Prof. N. de Vries MD PhD publications

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Publications Prof. N. de Vries MD PhD

Position
Full Professor
Main activities
Education, Patient care, Research
Specialisation
Rheumatology
Focus of research

Research Programe: “Adaptive immunomics”

In many autoimmune diseases, but also in immunity against infections and cancer cells, adaptive immune responses play a key role. Adequate monitoring of these responses and selective targeting offers hope of personalized, more selective and effective therapies with less side effects, and potentially cure. 

The adaptive responses mentioned above are driven by specific immune cells, T- and B-lymphocytes.  These cells are unique in that each individual lymphocyte has its own unique specificity, encoded within the antigen receptor, which is shared only with cells from the same clone. Dr de Vries and his team developed a novel tools that quantitatively fingerprint millions of individual lymphocyte receptors in blood or tissues, both in vitro and in vivo. This can be used to show which lymphocytes get activated and proliferate to form clones that dominate a given immune response. By comparing clonal expansion across tissues and across timelines, and combining these observations with results from in vitro assays, we are identifying and characterizing those clones that play a key role in health and specific disease states, with a focus on autoimmune disease. Detailed analysis of these clones helps to develop novel diagnostics, predictors and therapeutic targets.

Using this technology we developed:

1. a validated novel diagnostic marker for IgG4-related disease, which may prevent misdiagnosis of this relatively benign disease as cancer and lead to unnecessary surgery

  • Doorenspleet ME, Hubers LM, Culver EL, Maillette de Buy Wenniger LJ, Klarenbeek PL, Chapman RW, Baas F, van de Graaf SFJ, Verheij J, van Gulik TM, Barnes E, Beuers U, and N. de Vries. Immunoglobulin G4+ B-Cell Receptor Clones Distinguish Immunoglobulin G4-Related Disease From Primary Sclerosing Cholangitis and Biliary/ Pancreatic Malignancies. Hepatology 2016; 64(2):501-7.These results were validated in independent cohorts

2. a validated novel predictive marker that identifies a subgroup of individuals with autoantibody-positive arthralgia in which 91% of the individuals developed arthritis within 3 years. This patented technology might be used to prevent onset of arthritis in these individuals and reassure other patients who are not at imminent risk.

  • Tak PP, Doorenspleet ME, de Hair MJH, Klarenbeek PL, van Beers-Tas MH, van Kampen AHC, van Schaardenburg D, Gerlag DM, Baas F, de Vries N. Dominant B cell receptor clones in peripheral blood predict onset of arthritis in individuals at risk for rheumatoid arthritis. Ann Rheum Dis. 2017; 76(11):1924-30. doi: 10.1136/annrheumdis-2017-211351.

3. a novel diagnostic marker that identifies patients with active vasculitis

  • Al-Soudi A, M Doorenspleet, R. Esveldt, S. Tas, R, van Vollenhoven, P. Klarenbeek, N. De Vries. The IgG4:IgG RNA ratio is a new and promising disease activity marker in granulomatosis with polyangiitis. [abstract FRI0303]. EULAR June 16th 2017, Madrid, Spain. DOI: 10.1136/annrheumdis-2017-eular.5088.

Prospects

1. We are currently  expanding our analysis to other autoimmune diseases and happy to collaborate. Examples are rheumatoid arthritis, vasculitis, myositis, chronic inflammatory demyelinating polyneuropathy, Crohn's disease and IgG4-related disease. We also use our technologies to study related immune responses, e.g. anti-drug responses, or to get more insight into the development of immune responses in general. Many of these studies are performed in collaboration with local, national and international partners.

2. Also in collaboration with our partners we are characterizing the clones identified using single cell technologies. The ultimate goal is to develop tools that selectively downregulate disease-associated immune responses in autoimmune disease, thus providing the opportunity to intensify treatment of these diseases without the potential side-effects of standard immunosuppressive therapy, like infection or the slightly increased rates of tumor development. We think this approach will help to develop curative therapy in these diseases. 

3. In collaboration with partners we are aiming to implement our markers in health care in order to prevent autoimmune diseases, diagnose early and improve treatment results in our patients.


 

2020

  • Kavazović Inga, Han Hongya, Balzaretti Giulia, Slinger Erik, Lemmermann Niels A. W., ten Brinke Anja, Merkler Doron, Koster Jan, Bryceson Yenan T., de Vries Niek, Jonjić Stipan, Klarenbeek Paul L., Polić Bojan, Eldering Eric, Wensveen Felix M. Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity PLoS biology 2020;18 (3):e3000648 [PubMed]
  • Vroman Heleen, Balzaretti Giulia, Belderbos Robert A., Klarenbeek Paul L., van Nimwegen Menno, Bezemer Koen, Cornelissen Robin, Niewold Ilse T. G., van Schaik Barbera D., van Kampen Antione H., Aerts Joachim G. J. V., de Vries Niek, Hendriks Rudi W. T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma Journal for immunotherapy of cancer 2020;8 (1) [PubMed]

2019

  • Spiliopoulou Athina, Colombo Marco, Plant Darren, Nair Nisha, Cui Jing, Coenen Marieke J. H., Ikari Katsunori, Yamanaka Hisashi, Saevarsdottir Saedis, Padyukov Leonid, Bridges S. Louis, Kimberly Robert P., Okada Yukinori, van Riel Piet L. C. M., Wolbink Gertjan, van der Horst-Bruinsma Irene E., de Vries Niek, Tak Paul P., Ohmura Koichiro, Canhão Helena, Guchelaar Henk-Jan, Huizinga Tom W. J., Criswell Lindsey A., Raychaudhuri Soumya, Weinblatt Michael E., Wilson Anthony G., Mariette Xavier, Isaacs John D., Morgan Ann W., Pitzalis Costantino, Barton Anne, McKeigue Paul Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39 Annals of the rheumatic diseases 2019 [PubMed]
  • Prasetyanti Pramudita R., van Hooff Sander R., van Herwaarden Tessa, de Vries Nathalie, Kalloe Kieshen, Rodermond Hans, van Leersum Ronald, de Jong Joan H., Franitza Marek, Nürnberg Peter, Todaro Matilde, Stassi Giorgio, Medema Jan Paul Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models International journal of cancer. Journal international du cancer 2019;144 (2):366-371 [PubMed]
  • Gerlag Danielle M., Safy Mary, Maijer Karen I., Tang Man Wai, Tas Sander W., Starmans-Kool Mirian J. F., van Tubergen Astrid, Janssen Matthijs, de Hair Maria, Hansson Monika, de Vries Niek, Zwinderman Aeilko H., Tak Paul P. Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: The PRAIRI study Annals of the rheumatic diseases 2019;78 (2):179-185 [PubMed]
  • Germar Kristine, Fehres Cynthia M., Scherer Hans U., van Uden Nathalie, Pollastro Sabrina, Yeremenko Nataliya, Hansson Monika, Kerkman Priscilla F., van der Voort Ellen I. H., Reed Evan, Maassen Hanna, Kwakkenbos Mark J., Bakker Arjen Q., Klareskog Lars, Malmström Vivianne, de Vries Niek, Toes René E. M., Lundberg Karin, Spits Hergen, Baeten Dominique L. Generation and Characterization of Anti–Citrullinated Protein Antibody–Producing B Cell Clones From Rheumatoid Arthritis Patients Arthritis & rheumatology (Hoboken, N.J.) 2019;71 (3):340-350 [PubMed]
  • Schreurs Renée R. C. E., Baumdick Martin E., Sagebiel Adrian F., Kaufmann Max, Mokry Michal, Klarenbeek Paul L., Schaltenberg Nicola, Steinert Fenja L., van Rijn Jorik M., Drewniak Agata, The Sarah-May M. L., Bakx Roel, Derikx Joep P. M., de Vries Niek, Corpeleijn Willemijn E., Pals Steven T., Gagliani Nicola, Friese Manuel A., Middendorp Sabine, Nieuwenhuis Edward E. S., Reinshagen Konrad, Geijtenbeek Teunis B. H., van Goudoever Johannes B., Bunders Madeleine J. Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life Immunity 2019;50 (2):462-476.e8 [PubMed]
  • Bechara Rami, Pollastro Sabrina, Azoury Marie Eliane, Szely Natacha, Maillère Bernard, de Vries Niek, Pallardy Marc Identification and Characterization of Circulating Naïve CD4+ and CD8+ T Cells Recognizing Nickel Frontiers in immunology 2019;10:1331 [PubMed]
  • Al-Soudi A, Doorenspleet M E, Esveldt R E, Burgemeister L T, Hak A E, van den Born B J H, Tas S W, van Vollenhoven R F, Klarenbeek P L, de Vries N IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study Arthritis research & therapy 2019;21 (1):43 [PubMed]
  • Quistrebert Jocelyn, Hässler Signe, Bachelet Delphine, Mbogning Cyprien, Musters Anne, Tak Paul Peter, Wijbrandts Carla Ann, Herenius Marieke, Bergstra Sytske Anne, Akdemir G. lşah, Johannesson Martina, Combe Bernard, Fautrel Bruno, Chollet-Martin Sylvie, Gleizes Aude, Donnellan Naoimh, Deisenhammer Florian, Davidson Julie, Hincelin-Mery Agnès, Dönnes Pierre, Fogdell-Hahn Anna, de Vries Niek, Huizinga Tom, Abugessaisa Imad, Saevarsdottir Saedis, Hacein-Bey-Abina Salima, Pallardy Marc, Broët Philippe, Mariette Xavier Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritis: A European retrospective multicohort analysis Seminars in arthritis and rheumatism 2019;48 (6):967-975 [PubMed]
  • Pollastro Sabrina, Klarenbeek Paul L., Doorenspleet Marieke E., van Schaik Barbera D. C., Esveldt Rebecca E. E., Thurlings Rogier M., Boumans Maria J. H., Gerlag Danielle M., Tak Paul P., Vos Koen, Baas Frank, van Kampen Antoine H. C., de Vries Niek Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire Annals of the rheumatic diseases 2019;78 (10):1339-1345 [PubMed]
  • van Beers-Tas Marian H. Psychological and biological features influencing the risk for rheumatoid arthritis 2019. 233p. ISBN 9789463324281. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Schaardenburg D.; Co-supervisors: Nielen M. M. J., de Vries N.)

2018

  • Visser Annie, Doorenspleet Marieke E., de Vries Niek, Spijkervet Fred K. L., Vissink Arjan, Bende Richard J., Bootsma Hendrika, Kroese Frans G. M., Bos Nicolaas A. Acquisition of N-glycosylation sites in immunoglobulin heavy chain genes during local expansion in parotid salivary glands of primary Sjögren patients Frontiers in immunology 2018;9 (MAR) [PubMed]
  • de Jong Anja J., Pollastro Sabrina, Kwekkeboom Joanneke C., Andersen Stefan N., Dorjée Annemarie L., Bakker Aleida M., Alzaid Fawaz, Soprani Antoine, Nelissen Rob G. H. H., Mullers Jan B., Venteclef Nicolas, de Vries Niek, Kloppenburg Margreet, Toes René E. M., Ioan-Facsinay Andreea Functional and phenotypical analysis of IL-6-secreting CD4+ T cells in human adipose tissue European journal of immunology 2018;48 (3):471-48 [PubMed]
  • Roos Eva, Hubers Lowiek M., Coelen Robert J. S., Doorenspleet Marieke E., de Vries Niek, Verheij Joanne, Beuers Ulrich, van Gulik Thomas M. IgG4-Associated Cholangitis in Patients Resected for Presumed Perihilar Cholangiocarcinoma: A 30-Year Tertiary Care Experience American journal of gastroenterology 2018;113 (5):765-772 [PubMed]
  • Musters Anne, Klarenbeek Paul L., Doorenspleet Marieke E., Balzaretti Giulia, Esveldt Rebecca E. E., van Schaik Barbera D. C., Jongejan Aldo, Tas Sander W., van Kampen Antoine H. C., Baas Frank, de Vries Niek In rheumatoid arthritis, synovitis at different inflammatory sites is dominated by shared but patient-specific T cell clones Journal of immunology (Baltimore, Md. 2018;201 (2):417-422 [PubMed]
  • Maharaj Ajesh B., Naidoo Pragalathan, Ghazi Terisha, Abdul Naeem S., Dhani Shanel, Docrat Taskeen F., Ramkaran Prithiksha, Tak Paul-Peter, de Vries Niek, Chuturgoon Anil A. MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis BMC medical genetics 2018;19 (1) [PubMed]

2017

  • Cui Jing, Diogo Dorothee, Stahl Eli A., Canhao Helena, Mariette Xavier, Greenberg Jeffrey D., Okada Yukinori, Pappas Dimitrios A., Fulton Robert S., Tak Paul P., Nurmohamed Michael T., Lee Annette, Larson David E., Kurreeman Fina, Deluca Tracie L., O'Laughlin Michelle, Fronick Catrina C., Fulton Lucinda L., Mardis Elaine R., van der Horst-Bruinsma Irene E., Wolbink Gert-Jan, Gregersen Peter K., Kremer Joel M., Crusius J. Bart A., de Vries Niek, Huizinga Tom W. J., Fonseca João Eurico, Miceli-Richard Corinne, Karlson Elizabeth W., Coenen Marieke J. H., Barton Anne, Plenge Robert M., Raychaudhuri Soumya Brief Report: The Role of Rare Protein-Coding Variants in Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis Arthritis & rheumatology (Hoboken, N.J.) 2017;69 (4):735-741 [PubMed]
  • Reshetova Polina, van Schaik Barbera D. C., Klarenbeek Paul L., Doorenspleet Marieke E., Esveldt Rebecca E. E., Tak Paul-Peter, Guikema Jeroen E. J., de Vries Niek, van Kampen Antoine H. C. Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing Frontiers in immunology 2017;8:221 [PubMed]
  • Tak Paul P., Doorenspleet Marieke E., de Hair Maria J. H., Klarenbeek Paul L., van Beers-Tas Marian H., van Kampen Antoine H. C., van Schaardenburg Dirkjan, Gerlag Danielle M., Baas Frank, de Vries Niek Dominant B cell receptor clones in peripheral blood predict onset of arthritis in individuals at risk for rheumatoid arthritis Annals of the rheumatic diseases 2017;76 (11):1924-1930 [PubMed]
  • Ramos-Remus Cesar, Ramirez-Gomez Andrea, Brambila-Barba Victor, Barajas-Ochoa Aldo, Castillo-Ortiz Jose D., Adebajo Adewale O., Espinoza Luis R., Aceves-Avila Francisco J., Sánchez-González Jorge M., Boudersa Nadia, Slimani Samy, Ladjouze-Rezig Aicha, Diaz Mónica P., Kirmayr Karin I., Asnal Cecilia A., Catoggio Luis J., Citera Gustavo, Casado Gustavo C., Alvarez Analia P., Pisoni Cecilia N., Benavente Emilio, Lopez-Cabanillas Adriana, Baez Roberto M., Pons-Estel Bernardo A., Sacnún Mónica P., Cavallasca Javier A., Paniego Raúl H., Proudman Susanna M., Thomas Ranjeny, Major Gabor, Mathers David M., Schrieber Leslie, Haq Syed A., Islam Nazrul, Dessein Patrick H., von Muhlen Carlos A., Bianchi Washington A., da R Castelar-Pinheiro Geraldo, Feldman-Pollak Daniel, Cossermelli Waldenise, Bonfiglioli Karina R., Giorgi Rina D., Zabsonre-Tiendrebeogo Wendlassida J., Russell Anthony S., Olaru Lilia, Karsh Jacob, Fuentealba Carlos, Aguilera Sergio, de Vries Niek, van Vollenhoven Ronald F. Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey Clinical rheumatology 2017;36 (3):485-497 [PubMed]
  • Doorenspleet M. E., Westera L., Peters C. P., Hakvoort T. B. M., Esveldt R. E., Vogels E., van Kampen A. H. C., Baas F., Buskens C., Bemelman W. A., D'Haens G., Ponsioen C. Y., te Velde A. A., de Vries N. [=Niek], van den Brink G. R. Profoundly Expanded T-cell Clones in the Inflamed and Uninflamed Intestine of Patients With Crohn's Disease Journal of Crohn s & colitis 2017;11 (7):831-839 [PubMed]
  • Schultz Heidi S., Reedtz-Runge Stine Louise, Bäckström B. Thomas, Lamberth Kasper, Pedersen Christian R., Kvarnhammar Anne M., de Vries Niek Quantitative analysis of the CD4+ T cell response to therapeutic antibodies in healthy donors using a novel T cell:PBMC assay PLoS ONE 2017;12 (5):e0178544 [PubMed]
  • Jamnitski Anna, van Hall Odile, de Vries Niek, van der Valk Paul, Lems Willem F., van der Horst-Bruinsma Irene E. Symptomatic unilateral sacroiliitis as a first presenting feature of IgG4-related disease with successful response to treatment after 1 year of follow-up article Rheumatology (Oxford, England) 2017;56 (4):670-671 [PubMed]

2016

  • Chemin Karine, Pollastro Sabrina, James Eddie, Ge Changrong, Albrecht Inka, Herrath Jessica, Gerstner Christina, Tandre Karolina, Sampaio Rizzi Thais, Rönnblom Lars, Catrina Anca, Holmdahl Rikard, Klareskog Lars, de Vries Niek, Malmström Vivianne A Novel HLA-DRB1*10:01-Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis Arthritis & rheumatology (Hoboken, N.J.) 2016;68 (5):1124-1135 [PubMed]
  • Sieberts Solveig K., Zhu Fan, García-García Javier, Stahl Eli, Pratap Abhishek, Pandey Gaurav, Pappas Dimitrios, Aguilar Daniel, Anton Bernat, Bonet Jaume, Eksi Ridvan, Fornés Oriol, Guney Emre, Li Hongdong, Marín Manuel Alejandro, Panwar Bharat, Planas-Iglesias Joan, Poglayen Daniel, Cui Jing, Falcao Andre O., Suver Christine, Hoff Bruce, Balagurusamy Venkat S. K., Dillenberger Donna, Neto Elias Chaibub, Norman Thea, Aittokallio Tero, Ammad-Ud-Din Muhammad, Azencott Chloe-Agathe, Bellón Víctor, Boeva Valentina, Bunte Kerstin, Chheda Himanshu, Cheng Lu, Corander Jukka, Dumontier Michel, Goldenberg Anna, Gopalacharyulu Peddinti, Hajiloo Mohsen, Hidru Daniel, Jaiswal Alok, Kaski Samuel, Khalfaoui Beyrem, Khan Suleiman Ali, Kramer Eric R., Marttinen Pekka, Mezlini Aziz M., de Vries Niek, Tak Paul P., Gerlag Danielle Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis Nature communications 2016;7:12460 [PubMed]
  • Doorenspleet Marieke E., Hubers Lowiek M., Culver Emma L., Maillette de Buy Wenniger Lucas J., Klarenbeek Paul L., Chapman Roger W., Baas Frank, van de Graaf Stan F., Verheij Joanne, van Gulik Thomas M., Barnes Eleanor, Beuers Ulrich, de Vries Niek Immunoglobulin G4(+) B-cell receptor clones distinguish immunoglobulin G 4-related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies Hepatology (Baltimore, Md.) 2016;64 (2):501-507 [PubMed]
  • Maharaj Ajesh Basantharan, Rajkaran Michelle, Govender Jayandran, Maharaj Kasthurba, de Vries Niek, Tak Paul-Peter Psoriatic arthritis: An assessment of clinical, biochemical and radiological features in a single-centre South African cohort South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2016;106 (6):630-633 [PubMed]
  • Chemin Karine, Albrecht Inka, Pollastro Sabrina, de Vries Niek, Holmdahl Rikard, Malmström Vivianne Reply: Is citrullination required for the presence of restricted clonotypes reacting with type II collagen? Comment on the article by Chemin et al Arthritis & rheumatology (Hoboken, N.J.) 2016;68 (8):2053-2054 [PubMed]

2015

  • Bossini-Castillo L., de Kovel C., Kallberg H., van 't Slot R., Italiaander A., Coenen M., Tak P. P., Posthumus M. D., Wijmenga C., Huizinga T., van der Helm-van Mil A. H. M., Stoeken-Rijsbergen G., Rodriguez-Rodriguez Luis, Balsa Alejandro, González-Álvaro Isidoro, González-Gay Miguel Ángel, Gómez-Vaquero Carmen, Franke B., Vermeulen S., van der Horst-Bruinsma Ie, Dijkmans B. A. C., Wolbink G. J., Ophoff R. A., Maehlen M. T., van Riel P., Merriman M., Klareskog L., Lie B. A., Merriman T., Crusius J. B. A., Brouwer E., Martin J., de Vries N. [=Niek], Toes R., Padyukov L., Koeleman B. P. C. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides Annals of the rheumatic diseases 2015;74 (3):e15 [PubMed]
  • Remmerswaal Ester B. M., Klarenbeek Paul L., Alves Nuno L., Doorenspleet Marieke E., van Schaik Barbera D. C., Esveldt Rebecca E. E., Idu Mirza M., van Leeuwen Ester M. M., van der Bom-Baylon Nelly, van Kampen Antoine H. C., Koch Sven D., Pircher Hanspeter, Bemelman Frederike J., ten Brinke Anja, Baas Frank, ten Berge Ineke J. M., van Lier Rene A. W., de Vries Niek Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function Journal of virology 2015;89 (1):568-580 [PubMed]
  • Hubers Lowiek M., Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke E., Klarenbeek Paul L., Verheij Joanne, Rauws Erik A., van Gulik Thomas M., Oude Elferink Ronald P. J., van de Graaf Stan F. J., de Vries Niek, Beuers Ulrich IgG4-associated cholangitis: a comprehensive review Clinical reviews in allergy & immunology 2015;48 (2-3):198-206 [PubMed]
  • Beuers Ulrich, Hubers Lowiek M., Doorenspleet Marieke, Maillette de Buy Wenniger Lucas, Klarenbeek Paul L., Boonstra Kirsten, Ponsioen Cyriel, Rauws Erik, de Vries Niek IgG4-Associated Cholangitis--A Mimic of PSC Digestive diseases (Basel, Switzerland) 2015;33 (Suppl. 2):176-180 [PubMed]
  • Lee S. Hong, Byrne Enda M., Hultman Christina M., Kähler Anna, Vinkhuyzen Anna A. E., Ripke Stephan, Andreassen Ole A., Frisell Thomas, Gusev Alexander, Hu Xinli, Karlsson Robert, Mantzioris Vasilis X., McGrath John J., Mehta Divya, Stahl Eli A., Zhao Qiongyi, Kendler Kenneth S., Sullivan Patrick F., Price Alkes L., O'Donovan Michael, Okada Yukinori, Mowry Bryan J., Raychaudhuri Soumya, Wray Naomi R., Byerley William, Cahn Wiepke, Cantor Rita M., Cichon Sven, Cormican Paul, Curtis David, Djurovic Srdjan, Escott-Price Valentina, Gejman Pablo V., Georgieva Lyudmila, Giegling Ina, Hansen Thomas F., Ingason Andrés, Kim Yunjung, Konte Bettina, Lee Phil H., McIntosh Andrew, McQuillin Andrew, Morris Derek W., Nöthen Markus M., O'Dushlaine Colm, Olincy Ann, Olsen Line, Pato Carlos N., Pato Michele T., Pickard Benjamin S., Posthuma Danielle, Rasmussen Henrik B., Rietschel Marcella, Rujescu Dan, Schulze Thomas G., Silverman Jeremy M., Thirumalai Srinivasa, Werge Thomas, Agartz Ingrid, Amin Farooq, Azevedo Maria H., Bass Nicholas, Black Donald W., Blackwood Douglas H. R., Bruggeman Richard, Buccola Nancy G., Choudhury Khalid, Cloninger Robert C., Corvin Aiden, Craddock Nicholas, Daly Mark J., Datta Susmita, Donohoe Gary J., Duan Jubao, Dudbridge Frank, Fanous Ayman, Freedman Robert, Freimer Nelson B., Friedl Marion, Gill Michael, Gurling Hugh, de Haan Lieuwe, Hamshere Marian L., Hartmann Annette M., Holmans Peter A., Kahn René S., Keller Matthew C., Kenny Elaine, Kirov George K., Krabbendam Lydia, Krasucki Robert, Lawrence Jacob, Lencz Todd, Levinson Douglas F., Lieberman Jeffrey A., Lin Dan-Yu, Linszen Don H., Magnusson Patrik K. E., Maier Wolfgang, Malhotra Anil K., Mattheisen Manuel, Mattingsdal Morten, McCarroll Steven A., Medeiros Helena, Melle Ingrid, Milanova Vihra, Myin-Germeys Inez, Neale Benjamin M., Ophoff Roel A., Owen Michael J., Pimm Jonathan, Purcell Shaun M., Puri Vinay, Quested Digby J., Rossin Lizzy, Ruderfer Douglas, Sanders Alan R., Shi Jianxin, Sklar Pamela, St Clair David, Stroup T. Scott, van Os Jim, Visscher Peter M., Wiersma Durk, Zammit Stanley, Bridges S. Louis, Choi Hyon K., Coenen Marieke J. H., de Vries Niek, Dieud Philippe, Greenberg Jeffrey D., Huizinga Tom W. J., Padyukov Leonid, Siminovitch Katherine A., Tak Paul P., Worthington Jane, de Jager Philip L., Denny Joshua C., Gregersen Peter K., Klareskog Lars, Mariette Xavier, Plenge Robert M., van Laar Mart, van Riel Piet New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis International journal of epidemiology 2015;44 (5):1706-1721 [PubMed]
  • Klarenbeek Paul L., Doorenspleet Marieke E., Esveldt Rebecca E. E., van Schaik Barbera D. C., Lardy Neubury, van Kampen Antoine H. C., Tak Paul P., Plenge Robert M., Baas Frank, de Bakker Paul I. W., de Vries Niek Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction PLoS ONE 2015;10 (10):e0140815 [PubMed]
  • Rup B., Pallardy M., Sikkema D., Albert T., Allez M., Broet P., Carini C., Creeke P., Davidson J., de Vries N. [=Niek], Finco D., Fogdell-Hahn A., Havrdova E., Hincelin-Mery A., C Holland M., H Jensen P. E., Jury E. C., Kirby H., Kramer D., Lacroix-Desmazes S., Legrand J., Maggi E., Maillère B., Mariette X., Mauri C., Mikol V., Mulleman D., Oldenburg J., Paintaud G., R Pedersen C., Ruperto N., Seitz R., Spindeldreher S., Deisenhammer F. Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: recommendations of the Innovative Medicines Initiative ABIRISK consortium Clinical and experimental immunology 2015;181 (3):385-400 [PubMed]
  • Maillette de Buy Wenniger Lucas Joseph The biliary tree in health and immune-mediated disease 2015. 243p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Beuers U. H. W., Oude Elferink R. P. J.; Co-supervisor: de Vries N. [=Niek])
  • Diogo Dorothée, Bastarache Lisa, Liao Katherine P., Graham Robert R., Fulton Robert S., Greenberg Jeffrey D., Eyre Steve, Bowes John, Cui Jing, Lee Annette, Pappas Dimitrios A., Kremer Joel M., Barton Anne, Coenen Marieke J. H., Franke Barbara, Kiemeney Lambertus A., Mariette Xavier, Richard-Miceli Corrine, Canhão Helena, Fonseca João E., de Vries Niek, Tak Paul P., Crusius J. Bart A., Nurmohamed Michael T., Kurreeman Fina, Mikuls Ted R., Okada Yukinori, Stahl Eli A., Larson David E., Deluca Tracie L., O'Laughlin Michelle, Fronick Catrina C., Fulton Lucinda L., Kosoy Roman, Ransom Michael, Bhangale Tushar R., Ortmann Ward, Cagan Andrew, Gainer Vivian, Karlson Elizabeth W., Kohane Isaac, Murphy Shawn N., Martin Javier, Zhernakova Alexandra, Klareskog Lars, Padyukov Leonid, Worthington Jane, Mardis Elaine R., Seldin Michael F., Gregersen Peter K., Behrens Timothy, Raychaudhuri Soumya, Denny Joshua C., Plenge Robert M. TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits PLoS ONE 2015;10 (4):e0122271 [PubMed]

2014

  • van Schaik Barbera, Klarenbeek Paul, Doorenspleet Marieke, van Kampen Antoine, Moody D. Branch, de Vries Niek, van Rhijn Ildiko Discovery of invariant T cells by next-generation sequencing of the human TCR α-chain repertoire Journal of immunology (Baltimore, Md. 2014;193 (10):5338-5344 [PubMed]
  • Hoving J. L., Zoer I., van der Meer M., van der Straaten Y., Logtenberg-Rutten C., Kraak-Put S., de Vries N. [=Niek], Tak P. P., Sluiter J. K., Frings-Dresen M. H. W. E-health to improve work functioning in employees with rheumatoid arthritis in rheumatology practice: a feasibility study Scandinavian journal of rheumatology 2014;43 (6):481-487 [PubMed]
  • Okada Yukinori, Wu Di, Trynka Gosia, Raj Towfique, Terao Chikashi, Ikari Katsunori, Kochi Yuta, Ohmura Koichiro, Suzuki Akari, Yoshida Shinji, Graham Robert R., Manoharan Arun, Ortmann Ward, Bhangale Tushar, Denny Joshua C., Carroll Robert J., Eyler Anne E., Greenberg Jeffrey D., Kremer Joel M., Pappas Dimitrios A., Jiang Lei, Yin Jian, Ye Lingying, Su Ding-Feng, Yang Jian, Xie Gang, Keystone Ed, Westra Harm-Jan, Esko Tõnu, Metspalu Andres, Zhou Xuezhong, Gupta Namrata, Mirel Daniel, Stahl Eli A., Diogo Dorothée, Cui Jing, Liao Katherine, Guo Michael H., Myouzen Keiko, Kawaguchi Takahisa, Coenen Marieke J. H., van Riel Piet L. C. M., van de Laar Mart A. F. J., Guchelaar Henk-Jan, Huizinga Tom W. J., Dieudé Philippe, Mariette Xavier, Bridges S. Louis, Tak Paul P., de Vries Niek Genetics of rheumatoid arthritis contributes to biology and drug discovery Nature 2014;506 (7488):376-+ [PubMed]
  • Beuers Ulrich, Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke, Hubers Lowiek, Verheij Joanne, van Gulik Thomas, van de Graaf Stan F. J., de Vries Niek IgG4-associated cholangitis Digestive diseases (Basel, Switzerland) 2014;32 (5):605-608 [PubMed]
  • Okada Yukinori, Diogo Dorothee, Greenberg Jeffrey D., Mouassess Faten, Achkar Walid A. L., Fulton Robert S., Denny Joshua C., Gupta Namrata, Mirel Daniel, Gabriel Stacy, Li Gang, Kremer Joel M., Pappas Dimitrios A., Carroll Robert J., Eyler Anne E., Trynka Gosia, Stahl Eli A., Cui Jing, Saxena Richa, Coenen Marieke J. H., Guchelaar Henk-Jan, Huizinga Tom W. J., Dieudé Philippe, Mariette Xavier, Barton Anne, Canhão Helena, Fonseca João E., de Vries Niek, Tak Paul P., Moreland Larry W., Bridges S. Louis, Miceli-Richard Corinne, Choi Hyon K., Kamatani Yoichiro, Galan Pilar, Lathrop Mark, Raj Towfique, de Jager Philip L., Raychaudhuri Soumya, Worthington Jane, Padyukov Leonid, Klareskog Lars, Siminovitch Katherine A., Gregersen Peter K., Mardis Elaine R., Arayssi Thurayya, Kazkaz Layla A., Plenge Robert M. Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene PLoS ONE 2014;9 (2):e87645 [PubMed]
  • Doorenspleet M. E., Klarenbeek P. L., de Hair M. J. H., van Schaik B. D. C., Esveldt R. E. E., van Kampen A. H. C., Gerlag D. M., Musters A. [=Anne], Baas F., Tak P. P., de Vries N. [=Niek] Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity Annals of the rheumatic diseases 2014;73 (4):756-762 [PubMed]

2013

  • van Rhijn Ildiko, Kasmar Anne, de Jong Annemieke, Gras Stephanie, Bhati Mugdha, Doorenspleet Marieke E., de Vries Niek, Godfrey Dale I., Altman John D., de Jager Wilco, Rossjohn Jamie, Moody D. Branch A conserved human T cell population targets mycobacterial antigens presented by CD1b Nature immunology 2013;14 (7):706-713 [PubMed]
  • Herenius Marieke M. J. Anti-TNF therapy in rheumatoid arthritis: searching for mechanisms of effect 2013. 117p. ISBN 9789461822628. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Tak P. P.; Co-supervisors: Gerlag D. M., de Vries Niek)
  • Kuijpers Taco W., van Leeuwen Ester M. M., Barendregt Barbara H., Klarenbeek Paul, Aan de Kerk Daan J., Baars Paul A., Jansen Machiel H., de Vries Niek, van Lier René A. W., van der Burg Mirjam A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells Haematologica 2013;98 (7):1030-1038 [PubMed]
  • Klarenbeek Paul L. Beyond the keyhole perspective. Quantitative and full repertoire imaging of T- and B-cell receptors using next generation sequencing 2013. 145p. ISBN 9789461823601. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Tak P. P., Baas F.; Co-supervisor: de Vries Niek)
  • Plenge Robert M., Greenberg Jeffrey D., Mangravite Lara M., Derry Jonathan M. J., Stahl Eli A., Coenen Marieke J. H., Barton Anne, Padyukov Leonid, Klareskog Lars, Gregersen Peter K., Mariette Xavier, Moreland Larry W., Bridges S. Louis, de Vries Niek, Huizinga Tom W. J., Guchelaar Henk-Jan, Friend Stephen H., Stolovitzky Gustavo, Cui Jing, Saevarsdottir Saedis, Miceli Corinne, Diogo Dorothee, Mirkov N. N., Canhao Helena, Ikari Katsunori, Terao Chikashi, Okada Yukinori, Wedri Sara, Askling Johan, Yamanaka Hisashi, Momohara Shigeki, Taniguchi Atsuo, Ohmura Koichiro, Matsuda Fumihiko, Mimori Tsuneyo, Gupta Namrata, Kuchroo Manik, Morgan Ann W., Isaacs John D., Wilson Anthony G., Hyrich Kimme L., Herenius Marieke, Doorenspleet Marieke E., Tak Paul-Peter, Crusius J. Bart A., van der Horst-Bruinsma Irene E., Wolbink Gert Jan, van Riel Piet L. C. M., van de Laar Mart, Shadick Nancy A. Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge Nature genetics 2013;45 (5):468-469 [PubMed]
  • Umiċeviċ Mirkov Maša, Cui Jing, Vermeulen Sita H., Stahl Eli A., Toonen Erik J. M., Makkinje Remco R., Lee Annette T., Huizinga Tom W. J., Allaart Renee, Barton Anne, Mariette Xavier, Miceli Corinne Richard, Criswell Lindsey A., Tak Paul P., de Vries Niek, Saevarsdottir Saedis, Padyukov Leonid, Bridges S. Louis, van Schaardenburg Dirk-Jan, Jansen Tim L., Dutmer Ellen A. J., van de Laar Mart A. F. J., Barrera Pilar, Radstake Timothy R. D. J., van Riel Piet L. C. M., Scheffer Hans, Franke Barbara, Brunner Han G., Plenge Robert M., Gregersen Peter K., Guchelaar Henk-Jan, Coenen Marieke J. H. Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis Annals of the rheumatic diseases 2013;72 (8):1375-1381 [PubMed]
  • Cui Jing, Stahl Eli A., Saevarsdottir Saedis, Miceli Corinne, Diogo Dorothee, Trynka Gosia, Raj Towfique, Mirkov Maša Umiċeviċ, Canhao Helena, Ikari Katsunori, Terao Chikashi, Okada Yukinori, Wedrén Sara, Askling Johan, Yamanaka Hisashi, Momohara Shigeki, Taniguchi Atsuo, Ohmura Koichiro, Matsuda Fumihiko, Mimori Tsuneyo, Gupta Namrata, Kuchroo Manik, Morgan Ann W., Isaacs John D., Wilson Anthony G., Hyrich Kimme L., Herenius Marieke, Doorenspleet Marieke E., Tak Paul-Peter, Crusius J. Bart A., van der Horst-Bruinsma Irene E., Wolbink Gert Jan, van Riel Piet L. C. M., van de Laar Mart, Guchelaar Henk-Jan, Shadick Nancy A., Allaart Cornelia F., Huizinga Tom W. J., Toes Rene E. M., Kimberly Robert P., Bridges S. Louis, Criswell Lindsey A., Moreland Larry W., Fonseca João Eurico, de Vries Niek, Stranger Barbara E., de Jager Philip L., Raychaudhuri Soumya, Weinblatt Michael E., Gregersen Peter K., Mariette Xavier, Barton Anne, Padyukov Leonid, Coenen Marieke J. H., Karlson Elizabeth W., Plenge Robert M. Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis PLoS genetics 2013;9 (3):e1003394 [PubMed]
  • Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke E., Verheij Joanne, de Vries Niek, Beuers Ulrich IgG4-gerelateerde ziekte Nederlands tijdschrift voor geneeskunde 2013;157 (46):A6476 [PubMed]
  • Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke E., Klarenbeek Paul L., Verheij Joanne, Baas Frank, Elferink Ronald P. Oude, Tak Paul P., de Vries Niek, Beuers Ulrich Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis Hepatology (Baltimore, Md.) 2013;57 (6):2390-2398 [PubMed]
  • Wensveen Felix M., Klarenbeek Paul L., van Gisbergen Klaas P. J. M., Pascutti Maria F., Derks Ingrid A. M., van Schaik Barbera D. C., ten Brinke Anja, de Vries Niek, Cekinovic Durdica, Jonjic Stipan, van Lier René A. W., Eldering Eric Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology Journal of immunology (Baltimore, Md. 2013;190 (3):1180-1191 [PubMed]
  • Zoer Ilona, Hoving Jan, van der Meer Marrit, van der Straaten Yvonne, Logtenberg Carin, Kraak-Put Simone, de Vries Niek, Tak Paul-Peter, Sluiter Judith, Frings-Dresen Monique Reuma@work: Haalbaarheid van een e-healthinterventie om werkfunctioneren van werknemers met reuma te verbeteren Tijdschrift voor bedrijfs- en verzekeringsgeneeskunde 2013;21 (3):111-116

2012

  • Klarenbeek P. L., Remmerswaal E. B. M., ten Berge I. J. M., Doorenspleet M. E., van Schaik B. D. C., Esveldt R. E. E., Koch S. D., ten Brinke A., van Kampen A. H. C., Bemelman F. J., Tak P. P., Baas F., de Vries N. [=Niek], van Lier R. A. W. Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years PLoS pathogens 2012;8 (9):e1002889 [PubMed]
  • Kok M. R., de Vries N. [=Niek], Remans P. H. J., Van Warmerdam F. R. A. M., Tak P. P. Huidsclerosein: Tim L. Jansen, Piet L. C. M. van Riel, P. P. Tak, editors. Reumatologie in Beeld. Houten: Springer Media; 2012. p. 64-65, ISBN 9789031387830
  • Cantaert Tineke, Doorenspleet Marieke E., Francosalinas Gabriela, Paramarta Jaqueline E., Klarenbeek Paul L., Tiersma Yvonne, van der Loos Chris M., de Vries Niek, Tak Paul Peter, Baeten Dominique L. Increased numbers of CD5+ B lymphocytes with a regulatory phenotype in spondylarthritis Arthritis and rheumatism 2012;64 (6):1859-1868 [PubMed]
  • Klarenbeek P. L., de Hair M. J. H., Doorenspleet M. E., van Schaik B. D. C., Esveldt R. E. E., van de Sande M. G. H., Cantaert T., Gerlag D. M., Baeten D., van Kampen A. H. C., Baas F., Tak P. P., de Vries N. [=Niek] Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease Annals of the rheumatic diseases 2012;71 (6):1088-1093 [PubMed]
  • Bunders Madeleine J., van der Loos Chris M., Klarenbeek Paul L., van Hamme John L., Boer Kees, Wilde Jim C. H., de Vries Niek, van Lier Rene A. W., Kootstra Neeltje, Pals Steven T., Kuijpers Taco W. Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1 Blood 2012;120 (22):4383-4390 [PubMed]
  • Shen Nan Micromanagement of lupus autoimmunity by microRNAs 2012. 149p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Tak P. P.; Co-supervisor: de Vries N. [=Niek])
  • Shen Nan, Liang Dong, Tang Yuanjia, de Vries Niek, Tak Paul-Peter MicroRNAs-novel regulators of systemic lupus erythematosus pathogenesis Nature reviews. Rheumatology 2012;8 (12):701-709 [PubMed]

2011

  • Luo Xiaobing, Yang Wanling, Ye Dong-Qing, Cui Huijuan, Zhang Yan, Hirankarn Nattiya, Qian Xiaoxia, Tang Yuanjia, Lau Yu Lung, de Vries Niek, Tak Paul Peter, Tsao Betty P., Shen Nan A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus PLoS genetics 2011;7 (6):e1002128 [PubMed]
  • van de Sande M. G. H., de Hair M. J. H., van der Leij C., Klarenbeek P. L., Bos W. H., Smith M. D., Maas M., de Vries N. [=Niek], van Schaardenburg D., Dijkmans B. A. C., Gerlag D. M., Tak P. P. Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase Annals of the rheumatic diseases 2011;70 (5):772-777 [PubMed]

2010

  • Bos W. H., Wolbink G. J., Boers M., Tijhuis G. J., de Vries N. [=Niek], van der Horst-Bruinsma I. E., Tak P. P., van de Stadt R. J., van der Laken C. J., Dijkmans B. A. C., van Schaardenburg D. Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study Annals of the rheumatic diseases 2010;69 (3):490-494 [PubMed]
  • Stahl Eli A., Raychaudhuri Soumya, Remmers Elaine F., Xie Gang, Eyre Stephen, Thomson Brian P., Li Yonghong, Kurreeman Fina A. S., Zhernakova Alexandra, Hinks Anne, Guiducci Candace, Chen Robert, Alfredsson Lars, Amos Christopher I., Ardlie Kristin G., Barton Anne, Bowes John, Brouwer Elisabeth, Burtt Noel P., Catanese Joseph J., Coblyn Jonathan, Coenen Marieke J. H., Costenbader Karen H., Criswell Lindsey A., Crusius J. Bart A., Cui Jing, de Bakker Paul I. W., de Jager Philip L., Ding Bo, Emery Paul, Flynn Edward, Harrison Pille, Hocking Lynne J., Huizinga Tom W. J., Kastner Daniel L., Ke Xiayi, Lee Annette T., Liu Xiangdong, Martin Paul, Morgan Ann W., Padyukov Leonid, Posthumus Marcel D., Radstake Timothy R. D. J., Reid David M., Seielstad Mark, Seldin Michael F., Shadick Nancy A., Steer Sophia, Tak Paul P., Thomson Wendy, van der Helm-van Mil Annette H. M., van der Horst-Bruinsma Irene E., van der Schoot C. Ellen, van Riel Piet L. C. M., Weinblatt Michael E., Wilson Anthony G., Wolbink Gert Jan, Wordsworth B. Paul, Wijmenga Cisca, Karlson Elizabeth W., Toes Rene E. M., de Vries Niek, Begovich Ann B., Worthington Jane, Siminovitch Katherine A., Gregersen Peter K., Klareskog Lars, Plenge Robert M. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci Nature genetics 2010;42 (6):508-U56 [PubMed]
  • Klarenbeek Paul L., Tak Paul P., van Schaik Barbera D. C., Zwinderman Aeilko H., Jakobs Marja E., Zhang Zhuoli, van Kampen Antoine H. C., van Lier René A. W., Baas Frank, de Vries Niek Human T-cell memory consists mainly of unexpanded clones Immunology letters 2010;133 (1):42-48 [PubMed]
  • Cui Jing, Saevarsdottir Saedis, Thomson Brian, Padyukov Leonid, van der Helm-van Mil Annette H. M., Nititham Joanne, Hughes Laura B., de Vries Niek, Raychaudhuri Soumya, Alfredsson Lars, Askling Johan, Wedrén Sara, Ding Bo, Guiducci Candace, Wolbink Gert Jan, Crusius J. Bart A., van der Horst-Bruinsma Irene E., Herenius Marieke, Weinblatt Michael E., Shadick Nancy A., Worthington Jane, Batliwalla Franak, Kern Marlena, Morgan Ann W., Wilson Anthony G., Isaacs John D., Hyrich Kimme, Seldin Michael F., Moreland Larry W., Behrens Timothy W., Allaart Cornelia F., Criswell Lindsey A., Huizinga Tom W. J., Tak Paul P., Bridges S. Louis, Toes Rene E. M., Barton Anne, Klareskog Lars, Gregersen Peter K., Karlson Elizabeth W., Plenge Robert M. Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy Arthritis and rheumatism 2010;62 (7):1849-1861 [PubMed]

2009

  • Cantaert Tineke, Brouard Sophie, Thurlings Rogier M., Pallier Annaick, Salinas Gabriela Franco, Braud Christophe, Klarenbeek Paul L., de Vries Niek, Zhang Yiping, Soulillou Jean-Paul, Tak Paul P., Baeten Dominique Alterations of the Synovial T Cell Repertoire in Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Arthritis and rheumatism 2009;60 (7):1944-1956 [PubMed]
  • Bartelds G. M., Wijbrandts C. A., Nurmohamed M. T., Wolbink G. J., de Vries N. [=Niek], Tak P. P., Dijkmans B. A. C., Crusius J. B. A., Vand der Horst-Bruinsma I. E. Anti-adalimumab antibodies in rheumatoid arthritis patients are associated with interleukin-10 gene polymorphisms Arthritis and rheumatism 2009;60 (8):2541-2542 [PubMed]
  • Raychaudhuri Soumya, Thomson Brian P., Remmers Elaine F., Eyre Stephen, Hinks Anne, Guiducci Candace, Catanese Joseph J., Xie Gang, Stahl Eli A., Chen Robert, Alfredsson Lars, Amos Christopher I., Ardlie Kristin G., Barton Anne, Bowes John, Burtt Noel P., Chang Monica, Coblyn Jonathan, Costenbader Karen H., Criswell Lindsey A., Crusius J. Bart A., Cui Jing, de Jager Phillip L., Ding Bo, Emery Paul, Flynn Edward, Harrison Pille, Hocking Lynne J., Huizinga Tom W. J., Kastner Daniel L., Ke Xiayi, Kurreeman Fina A. S., Lee Annette T., Liu Xiangdong, Li Yonghong, Martin Paul, Morgan Ann W., Padyukov Leonid, Reid David M., Seielstad Mark, Seldin Michael F., Shadick Nancy A., Steer Sophia, Tak Paul P., Thomson Wendy, van der Helm-van Mil Annette H. M., van der Horst-Bruinsma Irene E., Weinblatt Michael E., Wilson Anthony G., Wolbink Gert Jan, Wordsworth Paul, Altshuler David, Karlson Elizabeth W., Toes Rene E. M., de Vries Niek, Begovich Ann B., Siminovitch Katherine A., Worthington Jane, Klareskog Lars, Gregersen Peter K., Daly Mark J., Plenge Robert M. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk Nature genetics 2009;41 (12):1313-U76 [PubMed]
  • Tang Yuanjia, Luo Xiaobing, Cui Huijuan, Ni Xuming, Yuan Min, Guo Yanzhi, Huang Xinfang, Zhou Haibo, de Vries Niek, Tak Paul Peter, Chen Shunle, Shen Nan MicroRNA-146a Contributes to Abnormal Activation of the Type I Interferon Pathway in Human Lupus by Targeting the Key Signaling Proteins Arthritis and rheumatism 2009;60 (4):1065-1075 [PubMed]
  • van der Laan Willemijn H., Faber William R., de Vries Niek, Maas Mario, Tak Paul Peter 'Reumatoïde artritis' bij een Surinaamse man: lepra Nederlands tijdschrift voor geneeskunde 2009;153:A246 [PubMed]

2008

  • Cantaert T., Stone M. A., ter Borg M., Mogg R., de Vries N. [=Niek], Wilson A. G., Tak P. P., Baeten D. A functional polymorphism of TIR-domain-containing adaptor protein is not associated with axial spondyloarthritis Annals of the rheumatic diseases 2008;67 (5):720-722 [PubMed]
  • Raychaudhuri Soumya, Remmers Elaine F., Lee Annette T., Hackett Rachel, Guiducci Candace, Burtt Noël P., Gianniny Lauren, Korman Benjamin D., Padyukov Leonid, Kurreeman Fina A. S., Chang Monica, Catanese Joseph J., Ding Bo, Wong Sandra, van der Helm-van Mil Annette H. M., Neale Benjamin M., Coblyn Jonathan, Cui Jing, Tak Paul P., Wolbink Gert Jan, Crusius J. Bart A., van der Horst-Bruinsma Irene E., Criswell Lindsey A., Amos Christopher I., Seldin Michael F., Kastner Daniel L., Ardlie Kristin G., Alfredsson Lars, Costenbader Karen H., Altshuler David, Huizinga Tom W. J., Shadick Nancy A., Weinblatt Michael E., de Vries Niek, Worthington Jane, Seielstad Mark, Toes Rene E. M., Karlson Elizabeth W., Begovich Ann B., Klareskog Lars, Gregersen Peter K., Daly Mark J., Plenge Robert M. Common variants at CD40 and other loci confer risk of rheumatoid arthritis Nature genetics 2008;40 (10):1216-1223 [PubMed]
  • Bos W. H., Ursum J., de Vries N. [=Niek], Bartelds G. M., Wolbink G. J., Nurmohamed M. T., van der Horst-Bruinsma I. E., van de Stadt R. J., Crusius J. B. A., Tak P. P., Dijkmans B. A. C., van Schaardenburg D. The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels Annals of the rheumatic diseases 2008;67 (9):1347-1350 [PubMed]

2007

  • Kaandorp C. J. E., van den Broek P. J., Dekhuijzen P. N. R., Dohle G. R., Tak P. P., de Vries Niek Klinische Probleemstellingen. Onderzoek en diagnostiek van 236 aandoeningen.S.l.: Prelum Uitgevers; 2007. 528p. ISBN 9789085620426 (Klinische diagnostiek; 1)

2006

  • Bonarius Hendrik P. J., Baas Frank, Remmerswaal Ester B. M., van Lier René A. W., ten Berge Ineke J. M., Tak Paul P., de Vries Niek Monitoring the T-cell receptor repertoire at single-clone resolution PLoS ONE 2006;1:e55 [PubMed]

2005

  • de Vries N. [=Niek], Shen N., Tak P. P., Shunie C. H. Frontiers in rheumatology research: report from the 1st Chinese-Dutch rheumatology workshopS.l.: s.n.; 2005.
  • de Vries Niek, Zwinderman Aeilko H., Tak Paul P. The interaction of smoking and the HLA-DRB1 shared epitope in rheumatoid factor-positive rheumatoid arthritis: comment on the article by Padyukov et al Arthritis and rheumatism 2005;52 (11):3676-3676; author reply 3678 [PubMed]
  • de Vries N. [=Niek], Tak P. P. The response to anti-TNF-alpha treatment: gene regulation at the bedside Rheumatology (Oxford, England) 2005;44 (6):705-707 [PubMed]

2003

  • de Vries Niek, Tak Paul P., Tijssen Henk, van Riel Piet L. C. M., van de Putte Leo B. A. Female sex increases risk for rheumatoid arthritis only in individuals encoding low-risk HLA-DRB1 alleles Arthritis and rheumatism 2003;48 (6):1762-1763 [PubMed]
  • de Vries Niek, Tak Paul P. Possible role of shared epitope status in the relationship between matrix metalloproteinase 3 genotype and radiographic progression of rheumatoid arthritis: comment on the article by Constantin et al Arthritis and rheumatism 2003;48 (4):1162-1163 [PubMed]

2002

  • de Vries N. [=Niek] Erfelijke aspecten van reumatoïde artritis Nederlands tijdschrift voor reumatologie 2002;3:32-35
  • de Vries Niek, van Riel Piet L. C. M., van de Putte Leo B. A. Research in complex diseases Lancet 2002;359 (9313):1243-1245 [PubMed]
  • de Vries Niek, Tijssen Henk, van Riel Piet L. C. M., van de Putte Leo B. A. Reshaping the shared epitope hypothesis - HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67-74 of the HLA-DRB1 molecule Arthritis and rheumatism 2002;46 (4):921-928 [PubMed]
  • de Vries N. [=Niek] Verhoogde kans op lymfomen bij patiënten met rheumatoïde artritis die worden behandeld met methotrexaat Nederlands tijdschrift voor geneeskunde 2002;146 (40):1998
  • Breedveld F. C., Bijlsma J. W. J., van de Laar M. A. F. J., Landewe R. B. M., van Riel P. L. C. M., van Rijswijk M. H., Tak P. P., de Vries N. [=Niek] Voorlopige behandelrichtlijn Anakinra. Stand van zaken: bericht van het bestuur Nederlands tijdschrift voor reumatologie 2002;4:69-71

2001

  • Rønningen K. S., Keiding N., Green A., de Vries N. [=Niek] Correlations between the incidence of childhood-onset type I diabetes in Europe and HLA genotypes Diabetologia 2001;44 (Suppl. 3):B51-B59 [PubMed]
  • Swinkels H. L., Laan R. F., van 't Hof M. A., van der Heijde D. M., de Vries N. [=Niek], van Riel P. L. Modified sharp method: factors influencing reproducibility and variability Seminars in arthritis and rheumatism 2001;31 (3):176-190 [PubMed]

1999

  • de Vries N. [=Niek], van Elderen C., Tijssen H., van Riel P. L., van de Putte L. B. No support for HLA-DQ encoded susceptibility in rheumatoid arthritis Arthritis and rheumatism 1999;42 (8):1621-1627 [PubMed]

1998

  • Cornélis F., Fauré S., Martinez M., Prud'homme J. F., Fritz P., Dib C., Alves H., Barrera P., de Vries N. [=Niek], Balsa A., Pascual-Salcedo D., Maenaut K., Westhovens R., Migliorini P., Tran T. H., Delaye A., Prince N., Lefevre C., Thomas G., Poirier M., Soubigou S., Alibert O., Lasbleiz S., Fouix S., Bouchier C., Lioté F., Loste M. N., Lepage V., Charron D., Gyapay G., Lopes-Vaz A., Kuntz D., Bardin T., Weissenbach J. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study Proceedings of the National Academy of Sciences of the United States of America 1998;95 (18):10746-10750 [PubMed]

1997

  • HLA-DRB1 in eight Finnish monozygotic twin pairs concordant for rheumatoid arthritis Tissue antigens 1997;49 (3 Part 1):277-279 [PubMed]

1995

  • A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis Annals of the rheumatic diseases 1995;54 (7):601-603 [PubMed]

1994

  • Wilson A. G., Gordon C., di Giovine F. S., de Vries N. [=Niek], van de Putte L. B., Emery P., Duff G. W. A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha European journal of immunology 1994;24 (1):191-195 [PubMed]

1993

  • Wilson A. G., de Vries N. [=Niek], Pociot F., di Giovine F. S., van der Putte L. B., Duff G. W. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles Journal of experimental medicine 1993;177 (2):557-560 [PubMed]
  • A novel HLA-DPB1 allele (DPB1*4501) in a Dutch Caucasian healthy control Tissue antigens 1993;41 (5):255-258 [PubMed]
  • A T cell receptor beta chain variable region polymorphism associated with radiographic progression in rheumatoid arthritis Annals of the rheumatic diseases 1993;52 (5):327-331 [PubMed]
  • Genetic factors influencing the outcome of early arthritis--the role of sulphoxidation status British journal of rheumatology 1993;32 (2):170-172 [PubMed]
  • HLA-DR1 and rheumatoid arthritis in Israeli Jews: sequencing reveals that DRB1*0102 is the predominant HLA-DR1 subtype Tissue antigens 1993;41 (1):26-30 [PubMed]

1992

  • PCR detection of a BglII polymorphism in intron I of the human p53 gene (TP53) Nucleic acids research 1992;20 (5):1172 [PubMed]

Corona-maatregelen

We zetten ons in om ons ziekenhuis veilig te houden tijdens de coronacrisis.

Lees deze extra maatregelen goed door voordat u een van onze locaties bezoekt: