Prof. PhD J.J. Voorberg publications

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Publications Prof. PhD J.J. Voorberg

Position
Research Associate
Main activities
Education, Research
Specialisation
Cellular Hemostasis
Focus of research
Within my research group we explore cellular components that are involved in maintenance of vascular homeostasis. Our research on “Cellular Haemostasis” aims to integrate biochemical and clinical research in the area of thrombosis and hemostasis, vascular biology as well as molecular and cellular immunology. Through this approach we aim to increase our current knowledge on the interactions of hemostatic proteins with the vessel wall as well as the immune system. We expect that studies in this area will result in novel therapeutic approaches for patients with vascular or haematological disorders.

Our current focus of research comprises the composition and regulatory mechanism involved in release of Weibel-Palade bodies, intracellular reservoirs of hemostatic protein, angiogenic factors and inflammatory components. In related studies we aim to characterize endothelial cells derived of peripheral blood of patient with vascular or hematological abnormalities. An important topic for the next 5 years comprises the interaction of hemostatic proteins with the immune system. These studies are relevant for a better understanding of the factor contribution to inhibitor development of hemophilia A as well the auto-immune disorder thrombotic thrombocytopenic purpura (TTP).

2019

  • van der Veen S. J., van Kuilenburg A. B. P., Hollak C. E. M., Kaijen P. H. P., Voorberg J., Langeveld M. Antibodies against recombinant alpha-galactosidase A in Fabry disease: Subclass analysis and impact on response to treatment Molecular genetics and metabolism 2019;126 (2):162-168 [PubMed]
  • Rijkers Maaike, Schmidt David, Lu Nina, Kramer Cynthia S M, Heidt Sebastiaan, Mulder Arend, Porcelijn Leendert, Claas Frans H J, Leebeek Frank W G, Jansen A J Gerard, Jongerius Ilse, Zeerleder Sacha S, Vidarsson Gestur, Voorberg Jan, de Haas Masja Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets Haematologica 2019;104 (2):403-416 [PubMed]
  • Rijkers Maaike Challenges in platelet transfusion; From storage to alloimmunization 2019. 188p. ISBN 9789463234375. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Voorberg J. J. , Leebeek F. W. G., Jansen A. J. G. , Vidarsson G.)
  • Schelpe An-Sofie, Roose Elien, Joly B. rangère S., Pareyn Inge, Mancini Ilaria, Biganzoli Marina, Deckmyn Hans, Voorberg Jan, Fijnheer Rob, Peyvandi Flora, de Meyer Simon F., Coppo Paul, Veyradier Agnès, Vanhoorelbeke Karen Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients Haematologica 2019;104 (6):1268-1276 [PubMed]
  • Schillemans Maaike, Karampini Ellie, Hoogendijk Arie J., Wahedi Maryam, van Alphen Floris P. J., van den Biggelaar Maartje, Voorberg Jan, Bierings Ruben Interaction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells Journal of proteomics 2019;205 [PubMed]
  • Delignat Sandrine, Russick Jules, Gangadharan Bagirath, Rayes Julie, Ing Mathieu, Voorberg Jan, Kaveri Srinivas V., Lacroix-Desmazes S. bastien Prevention of the anti-factor VIII memory B-cell response by inhibition of Bruton tyrosine kinase in experimental hemophilia A Haematologica 2019;104 (5):1046-1054 [PubMed]
  • Schillemans Maaike Weibel-Palade body logistics: Express delivery in the vasculature 2019. 205p. ISBN 9789463753722. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Voorberg J. J.; Co-supervisor: Bierings R.)

2018

  • Roose E., Schelpe A. S., Joly B. S., Peetermans M., Verhamme P., Voorberg J., Greinacher A., Deckmyn H., de Meyer S. F., Coppo P., Veyradier A., Vanhoorelbeke K. An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura Journal of thrombosis and haemostasis 2018;16 (2):378-388 [PubMed]
  • Roose Elien, Vidarsson Gestur, Kangro Kadri, Verhagen Onno J. H. M., Mancini Ilaria, Desender Linda, Pareyn Inge, Vandeputte Nele, Vandenbulcke Aline, Vendramin Chiara, Schelpe An-Sofie, Voorberg Jan, Azerad Marie-Agnès, Gilardin Laurent, Scully Marie, Dierickx Daan, Deckmyn Hans, de Meyer Simon F., Peyvandi Flora, Vanhoorelbeke Karen Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura Thrombosis and haemostasis 2018;118 (10):1729-1742 [PubMed]
  • Rijkers Maaike, Saris Anno, Heidt Sebastiaan, Mulder Arend, Porcelijn Leendert, Claas Frans H. J., Bierings Ruben, Leebeek Frank W. G., Jansen A. J. Gerard, Vidarsson Gestur, Voorberg Jan, de Haas Masja A subset of anti-HLA antibodies induces Fcγriia-dependent platelet activation Haematologica 2018;103 (10):1741-1752 [PubMed]
  • Peyron Ivan, Hartholt Robin B., Pedró-Cos Laura, van Alphen Floris, Brinke Anja Ten, Lardy Neubury, Meijer Alexander B., Voorberg Jan Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells Haematologica 2018;103 (1):172-178 [PubMed]
  • Loomans Janneke I., Kruip Marieke J. H. A., Carcao Manuel, Jackson Shannon, van Velzen Alice S., Peters Marjolein, Santagostino Elena, Platokouki Helen, Beckers Erik, Voorberg Jan, van der Bom Johanna G., Fijnvandraat Karin Desmopressin in moderate hemophilia A patients: a treatment worth considering Haematologica 2018;103:550-557 [PubMed]
  • Hrdinová Johana, D’Angelo Silvia, Graça Nuno A. G., Ercig Bogac, Vanhoorelbeke Karen, Veyradier Agnès, Voorberg Jan, Coppo Paul Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: Interplay between genes and environmental triggers Haematologica 2018;103 (7):1099-1109 [PubMed]
  • Lai J. D., Cartier D., Hartholt R. B., Swystun L. L., van Velzen A. S., den Haan J. M. M., Hough C., Voorberg J., Lillicrap D. Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice Journal of thrombosis and haemostasis 2018;16 (3):533-545 [PubMed]
  • Swinkels Maurice, Rijkers Maaike, Voorberg Jan, Vidarsson Gestur, Leebeek Frank W. G., Jansen A. J. Gerard Emerging concepts in immune thrombocytopenia Frontiers in immunology 2018;9 (APR) [PubMed]
  • Abdi Amal, Linari Silvia, Pieri Lisa, Voorberg Jan, Fijnvandraat Karin, Castaman Giancarlo Inhibitors in Nonsevere Hemophilia A: What Is Known and Searching for the Unknown Seminars in thrombosis and hemostasis 2018;44 (06):568-577 [PubMed]
  • Ercig Bogac, Wichapong Kanin, Reutelingsperger Chris P. M., Vanhoorelbeke Karen, Voorberg Jan, Nicolaes Gerry A. F. Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura Thrombosis and haemostasis 2018;118 (1):28-41 [PubMed]
  • Hrdinová Johana, Verbij Fabian C., Kaijen Paul H. P., Hartholt Robin B., van Alphen Floris, Lardy Neubury, Brinke Anja Ten, Vanhoorelbeke Karen, Hindocha Pooja J., de Groot Anne S., Meijer Alexander B., Voorberg Jan, Peyron Ivan Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ Haematologica 2018;103 (6):1083-1092 [PubMed]
  • Schillemans Maaike, Karampini Ellie, van den Eshof Bart L, Gangaev Anastasia, Hofman Menno, van Breevoort Dorothee, Meems Henriët, Janssen Hans, Mulder Aat A, Jost Carolina R, Escher Johanna C, Adam Rüdiger, Carter Tom, Koster Abraham J, van den Biggelaar Maartje, Voorberg Jan, Bierings Ruben Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells Arteriosclerosis, thrombosis, and vascular biology 2018;38 (7):1549-1561 [PubMed]

2017

  • Ciudad M. Teresa, Sorvillo Nicoletta, van Alphen Floris P., Catalán Diego, Meijer Alexander B., Voorberg Jan, Jaraquemada Dolores Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation Journal of leukocyte biology 2017;101 (1):15-27 [PubMed]
  • Hartholt Robin B. Determining factors of inhibitor formation in hemophilia A 2017. 182p. ISBN 9789492683410. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Voorberg J. J.; Co-supervisor: ten Brinke J. A.)
  • Hartholt R. B., Wroblewska A., Herczenik E., Peyron I., ten Brinke A., Rispens T., Nolte M. A., Slot E., Claassens J. W., Nimmerjahn F., Verbeek J. S., Voorberg J. Enhanced uptake of blood coagulation factor VIII containing immune complexes by antigen presenting cells Journal of thrombosis and haemostasis 2017;15 (2):329-340 [PubMed]
  • Ebberink Eduard H. T. M., Bouwens Eveline A. M., Bloem Esther, Boon-Spijker Mariëtte, van den Biggelaar Maartje, Voorberg Jan, Meijer Alexander B., Mertens Koen Factor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking Haematologica 2017;102 (4):686-694 [PubMed]
  • Verbij Fabian C. Immune recognition of ADAMTS13 in acquired TTP 2017. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Voorberg J. J.; Co-supervisors: Fijnheer R., ten Brinke J. A.)
  • Rijkers Maaike, van den Eshof Bart L., van der Meer Pieter F., van Alphen Floris P. J., de Korte Dirk, Leebeek Frank W. G., Meijer Alexander B., Voorberg Jan, Jansen A. J. Gerard Monitoring storage induced changes in the platelet proteome employing label free quantitative mass spectrometry Scientific reports 2017;7 (1):11045 [PubMed]
  • Smeets Michel W. J., Bierings Ruben, Meems Henriet, Mul Frederik P. J., Geerts Dirk, Vlaar Alexander P. J., Voorberg Jan, Hordijk Peter L. Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor PLoS ONE 2017;12 (3):e0173077 [PubMed]
  • Verbij Fabian C., Sorvillo Nicoletta, Kaijen Paul H. P., Hrdinova Johana, Peyron Ivan, Fijnheer Rob, ten Brinke Anja, Meijer Alexander B., van Alphen Floris P. J., van den Berg Timo K., Graversen Jonas J. H., Moestrup Soren K., Voorberg Jan The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages Blood advances 2017;1 (5):293-305 [PubMed]
  • Hartholt Robin B., van Velzen Alice S., Peyron Ivan, ten Brinke Anja, Fijnvandraat Karin, Voorberg Jan To serve and protect: The modulatory role of von Willebrand factor on factor VIII immunogenicity Blood reviews 2017;31 (5):339-347 [PubMed]
  • Loomans J. I., van Velzen A. S., Eckhardt C. L., Peters M., Mäkipernaa A., Holmstrom M., Brons P. P., Dors N., Haya S., Voorberg J., van der Bom J. G., Fijnvandraat K. Variation in baseline factor VIII concentration in a retrospective cohort of mild/moderate hemophilia A patients carrying identical F8 mutations Journal of thrombosis and haemostasis 2017;15 (2):246-254 [PubMed]

2016

  • Verbij Fabian C., Turksma Annelies W., de Heij Femke, Kaijen Paul, Lardy Neubury, Fijnheer Rob, Sorvillo Nicoletta, ten Brinke Anja, Voorberg Jan CD4+ T cells from patients with acquired thrombotic thrombocytopenic purpura recognize CUB2 domain-derived peptides Blood 2016;127 (12):1606-1609 [PubMed]
  • Rijkers M., van der Meer P. F., Bontekoe I. J., Daal B. B., de Korte D., Leebeek F. W. G., Voorberg J., Jansen A. J. G. Evaluation of the role of the GPIb-IX-V receptor complex in development of the platelet storage lesion Vox sanguinis 2016;111 (3):247-256 [PubMed]
  • Hartholt Robin B., Peyron Ivan, Voorberg Jan Hunting down factor VIII in the immunopeptidome Cellular immunology 2016;301:59-64 [PubMed]
  • Verbij Fabian C., Stokhuijzen Eva, Kaijen Paul H. P., van Alphen Floris, Meijer Alexander B., Voorberg Jan Identification of glycans on plasma-derived ADAMTS13 Blood 2016;128 (21):e51-e58 [PubMed]
  • Bierings Ruben, Voorberg Jan Up or out: polarity of VWF release Blood 2016;128 (2):154-155 [PubMed]
  • Sorvillo Nicoletta, Hartholt Robin B., Bloem Esther, Sedek Magdalena, ten Brinke Anja, van der Zwaan Carmen, van Alphen Floris P., Meijer Alexander B., Voorberg Jan von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII Haematologica 2016;101 (3):309-318 [PubMed]

2015

  • Groeneveld D. J., van Bekkum T., Dirven R. J., Wang J.-W., Voorberg J., Reitsma P. H., Eikenboom J. Angiogenic characteristics of blood outgrowth endothelial cells from patients with von Willebrand disease Journal of thrombosis and haemostasis 2015;13 (10):1854-1866 [PubMed]
  • Mourik Marjon J., Faas Frank G. A., Zimmermann Hans, Voorberg Jan, Koster Abraham J., Eikenboom Jeroen Content delivery to newly forming Weibel-Palade bodies is facilitated by multiple connections with the Golgi apparatus Blood 2015;125 (22):3509-3516 [PubMed]
  • Voorberg Jan, Verbij Fabian C., Fijnheer Rob Disappearing acts of ADAMTS13 EBioMedicine 2015;2 (8):800-801 [PubMed]

2014

  • Verbij Fabian C., Fijnheer Rob, Voorberg Jan, Sorvillo Nicoletta Acquired TTP: ADAMTS13 meets the immune system Blood reviews 2014;28 (6):227-234 [PubMed]
  • Voorberg Jan, Meems Henriët Decrypting C2 inhibitors Blood 2014;123 (17):2601-2602 [PubMed]
  • Sorvillo N., Kaijen P. H., Matsumoto M., Fujimura Y., van der Zwaan C., Verbij F. C., Pos W., Fijnheer R., Voorberg J., Meijer A. B. Identification of N-linked glycosylation and putative O-fucosylation, C-mannosylation sites in plasma derived ADAMTS13 Journal of thrombosis and haemostasis 2014;12 (5):670-679 [PubMed]
  • Martin-Ramirez Javier, Kok Maayke G. M., Hofman Menno, Bierings Ruben, Creemers Esther E., Meijers Joost C. M., Voorberg Jan, Pinto-Sietsma Sara-Joan Individual with subclinical atherosclerosis have impaired proliferation of blood outgrowth endothelial cells, which can be restored by statin therapy PLoS ONE 2014;9 (6):e99890 [PubMed]
  • van Hooren Kathinka W. E. M. Molecular Mechanisms involved in Weibel-Palade body exocytosis 2014. 134p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Voorberg J.; Co-supervisors: Bierings R., Fernandez-Borja M.)
  • van Hooren K. W. E. M., van Breevoort D., Fernandez-Borja M., Meijer A. B., Eikenboom J., Bierings R., Voorberg J. Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 regulates epinephrine-induced exocytosis of Weibel-Palade bodies Journal of thrombosis and haemostasis 2014;12 (2):273-281 [PubMed]
  • Nicolaes Gerry A. F., Kulharia Mahesh, Voorberg Jan, Kaijen Paul H., Wroblewska Aleksandra, Wielders Simone, Schrijver Roy, Sperandio Olivier, Villoutreix Bruno O. Rational design of small molecules targeting the C2 domain of coagulation factor VIII Blood 2014;123 (1):113-120 [PubMed]
  • van Hooren Kathinka W. E. M., Spijkers Léon J. A., van Breevoort Dorothee, Fernandez-Borja Mar, Bierings Ruben, van Buul Jaap D., Alewijnse Astrid E., Peters Stephan L. M., Voorberg Jan Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells PLoS ONE 2014;9 (3):e91346 [PubMed]
  • Groeneveld Dafna J., Wang Jiong-Wei, Mourik Marjon J., Dirven Richard J., Valentijn Karine M., Voorberg Jan, Reitsma Pieter H., Eikenboom Jeroen Storage and secretion of naturally occurring von Willebrand factor A domain variants British journal of haematology 2014;167 (4):529-540 [PubMed]
  • van Breevoort Dorothee, Snijders Ambrosius P., Hellen Nicola, Weckhuysen Sarah, van Hooren Kathinka W. E. M., Eikenboom Jeroen, Valentijn Karine, Fernandez-Borja Mar, Ceulemans Berten, de Jonghe Peter, Voorberg Jan, Hannah Matthew, Carter Tom, Bierings Ruben STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a Blood 2014;123 (20):3185-3194 [PubMed]
  • van Breevoort Dorothee Tuning the SNAREs that regulate Weibel-Palade body exocytosis 2014. 159p. ISBN 9789461824318. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Voorberg J.; Co-supervisors: Bierings R., Fernandez-Borja M.)

2013

  • Schaller M., Studt J.-D., Voorberg J., Kremer Hovinga J. A. Acquired thrombotic thrombocytopenic purpura. Development of an autoimmune response Hamostaseologie 2013;33 (2):121-130 [PubMed]
  • Sorvillo Nicoletta Acquired TTP: ADANTS13 meets the immune system 2013. 191p. ISBN 9789461823137. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Voorberg J. J.; Co-supervisors: Fijnheer R., ten Brinke J. A.)
  • McGrath Rachel T., van den Biggelaar Maartje, Byrne Barry, O'Sullivan Jamie M., Rawley Orla, O'Kennedy Richard, Voorberg Jan, Preston Roger J. S., O'Donnell James S. Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis Blood 2013;122 (25):4107-4110 [PubMed]
  • Wang Jiong-Wei, Bouwens Eveline A. M., Pintao Maria Carolina, Voorberg Jan, Safdar Huma, Valentijn Karine M., de Boer Hetty C., Mertens Koen, Reitsma Pieter H., Eikenboom Jeroen Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease Blood 2013;121 (14):2762-2772 [PubMed]
  • Wroblewska A., Reipert B. M., Pratt K. P., Voorberg J. Dangerous liaisons: how the immune system deals with factor VIII Journal of thrombosis and haemostasis 2013;11 (1):47-55 [PubMed]
  • Bloem Esther, van den Biggelaar Maartje, Wroblewska Aleksandra, Voorberg Jan, Faber Johan H., Kjalke Marianne, Stennicke Henning R., Mertens Koen, Meijer Alexander B. Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake Journal of biological chemistry 2013;288 (41):29670-29679 [PubMed]
  • van Haren Simon D., Wroblewska Aleksandra, Herczenik Eszter, Kaijen Paul H., Ruminska Aleksandra, ten Brinke Anja, Meijer Alexander B., Voorberg Jan Limited promiscuity of HLA-DRB1 presented peptides derived of blood coagulation factor VIII PLoS ONE 2013;8 (11):e80239 [PubMed]
  • Wróblewska Aleksandra Molecular determinants of FVIII immunogenecity in hemophilia A 2013. 163p. ISBN 9789461822635. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Voorberg J. J., Mertens K.; Co-supervisors: ten Brinke A., Meijer A. B.)
  • Sorvillo Nicoletta, van Haren Simon D., Kaijen Paul H., ten Brinke Anja, Fijnheer Rob, Meijer Alexander B., Voorberg Jan Preferential HLA-DRB1*11-dependent presentation of CUB2-derived peptides by ADAMTS13-pulsed dendritic cells Blood 2013;121 (17):3502-3510 [PubMed]
  • Dragt Bieuwke S. Unraveling von Willebrand factor extracellular traps 2013. 174p. ISBN 9789461823670. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Voorberg J. J.; Co-supervisor: de Laat B.)
  • Mourik M. J., Valentijn J. A., Voorberg J., Koster A. J., Valentijn K. M., Eikenboom J. von Willebrand factor remodeling during exocytosis from vascular endothelial cells Journal of thrombosis and haemostasis 2013;11 (11):2009-2019 [PubMed]

2012

  • Wang Jiong-Wei, Groeneveld Dafna J., Cosemans Guy, Dirven Richard J., Valentijn Karine M., Voorberg Jan, Reitsma Pieter H., Eikenboom Jeroen Biogenesis of Weibel-Palade bodies in von Willebrand's disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation Haematologica 2012;97 (6):859-866 [PubMed]
  • Dragt Bieuwke S., van Agtmaal Ellen L., de Laat Bas, Voorberg Jan Effect of laminar shear stress on the distribution of Weibel-Palade bodies in endothelial cells Thrombosis research 2012;130 (5):741-745 [PubMed]
  • Martin-Ramirez Javier, Hofman Menno, van den Biggelaar Maartje, Hebbel Robert P., Voorberg Jan Establishment of outgrowth endothelial cells from peripheral blood Nature protocols 2012;7 (9):1709-1715 [PubMed]
  • Froehlich-Zahnd Rahel, George James N., Vesely Sara K., Terrell Deirdra R., Aboulfatova Khatira, Dong Jing-Fei, Luken Brenda M., Voorberg Jan, Budde Ulrich, Sulzer Irmela, Lämmle Bernhard, Kremer Hovinga Johanna A. Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpura Haematologica 2012;97 (2):297-303 [PubMed]
  • Wang J. W., Valentijn J. A., Valentijn K. M., Dragt B. S., Voorberg J., Reitsma P. H., Eikenboom J. Formation of platelet-binding von Willebrand factor strings on non-endothelial cells Journal of thrombosis and haemostasis 2012;10 (10):2168-2178 [PubMed]
  • Hovinga Johanna A. Kremer, Voorberg Jan Improving on nature: redesigning ADAMTS13 Blood 2012;119 (16):3654-3655 [PubMed]
  • Chavez Christopher L., Keravala Annahita, Chu Jacqueline N., Farruggio Alfonso P., Cuéllar Vanessa E., Voorberg Jan, Calos Michele P. Long-Term Expression of Human Coagulation Factor VIII in a Tolerant Mouse Model Using the phi C31 Integrase System Human gene therapy 2012;23 (4):390-398 [PubMed]
  • Herczenik Eszter, van Haren Simon D., Wroblewska Aleksandra, Kaijen Paul, van den Biggelaar Maartje, Meijer Alexander B., ten Brinke Anja, Voorberg Jan Mannose-sensitive receptors mediate the uptake of factor VIII therapeutics by human dendritic cells Reply Journal of allergy and clinical immunology 2012;129 (4):1174-1175
  • Wroblewska Aleksandra, van Haren Simon D., Herczenik Eszter, Kaijen Paul, Ruminska Aleksandra, Jin Sheng-Yu, Zheng X. Long, van den Biggelaar Maartje, ten Brinke Anja, Meijer Alexander B., Voorberg Jan Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice Blood 2012;119 (22):5294-5300 [PubMed]
  • van Agtmaal Ellen L. Plasticity and Composition of Weibel-Palade Bodies in Endothelial Cells 2012. 145p. [UvA Dissertations Online] Utrecht University: Faculty of Science. (Supervisor: Mertens K.; Co-supervisors: Voorberg J. J., Fernandez-Borja M.)
  • van Breevoort Dorothee, van Agtmaal Ellen L., Dragt Bieuwke S., Gebbinck Jacqueline Klein, Dienava-Verdoold Ilze, Kragt Astrid, Bierings Ruben, Horrevoets Anton J. G., Valentijn Karine M., Eikenboom Jeroen C., Fernandez-Borja Mar, Meijer Alexander B., Voorberg Jan Proteomic Screen Identifies IGFBP7 as a Novel Component of Endothelial Cell-Specific Weibel-Palade Bodies Journal of proteome research 2012;11 (5):2925-2936 [PubMed]
  • van Haren Simon D., Wroblewska Aleksandra, Fischer Kathelijn, Voorberg Jan, Herczenik Eszter Requirements for immune recognition and processing of factor VIII by antigen-presenting cells Blood reviews 2012;26 (1):43-49 [PubMed]
  • van Hooren Kathinka W. E. M., van Agtmaal Ellen L., Fernandez-Borja Mar, van Mourik Jan A., Voorberg Jan, Bierings Ruben The Epac-Rap1 Signaling Pathway Controls cAMP-mediated Exocytosis of Weibel-Palade Bodies in Endothelial Cells Journal of biological chemistry 2012;287 (29):24713-24720 [PubMed]
  • Sorvillo Nicoletta, Pos Wouter, van den Berg Linda M., Fijnheer Rob, Martinez-Pomares Luisa, Geijtenbeek Teunis B., Herczenik Eszter, Voorberg Jan The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells Blood 2012;119 (16):3828-3835 [PubMed]
  • van Agtmaal Ellen L., Bierings Ruben, Dragt Bieuwke S., Leyen Thomas A., Fernandez-Borja Mar, Horrevoets Anton J. G., Voorberg Jan The shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies PLoS ONE 2012;7 (6):e38399 [PubMed]
  • Herczenik Eszter, van Haren Simon D., Wroblewska Aleksandra, Kaijen Paul, van den Biggelaar Maartje, Meijer Alexander B., Martinez-Pomares Luisa, ten Brinke Anja, Voorberg Jan Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain Journal of allergy and clinical immunology 2012;129 (2):501-U341 [PubMed]

2011

  • Xiao Juan, Jin Sheng-Yu, Xue Jing, Sorvillo Nicoletta, Voorberg Jan, Zheng X. Long Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis Arteriosclerosis, thrombosis, and vascular biology 2011;31 (10):2261-2269 [PubMed]
  • Bouwens Eveline A. M., Mourik Marjon J., van den Biggelaar Maartje, Eikenboom Jeroen C. J., Voorberg Jan, Valentijn Karine M., Mertens Koen Factor VIII alters tubular organization and functional properties of von Willebrand factor stored in Weibel-Palade bodies Blood 2011;118 (22):5947-5956 [PubMed]
  • Bouwens Eveline A. M. 'Factor VIII and von Willebrand factor co-delivery by endothelial cells 2011. 137p. [UvA Dissertations Online] Utrecht University: Faculty of Science. (Supervisor: Mertens K.; Co-supervisor: Voorberg J.)
  • Valentijn Karine M., Sadler J. Evan, Valentijn Jack A., Voorberg Jan, Eikenboom Jeroen Functional architecture of Weibel-Palade bodies Blood 2011;117 (19):5033-5043 [PubMed]
  • van Haren Simon D., Voorberg Jan Getting rid of bad memory Blood 2011;117 (1):7-8 [PubMed]
  • van Haren Simon D., Herczenik Eszter, ten Brinke Anja, Mertens Koen, Voorberg Jan, Meijer Alexander B. HLA-DR-presented peptide repertoires derived from human monocyte-derived dendritic cells pulsed with blood coagulation factor VIII Molecular & cellular proteomics 2011;10 (6):M110.002246 [PubMed]
  • Pos W., Luken B. M., Sorvillo N., Kremer Hovinga J. A., Voorberg J. Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura Journal of thrombosis and haemostasis 2011;9 (7):1285-1291 [PubMed]
  • van Haren Simon D. Immune recognition and processing of blood coagulation factor VIII by antigen-presenting cells 2011. 167p. [UvA Dissertations Online] Utrecht University: Faculty of Science. (Supervisor: Mertens K.; Co-supervisors: Voorberg J., Meijer A. B.)
  • Wang Jiong-Wei, Valentijn Karine M., de Boer Hetty C., Dirven Richard J., van Zonneveld Anton Jan, Koster Abraham J., Voorberg Jan, Reitsma Pieter H., Eikenboom Jeroen Intracellular Storage and Regulated Secretion of Von Willebrand Factor in Quantitative Von Willebrand Disease Journal of biological chemistry 2011;286 (27):24180-24188 [PubMed]
  • Dienava-Verdoold I., Boon-Spijker M. G., de Groot P. G., Brinkman H. J. M., Voorberg J., Mertens K., Derksen R. H. W. M., de Laat B. Patient-derived monoclonal antibodies directed towards beta2 glycoprotein-1 display lupus anticoagulant activity Journal of thrombosis and haemostasis 2011;9 (4):738-747 [PubMed]
  • Pos Wouter, Sorvillo Nicoletta, Fijnheer Rob, Feys Hendrik B., Kaijen Paul H. P., Vidarsson Gestur, Voorberg Jan Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain Haematologica 2011;96 (11):1670-1677 [PubMed]
  • van den Biggelaar Maartje, Bouwens Eveline A. M., Voorberg Jan, Mertens Koen Storage of factor VIII variants with impaired von Willebrand factor binding in Weibel-Palade bodies in endothelial cells PLoS ONE 2011;6 (8):e24163 [PubMed]
  • James E. A., van Haren S. D., Ettinger R. A., Fijnvandraat K., Liberman J. A., Kwok W. W., Voorberg J., Pratt K. P. T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site Journal of thrombosis and haemostasis 2011;9 (4):689-699 [PubMed]

2010

  • Pos Wouter, Crawley James T. B., Fijnheer Rob, Voorberg Jan, Lane David A., Luken Brenda M. An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF Blood 2010;115 (8):1640-1649 [PubMed]
  • Pos Wouter Characterization of human antibodies against ADAMTS13 that develop in patients with acquired TTP 2010. 160p. [UvA Dissertations Online] Utrecht University: Faculty of Science. (Supervisor: Mertens K.; Co-supervisors: Voorberg J. J., Fijnheer R.)
  • van Helden P. M. W., Kaijen P. H. P., Mauser-Bunschoten E. P., Fischer K., van den Berg H. M., Voorberg J. Domain specificity of factor VIII inhibitors during immune tolerance induction in patients with haemophilia A Haemophilia 2010;16 (6):892-901 [PubMed]
  • van Helden P. M. W., van Haren S. D., Fijnvandraat K., van den Berg H. Marijke, Voorberg J. Factor VIII-specific B cell responses in haemophilia A patients with inhibitors Haemophilia 2010;16 (102):35-43 [PubMed]

2009

  • Gouw S. C., ter Avest P. C., van Helden P. M., Voorberg J., van den Berg H. M. Discordant antibody response in monozygotic twins with severe haemophilia A caused by intensive treatment Haemophilia 2009;15 (3):712-717 [PubMed]
  • van den Biggelaar Maartje, Meijer Alexander B., Voorberg Jan, Mertens Koen Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles Blood 2009;113 (13):3102-3109 [PubMed]
  • van den Biggelaar Maartje, Bouwens Eveline A. M., Kootstra Neeltje A., Hebbel Robert P., Voorberg Jan, Mertens Koen Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells Haematologica 2009;94 (5):670-678 [PubMed]
  • Pos W., Luken B. M., Kremer Hovinga Johanna A., Turenhout E. A. M., Scheiflinger F., Dong J.-F., Fijnheer R., Voorberg J. VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura Journal of thrombosis and haemostasis 2009;7 (3):421-428 [PubMed]

2008

  • Li Y., Choi H., Zhou Z., Nolasco L., Pownall H. J., Voorberg J., Moake J. L., Dong J.-F. Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions Journal of thrombosis and haemostasis 2008;6 (7):1135-1143 [PubMed]
  • van den Biggelaar Maartje Factor VIII trafficking to Weibel-Palade bodies 2008. [UvA Dissertations Online] Universiteit van Utrecht: Sanquin research. (Supervisors: Mertens K., Storm G.; Co-supervisors: Voorberg J., Kootstra N. A.)
  • Rondaij Mariska G., Bierings Ruben, van Agtmaal Ellen L., Gijzen Karina A., Sellink Erica, Kragt Astrid, Ferguson Stephen S. G., Mertens Koen, Hannah Matthew J., van Mourik Jan A., Fernandez-Borja Mar, Voorberg Jan Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells Blood 2008;112 (1):56-63 [PubMed]
  • van Helden Pauline M. W., van den Berg H. Marijke, Gouw Samantha C., Kaijen Paul H. P., Zuurveld Marleen G., Mauser-Bunschoten Evelien P., Aalberse Rob C., Vidarsson Gestur, Voorberg Jan IgG subclasses of anti-FVIII antibodies during immune tolerance induction in patients with hemophilia A British journal of haematology 2008;142 (4):644-652 [PubMed]
  • Voorberg Jan Slipping out the Weibel-Palade body Blood 2008;111 (11):5264-5265 [PubMed]

2007

  • Riksen Niels P., Luken Brenda M., Klasen Ina S., Voorberg Jan, Crama Niels, van Deuren Marcel Antibodies against the CUB1-2 domains of ADAMTS13 in a patient with benign monoclonal gammopathy: no causal relationship Haematologica 2007;92 (7):e74-e76 [PubMed]
  • Bierings R., van den Biggelaar M., Kragt A., Mertens K., Voorberg J., van Mourik J. A. Efficiency of von Willebrand factor-mediated targeting of interleukin-8 into Weibel-Palade bodies Journal of thrombosis and haemostasis 2007;5 (12):2512-2519 [PubMed]
  • van Helden P. M. W., Kaijen P. H. P., Fijnvandraat K., van den Berg H. M., Voorberg J. Factor VIII-specific memory B cells in patients with hemophilia A Journal of thrombosis and haemostasis 2007;5 (11):2306-2308 [PubMed]
  • van den Biggelaar M., Bierings R., Storm G., Voorberg J., Mertens K. Requirements for cellular co-trafficking of factor VIII and von Willebrand factor to Weibel-Palade bodies Journal of thrombosis and haemostasis 2007;5 (11):2235-2242 [PubMed]

2006

  • Luken Brenda M., Turenhout Ellen A. M., Kaijen Paul H. P., Greuter Mascha J., Pos Wouter, van Mourik Jan A., Fijnheer Rob, Voorberg Jan Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP Thrombosis and haemostasis 2006;96 (3):295-301 [PubMed]
  • Tjernberg Pernilla, Vos Hans L., Spaargaren-van Riel Caroline C., Luken Brenda M., Voorberg Jan, Bertina Rogier M., Eikenboom Jeroen C. J. Differential effects of the loss of intrachain- versus interchain-disulfide bonds in the cystine-knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease Thrombosis and haemostasis 2006;96 (6):717-724 [PubMed]
  • Rondaij Mariska G., Bierings Ruben, Kragt Astrid, van Mourik Jan A., Voorberg Jan Dynamics and plasticity of Weibel-Palade bodies in endothelial cells Arteriosclerosis, thrombosis, and vascular biology 2006;26 (5):1002-1007 [PubMed]
  • Rondaij Mariska G., Bierings Ruben, Kragt Astrid, Gijzen Karina A., Sellink Erica, van Mourik Jan A., Fernandez-Borja Mar, Voorberg Jan Dynein-dynactin complex mediates protein kinase A-dependent clustering of Weibel-Palade bodies in endothelial cells Arteriosclerosis, thrombosis, and vascular biology 2006;26 (1):49-55 [PubMed]
  • Dekker Rob J., Boon Reinier A., Rondaij Mariska G., Kragt Astrid, Volger Oscar L., Elderkamp Yvonne W., Meijers Joost C. M., Voorberg Jan, Pannekoek Hans, Horrevoets Anton J. G. KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium Blood 2006;107 (11):4354-4363 [PubMed]
  • Luken B. M., Kaijen P. H. P., Turenhout E. A. M., Kremer Hovinga J. A., van Mourik J. A., Fijnheer R., Voorberg J. Multiple B-cell clones producing antibodies directed to the spacer and disintegrin/thrombospondin type-1 repeat 1 (TSP1) of ADAMTS13 in a patient with acquired thrombotic thrombocytopenic purpura Journal of thrombosis and haemostasis 2006;4 (11):2355-2364 [PubMed]
  • Bovenschen N., van Stempvoort G., Voorberg J., Mertens K., Meijer A. B. Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain Journal of thrombosis and haemostasis 2006;4 (7):1487-1493 [PubMed]
  • Bril Wendy S., van Helden Pauline M. W., Hausl Christina, Zuurveld Marleen G., Ahmad Rafi U., Hollestelle Martine J., Reitsma Pieter H., Fijnvandraat Karin, van Lier Rene A. W., Schwarz Hans Peter, Mertens Koen, Reipert Birgit M., Voorberg Jan Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg(593) to Cys substitution Thrombosis and haemostasis 2006;95 (2):341-347 [PubMed]

2005

  • Lewis Deborah A., Bovenschen Niels, Mertens Koen, Voorberg Jan, Ortel Thomas L. Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII Thrombosis and haemostasis 2005;93 (5):833-841 [PubMed]
  • Luken Brenda M., Turenhout Ellen A. M., Hulstein Janine J. J., van Mourik Jan A., Fijnheer Rob, Voorberg Jan The spacer domain of ADAMTS13 contains a major binding site for antibodies in patients with thrombotic thrombocytopenic purpura Thrombosis and haemostasis 2005;93 (2):267-274 [PubMed]

2004

  • Bril W. S., MacLean P. E., Kaijen P. H. P., van den Brink E. N., Lardy N. M., Fijnvandraat K., Peters M., Voorberg J. HLA class II genotype and factor VIII inhibitors in mild haemophilia A patients with an Arg593 to Cys mutation Haemophilia 2004;10 (5):509-514 [PubMed]
  • Rondaij Mariska G., Sellink Erica, Gijzen Karina A., ten Klooster Jean Paul, Hordijk Peter L., van Mourik Jan A., Voorberg Jan Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells Arteriosclerosis, thrombosis, and vascular biology 2004;24 (7):1315-1320 [PubMed]

2003

  • Schatz Simone, Turecek Peter L., Fiedler Christian, Zimmermann Klaus, Gritsch Herbert, Voorberg Jan, Schwarz Hans Peter, Dorner Friedrich, Scheiflinger Friedrich Evaluation of the haemostatic potential of factor VIII-heparin cofactor II hybrid proteins in a mouse model British journal of haematology 2003;123 (4):692-695 [PubMed]
  • Fijnvandraat Karin, Bril Wendy S., Voorberg Jan Immunobiology of inhibitor development in hemophilia A Seminars in thrombosis and hemostasis 2003;29 (1):61-68 [PubMed]
  • Astermark J., Voorberg J., Lenk H., Dimichele D., Shapiro A., Tjönnfjord G., Berntorp E. Impact of inhibitor epitope profile on the neutralizing effect against plasma-derived and recombinant factor VIII concentrates in vitro Haemophilia 2003;9 (5):567-572 [PubMed]
  • Bovenschen Niels, Boertjes Ria C., van Stempvoort Gunny, Voorberg Jan, Lenting Peter J., Meijer Alexander B., Mertens Koen Low density lipoprotein receptor-related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII Journal of biological chemistry 2003;278 (11):9370-9377 [PubMed]
  • Romani de Wit Thalia, Rondaij Mariska G., Hordijk Peter L., Voorberg Jan, van Mourik Jan A. Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies Arteriosclerosis, thrombosis, and vascular biology 2003;23 (5):755-761 [PubMed]
  • Romani de Wit Thalia, de Leeuw Hubert P. J. C., Rondaij Mariska G., de Laaf Rozalia T. M., Sellink Erica, Brinkman Herm-Jan, Voorberg Jan, van Mourik Jan A. Von Willebrand factor targets IL-8 to Weibel-Palade bodies in an endothelial cell line Experimental cell research 2003;286 (1):67-74 [PubMed]

2002

  • Bril Wendy S., Turenhout Ellen A. M., Kaijen Paul H. P., van den Brink Edward N., Koopman Maria M. W., Peters Marjolein, Voorberg Jan Analysis of factor VIII inhibitors in a haemophilia A patient with an Arg(593)-> Cys mutation using phage display British journal of haematology 2002;119 (2):393-396 [PubMed]
  • van Mourik Jan A., Romani de Wit Thalia, Voorberg Jan Biogenesis and exocytosis of Weibel-Palade bodies Histochemistry and cell biology 2002;117 (2):113-122 [PubMed]
  • Vlot André J., Wittebol Shulamiet, Strengers Paul F. W., Turenhout Ellen A. M., Voorberg Jan, van den Berg H. Marijke, Mauser-Bunschoten Eveline P. Factor VIII inhibitor in a patient with mild haemophilia A and an Asn618-->Ser mutation responsive to immune tolerance induction and cyclophosphamide British journal of haematology 2002;117 (1):136-140 [PubMed]
  • van den Brink Edward N., Bril Wendy S., Turenhout Ellen A. M., Zuurveld Marleen, Bovenschen Niels, Peters Marjolein, Yee Thynn Thynn, Mertens Koen, Lewis Deborah A., Ortel Thomas L., Lollar Pete, Scandella Dorothea, Voorberg Jan Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII Blood 2002;99 (8):2828-2834 [PubMed]

2001

  • van den Brink E. N., Turenhout E. A., Bovenschen N., Heijnen B. G., Mertens K., Peters M., Voorberg J. Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII Blood 2001;97 (4):966-972 [PubMed]
  • de Leeuw H. P., Fernandez-Borja M., Reits E. A., Romani de Wit T., Wijers-Koster P. M., Hordijk P. L., Neefjes J., van Mourik J. A., Voorberg J. Small GTP-binding protein Ral modulates regulated exocytosis of von Willebrand factor by endothelial cells Arteriosclerosis, thrombosis, and vascular biology 2001;21 (6):899-904 [PubMed]

2000

  • Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms Molecular biology of the cell 2000;11 (11):3819-3833 [PubMed]
  • Disappearance of factor VIII autoantibodies preceding autoimmune haemolytic anaemia Haemophilia 2000;6 (6):698-701 [PubMed]
  • Human antibodies with specificity for the C2 domain of factor VIII are derived from VH1 germline genes Blood 2000;95 (2):558-563 [PubMed]
  • Intracellular accumulation of factor VIII induced by missense mutations Arg593-->Cys and Asn618-->Ser explains cross-reacting material-reduced haemophilia A British journal of haematology 2000;108 (2):241-246 [PubMed]
  • Molecular analysis of human anti-factor VIII antibodies by V gene phage display identifies a new epitope in the acidic region following the A2 domain Blood 2000;96 (2):540-545 [PubMed]
  • Phage display technology: a tool to explore the diversity of inhibitors to blood coagulation factor VIII Seminars in thrombosis and hemostasis 2000;26 (2):143-150 [PubMed]

1999

  • Inhibitor development in a multitransfused patient with severe haemophilia A Thrombosis and haemostasis 1999;82 (1):151-152 [PubMed]
  • Longitudinal analysis of factor VIII inhibitors in a previously untreated mild haemophilia A patient with an Arg593-->Cys substitution Thrombosis and haemostasis 1999;81 (5):723-726 [PubMed]
  • Small GTP-binding protein RalA associates with Weibel-Palade bodies in endothelial cells Thrombosis and haemostasis 1999;82 (3):1177-1181 [PubMed]

1998

  • A human alloantibody interferes with binding of factor IXa to the factor VIII light chain Blood 1998;91 (7):2347-2352 [PubMed]
  • Small GTP-binding proteins in human endothelial cells British journal of haematology 1998;103 (1):15-19 [PubMed]

1997

  • The missense mutation Arg593 --> Cys is related to antibody formation in a patient with mild hemophilia A Blood 1997;89 (12):4371-4377 [PubMed]

1996

  • Arterial and venous thrombosis in two Italian families with the factor V Arg506-->Gln mutation European journal of haematology 1996;57 (1):96-100 [PubMed]
  • Enhanced thrombin sensitivity of a factor VIII-heparin cofactor II hybrid Journal of biological chemistry 1996;271 (35):20985-20988 [PubMed]
  • Factor V Arg506-->Gln mutation in patients with antiphospholipid antibodies Lupus 1996;5 (4):303-306 [PubMed]
  • Intracellular retention of a factor VIII protein with an Arg2307-->Gln mutation as a cause of haemophilia A Biochemical journal 1996;318 ( Pt 3):931-937 [PubMed]
  • Quantitative analysis of von Willebrand factor propeptide release in vivo: effect of experimental endotoxemia and administration of 1-deamino-8-D-arginine vasopressin in humans Blood 1996;88 (8):2951-2958 [PubMed]

1995

  • Binding of blood coagulation factor VIII and its light chain to phosphatidylserine/phosphatidylcholine bilayers as measured by ellipsometry Biochemical journal 1995;310 ( Pt 2):539-545 [PubMed]
  • Characterization of des-(741-1668)-factor VIII, a single-chain factor VIII variant with a fusion site susceptible to proteolysis by thrombin and factor Xa Biochemical journal 1995;312 ( Pt 1):49-55 [PubMed]

1994

  • Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V Lancet 1994;343 (8912):1535-1536 [PubMed]

1993

  • Biogenesis of von Willebrand factor-containing organelles in heterologous transfected CV-1 cells EMBO journal 1993;12 (2):749-758 [PubMed]

1992

  • Characterization of recombinant von Willebrand factor corresponding to mutations in type IIA and type IIB von Willebrand disease Journal of biological chemistry 1992;267 (32):23209-23215 [PubMed]

1991

  • Assembly and routing of von Willebrand factor variants: the requirements for disulfide-linked dimerization reside within the carboxy-terminal 151 amino acids Journal of cell biology 1991;113 (1):195-205 [PubMed]
  • The pro-polypeptide of von Willebrand factor is required for the formation of a functional factor VIII-binding site on mature von Willebrand factor Biochemical journal 1991;274 ( Pt 1):257-261 [PubMed]

1990

  • Domains involved in multimer assembly of von willebrand factor (vWF): multimerization is independent of dimerization EMBO journal 1990;9 (3):797-803 [PubMed]
  • Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes Molecular biology reports 1990;14 (4):265-275 [PubMed]

1989

  • Molecular cloning, expression and assembly of multimeric von Willebrand factor Baillière s clinical haematology 1989;2 (4):879-896 [PubMed]

1986

  • Characterization of three different flavodoxins from Azotobacter vinelandii European Journal of Biochemistry / FEBS 1986;155 (1):33-40 [PubMed]