- van der Velde Astrid E., Vrins Carlos L. J., van den Oever Karin, Kunne Cindy, Elferink Ronald P. J. Oude, Kljipers Folkert, Groen Albert K. Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice Gastroenterology 2007;133 (3):967-975 [PubMed]
- Kuipers Folkert, Bloks Vincent W., Groen Albert K. Beyond intestinal soap-bile acids in metabolic control Nature reviews. Endocrinology 2014;10 (8):488-498 [PubMed]
- Out Carolien, Hageman Jurre, Bloks Vincent W., Gerrits Han, Sollewijn Gelpke Maarten D., Bos Trijnie, Havinga Rick, Smit Martin J., Kuipers Folkert, Groen Albert K. Liver Receptor Homolog-1 Is Critical for Adequate Up-regulation of Cyp7a1 Gene Transcription and Bile Salt Synthesis During Bile Salt Sequestration Hepatology (Baltimore, Md.) 2011;53 (6):2075-2085 [PubMed]
- Jakulj Lily, van Dijk Theo H., de Boer Jan Freark, Kootte Ruud S., Schonewille Marleen, Paalvast Yared, Boer Theo, Bloks Vincent W., Boverhof Renze, Nieuwdorp Max, Beuers Ulrich H. W., Stroes Erik S. G., Groen Albert K. Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion Cell metabolism 2016;24 (6):783-794 [PubMed]
- de Boer Jan Freark, Schonewille Marleen, Boesjes Marije, Wolters Henk, Bloks Vincent W., Bos Trijnie, van Dijk Theo H., Jurdzinski Angelika, Boverhof Renze, Wolters Justina C., Kuivenhoven Jan A., van Deursen Jan M., Oude Elferink Ronald P. J., Moschetta Antonio, Kremoser Claus, Verkade Henkjan J., Kuipers Folkert, Groen Albert K. Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice Gastroenterology 2017;152 (5):1126-1138.e6 [PubMed]
Prof. PhD A.K. Groen (A systems biology approach to unravel the etiology of the Metabolic Syndrome)
Metabolic Syndrome is defined as the clustering of abdominal obesity, elevated blood pressure, impaired glucose tolerance, high triglycerides and low HDL-cholesterol and is widely used as simple clinical definition of overweight individuals at increased morbidity risk. The complexity of the interrelations between the different symptoms in Metabolic Syndrome has led to the need for the application of systems biology approaches to obtain a deep understanding of the mechanisms underlying the comorbidities. To gather mechanistic insight in the etiology and interdependence of the different components of the Metabolic Syndrome we are developing a multiscale systems biology approach using both dynamic and genomewide metabolic modelling approaches. We aim to obtain a comprehensive genomic and metabolic map of healthy humans and metabolic syndrome patients including their microbiome. This will generate detailed insight in the metabolic network dysregulation in Metabolic Syndrome patients and will suggest novel therapeutic strategies to rebalance the metabolic networks.
PhD Students
T. Paalvast
S.A.J. van der AA
M. van der Stee
X. Zhang
Prof. MD PhD M. Nieuwdorp (Gutmicrobiota as novel diagnostic and therapeutic targets in cardiometabolism)