- Ince Can, van Kuijen Anne-Marije, Milstein Dan M. J., Yürük Koray, Folkow Lars P., Fokkens Wytske J., Blix Arnoldus S. CHRISTMAS 2012: RESEARCH Why Rudolph's nose is red: observational study BMJ (Clinical research ed.) 2012;345:e8311 [PubMed]
- Ince Can, Groeneveld A. B. Johan The case for 0.9% NaCl: is the undefendable, defensible? Kidney international 2014;86 (6):1087-1095 [PubMed]
- Ince Can, Guerci Philippe Why and when the microcirculation becomes disassociated from the macrocirculation Intensive care medicine 2016;42 (10):1645-1646 [PubMed]
- Matejovic Martin, Ince Can, Chawla Lakhmir S., Blantz Roland, Molitoris Bruce A., Rosner Mitchell H., Okusa Mark D., Kellum John A., Ronco Claudio, Kellum John, Okusa Mark, Rosner Mitchell, Agarwal Anupam, Basile David P., Bonventre Joseph V., Cantaluppi Vincenzo, Dong Zheng, Griffin Matthew, Harris Raymond, Humphreys Benjamin, McKay Dianne, Mehta Ravindra, Molitoris Bruce, Murray Patrick, Nangaku Masaomi, Pickkers Peter, Portilla Didier, Rabb Hamid, Singbartl Kai, Swaminathan Sundararaman, Unwin Robert, Yang Li Renal Hemodynamics in AKI: In Search of New Treatment Targets Journal of the American Society of Nephrology 2016;27 (1):49-58 [PubMed]
- Wilson Mark H., Davagnanam Indran, Holland Graeme, Dattani Raj S., Tamm Alexander, Hirani Shashivadan P., Kolfschoten Nicky, Strycharczuk Lisa, Green Cathy, Thornton John S., Wright Alex, Edsell Mark, Kitchen Neil D., Sharp David J., Ham Timothy E., Murray Andrew, Holloway Cameron J., Clarke Kieran, Grocott Mike P. W., Montgomery Hugh, Imray Chris, Ahuja V., Aref-Adib G., Burnham R., Chisholm A., Clarke K., Coates D., Coates M., Cook D., Cox M., Dhillon S., Dougall C., Doyle P., Duncan P., Edsell M., Edwards L., Evans L., Gardiner P., Grocott M., Gunning P., Hart N., Harrington J., Harvey J., Holloway C., Howard D., Hurlbut D., Imray C., Ince C., Jonas M., van der Kaaij J. Cerebral venous system and anatomical predisposition to high-altitude headache Annals of neurology 2013;73 (3):381-389 [PubMed]
Prof. PhD C. Ince (Cardiovascular aspects of Surgery and Critical Illness)
Our research group has three main lines of research; 1)Clinical microcirculation research in perioperative phase 2)The red blood cell in critical illnes and surgery, 3)Experimental investigations into microcirculatory and mitochondrial dysfunction in sepsis, shock and resuscitation. Our research is translational in nature where we develop concepts and techniques fron bench-to-bedside. In theme 1 we identified 5 different classes of microcirculatory alterations in distributive shock. We identified microcirculatory recruitment maneuvers in the treatment of sepsis, and developed microcirculation research in cardiac and maxillofacial surgery. In theme 2 we investigated how storage affects the quality of blood transfusions. We found that fluid resuscitation causes enhancement in renal oxygen consumption and redistribution of oxygen transport. This line of research resulted in a grant awarded by the Landsteiner Foundation for Blood Transfusion Research. In theme 3 we developed a two-wave length technique for measuring the redistribution of tissue oxygenation in organs. Our year was rounded off by our publication in Nature Methods where we identified an endogenous mitochondrial molecule, protoporyphrin IX, with which, using quenching of delayed fluorescence, mitochondrial pO2 can be measured quantitatively in vivo. This new technique is expected to provide important new insights into the nature of mitochondrial dysfunction in critical illness.
Theme: Cardiovascular Diseases
Faculty
MSc B. Ergin
Postdocs
MD PhD E.C. Boerma
PhD D.M.J. Milstein
PhD Students
P. Guerci
H.W. He
Others
Y. Ince