Prof. PhD E.F. Eldering publications

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Publications Prof. PhD E.F. Eldering

Position
Full Professor
Main activities
Research
Specialisation
Immuno-Hematology
Focus of research

The group of Eric Eldering at the Dept of Experimental Immunology of the AMC works on apoptosis regulation in normal and pathological immune cells. We apply cellular, biochemical and molecular biology techniques in human cells and mouse models, in two main research lines. The first concerns translational research into leukemia, driven by clinical problems, in close collaboration with prof Arnon Kater (Dept of Hematology, AMC). We have studied apoptosis (dys)regulation in B cells since 2002, subsequently focusing on Chronic Lymphocytic Leukemia (CLL). We currently study three aspects of CLL biology:
1. CLL functional genetics and molecular diagnostics
2. The leukemic micro-environment, apoptosis dysregulation and novel drugs
3. Interaction between the immune system and CLL with focus on immune metabolism


Second is a research line devoted to more fundamental immunological issues.We have studied the role of Bcl-2 family members in T and B cells during initiation of the immune response. Bcl-2 members Noxa and Mcl-1 control outgrowth of high affinity lymphocytes as well as clonal diversity. Currently we are studying interactions among Bcl-2 family members using a novel technique called BH3 mimetic profiling (Peperzak 2017). The ultimate goal of this research is to apply the insight obtained in novel vaccination and anti-cancer strategies.

In 2014, three NWO Veni laureates have started their own projects: Felix Wensveen studies selection of high affinity T and B cells (finished January 2017), Victor Peperzak investigates regulation of pro-survival Mcl-1 in malignant B cells (moved to UMC Utrecht in Nov 2015), and Rianne van der Windt studies Immunometabolism, which has become an integral part of our Hemato-Oncology research line.
 

2020

  • Pal Singh Simar, de Bruijn Marjolein J. W., Velaso Gago da Graça Catarina, Corneth Odilia B. J., Rip Jasper, Stadhouders Ralph, Meijers Ruud W. J., Schurmans Stéphane, Kerr William G., ter Burg Johanna, Eldering Eric, Langerak Anton W., Pillai Saravanan Y., Hendriks Rudi W. Overexpression of SH2-Containing Inositol Phosphatase Contributes to Chronic Lymphocytic Leukemia Survival Journal of immunology (Baltimore, Md. 2020;204 (2):360-374 [PubMed]

2019

  • van Bruggen Jaco A. C., Martens Anne W. J., Fraietta Joseph A., Hofland Tom, Tonino Sanne H., Eldering Eric, Levin Mark-David, Siska Peter J., Endstra Sanne, Rathmell Jeffrey C., June Carl H., Porter David L., Melenhorst J. Joseph, Kater Arnon P., van der Windt Gerritje J. W. Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy Blood 2019;134 (1):44-58 [PubMed]
  • Leeksma Alexander C., Taylor Justin, Wu Bian, Gardner Jeffrey R., He Jie, Nahas Michelle, Gonen Mithat, Alemayehu Wendimagegn G., te Raa Doreen, Walther Tatjana, Hüllein Jennifer, Dietrich Sascha, Claus Rainer, de Boer Fransien, de Heer Koen, Dubois Julie, Dampmann Maria, Dürig Jan, van Oers Marinus H. J., Geisler Christian H., Eldering Eric, Levine Ross L., Miller Vincent, Mughal Tariq, Lamanna Nicole, Frattini Mark G., Heaney Mark L., Zelenetz Andrew, Zenz Thorsten, Abdel-Wahab Omar, Kater Arnon P. Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia Leukemia 2019;33 (2):390-402 [PubMed]
  • Hofland Tom, de Weerdt Iris, ter Burg Hanneke, de Boer Renate, Tannheimer Stacey, Tonino Sanne H., Kater Arnon P., Eldering Eric Dissection of the Effects of JAK and BTK Inhibitors on the Functionality of Healthy and Malignant Lymphocytes Journal of immunology (Baltimore, Md. 2019;203 (8):2100-2109 [PubMed]
  • de Weerdt Iris, Hofland Tom, de Boer Renate, Dobber Johan A., Dubois Julie, van Nieuwenhuize Denise, Mobasher Mehrdad, de Boer Fransien, Hoogendoorn Mels, Velders Gerjo A., van der Klift Marjolein, Remmerswaal Ester B. M., Bemelman Frederike J., Niemann Carsten U., Kersting Sabina, Levin Mark-David, Eldering Eric, Tonino Sanne H., Kater Arnon P. Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment Blood advances 2019;3 (17):2642-2652 [PubMed]
  • Hofland Tom, Eldering Eric, Kater Arnon P., Tonino Sanne H. Engaging Cytotoxic T and NK Cells for Immunotherapy in Chronic Lymphocytic Leukemia International journal of molecular sciences 2019;20 (17) [PubMed]
  • Leeksma Alexander Ch. Making sense of genomic complexity and nonsense-RNA in hematologic malignancies 2019. 194p. ISBN 9789463753432. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Eldering E. E. , Kater A. P.; Co-supervisor: Guikema J. E. J.)
  • Hofland Tom, Endstra Sanne, Gomes Calum K P, de Boer Renate, de Weerdt Iris, Bobkov Vladimir, Riedl Jurgen A, Heukers Raimond, Smit Martine J, Eldering Eric, Levin Mark-David, Kater Arnon P, Tonino Sanne H Natural Killer Cell Hypo-responsiveness in Chronic Lymphocytic Leukemia can be Circumvented In Vitro by Adequate Activating Signaling HemaSphere 2019;3 (6):e308 [PubMed]
  • Bahjat Mahnoush, de Wilde Guus, van Dam Tijmen, Maas Chiel, Bloedjes Timon, Bende Richard J, van Noesel Carel J M, Luijks Dieuwertje M, Eldering Eric, Kersten Marie José, Guikema Jeroen E J The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors Cell cycle (Georgetown, Tex.) 2019;18 (18):2307-2322 [PubMed]

2018

  • de Weerdt Iris, Hofland Tom, Lameris Roeland, Endstra Sanne, Jongejan Aldo, Moerland Perry D., de Bruin Renee C. G., Remmerswaal Ester B. M., ten Berge Ineke J. M., Liu Nora, van der Stelt Mario, Faber Laura M., Levin Mark-David, Eldering Eric, Tonino Sanne H., de Gruijl Tanja D., van der Vliet Hans J., Kater Arnon P. Improving CLL Vγ9Vδ2-T-cell fitness for cellular therapy by ex vivo activation and ibrutinib Blood 2018;132 (21):2260-2272 [PubMed]

2017

  • van Attekum Martijn H. A., van Bruggen Jaco A. C., Slinger Erik, Lebre M. Cristina, Reinen Emilie, Kersting Sabina, Eldering Eric, Kater Arnon P. CD40 signaling instructs chronic lymphocytic leukemia cells to attract monocytes via the CCR2 axis Haematologica 2017;102 (12):2069-2076 [PubMed]
  • van Attekum Martijn H. A., Eldering Eric, Kater Arnon P. Chronic lymphocytic leukemia cells are active participants in microenvironmental cross-talk Haematologica 2017;102 (9):1469-1476 [PubMed]
  • Wensveen Felix M., Slinger Erik, van Attekum Martijn Ha, Brink Robert, Eldering Eric Erratum: Antigen-affinity controls pre-germinal center B cell selection by promoting Mcl-1 induction through BAFF receptor signaling Scientific reports 2017;7:39366 [PubMed]
  • Guikema Jeroen E., Amiot Martine, Eldering Eric Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer Expert opinion on therapeutic targets 2017;21 (8):767-779 [PubMed]
  • van Attekum Martinus H. A. Formation of a tumor-supportive microenvironment in chronic lymphocytic leukemia: Addressing the reciprocal interactions in the CLL—T cell—macrophage triad 2017. 160p. ISBN 9789461827548. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Eldering E. F., Kater A. P.)
  • Peperzak Victor, Slinger Erik, ter Burg Johanna, Eldering Eric Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling Cell death and differentiation 2017;24 (1):111-119 [PubMed]
  • van Attekum M. H. A., Terpstra S., Slinger E., von Lindern M., Moerland P. D., Jongejan A., Kater A. P., Eldering E. Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia Oncogene 2017;36 (26):3651-3660 [PubMed]
  • Slinger E., Thijssen R., Kater A. P., Eldering E. Targeting antigen-independent proliferation in chronic lymphocytic leukemia through differential kinase inhibition Leukemia 2017;31 (12):2601-2607 [PubMed]

2016

  • Wensveen Felix M., Slinger Erik, van Attekum Martijn H. A., Brink Robert, Eldering Eric Antigen-affinity controls pregerminal centser B cell selection by promoting Mcl-1 induction through BAFF receptor signaling Scientific reports 2016;6:35673 [PubMed]
  • Slinger Erik, Wensveen Felix M., Guikema Jeroen E., Kater Arnon P., Eldering Eric Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA Haematologica 2016;101 (9):e374-e377 [PubMed]
  • Thijssen Rachel, ter Burg Johanna, Garrick Brett, van Bochove Gregor G. W., Brown Jennifer R., Fernandes Stacey M., Rodríguez María Solé, Michot Jean-Marie, Hallek Michael, Eichhorst Barbara, Reinhardt Hans Christian, Bendell Johanna, Derks Ingrid A. M., van Kampen Roel J. W., Hege Kristen, Kersten Marie José, Trowe Torsten, Filvaroff Ellen H., Eldering Eric, Kater Arnon P. Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia Blood 2016;128 (4):574-583 [PubMed]
  • van Attekum M. H. A., Terpstra S., Reinen E., Kater A. P., Eldering E. Macrophage-mediated chronic lymphocytic leukemia cell survival is independent of APRIL signaling Cell death discovery 2016;2:16020 [PubMed]
  • van Attekum M. H. A., Kater A. P., Eldering E. The APRIL paradox in normal versus malignant B cell biology Cell death & disease 2016;7 (6):e2276 [PubMed]
  • Thijssen Rachel The interplay between microenvironmental signaling and novel targeted drugs in CLL 2016. 171p. ISBN 9789461827333. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Eldering E. F., Kater A. P.; Co-supervisor: Kersten M. J.)
  • Thijssen R., ter Burg J., van Bochove G. G. W., de Rooij M. F. M., Kuil A., Jansen M. H., Kuijpers T. W., Baars J. W., Virone-Oddos A., Spaargaren M., Egile C., van Oers M. H. J., Eldering E., Kersten M. J., Kater A. P. The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells Leukemia 2016;30 (2):337-345 [PubMed]
  • Thijssen R., ter Burg J., van Bochove G. G. W., de Rooij M. F. M., Kuil A., Jansen M. H., Kuijpers T. W., Baars J. W., Virone-Oddos A., Spaargaren M., Egile C., van Oers M. H. J., Eldering E., Kersten M. J., Kater A. P. The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 ( voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells (Vol 30, pg 337, 2016) Leukemia 2016;30 (9):1963 [PubMed]

2015

  • te Raa G. D., Moerland P. D., Leeksma A. C., Derks I. A., Yigittop H., Laddach N., Loden-van Straaten M., Navrkalova V., Trbusek M., Luijks D. M., Zenz T., Skowronska A., Hoogendoorn M., Stankovic T., van Oers M. H., Eldering E., Kater A. P. Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification Cell death & disease 2015;6:e1852 [PubMed]
  • Vieira Braga Felipe A., Hertoghs Kirsten M. L., Kragten Natasja A. M., Doody Gina M., Barnes Nicholas A., Remmerswaal Ester B. M., Hsiao Cheng-Chih, Moerland Perry D., Wouters Diana, Derks Ingrid A. M., van Stijn Amber, Demkes Marc, Hamann Jörg, Eldering Eric, Nolte Martijn A., Tooze Reuben M., ten Berge Ineke J. M., van Gisbergen Klaas P. J. M., van Lier René A. W. Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans European journal of immunology 2015;45 (10):2945-2958 [PubMed]
  • Spaargaren M., de Rooij M. F. M., Kater A. P., Eldering E. BTK inhibitors in chronic lymphocytic leukemia: a glimpse to the future Oncogene 2015;34 (19):2426-2436 [PubMed]
  • Tonino Sanne H., Mulkens Chantal E., van Laar Jacoline, Derks Ingrid A. M., Suo Guangli, Croon-de Boer Fransien, van Oers Marinus H. J., Eldering Eric, Wang Jean Y., Kater Arnon P. Induction of TAp73 by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia Leukemia & lymphoma 2015;56 (8):2439-2447 [PubMed]
  • te Raa Gera Doreen Molecular characteristics and prognosis in CLL 2015. 240p. ISBN 9789461825315. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Oers M. H. J., Eldering E. F.; Co-supervisor: Kater A. P.)
  • Thijssen Rachel, Slinger Erik, Weller Katinka, Geest Christian R., Beaumont Tim, van Oers Marinus H. J., Kater Arnon P., Eldering Eric Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors Haematologica 2015;100 (8):e302-e306 [PubMed]
  • te Raa G. D., Derks I. A. M., Navrkalova V., Skowronska A., Moerland P. D., van Laar J., Oldreive C., Monsuur H., Trbusek M., Malcikova J., Lodén M., Geisler C. H., Hüllein J., Jethwa A., Zenz T., Pospisilova S., Stankovic T., van Oers M. H. J., Kater A. P., Eldering E. The impact of SF3B1 mutations in CLL on the DNA-damage response Leukemia 2015;29 (5):1133-1142 [PubMed]

2014

  • te Raa G. Doreen, Malčiková Jitka, Mraz Marek, Trbusek Martin, Le Garff-Tavernier Magali, Merle-Béral Hélène, Greil Rudolf, Merkel Olaf, Pospíšilová Sarka, Lin Ke, Pettitt Andrew R., Stankovic Tatjana, van Oers Marinus H., Eldering Eric, Stilgenbauer Stephan, Zenz Thorsten, Kater Arnon P. Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach British journal of haematology 2014;167 (4):565-569 [PubMed]
  • te Raa G. Doreen, Pascutti Maria Fernanda, García-Vallejo Juan J., Reinen Emilie, Remmerswaal Ester B. M., ten Berge Ineke J. M., van Lier René A. W., Eldering Eric, van Oers Marinus H. J., Tonino Sanne H., Kater Arnon P. CMV-specific CD8(+) T-cell function is not impaired in chronic lymphocytic leukemia Blood 2014;123 (5):717-724 [PubMed]
  • Kater Arnon P., Spiering Marjolein, Liu Roberto D., Doreen te Raa G., Slinger E., Tonino Sanne H., Beckers Marielle M., Daenen Simon, Doorduijn Jeanette K., Lankheet Nienke A. G., Luijks Dieuwertje M., Eldering Eric, van Oers Marinus H. J. Dasatinib in combination with fludarabine in patients with refractory chronic lymphocytic leukemia: a multicenter phase 2 study Leukemia research 2014;38 (1):34-41 [PubMed]
  • Kater Arnon P., Eldering Eric miR in CLL: more than mere markers of prognosis? Blood 2014;124 (1):2-4 [PubMed]

2013

  • Wensveen Felix M., Geest Christian R., Libregts Sten F. W. M., Derks Ingrid A. M., Ekert Paul G., Labi Verena, Villunger Andreas, Nolte Martijn A., Eldering Eric BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis Apoptosis 2013;18 (11):1306-1318 [PubMed]
  • Lascano Valeria, Guadagnoli Marco, Schot Jan G., Luijks Dieuwertje M., Guikema Jeroen E. J., Cameron Katherine, Hahne Michael, Pals Steven, Slinger Erik, Kipps Thomas J., van Oers Marinus H. J., Eldering Eric, Medema Jan Paul, Kater Arnon P. Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model Blood 2013;122 (24):3960-3963 [PubMed]
  • Maas C., Tromp J. M., van Laar J., Thijssen R., Elias J. A., Malara A., Krippner-Heidenreich A., Silke J., van Oers M. H. J., Eldering E. CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex Cell death & disease 2013;4:e782 [PubMed]
  • Bruijn Martijn, Lutter René, Eldering Eric, Bos Albert P., van Woensel Job B. M. Effect of oxidative stress on respiratory epithelium from children with Down syndrome European respiratory journal 2013;42 (4):1037-1045 [PubMed]
  • Pascutti Maria Fernanda, Jak Margot, Tromp Jacqueline M., Derks Ingrid A. M., Remmerswaal Ester B. M., Thijssen Rachel, van Attekum Martijn H. A., van Bochove Gregor G., Luijks Dieuwertje M., Pals Steven T., van Lier René A. W., Kater Arnon P., van Oers Marinus H. J., Eldering Eric IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells Blood 2013;122 (17):3010-3019 [PubMed]
  • te Raa G. Doreen, Malcikova Jitka, Pospisilova Sarka, Trbusek Martin, Mraz Mark, Garff-Tavernier Maria Le, Merle-Béral Hélène, Lin Ke, Pettitt Andrew R., Merkel Olaf, Stankovic Tatjana, van Oers Marinus H., Eldering Eric, Stilgenbauer Stephan, Zenz Thorsten, Kater Arnon P. Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia Leukemia & lymphoma 2013;54 (8):1849-1853 [PubMed]
  • Wensveen Felix M., Klarenbeek Paul L., van Gisbergen Klaas P. J. M., Pascutti Maria F., Derks Ingrid A. M., van Schaik Barbera D. C., ten Brinke Anja, de Vries Niek, Cekinovic Durdica, Jonjic Stipan, van Lier René A. W., Eldering Eric Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology Journal of immunology (Baltimore, Md. 2013;190 (3):1180-1191 [PubMed]
  • de Weerdt Iris, Eldering Eric, van Oers Marinus H., Kater Arnon P. The biological rationale and clinical efficacy of inhibition of signaling kinases in chronic lymphocytic leukemia Leukemia research 2013;37 (7):838-847 [PubMed]

2012

  • Wensveen Felix M., Derks Ingrid A. M., van Gisbergen Klaas P. J. M., de Bruin Alex M., Meijers Joost C. M., Yigittop Haciali, Nolte Martijn A., Eldering Eric, van Lier René A. W. BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation Blood 2012;119 (6):1440-1449 [PubMed]
  • Wensveen Felix M., Unger Peter-Paul A., Kragten Natasja A. M., Derks Ingrid A. M., ten Brinke Anja, Arens Ramon, van Lier Rene A. W., Eldering Eric, van Gisbergen Klaas P. J. M. CD70-Driven Costimulation Induces Survival or Fas-Mediated Apoptosis of T Cells Depending on Antigenic Load Journal of immunology (Baltimore, Md. 2012;188 (9):4256-4267 [PubMed]
  • Jak Margot Microenvironment and anti-CD20 based therapies in CLL 2012. 169p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Oers M. H. J., van Lier R. A. W.; Co-supervisor: Eldering E.)
  • Helbig Christina, Gentek Rebecca, Backer Ronald A., de Souza Yevan, Derks Ingrid A. M., Eldering Eric, Wagner Koen, Jankovic Dragana, Gridley Thomas, Moerland Perry D., Flavell Richard A., Amsen Derk Notch controls the magnitude of T helper cell responses by promoting cellular longevity Proceedings of the National Academy of Sciences of the United States of America 2012;109 (23):9041-9046 [PubMed]
  • de Rooij Martin F. M., Kuil Annemieke, Geest Christian R., Eldering Eric, Chang Betty Y., Buggy Joseph J., Pals Steven T., Spaargaren Marcel The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia Blood 2012;119 (11):2590-2594 [PubMed]
  • Wensveen Felix M., van Gisbergen Klaas P. J. M., Eldering Eric The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes Immunological reviews 2012;249 (1):84-103 [PubMed]
  • Tromp Jacqueline M. The microenvironment and treatment resistance in chronic lymphocytic leukemia 2012. 183p. ISBN 9789090269375. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Oers M. H. J., Eldering E. F.)
  • Tromp Jacqueline M., Geest Christian R., Breij Esther C. W., Elias Judith A., van Laar Jacoline, Luijks Dieuwertje M., Kater Arnon P., Beaumont Tim, van Oers Marinus H. J., Eldering Eric Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia Clinical cancer research 2012;18 (2):487-498 [PubMed]
  • Heutinck Kirstin M., Rowshani Ajda T., Kassies Jorien, Claessen Nike, van Donselaar-van der Pant Karlijn A. M. I., Bemelman Fréderike J., Eldering Eric, van Lier René A. W., Florquin Sandrine, ten Berge Ineke J. M., Hamann Jörg Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells Kidney international 2012;82 (6):664-675 [PubMed]

2011

  • Wensveen Felix M., Alves Nuno L., Derks Ingrid A. M., Reedquist Kris A., Eldering Eric Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1 Apoptosis 2011;16 (7):708-721 [PubMed]
  • Jak Margot, van Bochove Gregor G. W., Reits Eric A., Kallemeijn Wouter W., Tromp Jacqueline M., Umana Pablo, Klein Christian, van Lier Rene A. W., van Oers Marinus H. J., Eldering Eric CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101 Blood 2011;118 (19):5178-5188 [PubMed]
  • Jak M., van Bochove G. G. W., van Lier R. A. W., Eldering E., van Oers M. H. J. CD40 stimulation sensitizes CLL cells to rituximab-induced cell death Leukemia 2011;25 (6):968-978 [PubMed]
  • Guadagnoli Marco, Kimberley Fiona, Phan Uyen, Cameron Katherine, Vink Paul, Rodermond Hans, Eldering Eric, Kater Arnon, van Eenennaam Hans, Medema Jan Paul Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas Blood 2011;117 (25):6856-6865 [PubMed]
  • Mohr Julia, Helfrich Hanne, Fuge Maxi, Eldering Eric, Bühler Andreas, Winkler Dirk, Volden Matthias, Kater Arnon P., Mertens Daniel, te Raa Doreen, Döhner Hartmut, Stilgenbauer Stephan, Zenz Thorsten DNA damage-induced transcriptional program in CLL: biological and diagnostic implications for functional p53 testing Blood 2011;117 (5):1622-1632 [PubMed]
  • Tonino S. H., van Laar J., van Oers M. H., Wang J. Y., Eldering E., Kater A. P. ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia Oncogene 2011;30 (6):701-713 [PubMed]
  • Tonino Sanne H. Targets for the treatment of drug resistant chronic lymphocytic leukemia 2011. 175p. ISBN 9789090264820. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Oers M. H. J.; Co-supervisors: Kater A. P., Eldering E.)
  • van Gisbergen Klaas P. J. M., Klarenbeek Paul L., Kragten Natasja A. M., Unger Peter-Paul A., Nieuwenhuis Marieke B. B., Wensveen Felix M., ten Brinke Anja, Tak Paul P., Eldering Eric, Nolte Martijn A., van Lier Rene A. W. The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants Immunity 2011;35 (1):97-108 [PubMed]
  • Zeilstra Jurrit, Joosten Sander P. J., Wensveen Felix M., Dessing Mark C., Schütze Denise M., Eldering Eric, Spaargaren Marcel, Pals Steven T. WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer Biochemical and biophysical research communications 2011;406 (1):1-6 [PubMed]

2010

  • Wensveen Felix M., van Gisbergen Klaas P. J. M., Derks Ingrid A. M., Gerlach Carmen, Schumacher Ton N., van Lier René A. W., Eldering Eric Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones Immunity 2010;32 (6):754-765 [PubMed]
  • Kuijpers Taco W., Bende Richard J., Baars Paul A., Grummels Annette, Derks Ingrid A. M., Dolman Koert M., Beaumont Tim, Tedder Thomas F., van Noesel Carel J. M., Eldering Eric, van Lier René A. W. CD20 deficiency in humans results in impaired T cell-independent antibody responses Journal of clinical investigation 2010;120 (1):214-222 [PubMed]
  • Tromp J. M., Tonino S. H., Elias J. A., Jaspers A., Luijks D. M., Kater A. P., van Lier R. A. W., van Oers M. H. J., Eldering E. Dichotomy in NF-kappaB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering Oncogene 2010;29 (36):5071-5082 [PubMed]
  • Grabiec Aleksander M., Krausz Sarah, de Jager Wilco, Burakowski Tomasz, Groot Dion, Sanders Marjolein E., Prakken Berent J., Maslinski Wlodzimierz, Eldering Eric, Tak Paul P., Reedquist Kris A. Histone Deacetylase Inhibitors Suppress Inflammatory Activation of Rheumatoid Arthritis Patient Synovial Macrophages and Tissue Journal of immunology (Baltimore, Md. 2010;184 (5):2718-2728 [PubMed]
  • Tonino S. H., van Gelder M., Eldering E., van Oers M. H., Kater A. P. R-DHAP is effective in fludarabine-refractory chronic lymphocytic leukemia Leukemia 2010;24 (3):652-654 [PubMed]
  • Baou Maria, Kohlhaas Susan L., Butterworth Michael, Vogler Meike, Dinsdale David, Walewska Renata, Majid Aneela, Eldering Eric, Dyer Martin J. S., Cohen Gerald M. Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells Haematologica 2010;95 (9):1510-1518 [PubMed]
  • Wensveen Felix M. Survival of the fittest clone. Pro-apoptotic protein Noxa controls of lymphocytes under competitive conditions 2010. 198p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Lier R. A. W.; Co-supervisor: Eldering E. F.)

2009

  • Pasero Christine, Barbarat Bernadette, Just-Landi Sylvaine, Bernard Alain, Aurran-Schleinitz Thérèse, Rey Jérome, Eldering Eric, Truneh Alemsedeg, Costello Régis T., Olive Daniel A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production European journal of immunology 2009;39 (9):2502-2514 [PubMed]
  • Mous R., Jaspers A., Luijks D. M. P., Mellink C. H. M., van Oers M. H. J., Kater A. P., Eldering E. Detection of p53 dysfunction in chronic lymphocytic leukaemia cells through multiplex quantification of p53 target gene induction Leukemia 2009;23 (7):1352-1355 [PubMed]
  • Jak Margot, Mous Rogier, Remmerswaal Ester B. M., Spijker René, Jaspers Annelieke, Yagüe Adriana, Eldering Eric, van Lier René A. W., van Oers Marinus H. J. Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia Leukemia & lymphoma 2009;50 (5):788-801 [PubMed]
  • Zenz Thorsten, Mohr Julia, Eldering Eric, Kater Arnon P., Bühler Andreas, Kienle Dirk, Winkler Dirk, Dürig Jan, van Oers Marinus H. J., Mertens Daniel, Döhner Hartmut, Stilgenbauer Stephan miR-34a as part of the resistance network in chronic lymphocytic leukemia Blood 2009;113 (16):3801-3808 [PubMed]
  • Abreu Joana R. F., Grabiec Aleksander M., Krausz Sarah, Spijker René, Burakowski Tomasz, Maslinski Wlodzimierz, Eldering Eric, Tak Paul P., Reedquist Kris A. The Presumed Hyporesponsive Behavior of Rheumatoid Arthritis T Lymphocytes Can Be Attributed to Spontaneous Ex Vivo Apoptosis rather than Defects in T Cell Receptor Signaling Journal of immunology (Baltimore, Md. 2009;183 (1):621-630 [PubMed]

2008

  • Mous Rogier, Savage Philip, Eldering Eric, Teeling Peter, van Oers Marinus Hj, van Lier René Aw Adequate synapse formation between leukemic B cells and effector T cells following stimulation with artificial TCR ligands Leukemia & lymphoma 2008;49 (8):1592-1602 [PubMed]
  • Hallaert Delfine Y. H., Jaspers Annelieke, van Noesel Carel J., van Oers Marinus H. J., Kater Arnon P., Eldering Eric c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches Blood 2008;112 (13):5141-5149 [PubMed]
  • Hallaert Delfine Y. H. 'From the cradle to the grave' : novel therapeutic approaches to attack the microenvironment in chronic lymphocytic leukemia 2008. 171p. ISBN 9789090235479. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Oers M. H.; Co-supervisor: Eldering E.)
  • van Gent Rogier, Kater Arnon P., Otto Sigrid A., Jaspers A., Borghans José A. M., Vrisekoop Nienke, Ackermans Mariëtte A. T., Ruiter An F. C., Wittebol Shulamiet, Eldering Eric, van Oers Marinus H. J., Tesselaar Kiki, Kersten Marie José, Miedema Frank In vivo Dynamics of Stable Chronic Lymphocytic Leukemia Inversely Correlate with Somatic Hypermutation Levels and Suggest No Major Leukemic Turnover in Bone Marrow Cancer research 2008;68 (24):10137-10144 [PubMed]
  • Mous Rogier Studies on the immune system in CLL. 2008. 165p. ISBN 9789088910623. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Oers M. H. J., van Lier R. A. W.; Co-supervisor: Eldering E. F.)
  • Gunn Shelly R., Mohammed Mansoor S., Gorre Mercedes E., Cotter Philip D., Kim Jaeweon, Bahler David W., Preobrazhensky Sergey N., Higgins Russell A., Bolla Aswani R., Ismail Sahar H., de Jong Daphne, Eldering Eric, van Oers Marinus H. J., Mellink Clemens H. M., Keating Michael J., Schlette Ellen J., Abruzzo Lynne V., Robetorye Ryan S. Whole-genome scanning by array comparative genomic hybridization as a clinical tool for risk assessment in chronic lymphocytic leukemia Journal of molecular diagnostics 2008;10 (5):442-451 [PubMed]

2007

  • van Oosterwijk Michiel F., Juwana Hedi, Arens Ramon, Tesselaar Kiki, van Oers Marinus H. J., Eldering Eric, van Lier René A. W. CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development International immunology 2007;19 (6):713-718 [PubMed]
  • Hallaert D. Y. H., Spijker R., Jak M., Derks I. A. M., Alves N. L., Wensveen F. M., de Boer J. P., de Jong D., Green S. R., van Oers M. H. J., Eldering E. Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection Cell death and differentiation 2007;14 (11):1958-1967 [PubMed]
  • Smit Laura A., Hallaert Delfine Y. H., Spijker René, de Goeij Bart, Jaspers Annelieke, Kater Arnon P., van Oers Marinus H. J., van Noesel Carel J. M., Eldering Eric Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity Blood 2007;109 (4):1660-1668 [PubMed]
  • Alves Nuno L. 'How to keep T-cells alive and kicking': studies on extra-cellular cues and intra-cellular pathways involved in maintaining a dynamic T cell compartement 2007. 175p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Lier Rene A. W.; Co-supervisors: Eldering E. F., Arosa Fernando A.)
  • Knoops Laurent, Haas Rick, de Kemp Sanne, Majoor Donne, Broeks Annegien, Eldering Eric, de Boer Jan Paul, Verheij Marcel, van Ostrom Conny, de Vries Annemieke, van't Veer Laura, de Jong Daphne In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma Blood 2007;110 (4):1116-1122 [PubMed]
  • Alves Nuno L., van Lier René A. W., Eldering Eric Withdrawal symptoms on display: Bcl-2 members under investigation Trends in immunology 2007;28 (1):26-32 [PubMed]

2006

  • Kater A. P. Novel apoptosis inducting strategies in chronic lymphocytic leukemia 2006. 208p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Oers M. H. J., Kipps T. J.; Co-supervisor: Eldering E.)
  • Mous R., Savage P., Remmerswaal E. B. M., van Lier R. A. W., Eldering E., van Oers M. H. J. Redirection of CMV-specific CTL towards B-CLL via CD20-targeted HLA/CMV complexes Leukemia 2006;20 (6):1096-1102 [PubMed]
  • Alves Nuno L., Derks Ingrid A. M., Berk Erik, Spijker René, van Lier René A. W., Eldering Eric The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells Immunity 2006;24 (6):703-716 [PubMed]

2005

  • Eldering Eric, VanLier René A. W. B-cell antigen receptor-induced apoptosis: looking for clues Immunology letters 2005;96 (2):187-194 [PubMed]
  • Mackus W. J. M., Kater A. P., Grummels A., Evers L. M., Hooijbrink B., Kramer M. H. H., Castro J. E., Kipps T. J., van Lier R. A. W., van Oers M. H. J., Eldering E. Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation Leukemia 2005;19 (3):427-434 [PubMed]

2004

  • Eldering Eric, Mackus Wendelina J. M., Derks Ingrid A. M., Evers Ludo M., Beuling Esther, Teeling Peter, Lens Susanne M. A., van Oers Marinus H. J., van Lier René A. W. Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation European journal of immunology 2004;34 (7):1950-1960 [PubMed]
  • Planelles Lourdes, Carvalho-Pinto Carla E., Hardenberg Gijs, Smaniotto Salette, Savino Wilson, Gómez-Caro Ruth, Alvarez-Mon Melchor, de Jong Joan, Eldering Eric, Martínez-A Carlos, Medema Jan Paul, Hahne Michael APRIL promotes B-1 cell-associated neoplasm Cancer cell 2004;6 (4):399-408 [PubMed]
  • Kater Arnon P., Remmerswaal Ester B. M., Nolte Martijn A., Eldering Eric, van Oers Marinus H. J., van Lier René A. W. Autologous cytomegalovirus-specific T cells as effector cells in immunotherapy of B cell chronic lymphocytic leukaemia British journal of haematology 2004;126 (4):512-516 [PubMed]
  • Kater Arnon P., Evers Ludo M., Remmerswaal Ester B. M., Jaspers Annelieke, Oosterwijk Michiel F., van Lier René A. W., van Oers Marinus H. J., Eldering Eric CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack British journal of haematology 2004;127 (4):404-415 [PubMed]
  • Bos I. G. A., Lubbers Y. T. P., Eldering E., Abrahams J. P., Hack C. E. Effect of reactive site loop elongation on the inhibitory activity of C1-inhibitor BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 2004;1699 (1-2):139-144 [PubMed]
  • Hess C. J., Denkers F., Ossenkoppele G. J., Waisfisz Q., McElgunn C. J., Eldering E., Schouten J. P., Schuurhuis G. J. Gene expression profiling of minimal residual disease in acute myeloid leukaemia by novel multiplex-PCR-based method Leukemia 2004;18 (12):1981-1988 [PubMed]
  • Werner Arlette B., Tait Stephen W. G., de Vries Evert, Eldering Eric, Borst Jannie Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens Journal of biological chemistry 2004;279 (27):28771-28780 [PubMed]

2003

  • Mackus W. J. M. Antigen receptor triggering and apotopic pathways in neoplastic B cells 2003. 139p. ISBN 9789067340496. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Oers M. H. J., van Lier R. A. W.; Co-supervisor: Eldering E. F.)
  • Bos G. A. C. C1-inhibitor potentiation by glycosaminoglycans 2003. 144p. ISBN 9789090173863. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hack C. E., Abrahams J. P.; Co-supervisor: Eldering E. F.)
  • Eldering Eric, Spek C. Arnold, Aberson Hella L., Grummels Annette, Derks Ingrid A., de Vos Alex F., McElgunn Cathal J., Schouten Jan P. Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways Nucleic acids research 2003;31 (23):e153 [PubMed]
  • Bos I. G. A., de Bruin E. C., Karuntu Y. A., Modderman P. W., Eldering E., Hack C. E. Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 2003;1648 (1-2):75-83 [PubMed]
  • Bos Ineke G. A., Lubbers Yvonne T. P., Roem Dorina, Abrahams Jan Pieter, Hack C. Erik, Eldering Eric The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant Journal of biological chemistry 2003;278 (32):29463-29470 [PubMed]
  • Arkenbout E. Karin, van Bragt Maaike, Eldering Eric, van Bree Chris, Grimbergen Jos M., Quax Paul H. A., Pannekoek Hans, de Vries Carlie J. M. TR3 orphan receptor is expressed in vascular endothelial cells and mediates cell cycle arrest Arteriosclerosis, thrombosis, and vascular biology 2003;23 (9):1535-1540 [PubMed]

2002

  • van der Kolk L. E., Evers L. M., Omene C., Lens S. M. A., Lederman S., van Lier R. A. W., van Oers M. H. J., Eldering E. CD20-induced B cell death can bypass mitochondria and caspase activation Leukemia 2002;16 (9):1735-1744 [PubMed]
  • Leeksma Onno C., van Achterberg Tanja A. E., Tsumura Yoshikazu, Toshima Jiro, Eldering Eric, Kroes Wilma G. M., Mellink Clemens, Spaargaren Marcel, Mizuno Kensaku, Pannekoek Hans, de Vries Carlie J. M. Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 European Journal of Biochemistry / FEBS 2002;269 (10):2546-2556 [PubMed]
  • Mackus Wendelina J. M., Lens Susanne M. A., Medema René H., Kwakkenbos Mark J., Evers Ludo M., Oers Marinus H. J. van, van Lier René A. W., Eldering Eric Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation International immunology 2002;14 (9):973-982 [PubMed]

2001

  • Stoop A. A., Eldering E., Dafforn T. R., Read R. J., Pannekoek H. Different structural requirements for plasminogen activator inhibitor 1 (PAI-1) during latency transition and proteinase inhibition as evidenced by phage-displayed hypermutated PAI-1 libraries Journal of molecular biology 2001;305 (4):773-783 [PubMed]

2000

  • High-density mutagenesis by combined DNA shuffling and phage display to assign essential amino acid residues in protein-protein interactions: application to study structure-function of plasminogen activation inhibitor 1 (PAI-I) Journal of molecular biology 2000;301 (5):1135-1147 [PubMed]

1998

  • Selection of peptides that bind to plasminogen activator inhibitor 1 (PAI-1) using random peptide phage-display libraries FEBS letters 1998;431 (2):170-174 [PubMed]

1997

  • Potentiation of C1 inhibitor by glycosaminoglycans: dextran sulfate species are effective inhibitors of in vitro complement activation in plasma Journal of immunology (Baltimore, Md. 1997;159 (4):1953-1960 [PubMed]

1996

  • Characterization of C1 inhibitor-Ta. A dysfunctional C1INH with deletion of lysine 251 Journal of biological chemistry 1996;271 (39):24307-24312 [PubMed]
  • Modulation of contact system proteases by glycosaminoglycans. Selective enhancement of the inhibition of factor XIa Journal of biological chemistry 1996;271 (22):12913-12918 [PubMed]

1995

  • COOH-terminal substitutions in the serpin C1 inhibitor that cause loop overinsertion and subsequent multimerization Journal of biological chemistry 1995;270 (6):2579-2587 [PubMed]
  • Crucial residues in the carboxy-terminal end of C1 inhibitor revealed by pathogenic mutants impaired in secretion or function Journal of clinical investigation 1995;95 (1):350-359 [PubMed]

1993

  • A hinge region mutation in C1-inhibitor (Ala436-->Thr) results in nonsubstrate-like behavior and in polymerization of the molecule Journal of biological chemistry 1993;268 (24):18088-18094 [PubMed]
  • Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils Journal of clinical investigation 1993;91 (3):1035-1043 [PubMed]
  • The balance between inhibition and substrate-type reactions of recombinant C1 inhibitor P5/P3 variants Behring Institute Mitteilungen 1993;93:125-130 [PubMed]

1992

  • C1 inhibitor hinge region mutations produce dysfunction by different mechanisms Nature genetics 1992;1 (5):354-358 [PubMed]
  • Characterization of recombinant C1 inhibitor P1 variants Journal of biological chemistry 1992;267 (10):7013-7020 [PubMed]

1988

  • Expression of functional human C1 inhibitor in COS cells Journal of biological chemistry 1988;263 (24):11776-11779 [PubMed]