Prof. R.H.L. Houtkooper PhD publications

2021

• Otto Natasja A., Butler Joe M., Ramirez-Moral Ivan, van Weeghel Michel, van Heijst Jeroen W. J., Scicluna Brendon P., Houtkooper Riekelt H., de Vos Alex F., van der Poll Tom Adherence affects monocyte innate immune function and metabolic reprogramming after lipopolysaccharide stimulation in vitro Journal of immunology (Baltimore, Md. 2021;206 (4):827-838 [PubMed]
• Verkerk Arie O., Knottnerus Suzan J. G., Portero Vincent, Bleeker Jeannette C., Ferdinandusse Sacha, Guan Kaomei, IJlst Lodewijk, Visser Gepke, Wanders Ronald J. A., Wijburg Frits A., Bezzina Connie R., Mengarelli Isabella, Houtkooper Riekelt H. Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation Frontiers in pharmacology 2021;11
• Ramirez-Moral I., Yu X., Butler J. M., van Weeghel M., Otto N. A., Ferreira B. Lima, Maele L. Van, Sirard J. C., de Vos A. F., de Jong M. D., Houtkooper R. H., van der Poll T. mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin Mucosal immunology 2021 [PubMed]

2020

• Molenaars Marte, Janssens Georges E., Williams Evan G., Jongejan Aldo, Lan Jiayi, Rabot Sylvie, Joly Fatima, Moerland Perry D., Schomakers Bauke V., Lezzerini Marco, Liu Yasmine J., McCormick Mark A., Kennedy Brian K., van Weeghel Michel, van Kampen Antoine H. C., Aebersold Ruedi, MacInnes Alyson W., Houtkooper Riekelt H. A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways Cell metabolism 2020;31 (3):549-563.e7 [PubMed]
• Trembinski D. Julia, Bink Diewertje I., Theodorou Kosta, Sommer Janina, Fischer Ariane, van Bergen Anke, Kuo Chao-Chung, Costa Ivan G., Schürmann Christoph, Leisegang Matthias S., Brandes Ralf P., Alekseeva Tijna, Brill Boris, Wietelmann Astrid, Johnson Christopher N., Spring-Connell Alexander, Kaulich Manuel, Werfel Stanislas, Engelhardt Stefan, Hirt Marc N., Yorgan Kaja, Eschenhagen Thomas, Kirchhof Luisa, Hofmann Patrick, Jaé Nicolas, Wittig Ilka, Hamdani Nazha, Bischof Corinne, Krishnan Jaya, Houtkooper Riekelt H., Dimmeler Stefanie, Boon Reinier A. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction Nature communications 2020;11 (1) [PubMed]
• Mkrtchyan Garik V., Abdelmohsen Kotb, Andreux P. nélope, Bagdonaite Ieva, Barzilai Nir, Brunak S. ren, Cabreiro Filipe, Cabo Rafael de, Campisi Judith, Cuervo Ana Maria, Demaria Marсo, Ewald Collin Y., Fang Evandro Fei, Faragher Richard, Ferrucci Luigi, Freund Adam, Silva-García Carlos G., Georgievskaya Anastasia, Gladyshev Vadim N., Glass David J., Gorbunova Vera, Grey Aubrey de, He Wei-Wu, Hoeijmakers Jan, Hoffmann Eva, Horvath Steve, Houtkooper Riekelt H., Jensen Majken K., Jensen Martin Borch, Kane Alice, Kassem Moustapha, Keizer Peter de, Kennedy Brian, Karsenty Gerard, Lamming Dudley W., Lee Kai-Fu, MacAulay Nanna, Mamoshina Polina, Mellon Jim, Molenaars Marte, Moskalev Alexey, Mund Andreas, Niedernhofer Laura, Osborne Brenna, Pak Heidi H., Parkhitko Andrey, Raimundo Nuno, Rando Thomas A., Rasmussen Lene Juel, Reis Carolina, Riedel Christian G., Franco-Romero Anais, Schumacher Björn, Sinclair David A., Suh Yousin, Taub Pam R., Toiber Debra, Treebak Jonas T., Valenzano Dario Riccardo, Verdin Eric, Vijg Jan, Young Sergey, Zhang Lei, Bakula Daniela, Zhavoronkov Alex, Scheibye-Knudsen Morten ARDD 2020: from aging mechanisms to interventions Aging 2020;12 (24):24486-24503 [PubMed]
• Schnitzler Johan G., Hoogeveen Renate M., Ali Lubna, Prange Koen H. M., Waissi Farahnaz, van Weeghel Michel, Bachmann Julian C., Versloot Miranda, Borrelli Matthew J., Yeang Calvin, de Kleijn Dominique P. V., Houtkooper Riekelt H., Koschinsky Marlys L., de Winther Menno P. J., Groen Albert K., Witztum Joseph L., Tsimikas Sotirios, Stroes Erik S. G., Kroon Jeffrey Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation Circulation research 2020;126 (10):1346-1359 [PubMed]
• Wüst Rob C. I., Houtkooper Riekelt H., Auwerx Johan Confounding factors from inducible systems for spatiotemporal gene expression regulation Journal of cell biology 2020;219 (7) [PubMed]
• Knottnerus Suzan J. G., Mengarelli Isabella, Wüst Rob C. I., Baartscheer Antonius, Bleeker Jeannette C., Coronel Ruben, Ferdinandusse Sacha, Guan Kaomei, Ijlst Lodewijk, Li Wener, Luo Xiaojing, Portero Vincent M., Ulbricht Ying, Visser Gepke, Wanders Ronald J. A., Wijburg Frits A., Verkerk Arie O., Houtkooper Riekelt H., Bezzina Connie R. Electrophysiological abnormalities in VLCAD deficient hiPSC-cardiomyocytes can be improved by lowering accumulation of fatty acid oxidation intermediates International journal of molecular sciences 2020;21 (7) [PubMed]
• Zapata-Pérez Rubén, Houtkooper Riekelt H. Enzyme engineering to fight mitochondrial diseases Nature Metabolism 2020;2 (3):215-216 [PubMed]
• Held Ntsiki M. Exploring cellular metabolism to improve cardiometabolic health 2020. 256p. ISBN 9789463756990. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Houtkooper Riekelt H. L.; Co-supervisors: van Weeghel Michel, Vaz Fred M.)
• Knottnerus Suzan J. G., van Harskamp Dewi, Schierbeek Henk, Bleeker Jeannette C., Crefcoeur Loek L., Ferdinandusse Sacha, van Goudoever Johannes B., Houtkooper Riekelt H., IJlst Lodewijk, Langeveld Mirjam, Wanders Ronald J. A., Vaz Frédéric M., Wijburg Frits A., Visser Gepke Exploring the metabolic fate of medium-chain triglycerides in healthy individuals using a stable isotope tracer Clinical nutrition (Edinburgh, Scotland) 2020 [PubMed]
• Lei Yu, Hoogerland Joanne A., Bloks Vincent W., Bos Trijnie, Bleeker Aycha, Wolters Henk, Wolters Justina C., Hijmans Brenda S., van Dijk Theo H., Thomas Rachel, van Weeghel Michel, Mithieux Gilles, Houtkooper Riekelt H., de Bruin Alain, Rajas Fabienne, Kuipers Folkert, Oosterveer Maaike H. Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a Hepatology (Baltimore, Md.) 2020;72 (5):1638-1653 [PubMed]
• Janssens Georges E., Houtkooper Riekelt H. Identification of longevity compounds with minimized probabilities of side effects Biogerontology 2020;21 (6):709-719 [PubMed]
• Hoepel Willianne, Allahverdiyeva Sona, Harbiye Haneen, de Taeye Steven W., van der Ham Alwin J., de Boer Leonie, Zaat Sebastiaan A. J., van Weeghel Michel, Baeten Dominique L. P., Houtkooper Riekelt H., Everts Bart, Vidarsson Gestur, den Dunnen Jeroen IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming Journal of immunology (Baltimore, Md. 2020;205 (12):3400-3407 [PubMed]
• van der Rijt Sanne, Molenaars Marte, McIntyre Rebecca L., Janssens Georges E., Houtkooper Riekelt H. Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction Frontiers in cell and developmental biology 2020;8 [PubMed]
• Otto Natasja A., Butler Joe M., Ramirez-Moral Ivan, Hoogerwerf Jacobien J., Houtkooper Riekelt H., de Vos Alex F., van der Poll Tom Metabolic adaptations of human alveolar macrophages upon activation by lipopolysaccharide in vivo Scandinavian journal of immunology 2020 [PubMed]
• Molenaars Marte 'Mitochondrial communication is key': Cross-compartmental signals maintaining proteostasis and longevity 2020. 255p. ISBN 9789464211344. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Houtkooper Riekelt H. L.; Co-supervisors: Janssens Georges E., Maccines A. W.)
• Molenaars Marte, Daniels Eileen G., Meurs Amber, Janssens Georges E., Houtkooper Riekelt H. Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2020;375 (1801) [PubMed]
• Wanders Ronald J. A., Visser Gepke, Ferdinandusse Sacha, Vaz Frédéric M., Houtkooper Riekelt H. Mitochondrial fatty acid oxidation disorders: Laboratory diagnosis, pathogenesis, and the complicated route to treatment Journal of Lipid and Atherosclerosis 2020;9 (3):313-333 [PubMed]
• Liu Yasmine J., McIntyre Rebecca L., Janssens Georges E., Houtkooper Riekelt H. Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease Mechanisms of ageing and development 2020;186 [PubMed]
• Liu Yasmine J., McIntyre Rebecca L., Janssens Georges E., Williams Evan G., Lan Jiayi, van Weeghel Michel, Schomakers Bauke, van der Veen Henk, van der Wel Nicole N., Yao Pallas, Mair William B., Aebersold Ruedi, MacInnes Alyson W., Houtkooper Riekelt H. Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30 Journal of cell biology 2020;219 (6) [PubMed]
• Liu Jia Modulating diet and mitochondria to promote longevity 2020. 268p. ISBN 9789464162608. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Houtkooper Riekelt H. L.; Co-supervisor: Maccines A. W.)
• Remie Carlijn M. E., Roumans Kay H. M., Moonen Michiel P. B., Connell Niels J., Havekes Bas, Mevenkamp Julian, Lindeboom Lucas, de Wit Vera H. W., van de Weijer Tineke, Aarts Suzanne A. B. M., Lutgens Esther, Schomakers Bauke V., Elfrink Hyung L., Zapata-Pérez Rubén, Houtkooper Riekelt H., Auwerx Johan, Hoeks Joris, Schrauwen-Hinderling Vera B., Phielix Esther, Schrauwen Patrick Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans American journal of clinical nutrition 2020;112 (2):413-426 [PubMed]
• Bleeker Jeannette C., Visser Gepke, Clarke Kieran, Ferdinandusse Sacha, de Haan Ferdinand H., Houtkooper Riekelt H., IJlst Lodewijk, Kok Irene L., Langeveld Mirjam, van der Pol W. Ludo, de Sain-van der Velden Monique G. M., Sibeijn-Kuiper Anita, Takken Tim, Wanders Ronald J. A., van Weeghel Michel, Wijburg Frits A., van der Woude Luc H., Wüst Rob C. I., Cox Pete J., Jeneson Jeroen A. L. Nutritional ketosis improves exercise metabolism in patients with very long-chain acyl-CoA dehydrogenase deficiency Journal of inherited metabolic disease 2020;43 (4):787-799 [PubMed]
• Knottnerus Suzan J. G., Pras-Raves Mia L., van der Ham Maria, Ferdinandusse Sacha, Houtkooper Riekelt H., Schielen Peter C. J. I., Visser Gepke, Wijburg Frits A., de Sain-van der Velden Monique G. M. Prediction of VLCAD deficiency phenotype by a metabolic fingerprint in newborn screening bloodspots BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2020;1866 (6) [PubMed]
• Lezzerini Marco, Penzo Marianna, O'Donohue Marie-Françoise, Marques Dos Santos Vieira Carolina, Saby Manon, Elfrink Hyung L., Diets Illja J., Hesse Anne-Marie, Couté Yohann, Gastou Marc, Nin-Velez Alexandra, Nikkels Peter G. J., Olson Alexandra N., Zonneveld-Huijssoon Evelien, Jongmans Marjolijn C. J., Zhang GuangJun, van Weeghel Michel, Houtkooper Riekelt H., Wlodarski Marcin W., Kuiper Roland P., Bierings Marc B., van der Werff ten Bosch Jutte, Leblanc Thierry, Montanaro Lorenzo, Dinman Jonathan D., da Costa Lydie, Gleizes Pierre-Emmanuel, MacInnes Alyson W. Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism Nucleic acids research 2020;48 (2):770-787 [PubMed]
• Held Ntsiki M., Wefers Jakob, van Weeghel Michel, Daemen Sabine, Hansen Jan, Vaz Frédéric M., van Moorsel Dirk, Hesselink Matthijs K. C., Houtkooper Riekelt H., Schrauwen Patrick Skeletal muscle in healthy humans exhibits a day-night rhythm in lipid metabolism Molecular metabolism 2020;37 [PubMed]
• Knottnerus Suzan J. G., Bleeker Jeannette C., Ferdinandusse Sacha, Houtkooper Riekelt H., Langeveld Mirjam, Nederveen Aart J., Strijkers Gustav J., Visser Gepke, Wanders Ronald J. A., Wijburg Frits A., Boekholdt S. Matthijs, Bakermans Adrianus J. Subclinical effects of long-chain fatty acid β-oxidation deficiency on the adult heart: A case-control magnetic resonance study Journal of inherited metabolic disease 2020;43 (5):969-980 [PubMed]
• Bou Sleiman Maroun, Jha Pooja, Houtkooper Riekelt, Williams Robert W., Wang Xu, Auwerx Johan The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators Cell reports 2020;32 (13) [PubMed]

2019

• Giroud-Gerbetant Judith, Joffraud Magali, Giner Maria Pilar, Cercillieux Angelique, Bartova Simona, Makarov Mikhail V., Zapata-Pérez Rubén, Sánchez-García José L., Houtkooper Riekelt H., Migaud Marie E., Moco Sofia, Canto Carles A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor Molecular metabolism 2019;30:192-202 [PubMed]
• Kuipers Eline N., Held Ntsiki M., in Het Panhuis Wietse, Modder Melanie, Ruppert Philip M. M., Kersten Sander, Kooijman Sander, Guigas Bruno, Houtkooper Riekelt H., Rensen Patrick C. N., Boon Mariëtte R. A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice American journal of physiology. Endocrinology and metabolism 2019;317 (5):E820-E830 [PubMed]
• Daniels Eileen G., Alders Marielle, Lezzerini Marco, McDonald Andrew, Peters Marjolein, Kuijpers Taco W., Lakeman Phillis, Houtkooper Riekelt H., MacInnes Alyson W. A uniparental isodisomy event introducing homozygous pathogenic variants drives a multisystem metabolic disorder Cold Spring Harbor molecular case studies 2019;5 (6) [PubMed]
• Li Yiran, Lou Wenjia, Raja Vaishnavi, Denis Simone, Yu Wenxi, Schmidtke Michael W., Reynolds Christian A., Schlame Michael, Houtkooper Riekelt H., Greenberg Miriam L. Cardiolipin-induced activation of pyruvate dehydrogenase links mitochondrial lipid biosynthesis to TCA cycle function Journal of biological chemistry 2019;294 (30):11568-11578 [PubMed]
• Van Strien Joeri, Guerrero-Castillo Sergio, Chatzispyrou Iliana A., Houtkooper Riekelt H., Brandt Ulrich, Huynen Martijn A. COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome Bioinformatics (Oxford, England) 2019;35 (17):3083-3091 [PubMed]
• Yetkin-Arik B., Vogels I. M. C., Neyazi N., van Duinen V., Houtkooper R. H., van Noorden C. J. F., Klaassen I., Schlingemann R. O. Endothelial tip cells in vitro are less glycolytic and have a more flexible response to metabolic stress than non-tip cells Scientific reports 2019;9 (1):10414 [PubMed]
• McIntyre Rebecca L., Daniels Eileen G., Molenaars Marte, Houtkooper Riekelt H., Janssens Georges E. From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs EMBO molecular medicine 2019 [PubMed]
• Liu Yasmine J., Janssens Georges E., McIntyre Rebecca L., Molenaars Marte, Kamble Rashmi, Gao Arwen W., Jongejan Aldo, Van Weeghel Michel, Macinnes Alyson W., Houtkooper Riekelt H. Glycine promotes longevity in caenorhabditis elegans in a methionine cycle-dependent fashion PLoS genetics 2019;15 (3) [PubMed]
• Duijkers Floor A., McDonald Andrew, Janssens Georges E., Lezzerini Marco, Jongejan Aldo, van Koningsbruggen Silvana, Leeuwenburgh-Pronk Wendela G., Wlodarski Marcin W., Moutton S. bastien, Tran-Mau-Them Frédéric, Thauvin-Robinet Christel, Faivre Laurence, Monaghan Kristin G., Smol Thomas, Boute-Benejean Odile, Ladda Roger L., Sell Susan L., Bruel Ange-Line, Houtkooper Riekelt H., MacInnes Alyson W. HNRNPR Variants that Impair Homeobox Gene Expression Drive Developmental Disorders in Humans American journal of human genetics 2019;104 (6):1040-1059 [PubMed]
• Pryor Rosina, Norvaisas Povilas, Marinos Georgios, Best Lena, Thingholm Louise B., Quintaneiro Leonor M., de Haes Wouter, Esser Daniela, Waschina Silvio, Lujan Celia, Smith Reuben L., Scott Timothy A., Martinez-Martinez Daniel, Woodward Orla, Bryson Kevin, Laudes Matthias, Lieb Wolfgang, Houtkooper Riekelt H., Franke Andre, Temmerman Liesbet, Bjedov Ivana, Cochemé Helena M., Kaleta Christoph, Cabreiro Filipe Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy Cell 2019;178 (6):1299-1312.e29 [PubMed]
• Bleeker Jeannette C., Kok Irene L., Ferdinandusse Sacha, van der Pol W. Ludo, Cuppen Inge, Bosch Annet M., Langeveld Mirjam, Derks Terry G. J., Williams Monique, de Vries Maaike, Mulder Margot F., Gozalbo Estela R., de Sain-van der Velden Monique G. M., Rennings Alexander J., Schielen Peter J. C. I., Dekkers Eugenie, Houtkooper Riekelt H., Waterham Hans R., Pras-Raves Mia L., Wanders Ronald J. A., van Hasselt Peter M., Schoenmakers Marja, Wijburg Frits A., Visser Gepke Impact of newborn screening for very-long-chain acyl-CoA dehydrogenase deficiency on genetic, enzymatic, and clinical outcomes Journal of inherited metabolic disease 2019;42 (3):414-423 [PubMed]
• Wiersma Marit, van Marion Denise M S, Wüst Rob C I, Houtkooper Riekelt H, Zhang Deli, Groot Natasja M S de, Henning Robert H, Brundel Bianca J J M Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation Cells 2019;8 (10) [PubMed]
• Connell Niels J., Houtkooper Riekelt H., Schrauwen Patrick NAD + metabolism as a target for metabolic health: have we found the silver bullet? Diabetologia 2019;62 (6):888-899 [PubMed]
• Claushuis Theodora A. M., van der Veen Annelou I. P., Horn Janneke, Schultz Marcus J., Houtkooper Riekelt H., van ’t Veer Cornelis, van der Poll Tom Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis Platelets 2019;30 (3):296-304 [PubMed]
• Yetkin-Arik Bahar, Vogels Ilse M. C., Nowak-Sliwinska Patrycja, Weiss Andrea, Houtkooper Riekelt H., van Noorden Cornelis J. F., Klaassen Ingeborg, Schlingemann Reinier O. The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis Scientific reports 2019;9 (1) [PubMed]
• Wanders Ronald J. A., Vaz Frederic M., Ferdinandusse Sacha, van Kuilenburg André B. P., Kemp Stephan, van Karnebeek Clara D., Waterham Hans R., Houtkooper Riekelt H. Translational Metabolism: A multidisciplinary approach towards precision diagnosis of inborn errors of metabolism in the omics era Journal of inherited metabolic disease 2019;42 (2):197-208 [PubMed]
• Connell Niels J., Houtkooper Riekelt H., Schrauwen Patrick Underpowered or negative? A crucial distinction. Reply to Dollerup OL, Treebak JT, Jessen N [letter] Diabetologia 2019;62 (6):1096 [PubMed]

2018

• Baardman Jeroen, Verberk Sanne G. S., Prange Koen H. M., van Weeghel Michel, van der Velden Saskia, Ryan Dylan G., Wüst Rob C. I., Neele Annette E., Speijer Dave, Denis Simone W., Witte Maarten E., Houtkooper Riekelt H., O'neill Luke A., Knatko Elena V., Dinkova-Kostova Albena T., Lutgens Esther, de Winther Menno P. J., van den Bossche Jan A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia Cell reports 2018;25 (8):2044-2052 [PubMed]
• Adam Aziza A. A., van Wenum Martien, van der Mark Vincent A., Jongejan Aldo, Moerland Perry D., Houtkooper Riekelt H., Wanders Ronald J. A., Oude Elferink Ronald P., Chamuleau Robert A. F. M., Hoekstra Ruurdtje AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration Mitochondrion 2018;39:30-42 [PubMed]
• Chatzispyrou Iliana A., Guerrero-Castillo Sergio, Held Ntsiki M., Ruiter Jos P. N., Denis Simone W., IJlst Lodewijk, Wanders Ronald J., van Weeghel Michel, Ferdinandusse Sacha, Vaz Frédéric M., Brandt Ulrich, Houtkooper Riekelt H. Barth syndrome cells display widespread remodeling of mitochondrial complexes without affecting metabolic flux distribution BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018;1864 (11):3650-3658 [PubMed]
• Moore Kat S., Yagci Nurcan, van Alphen Floris, Paolini Nahuel A., Horos Rastislav, Held Ntsiki M., Houtkooper Riekelt H., van den Akker Emile, Meijer Alexander B., 't Hoen Peter A. C., von Lindern Marieke Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line Scientific reports 2018;8 (1):2628 [PubMed]
• Houtkooper Riekelt H. L., Daniels Eileen G., Visser Gepke, van Everdingen Jannes J., Buiter Rob De hielprik Stichting Bio-Wetenschappen en Maatschappij; 2018.
• Kors Lotte, Rampanelli Elena, Stokman Geurt, Butter Loes M., Held Ntsiki M., Claessen Nike, Larsen Per W. B., Verheij Joanne, Zuurbier Coert J., Liebisch Gerhard, Schmitz Gerd, Girardin Stephen E., Florquin Sandrine, Houtkooper Riekelt H., Leemans Jaklien C. Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018;1864 (5):1883-1895 [PubMed]
• Houtkooper Riekelt Dieting bacteria cure fatty liver disease Science translational medicine 2018;10 (432)
• Knottnerus Suzan J. G., Bleeker Jeannette C., Wüst Rob C. I., Ferdinandusse Sacha, IJlst Lodewijk, Wijburg Frits A., Wanders Ronald J. A., Visser Gepke, Houtkooper Riekelt H. Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle Reviews in endocrine & metabolic disorders 2018;19 (1):93-106 [PubMed]
• Houtkooper Riekelt Fat up to BAT Science translational medicine 2018;10 (448)
• Houtkooper Riekelt Fetal against fatal: In utero genome editing to prevent metabolic disease Science translational medicine 2018;10 (464)
• Gao Arwen W., Uit de Bos Jelmi, Sterken Mark G., Kammenga Jan E., Smith Reuben L., Houtkooper Riekelt H. Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 2018;1864 (9B):2697-2706 [PubMed]
• Gao Arwen W., Smith Reuben L., van Weeghel Michel, Kamble Rashmi, Janssens Georges E., Houtkooper Riekelt H. Identification of key pathways and metabolic fingerprints of longevity in C. elegans Experimental gerontology 2018;113:128-140 [PubMed]
• van Weeghel Michel, Abdurrachim Desiree, Nederlof Rianne, Argmann Carmen A., Houtkooper Riekelt H., Hagen Jacob, Nabben Miranda, Denis Simone, Ciapaite Jolita, Kolwicz Stephen C., Lopaschuk Gary D., Auwerx Johan, Nicolay Klaas, Des Rosiers Christine, Wanders Ronald J., Zuurbier Coert J., Prompers Jeanine J., Houten Sander M. Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B Cardiovascular research 2018;114 (10):1324-1334 [PubMed]
• Bleeker Jeannette C. Long-chain fatty acid oxidation disorders: changing perspectives 2018. 230p. ISBN 9789463751995. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Wijburg F. A., Nieuwenhuis E. E. S.; Co-supervisors: Visser G., Houtkooper R. H.)
• Gao Wen Metabolic control of aging in C. elegans 2018. 201p. ISBN 9789462998858. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Wanders R. J. A.; Co-supervisor: Houtkooper R. H. L.)
• Smith Reuben L., Soeters Maarten R., Wüst Rob C. I., Houtkooper Riekelt H. Metabolic flexibility as an adaptation to energy resources and requirements in health and disease Endocrine reviews 2018;39 (4):489-517 [PubMed]
• Molenaars Marte, Janssens Georges E., Santermans Toon, Lezzerini Marco, Jelier Rob, MacInnes Alyson W., Houtkooper Riekelt H. Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation Life Science Alliance 2018;1 (5) [PubMed]
• Witting Michael, Hastings Janna, Rodriguez Nicolas, Joshi Chintan J., Hattwell Jake P. N., Ebert Paul R., van Weeghel Michel, Gao Arwen W., Wakelam Michael J. O., Houtkooper Riekelt H., Mains Abraham, Novère Nicolas Le, Sadykoff Sean, Schroeder Frank, Lewis Nathan E., Schirra Horst-Joachim, Kaleta Christoph, Casanueva Olivia Modeling meets metabolomics-the wormjam consensus model as basis for metabolic studies in the model organism Caenorhabditis elegans Frontiers in Molecular Biosciences 2018;5 (NOV) [PubMed]
• Gao Arwen W., Sterken Mark G., de Bos Jelmi uit, van Creij Jelle, Kamble Rashmi, Snoek Basten L., Kammenga Jan E., Houtkooper Riekelt H. Natural genetic variation in C. Elegans identified genomic loci controlling metabolite levels Genome research 2018;28 (9):1296-1308 [PubMed]
• Houtkooper Riekelt H. Preface - Animal models for aging BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018;1864 (9):2679 [PubMed]
• Held Ntsiki M., Kuipers Eline N., van Weeghel Michel, van Klinken Jan Bert, Denis Simone W., Lombès Marc, Wanders Ronald J., Vaz Frédéric M., Rensen Patrick C. N., Verhoeven Arthur J., Boon Mariëtte R., Houtkooper Riekelt H. Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation Scientific reports 2018;8 (1) [PubMed]
• Kuipers Eline N., van Dam Andrea D., Held Ntsiki M., Mol Isabel M., Houtkooper Riekelt H., Rensen Patrick C. N., Boon Mariëtte R. Quercetin lowers plasma triglycerides accompanied by white adipose tissue browning in diet-induced obese mice International journal of molecular sciences 2018;19 (6) [PubMed]
• Wlodarski Marcin W., da Costa Lydie, O'donohue Marie-Françoise, Gastou Marc, Karboul Narjesse, Montel-Lehry Nathalie, Hainmann Ina, Danda Dominika, Szvetnik Amina, Pastor Victor, Paolini Nahuel, di Summa Franca M., Tamary Hannah, Quider Abed Abu, Aspesi Anna, Houtkooper Riekelt H., Leblanc Thierry, Niemeyer Charlotte M., Gleizes Pierre-Emmanuel, Macinnes Alyson W. Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in diamond-blackfan anemia Haematologica 2018;103 (6):949-958 [PubMed]
• Houtkooper Riekelt Sweet skin remedy Science translational medicine 2018;10 (440)
• Chatzispyrou Iliana A. The role of mitochondrial metabolism in health and disease 2018. ISBN 9789402810172. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Wanders R. J. A.; Co-supervisor: Houtkooper R. H. L.)
• Houtkooper Riekelt Treating phenylketonuria now Phe-sible with engineered bacteria? Science translational medicine 2018;10 (456)

2017

• Nederlof Rianne, Denis Simone, Lauzier Benjamin, Rosiers Christine Des, Laakso Markku, Hagen Jacob, Argmann Carmen, Wanders Ronald, Houtkooper Riekelt H., Hollmann Markus W., Houten Sander M., Zuurbier Coert J. Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart Metabolism: clinical and experimental 2017;72:66-74 [PubMed]
• Chatzispyrou Iliana A., Alders Marielle, Guerrero-Castillo Sergio, Zapata Perez Ruben, Haagmans Martin A., Mouchiroud Laurent, Koster Janet, Ofman Rob, Baas Frank, Waterham Hans R., Spelbrink Johannes N., Auwerx Johan, Mannens Marcel M., Houtkooper Riekelt H., Plomp Astrid S. A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome Human molecular genetics 2017;26 (13):2541-2550 [PubMed]
• Paolini Nahuel A., Attwood Martin, Sondalle Samuel B., Vieira Carolina Marques Dos Santos, van Adrichem Anita M., di Summa Franca M., O'Donohue Marie-Françoise, Gleizes Pierre-Emmanuel, Rachuri Swaksha, Briggs Joseph W., Fischer Roman, Ratcliffe Peter J., Wlodarski Marcin W., Houtkooper Riekelt H., von Lindern Marieke, Kuijpers Taco W., Dinman Jonathan D., Baserga Susan J., Cockman Matthew E., MacInnes Alyson W. A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism American journal of human genetics 2017;100 (3):506-522 [PubMed]
• Gao Arwen W., Chatzispyrou Iliana A., Kamble Rashmi, Liu Yasmine J., Herzog Katharina, Smith Reuben L., van Lenthe Henk, Vervaart Martin A. T., van Cruchten Arno, Luyf Angela C., van Kampen Antoine, Pras-Raves Mia L., Vaz Frédéric M., Houtkooper Riekelt H. A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C-elegans Scientific reports 2017;7 (1):2408 [PubMed]
• van Valkengoed Irene G. M., Argmann Carmen, Ghauharali-van der Vlugt Karen, Aerts Johannes M. F. G., Brewster Lizzy M., Peters R. J. G., Vaz Frédéric M., Houtkooper Riekelt H. Ethnic differences in metabolite signatures and type 2 diabetes: a nested case-control analysis among people of South Asian, African and European origin NUTRITION & DIABETES 2017;7 (12) [PubMed]
• Palir Neža, Ruiter Jos P. N., Wanders Ronald J. A., Houtkooper Riekelt H. Identification of enzymes involved in oxidation of phenylbutyrate Journal of lipid research 2017;58 (5):955-961 [PubMed]
• Wüst Rob C. I., Visser Gepke, Wanders Ronald J. A., Houtkooper Riekelt H. Ketones and inborn errors of metabolism: old friends revisited Journal of inherited metabolic disease 2017;40 (1):3-4 [PubMed]
• Gao Yuanqing, Vidal-Itriago Andrés, Kalsbeek Martin J., Layritz Clarita, García-Cáceres Cristina, Tom Robby Zachariah, Eichmann Thomas O., Vaz Frédéric M., Houtkooper Riekelt H., van der Wel Nicole, Verhoeven Arthur J., Yan Jie, Kalsbeek Andries, Eckel Robert H., Hofmann Susanna M., Yi Chun-Xia Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity Cell reports 2017;20 (13):3034-3042 [PubMed]
• Lachmandas Ekta, Boutens Lily, Ratter Jacqueline M., Hijmans Anneke, Hooiveld Guido J., Joosten Leo A. B., Rodenburg Richard J., Fransen Jack A. M., Houtkooper Riekelt H., van Crevel Reinout, Netea Mihai G., Stienstra Rinke Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes Nature microbiology 2017;2 (3):16246 [PubMed]
• Lankelma Jacqueline M., Birnie Emma, Weehuizen Tassili A. F., Scicluna Brendon P., Belzer Clara, Houtkooper Riekelt H., Roelofs Joris J. T. H., de Vos Alex F., van der Poll Tom, Budding Andries E., Wiersinga W. Joost The gut microbiota as a modulator of innate immunity during melioidosis PLoS neglected tropical diseases 2017;11 (4):e0005548 [PubMed]

2016

• Koopman Mandy, Michels Helen, Dancy Beverley M., Kamble Rashmi, Mouchiroud Laurent, Auwerx Johan, Nollen Ellen A. A., Houtkooper Riekelt H. A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans Nature protocols 2016;11 (10):1798-1816 [PubMed]
• Thiels Charlotte, Fleger Martin, Huemer Martina, Rodenburg Richard J., Vaz Frederic M., Houtkooper Riekelt H., Haack Tobias B., Prokisch Holger, Feichtinger René G., Lücke Thomas, Mayr Johannes A., Wortmann Saskia B. Atypical Clinical Presentations of TAZ Mutations: An Underdiagnosed Cause of Growth Retardation? JIMD reports 2016;29:89-93 [PubMed]
• Hornberger Troy A., Carter Heather N., Hood David A., Figueiredo Vandré Casagrande, Dupont-Versteegden Esther E., Peterson Charlotte A., McCarthy John J., Camera Donny M., Hawley John A., Chaillou Thomas, Cheng Arthur J., Nader Gustavo A., Wüst Rob C. I., Houtkooper Riekelt H. Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough Journal of applied physiology (Bethesda, Md. 2016;121 (2):597-600 [PubMed]
• Wust Rob C. I., Houtkooper Riekelt H. EXERCISE ADAPTATIONS: THE WHOLE IS GREATER THAN THE SUM OF ITS PARTS Journal of applied physiology (Bethesda, Md. 2016;121 (2):599-600
• Kulkarni Sameer S., Joffraud Magali, Boutant Marie, Ratajczak Joanna, Gao Arwen W., Maclachlan Catherine, Hernandez-Alvarez Maria Isabel, Raymond Frédéric, Metairon Sylviane, Descombes Patrick, Houtkooper Riekelt H., Zorzano Antonio, Cantó Carles Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin Diabetes 2016;65 (12):3552-3560 [PubMed]
• Houtkooper Riekelt H. NAD+ as a Pharmacological Tool to Boost Sirtuin Activityin: Riekelt Houtkooper, editors. Sirtuins. Amsterdam: Springer; 2016. p. 29-40, ISBN 9789402409611; 9789402409628
• Bleeker Jeannette C., Houtkooper Riekelt H. Sirtuin activation as a therapeutic approach against inborn errors of metabolism Journal of inherited metabolic disease 2016;39 (4):565-572 [PubMed]
• Houtkooper Riekelt SirtuinsAmsterdam: Springer; 2016. ISBN 9789402409611; 9789402409628 (Proteins and Cell Regulation; 10)
• Cantó Carles, Houtkooper Riekelt H. Sirtuins and Agingin: Riekelt Houtkooper, editors. Sirtuins. Amsterdam: Springer; 2016. p. 213-227, ISBN 9789402409611; 9789402409628
• Schooneman Marieke G., Houtkooper Riekelt H., Hollak Carla E. M., Wanders Ronald J. A., Vaz Frédéric M., Soeters Maarten R., Houten Sander M. The impact of altered carnitine availability on acylcarnitine metabolism, energy expenditure and glucose tolerance in diet-induced obese mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2016;1862 (8):1375-1382 [PubMed]

2015

• Wang Xu, Ryu Dongryeol, Houtkooper Riekelt H., Auwerx Johan Antibiotic use and abuse: a threat to mitochondria and chloroplasts with impact on research, health, and environment BioEssays 2015;37 (10):1045-1053 [PubMed]
• Diekman Eugene F., Ferdinandusse Sacha, van der Pol Ludo, Waterham Hans R., Ruiter Jos P. N., Ijlst Lodewijk, Wanders Ronald J., Houten Sander M., Wijburg Frits A., Blank A. Christiaan, Asselbergs Folkert W., Houtkooper Riekelt H., Visser Gepke Fatty acid oxidation flux predicts the clinical severity of VLCAD deficiency Genetics in medicine 2015;17 (12):989-994 [PubMed]
• Doddaballapur Anuradha, Michalik Katharina M., Manavski Yosif, Lucas Tina, Houtkooper Riekelt H., You Xintian, Chen Wei, Zeiher Andreas M., Potente Michael, Dimmeler Stefanie, Boon Reinier A. Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3 Arteriosclerosis, thrombosis, and vascular biology 2015;35 (1):137-145 [PubMed]
• Held Ntsiki M., Houtkooper Riekelt H. Mitochondrial quality control pathways as determinants of metabolic health BioEssays 2015;37 (8):867-876 [PubMed]
• Kooijman Sander, van den Berg Rosa, Ramkisoensing Ashna, Boon Mariëtte R., Kuipers Eline N., Loef Marieke, Zonneveld Tom C. M., Lucassen Eliane A., Sips Hetty C. M., Chatzispyrou Iliana A., Houtkooper Riekelt H., Meijer Johanna H., Coomans Claudia P., Biermasz Nienke R., Rensen Patrick C. N. Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity Proceedings of the National Academy of Sciences of the United States of America 2015;112 (21):6748-6753 [PubMed]
• Chatzispyrou Iliana A., Held Ntsiki M., Mouchiroud Laurent, Auwerx Johan, Houtkooper Riekelt H. Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research Cancer research 2015;75 (21):4446-4449 [PubMed]
• Moullan Norman, Mouchiroud Laurent, Wang Xu, Ryu Dongryeol, Williams Evan G., Mottis Adrienne, Jovaisaite Virginija, Frochaux Michael V., Quiros Pedro M., Deplancke Bart, Houtkooper Riekelt H., Auwerx Johan Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research Cell reports 2015;10 (10):1681-1691 [PubMed]
• Vatner Dorothy E., Yan Lin, Lai Lo, Yuan Chujun, Mouchiroud Laurent, Pachon Ronald E., Zhang Jie, Dillinger Jean-Guillaume, Houtkooper Riekelt H., Auwerx Johan, Vatner Stephen F. Type 5 adenylyl cyclase disruption leads to enhanced exercise performance Aging cell 2015;14 (6):1075-1084 [PubMed]

2014

• Andreux Pénélope A., Mouchiroud Laurent, Wang Xu, Jovaisaite Virginija, Mottis Adrienne, Bichet Sabrina, Moullan Norman, Houtkooper Riekelt H., Auwerx Johan A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans Scientific reports 2014;4:5285 [PubMed]
• Wijnen Wino J., van der Made Ingeborg, van den Oever Stephanie, Hiller Monika, de Boer Bouke A., Picavet Daisy I., Chatzispyrou Iliana A., Houtkooper Riekelt H., Tijsen Anke J., Hagoort Jaco, van Veen Henk, Everts Vincent, Ruijter Jan M., Pinto Yigal M., Creemers Esther E. Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy PLoS ONE 2014;9 (5):e96290 [PubMed]
• Ye Cunqi, Lou Wenjia, Li Yiran, Chatzispyrou Iliana A., Hüttemann Maik, Lee Icksoo, Houtkooper Riekelt H., Vaz Frédéric M., Chen Shuliang, Greenberg Miriam L. Deletion of the cardiolipin-specific phospholipase Cld1 rescues growth and life span defects in the tafazzin mutant: implications for Barth syndrome Journal of biological chemistry 2014;289 (6):3114-3125 [PubMed]
• Stienstra Rinke, Dijk Wieneke, van Beek Lianne, Jansen Henry, Heemskerk Mattijs, Houtkooper Riekelt H., Denis Simone, van Harmelen Vanessa, Willems van Dijk Ko, Tack Cees J., Kersten Sander Mannose-binding lectin is required for the effective clearance of apoptotic cells by adipose tissue macrophages during obesity Diabetes 2014;63 (12):4143-4153 [PubMed]
• Gao Arwen W., Houtkooper Riekelt H. Mitochondrial fission: firing up mitochondria in brown adipose tissue EMBO journal 2014;33 (5):401-402 [PubMed]
• Gao Arwen W., Cantó Carles, Houtkooper Riekelt H. Mitochondrial response to nutrient availability and its role in metabolic disease EMBO molecular medicine 2014;6 (5):580-589 [PubMed]
• Chatzispyrou Iliana A., Houtkooper Riekelt H. The two-faced progeria gene and its implications in aging and metabolism EMBO reports 2014;15 (5):470-471 [PubMed]

2013

• Gonzalvez François, D'Aurelio Marilena, Boutant Marie, Moustapha Aoula, Puech Jean-Philippe, Landes Thomas, Arnauné-Pelloquin Laeticia, Vial Guillaume, Taleux Nellie, Slomianny Christian, Wanders Ronald J., Houtkooper Riekelt H., Bellenguer Pascale, Møller Ian Max, Gottlieb Eyal, Vaz Frederic M., Manfredi Giovanni, Petit Patrice X. Barth syndrome: cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2013;1832 (8):1194-1206 [PubMed]
• Andreux Penelope Identification of genetic determinants and pharmacological modulators of mitochondrial function 2013. 194p. [UvA Dissertations Online] École polytechnique fédérale de Lausanne EPFL: Faculté des sciences de la vie. (Supervisor: Auwerx J.; Co-supervisor: Houtkooper R. H. L.)
• Houtkooper Riekelt H., Mouchiroud Laurent, Ryu Dongryeol, Moullan Norman, Katsyuba Elena, Knott Graham, Williams Robert W., Auwerx Johan Mitonuclear protein imbalance as a conserved longevity mechanism Nature 2013;497 (7450):451-+ [PubMed]
• Mouchiroud Laurent, Houtkooper Riekelt H., Auwerx Johan NAD(+) metabolism: A therapeutic target for age-related metabolic disease Critical reviews in biochemistry and molecular biology 2013;48 (4):397-408 [PubMed]
• Andreux Pénélope A., Houtkooper Riekelt H., Auwerx Johan Pharmacological approaches to restore mitochondrial function Nature reviews. Drug discovery 2013;12 (6):465-483 [PubMed]
• Mouchiroud Laurent, Houtkooper Riekelt H., Moullan Norman, Katsyuba Elena, Ryu Dongryeol, Cantó Carles, Mottis Adrienne, Jo Young-Suk, Viswanathan Mohan, Schoonjans Kristina, Guarente Leonard, Auwerx Johan The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling Cell 2013;154 (2):430-441 [PubMed]

2012

• Kloek Jaap J., Maréchal Xavier, Roelofsen Jeroen, Houtkooper Riekelt H., van Kuilenburg André B. P., Kulik Willem, Bezemer Rick, Nevière Rémi, van Gulik Thomas M., Heger Michal Cholestasis is associated with hepatic microvascular dysfunction and aberrant energy metabolism before and during ischemia-reperfusion Antioxidants & redox signaling 2012;17 (8):1109-1123 [PubMed]
• Houtkooper Riekelt H., Auwerx Johan Exploring the therapeutic space around NAD(+) Journal of cell biology 2012;199 (2):205-209 [PubMed]
• Janiszewska Michalina, Suvà Mario L., Riggi Nicolo, Houtkooper Riekelt H., Auwerx Johan, Clément-Schatlo Virginie, Radovanovic Ivan, Rheinbay Esther, Provero Paolo, Stamenkovic Ivan Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells Genes & development 2012;26 (17):1926-1944 [PubMed]
• Hinard Valérie, Mikhail Cyril, Pradervand Sylvain, Curie Thomas, Houtkooper Riekelt H., Auwerx Johan, Franken Paul, Tafti Mehdi Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures Journal of neuroscience 2012;32 (36):12506-12517 [PubMed]
• Houtkooper Riekelt H., Pirinen Eija, Auwerx Johan Sirtuins as regulators of metabolism and healthspan Nature reviews. Molecular cell biology 2012;13 (4):225-238 [PubMed]
• Andreux Pénélope A., Williams Evan G., Koutnikova Hana, Houtkooper Riekelt H., Champy Marie-France, Henry Hugues, Schoonjans Kristina, Williams Robert W., Auwerx Johan Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits Cell 2012;150 (6):1287-1299 [PubMed]
• Cantó Carles, Houtkooper Riekelt H., Pirinen Eija, Youn Dou Y., Oosterveer Maaike H., Cen Yana, Fernandez-Marcos Pablo J., Yamamoto Hiroyasu, Andreux Pénélope A., Cettour-Rose Philippe, Gademann Karl, Rinsch Chris, Schoonjans Kristina, Sauve Anthony A., Auwerx Johan The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity Cell metabolism 2012;15 (6):838-847 [PubMed]

2011

• Schug Z. T., Gonzalvez F., Houtkooper R. H., Vaz F. M., Gottlieb E. BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane Cell death and differentiation 2011;18 (3):538-548 [PubMed]
• Timmers Silvie, Konings Ellen, Bilet Lena, Houtkooper Riekelt H., van de Weijer Tineke, Goossens Gijs H., Hoeks Joris, van der Krieken Sophie, Ryu Dongryeol, Kersten Sander, Moonen-Kornips Esther, Hesselink Matthijs K. C., Kunz Iris, Schrauwen-Hinderling Vera B., Blaak Ellen E., Auwerx Johan, Schrauwen Patrick Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans Cell metabolism 2011;14 (5):612-622 [PubMed]
• Acehan Devrim, Vaz Frederic, Houtkooper Riekelt H., James Jeanne, Moore Vicky, Tokunaga Chonan, Kulik Willem, Wansapura Janaka, Toth Matthew J., Strauss Arnold, Khuchua Zaza Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome Journal of biological chemistry 2011;286 (2):899-908 [PubMed]
• Bai Péter, Cantó Carles, Oudart Hugues, Brunyánszki Attila, Cen Yana, Thomas Charles, Yamamoto Hiroyasu, Huber Aline, Kiss Borbála, Houtkooper Riekelt H., Schoonjans Kristina, Schreiber Valérie, Sauve Anthony A., Menissier-de Murcia Josiane, Auwerx Johan PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation Cell metabolism 2011;13 (4):461-468 [PubMed]
• Houtkooper Riekelt H., Argmann Carmen, Houten Sander M., Cantó Carles, Jeninga Ellen H., Andreux Pénélope A., Thomas Charles, Doenlen Raphaël, Schoonjans Kristina, Auwerx Johan The metabolic footprint of aging in mice Scientific reports 2011;1:134 [PubMed]

2010

• Houtkooper Riekelt H., Williams Robert W., Auwerx Johan Metabolic networks of longevity Cell 2010;142 (1):9-14 [PubMed]
• Zaltsman Yehudit, Shachnai Liat, Yivgi-Ohana Natalie, Schwarz Michal, Maryanovich Maria, Houtkooper Riekelt H., Vaz Frédéric Maxime, de Leonardis Francesco, Fiermonte Giuseppe, Palmieri Ferdinando, Gillissen Bernhard, Daniel Peter T., Jimenez Erin, Walsh Susan, Koehler Carla M., Roy Soumya Sinha, Walter Ludivine, Hajnóczky György, Gross Atan MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria Nature cell biology 2010;12 (6):553-562 [PubMed]
• Houtkooper Riekelt H., Auwerx Johan Obesity: New life for antidiabetic drugs Nature 2010;466 (7305):443-444 [PubMed]
• Xu Fred Y., McBride Heidi, Acehan Devrim, Vaz Frédéric M., Houtkooper Riekelt H., Lee Raymond M., Mowat Michael A., Hatch Grant M. The dynamics of cardiolipin synthesis post-mitochondrial fusion BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 2010;1798 (8):1577-1585 [PubMed]
• Houtkooper Riekelt H., Cantó Carles, Wanders Ronald J., Auwerx Johan The Secret Life of NAD(+): An Old Metabolite Controlling New Metabolic Signaling Pathways Endocrine reviews 2010;31 (2):194-223 [PubMed]

2009

• Houtkooper Riekelt H., Rodenburg Richard J., Thiels Charlotte, van Lenthe Henk, Stet Femke, Poll-The Bwee Tien, Stone Janet E., Steward Colin G., Wanders Ronald J., Smeitink Jan, Kulik Willem, Vaz Frédéric M. Cardiolipin and monolysocardiolipin analysis in fibroblasts, lymphocytes, and tissues using high-performance liquid chromatography-mass spectrometry as a diagnostic test for Barth syndrome Analytical biochemistry 2009;387 (2):230-237 [PubMed]
• Houtkooper R. H. L. Cardiolipin metabolism in Barth syndrome 2009. 122p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Wanders R. J. A.; Co-supervisor: Vaz F. M.)
• Rijken Pieter J., Houtkooper Riekelt H., Akbari Hana, Brouwers Jos F., Koorengevel Martijn C., de Kruijff Ben, Frentzen Margrit, Vaz Frédéric M., de Kroon Anton I. P. M. Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: new insights into acyl chain remodeling of cardiolipin Journal of biological chemistry 2009;284 (40):27609-27619 [PubMed]
• Acehan Devrim, Khuchua Zaza, Houtkooper Riekelt H., Malhotra Ashim, Kaufman Johanna, Vaz Frédéric M., Ren Mindong, Rockman Howard A., Stokes David L., Schlame Michael Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria Mitochondrion 2009;9 (2):86-95 [PubMed]
• Houtkooper Riekelt H., van Lenthe Henk, Stet Femke S., Wanders Ronald J. A., Kulik Wim, Vaz Frederic M. HPLC-massaspectrometrie voor de diagnose van het Barth-syndroom Analyse (Amsterdam) 2009;64 (7):200-205
• Houtkooper Riekelt H., Turkenburg Marjolein, Poll-The Bwee Tien, Karall Daniela, Pérez-Cerdá Celia, Morrone Amelia, Malvagia Sabrina, Wanders Ronald J., Kulik Willem, Vaz Frédéric M. The enigmatic role of tafazzin in cardiolipin metabolism BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 2009;1788 (10):2003-2014 [PubMed]

2008

• Kulik Willem, van Lenthe Henk, Stet Femke S., Houtkooper Riekelt H., Kemp Helena, Stone Janet E., Steward Colin G., Wanders Ronald J., Vaz Frédéric M. Bloodspot assay using HPLC-tandem mass spectrometry for detection of Barth syndrome Clinical chemistry 2008;54 (2):371-378 [PubMed]
• Gonzalvez Francois, Schug Zachary T., Houtkooper Riekelt H., Mackenzie Elaine D., Brooks David G., Wanders Ronald J. A., Petit Patrice X., Vaz Frédéric M., Gottlieb Eyal Cardiolipin provides an essential activating platform for caspase-8 on mitochondria Journal of cell biology 2008;183 (4):681-696 [PubMed]
• Houtkooper R. H., Vaz F. M. Cardiolipin, the heart of mitochondrial metabolism Cellular and molecular life sciences 2008;65 (16):2493-2506 [PubMed]
• Zeharia Avraham, Shaag Avraham, Houtkooper Riekelt H., Hindi Tareq, de Lonlay Pascale, Erez Gilli, Hubert Laurence, Saada Ann, de Keyzer Yves, Eshel Gideon, Vaz Frédéric M., Pines Ophry, Elpeleg Orly Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood American journal of human genetics 2008;83 (4):489-494 [PubMed]

2006

• Houtkooper Riekelt H., Akbari Hana, van Lenthe Henk, Kulik Willem, Wanders Ronald J. A., Frentzen Margrit, Vaz Frédéric M. Identification and characterization of human cardiolipin synthase FEBS letters 2006;580 (13):3059-3064 [PubMed]

2003

• Vaz Frédéric M., Houtkooper Riekelt H., Valianpour Fredoen, Barth Peter G., Wanders Ronald J. A. Only one splice variant of the human TAZ gene encodes a functional protein with a role in cardiolipin metabolism Journal of biological chemistry 2003;278 (44):43089-43094 [PubMed]