789463321624. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Smit T. H.; Co-supervisor: Roovers J. P.)
  • Teunissen M., van der Veen A. J., Smit T. H., Tryfonidou M. A., Meij B. P. Effect of a titanium cage as a stand-alone device on biomechanical stability in the lumbosacral spine of canine cadavers Veterinary journal (London, England 2017;220:17-23 [PubMed]
  • Beekmans Steven V., Emanuel Kaj S., Smit Theodoor H., Iannuzzi Davide Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle Scientific reports 2017;7 (1):11364 [PubMed]
  • Crijns Tom Joris, Stadhouder Agnita, Smit Theodoor Henri Restrained Differential Growth: The Initiating Event of Adolescent Idiopathic Scoliosis? Spine 2017;42 (12):E726-E732 [PubMed]
  • Paul Cornelis P. L., de Graaf Magda, Bisschop Arno, Holewijn Roderick M., van de Ven Peter M., van Royen Barend J., Mullender Margriet G., Smit Theodoor H., Helder Marco N. Static axial overloading primes lumbar caprine intervertebral discs for posterior herniation PLoS ONE 2017;12 (4):e0174278 [PubMed]
  • de Jong T., Bakker A. D., Everts V., Smit T. H. The intricate anatomy of the periodontal ligament and its development: Lessons for periodontal regeneration Journal of periodontal research 2017;52 (6):965-974 [PubMed]
  • Vashaghian Mahshid, Ruiz-Zapata Alejandra M., Kerkhof Manon H., Zandieh-Doulabi Behrouz, Werner Arie, Roovers Jan Paul, Smit Theo H. Toward a new generation of pelvic floor implants with electrospun nanofibrous matrices: A feasibility study Neurourology and urodynamics 2017;36 (3):565-573 [PubMed]

2016

  • Schmitz Manuel, Nelemans Ben K. A., Smit Theodoor H. A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos Journal of visualized experiments 2016;2016 (118):e54636 [PubMed]
  • Vashaghian Mahshid, Zandieh-Doulabi Behrouz, Roovers Jan-Paul, Smit Theodoor Henri Electrospun Matrices for Pelvic Floor Repair: Effect of Fiber Diameter on Mechanical Properties and Cell Behavior Tissue engineering. Part A 2016;22 (23-24):1305-1316 [PubMed]
  • Mader Kerstin T., Peeters Mirte, Detiger Suzanne E. L., Helder Marco N., Smit Theo H., Le Maitre Christine L., Sammon Chris Investigation of intervertebral disc degeneration using multivariate FTIR spectroscopic imaging Faraday discussions 2016;187:393-414 [PubMed]
  • Ghazanfari Samaneh, Khademhosseini Ali, Smit Theodoor H. Mechanisms of lamellar collagen formation in connective tissues Biomaterials 2016;97:74-84 [PubMed]
  • Detiger Suzanne E. L. Preclinical challenges in the surgical treatment of intervertebral disc degeneration 2016. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisors: van Royen B. J., Smit T. H.; Co-supervisors: Helder M. N., Hoogendoorn R. J. W.)
  • Emanuel Kaj S., Kingma Idsart, Helder Marco N., Smit Theodoor H. Response to: 'A dose-response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine' Arthritis research & therapy 2016;18:41 [PubMed]
  • Fazaeli S., Ghazanfari S., Everts V., Smit T. H., Koolstra J. H. The contribution of collagen fibers to the mechanical compressive properties of the temporomandibular joint disc Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2016;24 (7):1292-1301 [PubMed]
  • Vergroesen Pieter-Paul A., van der Veen Albert J., Emanuel Kaj S., van Dieën Jaap H., Smit Theodoor H. The poro-elastic behaviour of the intervertebral disc: A new perspective on diurnal fluid flow Journal of biomechanics 2016;49 (6):857-863 [PubMed]
  • Detiger S. E. L., de Bakker J. Y., Emanuel K. S., Schmitz M., Vergroesen P. P. A., van der Veen A. J., Mazel C., Smit T. H. Translational challenges for the development of a novel nucleus pulposus substitute: Experimental results from biomechanical and in vivo studies Journal of biomaterials applications 2016;30 (7):983-994 [PubMed]
  • Ruiz-Zapata Alejandra M., Kerkhof Manon H., Ghazanfari Samaneh, Zandieh-Doulabi Behrouz, Stoop Reinout, Smit Theo H., Helder Marco N. Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content Scientific reports 2016;6:22971 [PubMed]

2015

  • Vergroesen Pieter-Paul A., Bochyn Ska Agnieszka I., Emanuel Kaj S., Sharifi Shahriar, Kingma Idsart, Grijpma Dirk W., Smit Theodoor H. A Biodegradable Glue for Annulus Closure Evaluation of Strength and Endurance Spine 2015;40 (9):622-628 [PubMed]
  • Detiger Suzanne E. L., Helder Marco N., Smit Theodoor H., Hoogendoorn Roel J. W. Adverse effects of stromal vascular fraction during regenerative treatment of the intervertebral disc: observations in a goat model European spine journal 2015;24 (9):1992-2000 [PubMed]
  • Schutgens E. M., Tryfonidou M. A., Smit T. H., Öner F. C., Krouwels A., Ito K., Creemers L. B. Biomaterials for intervertebral disc regeneration: past performance and possible future strategies European cells & materials 2015;30:210-231 [PubMed]
  • Peeters Mirte, Detiger Suzanne E. L., Karfeld-Sulzer Lindsay S., Smit Theo H., Yayon Avner, Weber Franz E., Helder Marco N. BMP-2 and BMP-2/7 Heterodimers Conjugated to a Fibrin/Hyaluronic Acid Hydrogel in a Large Animal Model of Mild Intervertebral Disc Degeneration BioResearch open access 2015;4 (1):398-406 [PubMed]
  • Klumpers Darinka D., Mooney David J., Smit Theo H. From Skeletal Development to Tissue Engineering: Lessons from the Micromass Assay Tissue engineering. Part B, Reviews 2015;21 (5):427-437 [PubMed]
  • Vergroesen Pieter-Paul A. Intervertebral disc biomechanics: long-term axial loading studies 2015. 232p. ISBN 9789064649134. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisors: van Royen B. J., Smit T. H.; Co-supervisor: Kingma I.)
  • Vergroesen P.-P. A., Kingma I., Emanuel K. S., Hoogendoorn R. J. W., Welting T. J., van Royen B. J., van Dieën J. H., Smit T. H. Mechanics and biology in intervertebral disc degeneration: a vicious circle Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2015;23 (7):1057-1070 [PubMed]
  • Detiger Suzanne E. L., Holewijn Roderick M., Hoogendoorn Roel J. W., van Royen Barend J., Helder Marco N., Berger Ferco H., Kuijer Joost P. A., Smit Theo H. MRI T2* mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model European spine journal 2015;24 (9):1935-1943 [PubMed]
  • Ruiz Zapata Alejandra M. Pathophysiology of pelvic organ prolapse: cells, matrices and their interactions 2015. 147p. ISBN 9789064649059. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisor: Smit T. H.; Co-supervisors: Helder M. N., Kerkhof M. H.)
  • Emanuel K. S., Vergroesen P.-P. A., Peeters M., Holewijn R. M., Kingma I., Smit T. H. Poroelastic behaviour of the degenerating human intervertebral disc: a ten-day study in a loaded disc culture system European cells & materials 2015;29:330-40; discussion 340-1 [PubMed]
  • Kroeze Robert J., Smit Theo H., Vergroesen Pieter P., Bank Ruud A., Stoop Reinout, van Rietbergen Bert, van Royen Barend J., Helder Marco N. Spinal fusion using adipose stem cells seeded on a radiolucent cage filler: a feasibility study of a single surgical procedure in goats European spine journal 2015;24 (5):1031-1042 [PubMed]
  • Klumpers Darinka D., Smit Theo H., Mooney David J. The effect of growth-mimicking continuous strain on the early stages of skeletal development in micromass culture PLoS ONE 2015;10 (4):e0124948 [PubMed]
  • van Engelen Susanne J. P. M., Bisschop Arno, Smit Theo H., van Royen Barend J., van Dieën Jaap H. The effect of neighboring segments on the measurement of segmental stiffness in the intact lumbar spine spine journal 2015;15 (6):1302-1309 [PubMed]

2014

  • Kroeze Robert J. Adipose stem cells on a biodegradable polymer for spinal fusion: pre-clinical studies 2014. 178p. ISBN 9789461088413. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisors: van Royen B. J., Smit T. H.; Co-supervisor: Helder M. N.)
  • Blaauboer Marjolein E., Boeijen Fee R., Emson Claire L., Turner Scott M., Zandieh-Doulabi Behrouz, Hanemaaijer Roeland, Smit Theo H., Stoop Reinout, Everts Vincent Extracellular matrix proteins: A positive feedback loop in lung fibrosis? Matrix biology 2014;34:170-178 [PubMed]
  • Ruiz-Zapata Alejandra M., Kerkhof Manon H., Zandieh-Doulabi Behrouz, Brölmann Hans A. M., Smit Theo H., Helder Marco N. Functional characteristics of vaginal fibroblastic cells from premenopausal women with pelvic organ prolapse Molecular human reproduction 2014;20 (11):1135-1143 [PubMed]
  • Vergroesen Pieter-Paul A., van der Veen Albert J., van Royen Barend J., Kingma Idsart, Smit Theo H. Intradiscal pressure depends on recent loading and correlates with disc height and compressive stiffness European spine journal 2014;23 (11):2359-2368 [PubMed]
  • Klumpers Darinka D. In vitro studies of the role of mechanical cues in skeletal patterning and differentiation 2014. 142p. ISBN 9789086596836. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisors: Smit T. H., Mooney D. J.)
  • Klumpers Darinka D., Mao Angelo S., Smit Theo H., Mooney David J. Linear patterning of mesenchymal condensations is modulated by geometric constraints Journal of the Royal Society, Interface / the Royal Society 2014;11 (95):20140215 [PubMed]
  • Castro A. P. G., Paul C. P. L., Detiger S. E. L., Smit T. H., van Royen B. J., Pimenta Claro J. C., Mullender M. G., Alves J. L. Long-Term Creep Behavior of the Intervertebral Disk: Comparison between Bioreactor Data and Numerical Results Frontiers in bioengineering and biotechnology 2014;2:56 [PubMed]
  • Kerkhof Manon H. Pelvic organ prolapse: Matrix, Cells and Genes 2014. 191p. ISBN 9789461087096. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisors: Smit T. H., Brolmann H. A. M.; Co-supervisors: Helder M. N., Zandieh Doulabi B.)

2013

  • Detiger Suzanne E. L., Hoogendoorn Roel J. W., van der Veen Albert J., van Royen Barend J., Helder Marco N., Koenderink Gijsje H., Smit Theo H. Biomechanical and rheological characterization of mild intervertebral disc degeneration in a large animal model Journal of orthopaedic research 2013;31 (5):703-709 [PubMed]
  • Blaauboer Marjolein E. Cell matrix interactions in lung fibrosis 2013. 143p. ISBN 9789461918239. [UvA Dissertations Online] Vrije Universiteit: Faculteit Tandheelkunde. (Supervisors: Everts V., Smit T. H.; Co-supervisor: Stoop R.)
  • Klumpers Darinka D., Zhao Xuanhe, Mooney David J., Smit Theo H. Cell mediated contraction in 3D cell-matrix constructs leads to spatially regulated osteogenic differentiation INTEGRATIVE BIOLOGY 2013;5 (9):1174-1183 [PubMed]
  • Paul Cornelis P. L., Schoorl Tom, Zuiderbaan Hendrik A., Zandieh Doulabi Behrouz, van der Veen Albert J., van de Ven Peter M., Smit Theo H., van Royen Barend J., Helder Marco N., Mullender Margriet G. Dynamic and static overloading induce early degenerative processes in caprine lumbar intervertebral discs PLoS ONE 2013;8 (4):e62411 [PubMed]
  • Ruiz-Zapata Alejandra M., Kerkhof Manon H., Zandieh-Doulabi Behrouz, Brölmann Hans A. M., Smit Theo H., Helder Marco N. Fibroblasts from women with pelvic organ prolapse show differential mechanoresponses depending on surface substrates International urogynecology journal and pelvic floor dysfunction 2013;24 (9):1567-1575 [PubMed]
  • Jurgens Wouter J. F. M., Kroeze Robert Jan, Zandieh-Doulabi Behrouz, van Dijk Annemieke, Renders Greetje A. P., Smit Theo H., van Milligen Florine J., Ritt Marco J. P. F., Helder Marco N. One-step surgical procedure for the treatment of osteochondral defects with adipose-derived stem cells in a caprine knee defect: a pilot study BioResearch open access 2013;2 (4):315-325 [PubMed]
  • Gadikota Hemanth R. Reconstruction of the Anterior Cruciate Ligament: Optimal techniques for restoration of normal anatomy, knee joint kinematics and function 2013. 197p. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisor: Smit T. H.; Co-supervisor: Li G.)
  • Kroeze R. J., van der Veen A. J., van Royen B. J., Bank R. A., Helder M. N., Smit T. H. Relation between radiological assessment and biomechanical stability of lumbar interbody fusion in a large animal model European spine journal 2013;22 (12):2731-2739 [PubMed]

2012

  • Smolders Lucas Adam, Bergknut Niklas, Kingma Idsart, van der Veen Albert Jan, Smit Theodoor Henri, Koole Levinus Hendrik, Hazewinkel Herman Anthonie Willem, Meij Björn Petrus Biomechanical evaluation of a novel nucleus pulposus prosthesis in canine cadaveric spines Veterinary journal (London, England 2012;192 (2):199-205 [PubMed]
  • Bron Johannes L., Mulder Harriet W., Vonk Lucienne A., Doulabi Bherouz Zandieh, Oudhoff M. J., Smit Theodoor H. Migration of intervertebral disc cells into dense collagen scaffolds intended for functional replacement Journal of materials science. Materials in medicine 2012;23 (3):813-821 [PubMed]
  • Bron Johannes L. Novel Regenerative Strategies For The Treatment Of Intervertebral Disc Herniation 2012. 168p. ISBN 9789461083517. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisors: van Royen B. J., Smit T. H.; Co-supervisor: Koenderink G. H.)
  • Paul Cornelis P. L., Zuiderbaan Hendrik A., Zandieh Doulabi Behrouz, van der Veen Albert J., van de Ven Peter M., Smit Theo H., Helder Marco N., van Royen Barend J., Mullender Margriet G. Simulated-physiological loading conditions preserve biological and mechanical properties of caprine lumbar intervertebral discs in ex vivo culture PLoS ONE 2012;7 (3):e33147 [PubMed]
  • Kraan Gerald A. The extraforaminal ligaments of the human spinal nerves: Anatomical and Biomechanical study 2012. 137p. ISBN 9789461693204. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisors: Hoogland P. V. J. M., van Royen B. J.; Co-supervisors: Smit T. H., Bloem R. M.)
  • Söntjens Serge H. M., Engels Tom A. P., Smit Theo H., Govaert Leon E. Time-dependent failure of amorphous poly-D,L-lactide: influence of molecular weight Journal of the mechanical behavior of biomedical materials 2012;13:69-77 [PubMed]

2011

  • van Haaren Emil H. Clinical, mechanical and biological aspects of impaction bone grafting in orthopaedic revision implantology 2011. 167p. ISBN 9789085900498. [UvA Dissertations Online] Vrije Universiteit: Faculteit Geneeskunde. (Supervisors: Klein-Nuland J., Wuisman P. I. J. M.; Co-supervisors: Heyligers I. C., Smit T. H.)
  • Blaauboer Marjolein E., Smit Theo H., Hanemaaijer Roeland, Stoop Reinout, Everts Vincent Cyclic mechanical stretch reduces myofibroblast differentiation of primary lung fibroblasts Biochemical and biophysical research communications 2011;404 (1):23-27 [PubMed]
  • Bron Johannes L., Vonk Lucienne A., Smit Theodoor H., Koenderink Gijsje H. Engineering alginate for intervertebral disc repair Journal of the mechanical behavior of biomedical materials 2011;4 (7):1196-1205 [PubMed]
  • Kraan Gerald A., Smit Theo H., Hoogland Piet V. J. M. Extraforaminal ligaments of the cervical spinal nerves in humans spine journal 2011;11 (12):1128-1134 [PubMed]
  • Smit Theodoor H., van Tunen Manon Slm, van der Veen Albert J., Kingma Idsart, van Dieën Jaap H. Quantifying intervertebral disc mechanics: a new definition of the neutral zone BMC musculoskeletal disorders 2011;12:38 [PubMed]
  • van Engelen S. J. P. M., van der Veen A. J., de Boer A., Ellenbroek M. H. M., Smit T. H., van Royen B. J., van Dieën J. H. The feasibility of modal testing for measurement of the dynamic characteristics of goat vertebral motion segments Journal of biomechanics 2011;44 (8):1478-1483 [PubMed]
  • Vergroesen Pieter-Paul A., Kroeze Robert-Jan, Helder Marco N., Smit Theodoor H. The use of poly(L-lactide-co-caprolactone) as a scaffold for adipose stem cells in bone tissue engineering: application in a spinal fusion model Macromolecular bioscience 2011;11 (6):722-730 [PubMed]

2010

  • Bron Johannes L., van der Veen Albert J., Helder Marco N., van Royen Barend J., Smit Theodoor H. Biomechanical and in vivo evaluation of experimental closure devices of the annulus fibrosus designed for a goat nucleus replacement model European spine journal 2010;19 (8):1347-1355 [PubMed]
  • Berendsen Agnes D., Smit Theo H., Schoenmaker Ton, Walboomers X. Frank, Harris Stephen E., Everts Vincent, Bronckers Antonius L. J. J. Inorganic Phosphate Stimulates DMP1 Expression in Human Periodontal Ligament Fibroblasts Embedded in Three-Dimensional Collagen Gels Cells, tissues, organs 2010;192 (2):116-124 [PubMed]
  • Kraan G. A., Smit T. H., Hoogland P. V. J. M., Snijders C. J. Lumbar extraforaminal ligaments act as a traction relief and prevent spinal nerve compression Clinical biomechanics (Bristol, Avon) 2010;25 (1):10-15 [PubMed]
  • Kroeze R. J., Helder M. N., Roos W. H., Wuite G. J. L., Bank R. A., Smit T. H. The effect of ethylene oxide, glow discharge and electron beam on the surface characteristics of poly(L-lactide-co-caprolactone) and the corresponding cellular response of adipose stem cells Acta biomaterialia 2010;6 (6):2060-2065 [PubMed]
  • Smit T. H., Engels T. A. P., Söntjens S. H. M., Govaert L. E. Time-dependent failure in load-bearing polymers: a potential hazard in structural applications of polylactides Journal of materials science. Materials in medicine 2010;21 (3):871-878 [PubMed]
  • Engels Tom A. P., Söntjens Serge H. M., Smit Theo H., Govaert Leon E. Time-dependent failure of amorphous polylactides in static loading conditions Journal of materials science. Materials in medicine 2010;21 (1):89-97 [PubMed]

2009

  • Breuls Roel G. M., Klumpers Darinka D., Everts Vincent, Smit Theo H. Collagen type V modulates fibroblast behavior dependent on substrate stiffness Biochemical and biophysical research communications 2009;380 (2):425-429 [PubMed]
  • Bacabac Rommel G., van Loon Jack J. W. A., Smit Theo H., Klein-Nulend Jenneke Noise enhances the rapid nitric oxide production by bone cells in response to fluid shear stress Technology and health care 2009;17 (1):57-65 [PubMed]
  • van Hove Ruud P., Nolte Peter A., Vatsa Aviral, Semeins Cornelis M., Salmon Philip L., Smit Theo H., Klein-Nulend Jenneke Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density - Is there a role for mechanosensing? Bone 2009;45 (2):321-329 [PubMed]
  • Krijnen Matthijs R., Smit Theo H., Everts Vincent, Wuisman Paul I. J. M. PLDLA mesh and 60/40 biphasic calcium phosphate in iliac crest regeneration in the goat Journal of biomedical materials research. Part B, Applied biomaterials 2009;89 (1):9-17 [PubMed]
  • Smit Theodoor H. Preface Degradable Polymers for Skeletal Implants 2009:ix-x
  • Smit Theodoor H. Preface Degradable Polymers for Skeletal Implants 2009:ix-x
  • Bron Johannes Leendert, Helder Marco N., Meisel Hans-Jorg, van Royen Barend J., Smit Theodoor H. Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges European spine journal 2009;18 (3):301-313 [PubMed]
  • Bron J. L., Koenderink G. H., Everts V., Smit T. H. Rheological characterization of the nucleus pulposus and dense collagen scaffolds intended for functional replacement Journal of orthopaedic research 2009;27 (5):620-626 [PubMed]
  • Berendsen Agnes D., Smit Theo H., Walboomers X. Frank, Everts Vincent, Jansen John A., Bronckers Antonius L. J. J. Three-Dimensional Loading Model for Periodontal Ligament Regeneration In Vitro Tissue engineering. Part C, Methods 2009;15 (4):561-570 [PubMed]

2008

  • Hoogendoorn Roel J. W., Helder Macro N., Wuisman Paul I. J. M., Bank Ruud A., Everts Vincent E., Smit Theo H. Adjacent segment degeneration: observations in a goat spinal fusion study Spine 2008;33 (12):1337-1343 [PubMed]
  • van der Veen Albert J., Mullender Margriet G., Kingma Idsart, van Dieen Jaap H., Smit Theo H. Contribution of vertebral [corrected] bodies, endplates, and intervertebral discs to the compression creep of spinal motion segments Journal of biomechanics 2008;41 (6):1260-1268 [PubMed]
  • Pigge Roy R., Scheerder Famke J., Smit Theo H., Mullender Margriet G., van Royen Barend J. Effectiveness of preoperative planning in the restoration of balance and view in ankylosing spondylitis Neurosurgical focus 2008;24 (1):E7 [PubMed]
  • van Haaren Emil H., van der Zwaard Babette C., van der Veen Albert J., Heyligers Ide C., Wuisman Paul I. J. M., Smit Theo H. Effect of long-term preservation on the mechanical properties of cortical bone in goats Acta orthopaedica 2008;79 (5):708-716 [PubMed]
  • Hoogendoorn Roel J. W., Helder Marco N., Kroeze Robert Jan, Bank Ruud A., Smit Theo H., Wuisman Paul I. J. M. Molecular changes in the degenerated goat intervertebral disc Spine 2008;33 (16):1714-1721 [PubMed]
  • Vatsa Aviral, Breuls Roel G., Semeins Cornelis M., Salmon Philip L., Smit Theo H., Klein-Nulend Jenneke Osteocyte morphology in fibula and calvaria - Is there a role for mechanosensing? Bone 2008;43 (3):452-458 [PubMed]
  • Vatsa A., Semeins C. M., Smit T. H., Klein-Nulend J. Paxillin localisation in osteocytes-Is it determined by the direction of loading? Biochemical and biophysical research communications 2008;377 (4):1019-1024 [PubMed]
  • Bacabac Rommel G., Mizuno Daisuke, Schmidt Christoph F., MacKintosh Fred C., van Loon Jack J. W. A., Klein-Nulend Jenneke, Smit Theo H. Round versus flat: Bone cell morphology, elasticity, and mechanosensing Journal of biomechanics 2008;41 (7):1590-1598 [PubMed]
  • Breuls Roel G. M., Jiya Timothy U., Smit Theo H. Scaffold stiffness influences cell behavior: opportunities for skeletal tissue engineering open orthopaedics journal 2008;2:103-109 [PubMed]
  • Smit Theo H., Engels Tom A. P., Wuisman Paul I. J. M., Govaert Leon E. Time-dependent mechanical strength of 70/30 Poly(L, DL-lactide): shedding light on the premature failure of degradable spinal cages Spine 2008;33 (1):14-18 [PubMed]
  • Uffen M. P., Krijnen M. R., Hoogendoorn R. J., Strijkers G. J., Everts V., Wuisman P. I., Smit T. H. Tissue identification with micro-magnetic resonance imaging in a caprine spinal fusion model European spine journal 2008;17 (8):1006-1011 [PubMed]

2007

  • van Laar Wilbert, Meester Rinse J., Smit Theo H., van Royen Barend J. A biomechanical analysis of the self-retaining pedicle hook device in posterior spinal fixation European spine journal 2007;16 (8):1209-1214 [PubMed]
  • Berendsen Agnes D., Smit Theo H., Hoeben Kees A., Walboomers X. Frank, Bronckers Antonius L. J. J., Everts Vincent Alkaline phosphatase-induced mineral deposition to anchor collagen fibrils to a solid surface Biomaterials 2007;28 (24):3530-3536 [PubMed]
  • van Royen Barend J., Scheerder Famke J., Jansen Eric, Smit Theo H. ASKyphoplan: a program for deformity planning in ankylosing spondylitis European spine journal 2007;16 (9):1445-1449 [PubMed]
  • Kouwenhoven Jan-Willem M., Smit Theo H., van der Veen Albert J., Kingma Idsart, van Dieën Jaap H., Castelein René M. Effects of dorsal versus ventral shear loads on the rotational stability of the thoracic spine: a biomechanical porcine and human cadaveric study Spine 2007;32 (23):2545-2550 [PubMed]
  • Hoogendoorn Roel J., Wuisman Paul I., Smit Theo H., Everts Vincent E., Helder Marco N. Experimental intervertebral disc degeneration induced by chondroitinase ABC in the goat Spine 2007;32 (17):1816-1825 [PubMed]
  • Vatsa Aviral, Smit Theo H., Klein-Nulend Jenneke Extracellular NO signalling from a mechanically stimulated osteocyte Journal of biomechanics 2007;40 (Suppl. 1):S89-S95 [PubMed]
  • van der Veen A. J., van Dieën J. H., Nadort A., Stam B., Smit T. H. Intervertebral disc recovery after dynamic or static loading in vitro: is there a role for the endplate? Journal of biomechanics 2007;40 (10):2230-2235 [PubMed]
  • Mullender Margriet G., Krijnen Matthijs R., Helder Marco N., Smit Theo H., Everts Vincent, Wuisman Paul I. J. M. Lumbar body fusion with a bioresorbable cage in a goat model is delayed by the use of a carboxymethylcellulose-stabilized collagenous rhOP-1 device Journal of orthopaedic research 2007;25 (1):132-141 [PubMed]
  • Smit Theo H., Thomas Kevin A., Hoogendoorn Roel J. W., Strijkers Gustav J., Helder Marco N., Wuisman Paul I. J. M. Sterilization and strength of 70/30 polylactide cages: e-beam versus ethylene oxide Spine 2007;32 (7):742-747 [PubMed]

2006

  • Smit T. H., Krijnen M. R., van Dijk M., Wuisman P. I. J. M. Application of polylactides in spinal cages: studies in a goat model Journal of materials science. Materials in medicine 2006;17 (12):1237-1244 [PubMed]
  • Vatsa Aviral, Mizuno Daisuke, Smit Theo H., Schmidt Christoph F., MacKintosh Fred C., Klein-Nulend Jenneke Bio imaging of intracellular NO production in single bone cells after mechanical stimulation Journal of bone and mineral research 2006;21 (11):1722-1728 [PubMed]
  • van Schoor N. M., van der Veen A. J., Schaap L. A., Smit T. H., Lips P. Biomechanical comparison of hard and soft hip protectors, and the influence of soft tissue Bone 2006;39 (2):401-407 [PubMed]
  • Wuisman P. I. J. M., Smit T. H. Bioresorbable polymers: heading for a new generation of spinal cages European spine journal 2006;15 (2):133-148 [PubMed]
  • Bacabac Rommel G., Smit Theo H., van Loon Jack J. W. A., Doulabi Behrouz Zandieh, Helder Marco, Klein-Nulend Jenneke Bone cell responses to high-frequency vibration stress: does the nucleus oscillate within the cytoplasm? FASEB journal 2006;20 (7):858-864 [PubMed]
  • Berendsen Agnes D., Bronckers Antonius L. J. J., Smit Theo H., Walboomers X. Frank, Everts Vincent Collagen type V enhances matrix contraction by human periodontal ligament fibroblasts seeded in three-dimensional collagen gels Matrix biology 2006;25 (8):515-522 [PubMed]
  • Krijnen Matthijs R., Valstar E. R., Smit Theo H., Wuisman Paul I. J. M. Does bioresorbable cage material influence segment stability in spinal interbody fusion? Clinical orthopaedics and related research 2006;448:33-38 [PubMed]
  • Krijnen Matthijs R., Mensch Daniel, van Dieen Jaap H., Wuisman Paul I., Smit Theo H. Primary spinal segment stability with a stand-alone cage: in vitro evaluation of a successful goat model Acta orthopaedica 2006;77 (3):454-461 [PubMed]
  • Krijnen Matthijs R., Mullender Margriet G., Smit Theo H., Everts Vincent, Wuisman Paul I. J. M. Radiographic, histologic, and chemical evaluation of bioresorbable 70/30 poly-L-lactide-CO-D, L-lactide interbody fusion cages in a goat model Spine 2006;31 (14):1559-1567 [PubMed]
  • van Royen B. J., Kastelijns R. C. A., Noske D. P., Oner F. C., Smit T. H. Transpedicular wedge resection osteotomy for the treatment of a kyphotic Andersson lesion-complicating ankylosing spondylitis European spine journal 2006;15 (2):246-252 [PubMed]

2005

  • van Haaren E. H., Smit T. H., van der Veen A. J., Wuisman P. I. J. M., Heyligers I. C. A bioresorbable molding mesh for impaction grafting revision hip surgery Clinical orthopaedics and related research 2005;432:167-173 [PubMed]
  • Wuisman Paul I. J. M., Krijnen Matthijs R., Helder Marco N., Smit Theo H. Bioabsorbable interbody cages in a sheep cervical spine fusion model Spine 2005;30 (17):2005-2006 [PubMed]
  • Bacabac Rommel G., Smit Theo H., Cowin Stephen C., van Loon Jack J. W. A., Nieuwstadt Frans T. M., Heethaar Rob, Klein-Nulend Jenneke Dynamic shear stress in parallel-plate flow chambers Journal of biomechanics 2005;38 (1):159-167 [PubMed]
  • van der Veen Albert J., Mullender Margriet, Smit Theo H., Kingma Idsart, van Dieën Jaap H. Flow-related mechanics of the intervertebral disc: the validity of an in vitro model Spine 2005;30 (18):E534-E539 [PubMed]
  • van Dijk Martijn, van Diest Paul J., Smit Theo H., Berkhof Hans, Burger Elisabeth H., Wuisman Paul I. J. M. Four-year follow-up of poly-L-lactic Acid cages for lumbar interbody fusion in goats Journal of long-term effects of medical implants 2005;15 (2):125-138 [PubMed]
  • Bacabac Rommel G., Smit Theo H., Mullender Margriet G., van Loon Jack J. W. A., Klein-Nulend Jenneke Initial stress-kick is required for fluid shear stress-induced rate dependent activation of bone cells Annals of biomedical engineering 2005;33 (1):104-110 [PubMed]
  • Faber C., Hoogendoorn R. J. W., Lyaruu D. M., Stallmann H. P., van Marle J., van Nieuw Amerongen A., Smit T. H., Wuisman P. I. J. M. The effect of the antimicrobial peptide, Dhvar-5, on gentamicin release from a polymethyl methacrylate bone cement Biomaterials 2005;26 (28):5717-5726 [PubMed]
  • Castelein René M., van Dieën Jaap H., Smit Theo H. The role of dorsal shear forces in the pathogenesis of adolescent idiopathic scoliosis--a hypothesis Medical hypotheses 2005;65 (3):501-508 [PubMed]
  • van Haaren E. H., Smit T. H., Phipps K., Wuisman P. I. J. M., Blunn G., Heyligers I. C. Tricalcium-phosphate and hydroxyapatite bone-graft extender for use in impaction grafting revision surgery. An in vitro study on human femora Journal of bone and joint surgery. British volume 2005;87B (2):267-271 [PubMed]

2004

  • van Loon Jack J. W. A., Folgering Erik H. T. E., Bouten Carlijn V. C., Smit Theo H. Centrifuges and inertial shear forces Journal of gravitational physiology 2004;11 (1):29-38 [PubMed]
  • Bacabac Rommel G., Smit Theo H., Mullender Margriet G., Dijcks Saskia J., van Loon Jack J. W. A., Klein-Nulend Jenneke Nitric oxide production by bone cells is fluid shear stress rate dependent Biochemical and biophysical research communications 2004;315 (4):823-829 [PubMed]
  • Krijnen Matthijs R., Smit Theo H., Strijkers Gustav J., Nicolay Klaas, Pouwels Petra J. W., Wuisman Paul I. J. M. The use of high-resolution magnetic resonance imaging for monitoring interbody fusion and bioabsorbable cages: an ex vivo pilot study Neurosurgical focus 2004;16 (3):E3 [PubMed]

2003

  • Smit Theo H., Müller Ralph, van Dijk Martijn, Wuisman Paul I. J. M. Changes in bone architecture during spinal fusion: three years follow-up and the role of cage stiffness Spine 2003;28 (16):1802-8; discussion 1809 [PubMed]
  • van Loon Jack J., Folgering Erik H., Bouten Carlijn V., Veldhuijzen J. Paul, Smit Theo H. Inertial shear forces and the use of centrifuges in gravity research. What is the proper control? Journal of biomechanical engineering 2003;125 (3):342-346 [PubMed]
  • Burger Elisabeth H., Klein-Nulend Jenneke, Smit Theo H. Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon--a proposal Journal of biomechanics 2003;36 (10):1453-1459 [PubMed]
  • van Dijk Martijn, Smit Theo H., Arnoe Maurice F., Burger Elisabeth H., Wuisman Paul I. The use of poly-L-lactic acid in lumbar interbody cages: design and biomechanical evaluation in vitro European spine journal 2003;12 (1):34-40 [PubMed]

2002

  • Smit Theo H., Burger Elisabeth H., Huyghe Jacques M. A case for strain-induced fluid flow as a regulator of BMU-coupling and osteonal alignment Journal of bone and mineral research 2002;17 (11):2021-2029 [PubMed]
  • van Dijk Martijn, Smit Theo H., Burger Elisabeth H., Wuisman Paul I. Bioabsorbable poly-L-lactic acid cages for lumbar interbody fusion: three-year follow-up radiographic, histologic, and histomorphometric analysis in goats Spine 2002;27 (23):2706-2714 [PubMed]
  • van Dijk M., Smit Th H., Burger E. H., Wuisman P. I. M. J. Bone histomorphometric evaluation of a clinically fused titanium tumour cage in a child European spine journal 2002;11 (5):507-511 [PubMed]
  • Bacabac R. G., Smit Th H., Heethaar R. M., van Loon J. J. W. A., Pourquie M. J. M. B., Nieuwstadt F. T. M., Klein-Nulend J. Characteristics of the parallel-plate flow chamber for mechanical stimulation of bone cells under microgravity Journal of gravitational physiology 2002;9 (1):P181-P182 [PubMed]
  • Smit Theo H., Huyghe Jacques M., Cowin Stephen C. Estimation of the poroelastic parameters of cortical bone Journal of biomechanics 2002;35 (6):829-835 [PubMed]
  • van Loon Jack J. W. A., Folgering Erik H. T. E., Bouten Carlijn V. C., Veldhuijzen J. Paul, Smit Theo H. Inertial shear force and the impact on facilities for the International Space Station Journal of gravitational physiology 2002;9 (1):P359-P360 [PubMed]
  • van Dijk M., Tunc D. C., Smit T. H., Higham P., Burger E. H., Wuisman P. I. J. M. In vitro and in vivo degradation of bioabsorbable PLLA spinal fusion cages Journal of biomedical materials research 2002;63 (6):752-759 [PubMed]
  • Wuisman P. I. J. M., van Dijk M., Smit T. H. Resorbable cages for spinal fusion: an experimental goat model Orthopedics 2002;25 (10 Suppl):s1141-s1148 [PubMed]
  • Wuisman P. I. J. M., van Dijk M., Smit T. H. Resorbable cages for spinal fusion: an experimental goat model Journal of neurosurgery 2002;97 (4 Suppl):433-439 [PubMed]
  • van Dijk Martijn, Smit Theo H., Sugihara S., Burger Elisabeth H., Wuisman Paul I. The effect of cage stiffness on the rate of lumbar interbody fusion: an in vivo model using poly(l-lactic Acid) and titanium cages Spine 2002;27 (7):682-688 [PubMed]
  • Smit Theo H. The use of a quadruped as an in vivo model for the study of the spine - biomechanical considerations European spine journal 2002;11 (2):137-144 [PubMed]

2001

  • Selles R. W., Wagenaar R. C., Smit T. H., Wuisman P. I. Disorders in trunk rotation during walking in patients with low back pain: a dynamical systems approach Clinical biomechanics (Bristol, Avon) 2001;16 (3):175-181 [PubMed]
  • van Dijk M., Smit T. H., Jiya T. U., Wuisman P. I. Polyurethane real-size models used in planning complex spinal surgery Spine 2001;26 (17):1920-1926 [PubMed]

2000

  • Deformity planning for sagittal plane corrective osteotomies of the spine in ankylosing spondylitis European spine journal 2000;9 (6):492-498 [PubMed]
  • Is BMU-coupling a strain-regulated phenomenon? A finite element analysis Journal of bone and mineral research 2000;15 (2):301-307 [PubMed]

1998

  • Star length distribution: a volume-based concept for the characterization of structural anisotropy Journal of microscopy 1998;191 (3):249-257 [PubMed]

1997

  • Structure and function of vertebral trabecular bone Spine 1997;22 (24):2823-2833 [PubMed]