Prof. R.P.J. Oude Elferink PhD publications

Publications Prof. PhD R.P.J. Oude Elferink

Position

Full Professor

Main activities

Education, Research, Other

Specialisation

Experimental Hepatology

Focus of research

Hepatic transport processes

Many cholestatic patients suffer from itch (pruritus) and this can develop into an enormous burden to the patient. Nevertheless, the mechanism of cholestatic itch is unresolved and therapy therefore remains problematic. We have initiated a study into the fundamental basis of this clinical problem and discovered that autotaxin, the serum levels of this enzyme, which produces the signaling molecule LPA, closely correlate with the extent of itch in patients with any form of cholestasis. However, this cannot be the only factor contributing to itch as the enzyme is also increased in other disease states that are not associated with itch. We are currently unravelling which other factors in plasma of patients can further contribute to itch perception.
Primary biliary cirrhosis is a relatively frequent liver disease that occurs mainly in middle aged women. It is regarded as an autoimmune disease, but the mechanism by which it develops remains obscure. Most likely it involves a combination of dysregulation of the immune ssystem and dysfunction of bile duct epithelial cells. It has been reported that bile duct epithelial cells in PBC patients have reduced expression of the chloride bicarbonate exchanger, SLC4A2. We have found that SLC4A2 deficiency causes bicarbonate accumulation and increased expression of soluble adenylyl cyclase which makes the cells more vulnerable to apoptosis. We are currently investigating the various signaling roles of soluble adenylyl cyclase.
Focus of research is the role of transporter proteins in the canalicular membrane, which are involved in the formation of bile, particularly the mechanism of bile salt and lipid excretion across the canalicular membrane. This process is unique in the sense that bile salt (=detergent) concentrations are reached which are high enough to dissolve any biological membrane. Hence, the canalicular membrane needs to harness itself against this highly toxic fluid. We study inherited liver diseases in which this mechanism of self defense is compromised.
The plasma membrane of hepatocytes harbors several drug extrusion pumps, such as MRP2 (ABCC2), ABCG2 and MDR1 (ABCB1) in the canalicular membrane and MRP3 (ABCC3) and MRP4 (ABCC4) in the basolateral membrane. These ATP-dependent transporters are expressed both in liver and in the intestine; therefore they determine to a large extent the pharmacokinetic behaviour of drugs. In mouse strains with disruptions of the various transporter genes (as well as combined gene disruptions) we determine the role of these transporters in pharmacokinetics of various classes of drugs. These issues will become increasingly important for drug development as well as the elucidation of drug-drug interactions.

Amsterdam UMC Research Institutes

AMC departments

Tytgat Institute for Liver and Intestinal Research

All publications

2021

Shi Xiaoxia, Aronson Sem J., ten Bloemendaal Lysbeth, Duijst Suzanne, Bakker Robert S., de Waart Dirk R., Bortolussi Giulia, Collaud Fanny, Oude Elferink Ronald P., Muro Andrés F., Mingozzi Federico, Ronzitti Giuseppe, Bosma Piter J. Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients Molecular therapy. Methods & clinical development 2021;20:287-297
de Vries Elsemieke, Bolier Ruth, Goet Jorn, Parés Albert, Verbeek Jef, de Vree Marleen, Drenth Joost, van Erpecum Karel, van Nieuwkerk Karin, van der Heide Frans, Mostafavi Nahid, Helder Jeltje, Ponsioen Cyriel, Oude Elferink Ronald, van Buuren Henk, Beuers Ulrich Fibrates for Itch (FITCH) in Fibrosing Cholangiopathies: A Double-Blind, Randomized, Placebo-Controlled Trial Gastroenterology 2021;160 (3):734-743.e6 [PubMed]
Bosma Piter J., Wits Marius, Oude-Elferink Ronald P. J. Gene therapy for progressive familial intrahepatic cholestasis: Current progress and future prospects International journal of molecular sciences 2021;22 (1):1-13 [PubMed]
Trampert David C, van de Graaf Stan F J, Jongejan Aldo, Oude Elferink Ronald P J, Beuers Ulrich Hepatobiliary acid-base homeostasis: Insights from analogous secretory epithelia Journal of hepatology 2021;74 (2):428-441 [PubMed]
Chang Jung-Chin, Go Simei, Gilglioni Eduardo H., Duijst Suzanne, Panneman Daan M., Rodenburg Richard J., Li Hang Lam, Huang Hsu-Li, Levin Lonny R., Buck Jochen, Verhoeven Arthur J., Oude Elferink Ronald P. J. Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 2021;1862 (4) [PubMed]

2020

Roscam Abbing Reinout L. P., Slijepcevic Davor, Donkers Joanne M., Havinga Rick, Duijst Suzanne, Paulusma Coen C., Kuiper Johan, Kuipers Folkert, Groen Albert K., Oude Elferink Ronald P. J., van de Graaf Stan F. J. Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice Hepatology (Baltimore, Md.) 2020;71 (1):247-258 [PubMed]
Corso Claudia Rita, Stipp Maria Carolina, Radulski D. bora Rasec, Mariott Marihá, da Silva Luisa Mota, de Souza Ramos Edneia Amancio, Klassen Giseli, Queiroz Telles José Ederaldo, Oliveira Cristhian Santos, Stefanello Maria Élida Alves, Verhoeven Arthur J., Oude Elferink Ronald P. J., Acco Alexandra Fruticuline A, a chemically-defined diterpene, exerts antineoplastic effects in vitro and in vivo by multiple mechanisms Scientific reports 2020;10 (1) [PubMed]
Adam Aziza A. A., Jongejan Aldo, Moerland Perry D., van der Mark Vincent A., Oude Elferink Ronald P., Chamuleau Robert A. F. M., Hoekstra Ruurdtje Genome-wide expression profiling reveals increased stability and mitochondrial energy metabolism of the human liver cell line HepaRG-CAR Cytotechnology 2020;72 (3):377-395 [PubMed]
Donkers Joanne M., Roscam Abbing Reinout L. P., van Weeghel Michel, Levels Johannes H. M., Boelen Anita, Schinkel Alfred H., Oude Elferink Ronald P. J., van de Graaf Stan F. J. Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity Cellular and molecular gastroenterology and hepatology 2020;10 (3):451-466 [PubMed]
van de Wiel Sandra M. W. Intestinal transport and signaling of bile salts: A focus on OSTα-OSTβ 2020. 189p. ISBN 9789493184398. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Graaf Stan F. J., Oude Elferink Ronald P. J.)
Appelman Monique D. Molecular insight into the bile acid transporter NTCP 2020. 194p. ISBN 9789493197039. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Graaf Stan F. J., Oude Elferink Ronald P. J.)
van der Mark Vincent A., Adam Aziza A. A., Chang Jung-Chin, Oude Elferink Ronald P., Chamuleau Robert A. F. M., Hoekstra Ruurdtje Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells Toxicology and applied pharmacology 2020;399 [PubMed]
Roscam Abbing Reinout L. P., Kuipers Folkert, Paulusma Coen C., Verkade Henkjan J., Groen Albert K., Oude Elferink Ronald P. J., van de Graaf Stan F. J. REPLY: Hepatology (Baltimore, Md.) 2020;72 (5):1885-1886 [PubMed]
Go Simei, Kramer Thorquil T., Verhoeven Arthur J., Oude Elferink Ronald P. J., Chang Jung-Chin The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state Apoptosis 2020 [PubMed]

2019

van Dijk Remco Advanced treatment of severe hyperbilirubinemia and cholestasis 2019. 252p. ISBN 9789402813630. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Beuers U. H. W., Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
Wu Yi A sectional approach to pelvic floor anatomy: Differences with the dissectional technique 2019. 121p. ISBN 9789402817416. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Oude Elferink R. P. J. , Zhang S. X.; Co-supervisors: Lamers W. , Dabhoiwala N. F.)
Dhillon Amandeep K., Kremer Andreas E., Kummen Martin, Boberg Kirsten M., Elferink Ronald P. Oude, Karlsen Tom H., Beuers Ulrich, Vesterhus Mette, Hov Johannes R. Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis Scientific reports 2019;9 (1) [PubMed]
Hohenester Simon D. Fibrosing cholangiopathies: Novel pathophysiological concepts 2019. 235p. ISBN 9783000620621. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Beuers U. H. W. , Oude Elferink R. P. J.; Co-supervisor: van de Graaf K. F. J.)
Straub Danielle, Oude Elferink Ronald P. J., Jansen Peter L. M., Bergman Jacques J. G. H. M., Parikh Kaushal, Krishnadath Kausilia K. Glyco-conjugated bile acids drive the initial metaplastic gland formation from multilayered glands through crypt-fission in a murine model PLoS ONE 2019;14 (7) [PubMed]
Slijepčević Davor Hepatic bile salt uptake: The role of NTCP revisited 2019. 159p. ISBN 9789492801685. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Beuers U. H. W. , Oude Elferink R. P. J. , van de Graaf K. F. J.)
Aronson Sem J., Bakker Robert S., Shi Xiaoxia, Duijst Suzanne, ten Bloemendaal Lysbeth, de Waart Dirk R., Verheij Joanne, Ronzitti Giuseppe, Oude Elferink Ronald P., Beuers Ulrich, Paulusma Coen C., Bosma Piter J. Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice Journal of hepatology 2019;71 (1):153-162 [PubMed]
Botschuijver Sara, van Diest Sophie A., van Thiel Isabelle A. M., Saia Rafael S., Strik Anne S., Yu Zhumei, Maria-Ferreira Daniele, Welting Olaf, Keszthelyi Daniel, Jennings Gary, Heinsbroek Sigrid E. M., Elferink Ronald P. Oude, Schuren Frank H. J., de Jonge Wouter J., van den Wijngaard René M. Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms Scientific reports 2019;9 (1) [PubMed]
Roscam Abbing Reinout L. P. Modulation of hepatic bile salt uptake potential therapeutic applications 2019. 189p. ISBN 9789461829702. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Graaf K. F. J. , Oude Elferink R. P. J.; Co-supervisor: Beuers U. H. W.)
Donkers Joanne M., Kooijman Sander, Slijepcevic Davor, Kunst Roni F., Roscam Abbing Reinout L. P., Haazen Lizette, de Waart Dirk R., Levels Johannes H. M., Schoonjans Kristina, Rensen Patrick C. N., Oude Elferink Ronald P. J., van de Graaf Stan F. J. NTCP deficiency in mice protects against obesity and hepatosteatosis JCI insight 2019;4 (14) [PubMed]
Adam Aziza A. A., van der Mark Vincent A., Ruiter Jos P. N., Wanders Ronald J. A., Oude Elferink Ronald P. J., Chamuleau Robert A. F. M., Hoekstra Ruurdtje Overexpression of carbamoyl-phosphate synthase 1 significantly improves ureagenesis of human liver HepaRG cells only when cultured under shaking conditions Mitochondrion 2019;47:298-308 [PubMed]
Donkers Joanne M. Targeting hepatic bile salt uptake to treat obesity-related metabolic disorders 2019. 175p. ISBN 9789461829733. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Graaf K. F. J. , Oude Elferink R. P. J.)
Adam Aziza A. A. The role of mitochondria in human liver cell line differentiation for bioartificial livers 2019. 221p. ISBN 9789492679895. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisors: Chamuleau R. A. F. M., Hoekstra R.)

2018

Adam Aziza A. A., van Wenum Martien, van der Mark Vincent A., Jongejan Aldo, Moerland Perry D., Houtkooper Riekelt H., Wanders Ronald J. A., Oude Elferink Ronald P., Chamuleau Robert A. F. M., Hoekstra Ruurdtje AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration Mitochondrion 2018;39:30-42 [PubMed]
Hubers Lowiek M., Vos Harmjan, Schuurman Alex R., Erken Robin, Oude Elferink Ronald P., Burgering Boudewijn, van de Graaf Stan F. J., Beuers Ulrich Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease Gut 2018;67 (4):728-735 [PubMed]
Adam Aziza A. A., van der Mark Vincent A., Donkers Joanne M., Wildenberg Manon E., Oude Elferink Ronald P. J., Chamuleau Robert A. F. M., Hoekstra Ruurdtje A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines PLoS ONE 2018;13 (4) [PubMed]
van Wenum Martien, Treskes Philipp, Adam Aziza A. A., van der Mark Vincent. A., Jongejan Aldo, Moerland Perry D., van Gulik Thomas M., Oude Elferink Ronald P. J., Chamuleau Robert A. F. M., Hoekstra Ruurdtje HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity Cellular physiology and biochemistry 2018;48 (5):2189-2204 [PubMed]
Gilglioni Eduardo H., Chang Jung Chin, Duijst Suzanne, Go Simei, Adam Aziza A. A. , Hoekstra Ruurdtje, Verhoeven Arthur J., Ishii-Iwamoto Emy L., Oude Elferink Ronald P. J. Improved oxygenation dramatically alters metabolism and gene expression in cultured primary mouse hepatocytes Hepatology Communications 2018;2 (3):299-312 [PubMed]
van de Wiel Sandra M. W., de Waart D. Rudi, Oude Elferink Ronald P. J., van de Graaf Stan F. J. Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β Cellular and molecular gastroenterology and hepatology 2018;5 (3):223-237 [PubMed]
Erice Oihane, Munoz-Garrido Patricia, Vaquero Javier, Perugorria Maria J., Fernandez-Barrena Maite G., Saez Elena, Santos-Laso Alvaro, Arbelaiz Ander, Jimenez-Agüero Raul, Fernandez-Irigoyen Joaquin, Santamaria Enrique, Torrano Verónica, Carracedo Arkaitz, Ananthanarayanan Meenakshisundaram, Marzioni Marco, Prieto Jesus, Beuers Ulrich, Oude Elferink Ronald P., LaRusso Nicholas F., Bujanda Luis, Marin Jose J. G., Banales Jesus M. MiRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation Hepatology (Baltimore, Md.) 2018;67 (4):1420-1440 [PubMed]
Slijepcevic Davor, Roscam Abbing Reinout L. P., Fuchs Claudia D., Haazen Lizette C. M., Beuers Ulrich, Trauner Michael, Oude Elferink Ronald P. J., van de Graaf Stan F. J. Na+-taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice Hepatology (Baltimore, Md.) 2018;68 (3):1057-1069 [PubMed]
van Wenum Martien, Adam Aziza A. A., van der Mark Vincent A., Chang Jung-Chin, Wildenberg Manon E., Hendriks Erik J., Jongejan Aldo, Moerland Perry D., van Gulik Thomas M., Oude Elferink Ronald P., Chamuleau Robert A. F. M., Hoekstra Ruurdtje Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines Journal of cell communication and signaling 2018;12 (3):575 [PubMed]
Al-Dury Samer, Wahlström Annika, Wahlin Staffan, Langedijk Jacqueline, Elferink Ronald Oude, Ståhlman Marcus, Marschall Hanns Ulrich Pilot study with IBAT inhibitor A4250 for the treatment of cholestatic pruritus in primary biliary cholangitis Scientific reports 2018;8 (1) [PubMed]
Chang Jung-Chin, Go Simei, Verhoeven Arthur J., Beuers Ulrich, Oude Elferink Ronald P. J. Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018;1864 (4B):1232-1239 [PubMed]
Macias Rocio I. R., Matilla Sonia, Lozano Elisa, Estiú Maria C., Oude Elferink Ronald P., Marin Jose J. G. Role of the placenta in serum autotaxin elevation during maternal cholestasis American journal of physiology. Gastrointestinal and liver physiology 2018;315 (3):G399-G407 [PubMed]
Gasparin Fabiana Rodrigues Silva, Carreño Fernando Olinto, Mewes Juliana Moraes, Gilglioni Eduardo Hideo, Pagadigorria Clairce Luzia Salgueiro, Natali Maria Raquel Marçal, Utsunomiya Karina Sayuri, Constantin Rodrigo Polimeni, Ouchida Amanda Tomie, Curti Carlos, Gaemers Ingrid C., Elferink Ronald Petrus Johannes Oude, Constantin Jorgete, Ishii-Iwamoto Emy Luiza Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018;1864 (7):2495-2509 [PubMed]
Chang Jung-Chin Soluble adenylyl cyclase: A regulator of intrinsic cellular functions 2018. 259p. ISBN 9789402812961. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Oude Elferink R. P. J., Verhoeven A. J.; Co-supervisor: Paulusma C. C.)
Ovadia Caroline, Lövgren-Sandblom Anita, Edwards Lindsey A., Langedijk Jacqueline, Geenes Victoria, Chambers Jenny, Cheng Floria, Clarke Louise, Begum Shahina, Noori Muna, Pusey Charles, Padmagirison Radhika, Agarwal Sangita, Peerless James, Cheesman Kate, Heneghan Michael, Oude Elferink Ronald, Patel Vishal C., Marschall Hanns-Ulrich, Williamson Catherine Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action Journal of clinical apheresis 2018;33 (6):638-644 [PubMed]

2017

van der Mark Vincent A. ATP8B1 and cellular trafficking 2017. 175p. ISBN 9789491602986. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Paulusma C. C.)
van Dijk Remco, Aronson Sem J., de Waart Dirk R., van de Graaf Stan F., Duijst Suzanne, Seppen Jurgen, Oude Elferink Ronald, Beuers Ulrich, Bosma Piter J. Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo Scientific reports 2017;7 (1):1646 [PubMed]
Hegade Vinod S., Kendrick Stuart F. W., Dobbins Robert L., Miller Sam R., Thompson Douglas, Richards Duncan, Storey James, Dukes George E., Corrigan Margaret, Oude Elferink Ronald P. J., Beuers Ulrich, Hirschfield Gideon M., Jones David E. Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study Lancet 2017;389 (10074):1114-1123 [PubMed]
Bolier Ruth, de Vries Elsemieke S., Parés Albert, Helder Jeltje, Kemper E. Marleen, Zwinderman Koos, Oude Elferink Ronald P., Beuers Ulrich, van Buuren Henk R., Drenth Joost P., van Erpecum Karel J., van Hoek Bart, Jansen Peter L. M., van Nieuwkerk Karin M., de Vree J. Marleen Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial Trials 2017;18 (1):230 [PubMed]
Slijepcevic Davor, Roscam Abbing Reinout L. P., Katafuchi Takeshi, Blank Antje, Donkers Joanne M., van Hoppe Stéphanie, de Waart Dirk R., Tolenaars Dagmar, van der Meer Jonathan H. M., Wildenberg Manon, Beuers Ulrich, Oude Elferink Ronald P. J., Schinkel Alfred H., van de Graaf Stan F. J. Hepatic Uptake of Conjugated Bile Acids Is Mediated by Both Sodium Taurocholate Cotransporting Polypeptide and Organic Anion Transporting Polypeptides and Modulated by Intestinal Sensing of Plasma Bile Acid Levels in Mice Hepatology (Baltimore, Md.) 2017;66 (5):1631-1643 [PubMed]
de Boer Jan Freark, Schonewille Marleen, Boesjes Marije, Wolters Henk, Bloks Vincent W., Bos Trijnie, van Dijk Theo H., Jurdzinski Angelika, Boverhof Renze, Wolters Justina C., Kuivenhoven Jan A., van Deursen Jan M., Oude Elferink Ronald P. J., Moschetta Antonio, Kremoser Claus, Verkade Henkjan J., Kuipers Folkert, Groen Albert K. Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice Gastroenterology 2017;152 (5):1126-1138.e6 [PubMed]
Maroni Luca, Hohenester Simon D., van de Graaf Stan F. J., Tolenaars Dagmar, van Lienden Krijn, Verheij Joanne, Marzioni Marco, Karlsen Tom H., Oude Elferink Ronald P. J., Beuers Ulrich Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice Hepatology (Baltimore, Md.) 2017;66 (2):542-554 [PubMed]
van der Mark Vincent A., Ghiboub Mohammed, Marsman Casper, Zhao Jing, van Dijk Remco, Hiralall Johan K., Ho-Mok Kam S., Castricum Zoë, de Jonge Wouter J., Oude Elferink Ronald P. J., Paulusma Coen C. Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 Cellular and molecular life sciences 2017;74 (4):715-730 [PubMed]
van der Mark Vincent A., Ghiboub Mohammed, Marsman Casper, Zhao Jing, van Dijk Remco, Hiralall Johan K., Ho-Mok Kam S., Castricum Zoë, de Jonge Wouter J., Elferink Ronald P. J. Oude, Paulusma Coen C. Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 (vol 74, pg 715, 2017) Cellular and molecular life sciences 2017;74 (7):1365 [PubMed]
Donkers Joanne M., Zehnder Benno, van Westen Gerard J. P., Kwakkenbos Mark J., IJzerman Adriaan P., Oude Elferink Ronald P. J., Beuers Ulrich, Urban Stephan, van de Graaf Stan F. J. Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP Scientific reports 2017;7 (1):15307 [PubMed]
van der Mark Vincent A., Rudi de Waart D., Shevchenko Valery, Elferink Ronald P. J. Oude, Chamuleau Robert A. F. M., Hoekstra Ruurdtje Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells Drug metabolism and disposition: the biological fate of chemicals 2017;45 (1):56-67 [PubMed]
Chang Jung-Chin, Beuers Ulrich, Oude Elferink Ronald P. J. The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis Digestive diseases (Basel, Switzerland) 2017;35 (3):217-223 [PubMed]
Bolier Anne Ruth The role of autotaxin in cholestatic pruritus 2017. 178p. ISBN 9789461827975. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Oude Elferink R. P. J. , Beuers U. H. W.; Co-supervisor: Bosma P. J.)

2016

Hegade Vinod S., Bolier Ruth, Oude Elferink Ronald P. J., Beuers Ulrich, Kendrick Stuart, Jones David E. J. A systematic approach to the management of cholestatic pruritus in primary biliary cirrhosis Frontline gastroenterology 2016;7 (3):158-166 [PubMed]
de Waart Dirk R., Naik Jyoti, Utsunomiya Karina S., Duijst Suzanne, Ho-Mok Kam, Bolier A. Ruth, Hiralall Johan, Bull Laura N., Bosma Piter J., Oude Elferink Ronald P. J., Paulusma Coen C. ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes Hepatology (Baltimore, Md.) 2016;64 (1):161-174 [PubMed]
de Oliveira Monique C., Gilglioni Eduardo H., de Boer Bouke A., Runge Jurgen H., de Waart Dirk R., Salgueiro Clairce L., Ishii-Iwamoto Emy L., Oude Elferink Ronald P. J., Gaemers Ingrid C. Bile acid receptor agonists. INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2016;1862 (11):2054-2062 [PubMed]
Bolier Ruth, Tolenaars Dagmar, Kremer Andreas E., Saris Job, Parés Albert, Verheij Joanne, Bosma Piter J., Beuers Ulrich, Oude Elferink Ronald P. J. Enteroendocrine cells are a potential source of serum autotaxin in men BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2016;1862 (4):696-704 [PubMed]
Lívero Francislaine A. Dos Reis, Martins Gracianny Gomes, Queiroz Telles José Ederaldo, Beltrame Olair Carlos, Petris Biscaia Stellee Marcela, Cavicchiolo Franco Célia Regina, Oude Elferink Ronald P. J., Acco Alexandra Hydroethanolic extract of Baccharis trimera ameliorates alcoholic fatty liver disease in mice Chemico-biological interactions 2016;260:22-32 [PubMed]
Abu-Hayyeh Shadi, Ovadia Caroline, Lieu TinaMarie, Jensen Dane D., Chambers Jenny, Dixon Peter H., Lövgren-Sandblom Anita, Bolier Ruth, Tolenaars Dagmar, Kremer Andreas E., Syngelaki Argyro, Noori Muna, Williams David, Marin Jose J. G., Monte Maria J., Nicolaides Kypros H., Beuers Ulrich, Oude-Elferink Ronald, Seed Paul T., Chappell Lucy, Marschall Hanns-Ulrich, Bunnett Nigel W., Williamson Catherine Prognostic and Mechanistic Potential of Progesterone Sulfates in Intrahepatic Cholestasis of Pregnancy and Pruritus Gravidarum Hepatology (Baltimore, Md.) 2016;63 (4):1287-1298 [PubMed]
Kremer Andreas E., Gonzales Emmanuel, Schaap Frank G., Oude Elferink Ronald P. J., Jacquemin Emmanuel, Beuers Ulrich Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders Journal of pediatric gastroenterology and nutrition 2016;62 (4):530-535 [PubMed]
Chang Jung-Chin, Go Simei, de Waart Dirk R., Munoz-Garrido Patricia, Beuers Ulrich, Paulusma Coen C., Oude Elferink Ronald Soluble Adenylyl Cyclase Regulates Bile Salt-Induced Apoptosis in Human Cholangiocytes Hepatology (Baltimore, Md.) 2016;64 (2):522-534 [PubMed]
Keune Willem-Jan, Hausmann Jens, Bolier Ruth, Tolenaars Dagmar, Kremer Andreas, Heidebrecht Tatjana, Joosten Robbie P., Sunkara Manjula, Morris Andrew J., Matas-Rico Elisa, Moolenaar Wouter H., Oude Elferink Ronald P., Perrakis Anastassis Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling Nature communications 2016;7:11248 [PubMed]
van der Mark Vincent A., de Jonge Hugo R., Chang Jung-Chin, Ho-Mok Kam S., Duijst Suzanne, Vidović Dragana, Carlon Marianne S., Oude Elferink Ronald P. J., Paulusma Coen C. The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 2016;1863 (9):2280-2288 [PubMed]

2015

Naik Jyoti, de Waart Dirk R., Utsunomiya Karina, Duijst Suzanne, Mok Kam Ho, Oude Elferink Ronald P. J., Bosma Piter J., Paulusma Coen C. ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function Digestive diseases (Basel, Switzerland) 2015;33 (3):314-318 [PubMed]
Kremer Andreas E., Bolier Ruth, Dixon Peter H., Geenes Victoria, Chambers Jenny, Tolenaars Dagmar, Ris-Stalpers Carrie, Kaess Bernhard M., Rust Christian, van der Post Joris A., Williamson Catherine, Beuers Ulrich, Oude Elferink Ronald P. J. Autotaxin activity has a high accuracy to diagnose intrahepatic cholestasis of pregnancy Journal of hepatology 2015;62 (4):897-904 [PubMed]
Concepcion Axel R., Salas January T., Sáez Elena, Sarvide Sarai, Ferrer Alex, Portu Ainhoa, Uriarte Iker, Hervás-Stubbs Sandra, Oude Elferink Ronald P. J., Prieto Jesús, Medina Juan F. CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis Oncotarget 2015;6 (30):28588-28606 [PubMed]
Maroni Luca, van de Graaf Stan F. J., Hohenester Simon D., Oude Elferink Ronald P. J., Beuers Ulrich Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review Clinical reviews in allergy & immunology 2015;48 (2-3):182-191 [PubMed]
Hubers Lowiek M., Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke E., Klarenbeek Paul L., Verheij Joanne, Rauws Erik A., van Gulik Thomas M., Oude Elferink Ronald P. J., van de Graaf Stan F. J., de Vries Niek, Beuers Ulrich IgG4-associated cholangitis: a comprehensive review Clinical reviews in allergy & immunology 2015;48 (2-3):198-206 [PubMed]
Slijepcevic Davor, Kaufman Christina, Wichers Catharina G. K., Gilglioni Eduardo H., Lempp Florian A., Duijst Suzanne, de Waart Dirk R., Elferink Ronald P. J. Oude, Mier Walter, Stieger Bruno, Beuers Ulrich, Urban Stephan, van de Graaf Stan F. J. Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice Hepatology (Baltimore, Md.) 2015;62 (1):207-219 [PubMed]
Oude Elferink Ronald P. J., Bolier Ruth, Beuers Ulrich H. Lysophosphatidic acid and signaling in sensory neurons BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2015;1851 (1):61-65 [PubMed]
Kremer Andreas Emanuel Molecular mechanisms of pruritus in cholestasis 2015. 267p. ISBN 9789462598119. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Oude Elferink R. P. J., Beuers U. H. W.)
Elferink Ronald P. J. Oude, Paulusma Coen C. MRP2 in cholestasis: Putting down the anchor Journal of hepatology 2015;63 (6):1309-1310 [PubMed]
Kremer Andreas E., Namer Barbara, Bolier Ruth, Fischer Michael J., Oude Elferink Ronald P., Beuers Ulrich Pathogenesis and Management of Pruritus in PBC and PSC Digestive diseases (Basel, Switzerland) 2015;33 (Suppl. 2):164-175 [PubMed]
Elferink Ronald Oude, Bolier Ruth, Kremer Andreas E., Beuers Ulrich Reply Hepatology (Baltimore, Md.) 2015;61 (6):2115 [PubMed]
Martins Gracianny Gomes, Lívero Francislaine Aparecida Dos Reis, Stolf Aline Maria, Kopruszinski Caroline Machado, Cardoso Cibele Campos, Beltrame Olair Carlos, Queiroz-Telles José Ederaldo, Strapasson Regiane Lauriano Batista, Stefanello Maria Élida Alves, Oude-Elferink Ronald, Acco Alexandra Sesquiterpene lactones of Moquiniastrum polymorphum subsp. floccosum have antineoplastic effects in Walker-256 tumor-bearing rats Chemico-biological interactions 2015;228:46-56 [PubMed]
Vaz Frédéric M., Paulusma Coen C., Huidekoper Hidde, de Ru Minke, Lim Cynthia, Koster Janet, Ho-Mok Kam, Bootsma Albert H., Groen Albert K., Schaap Frank G., Oude Elferink Ronald P. J., Waterham Hans R., Wanders Ronald J. A. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype Hepatology (Baltimore, Md.) 2015;61 (1):260-267 [PubMed]
Maillette de Buy Wenniger Lucas Joseph The biliary tree in health and immune-mediated disease 2015. 243p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Beuers U. H. W., Oude Elferink R. P. J.; Co-supervisor: de Vries N. [=Niek])
Maillette de Buy Wenniger Lucas J., Hohenester Simon, Maroni Luca, van Vliet Sandra J., Oude Elferink Ronald P., Beuers Ulrich The Cholangiocyte Glycocalyx Stabilizes the 'Biliary HCO3 Umbrella': An Integrated Line of Defense against Toxic Bile Acids Digestive diseases (Basel, Switzerland) 2015;33 (3):397-407 [PubMed]
Jebbink Jiska, Veenboer Geertruda, Boussata Souad, Keijser Remco, Kremer Andreas E., Elferink Ronald Oude, van der Post Joris, Afink Gijs, Ris-Stalpers Carrie Total bile acids in the maternal and fetal compartment in relation to placental ABCG2 expression in preeclamptic pregnancies complicated by HELLP syndrome BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2015;1852 (1):131-136 [PubMed]

2014

Jansen Robert S., Duijst Suzanne, Mahakena Sunny, Sommer Daniela, Szeri Flóra, Váradi András, Plomp Astrid, Bergen Arthur A., Oude Elferink Ronald P. J., Borst Piet, van de Wetering Koen ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report Arteriosclerosis, thrombosis, and vascular biology 2014;34 (9):1985-1989 [PubMed]
Kremer Andreas E., Bolier Ruth, van Dijk Remco, Oude Elferink Ronald P. J., Beuers Ulrich Advances in pathogenesis and management of pruritus in cholestasis Digestive diseases (Basel, Switzerland) 2014;32 (5):637-645 [PubMed]
Concepcion Axel R., Salas January T., Sarvide Sarai, Sáez Elena, Ferrer Alex, López María, Portu Ainhoa, Banales Jesús M., Hervás-Stubbs Sandra, Oude Elferink Ronald P. J., Prieto Jesús, Medina Juan F. Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses European journal of immunology 2014;44 (5):1341-1351 [PubMed]
Mardones Pablo, Chang Jung Chin, Oude Elferink Ronald P. J. Cyclic AMP and alkaline pH downregulate carbonic anhydrase 2 in mouse fibroblasts BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 2014;1840 (6):1765-1770 [PubMed]
Kunne Cindy, Acco Alexandra, Duijst Suzanne, de Waart Dirk R., Paulusma Coen C., Gaemers Ingrid, Oude Elferink Ronald P. J. FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2014;1842 (5):739-746 [PubMed]
Jebbink Jiska, Tabbers Merit, Afink Gijs, Beuers Ulrich, Oude Elferink Ronald, Ris-Stalpers Carrie, van der Post Joris HELLP syndrome preceded by intrahepatic cholestasis of pregnancy: one serious itch BMJ case reports 2014;2014:bcr2013203208 [PubMed]
Kunne Cindy, de Graaff Marijke, Duijst Suzanne, de Waart Dirk R., Oude Elferink Ronald P. J., Paulusma Coen C. Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis Laboratory investigation; a journal of technical methods and pathology 2014;94 (10):1103-1113 [PubMed]
Bolier A. Ruth, Jebbink Jiska M., van der Post Joris A. M., Oude Elferink Ronald P. J., Beuers Ulrich Intrahepatische zwangerschapscholestase: riskante jeuk Nederlands tijdschrift voor geneeskunde 2014;158:A7713 [PubMed]
El Filali Ebtisam Mice with humanized liver endothelium 2014. 165p. ISBN 9789461824844. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Seppen J. E.)
Beuers Ulrich, Kremer Andreas E., Bolier Ruth, Elferink Ronald P. J. Oude Pruritus in cholestasis: facts and fiction Hepatology (Baltimore, Md.) 2014;60 (1):399-407 [PubMed]
Kremer Andreas E., Feramisco Jamison, Reeh Peter W., Beuers Ulrich, Oude Elferink Ronald P. J. Receptors, cells and circuits involved in pruritus of systemic disorders BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2014;1842 (7):869-892 [PubMed]
Chang Jung-Chin, Oude-Elferink Ronald P. J. Role of the bicarbonate-responsive soluble adenylyl cyclase in pH sensing and metabolic regulation Frontiers in physiology 2014;5:42 [PubMed]
Lívero F. A. R., Stolf Aline Maria, Dreifuss Arturo Alejandro, Bastos-Pereira Amanda Leite, Chicorski Raphaella, de Oliveira Liana Gomes, de Souza Carlos Eduardo Alves, Fabossi Isabella Aviles, Rabitto I. S., Gremski Luiza Helena, Henneberg Raílson, Telles José Ederaldo Queiroz, Oude Elferink Ronald P. J., Acco Alexandra The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice Chemico-biological interactions 2014;217:19-27 [PubMed]
van der Mark Vincent A., de Waart D. Rudi, Ho-Mok Kam S., Tabbers Merit M., Voogt Heleen W., Oude Elferink Ronald P. J., Knisely A. S., Paulusma Coen C. The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2014;1842 (12 Part A):2378-2386 [PubMed]

2013

Bolier Ruth, Oude Elferink Ronald P. J., Beuers Ulrich Advances in pathogenesis and treatment of pruritus Clinics in liver disease 2013;17 (2):319-329 [PubMed]
Hohenester Simon, Beuers Ulrich, Medina Juan F., Elferink Ronald P. Oude Antimitochondrial antibodies may be insufficiently specific to define primary biliary cirrhosis-like disease in mouse models Hepatology (Baltimore, Md.) 2013;58 (2):828-830 [PubMed]
Kunne Cindy, Acco Alexandra, Hohenester Simon, Duijst Suzanne, de Waart Dirk R., Zamanbin Alaleh, Oude Elferink Ronald P. J. Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome P450 activity Hepatology (Baltimore, Md.) 2013;57 (4):1509-1517 [PubMed]
Sokolović Aleksandar, van Roomen Cindy P. A. A., Ottenhoff Roelof, Scheij Saskia, Hiralall Johan K., Claessen Nike, Aten Jan, Oude Elferink Ronald P. J., Groen Albert K., Sokolović Milka Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2013;1832 (10):1482-1491 [PubMed]
Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke E., Klarenbeek Paul L., Verheij Joanne, Baas Frank, Elferink Ronald P. Oude, Tak Paul P., de Vries Niek, Beuers Ulrich Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis Hepatology (Baltimore, Md.) 2013;57 (6):2390-2398 [PubMed]
Sokolović Aleksandar, Rodriguez-Ortigosa Carlos M., Bloemendaal Lysbeth Ten, Oude Elferink Ronald P. J., Prieto Jesús, Bosma Piter J. Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2013;1832 (6):697-704 [PubMed]
Kunne Cindy Mouse models of cholestatic liver disease. pfic reviisited 2013. 153p. ISBN 9789461823489. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Paulusma C. C.)
Mardones Hiche Pablo A. On the role of the anion exchanger 2 (AE2, SLC4A2) in intracellular pH homeostasis and bone remodeling 2013. 118p. ISBN 9789739461917. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.)
van der Mark Vincent A., Oude Elferink Ronald P. J., Paulusma Coen C. P4 ATPases: Flippases in Health and Disease International journal of molecular sciences 2013;14 (4):7897-7922 [PubMed]
Sokolović Aleksandar Pathogenesis and reversal of liver fibrosis: effects of genes and environment 2013. 125p. ISBN 9789461916235. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
Hoekstra Ruurdtje, Nibourg Geert A. A., van der Hoeven Tessa V., Plomer Gabrielle, Seppen Jurgen, Ackermans Mariëtte T., Camus Sandrine, Kulik Wim, van Gulik Thomas M., Elferink Ronald P. Oude, Chamuleau Robert A. F. M. Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide Drug metabolism and disposition: the biological fate of chemicals 2013;41 (3):562-567 [PubMed]

2012

Hohenester Simon, Wenniger Lucas Maillette de Buy, Paulusma Coen C., van Vliet Sandra J., Jefferson Douglas M., Elferink Ronald P. Oude, Beuers Ulrich A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes Hepatology (Baltimore, Md.) 2012;55 (1):173-183 [PubMed]
Folmer Dineke E., Mok Kam S., de Wee Sebastiaan W., Duijst Suzanne, Hiralall Johan K., Seppen Jurgen, Oude Elferink Ronald P. J., Paulusma Coen C. Cellular Localization and Biochemical Analysis of Mammalian CDC50A, a Glycosylated beta-subunit for P4 ATPases journal of histochemistry and cytochemistry 2012;60 (3):205-218 [PubMed]
Kremer A. E., Oude Elferink R. P. J., Beuers U. Cholestatic pruritus. New insights into pathophysiology and current treatment Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 2012;63 (7):532-538 [PubMed]
van de Steeg Evita, Stránecký Viktor, Hartmannová Hana, Nosková Lenka, Hřebíček Martin, Wagenaar Els, van Esch Anita, de Waart Dirk R., Oude Elferink Ronald P. J., Kenworthy Kathryn E., Sticová Eva, Al-Edreesi Mohammad, Knisely A. S., Kmoch Stanislav, Jirsa Milan, Schinkel Alfred H. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver Journal of clinical investigation 2012;122 (2):519-528 [PubMed]
Stolf Aline Maria, Lívero Francislaine dos Reis, Dreifuss Arturo Alejandro, Bastos-Pereira Amanda Leite, Fabosi Isabella Aviles, Alves de Souza Carlos Eduardo, Gomes Liana de Oliveira, Chicorski Raphaella, Brandt Anna Paula, Cadena Silvia Maria Suter, Telles José Ederaldo Queiroz, Hauser Aline Borsato, Elferink Ronald Oude, Zampronio Aleksander Roberto, Acco Alexandra Effects of statins on liver cell function and inflammation in septic rats Journal of surgical research 2012;178 (2):888-897 [PubMed]
Montenegro Miranda Paula S. Gene therapy with adeno-associated viral vectors for inherited hyperbilirubinemia. Towards a clinical trial for Crigler-Najjar syndrome 2012. 197p. ISBN 9789090266633. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
Fernández-Barrena Maite G., Monte Maria J., Latasa Maria U., Uriarte Iker, Vicente Eva, Chang Haisul C. Y., Rodriguez-Ortigosa Carlos M., Elferink Ronald Oude, Berasain Carmen, Marin Jose J. G., Prieto Jesus, Ávila Matias A. Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice Journal of hepatology 2012;56 (2):367-373 [PubMed]
Nibourg Geert A. A., Chamuleau Robert A. F. M., van der Hoeven Tessa V., Maas Martinus A. W., Ruiter An F. C., Lamers Wouter H., Oude Elferink Ronald P. J., van Gulik Thomas M., Hoekstra Ruurdtje Liver Progenitor Cell Line HepaRG Differentiated in a Bioartificial Liver Effectively Supplies Liver Support to Rats with Acute Liver Failure PLoS ONE 2012;7 (6):e38778 [PubMed]
Jansen Peter L. M., Beuers U., Oude Elferink Ronald P. J. Mechanisms of Bile Secretionin: T. D. Boyer, Michael P. Manns, Arun J. Sanyal, editors. Hepatology : A Textbook of Liver Disease. Philadelphia: Elsevier Saunders; 2012. p. 20-36, ISBN 9781437708813
Maillette de Buy Wenniger L. J., Oude Elferink R. P., Beuers U. Molecular Targets for the Treatment of Fibrosing Cholangiopathies Clinical pharmacology and therapeutics 2012;92 (3):381-387 [PubMed]
Nur Erfan, Brandjes Dees P., Teerlink Tom, Otten Hans-Martin, Oude Elferink Ronald P. J., Muskiet Frits, Evers Ludo M., ten Cate Hugo, Biemond Bart J., Duits Ashley J., Schnog John-John B. N-acetylcysteine reduces oxidative stress in sickle cell patients Annals of hematology 2012;91 (7):1097-1105 [PubMed]
de Waart Dirk R., van de Wetering Koen, Kunne Cindy, Duijst Suzanne, Paulusma Coen C., Oude Elferink Ronald P. J. Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4 Drug metabolism and disposition: the biological fate of chemicals 2012;40 (3):515-521 [PubMed]
Kremer Andreas E., De Buy Wenniger Lucas Maillette, Elferink Ronald P.J.Oude, Beuers Ulrich Pruritus bij leverziekten Nederlands tijdschrift voor geneeskunde 2012;156 (2)
ter Riet Gerben, Korevaar Daniel A., Leenaars Marlies, Sterk Peter J., van Noorden Cornelis J. F., Bouter Lex M., Lutter René, Elferink Ronald P. Oude, Hooft Lotty Publication Bias in Laboratory Animal Research: A Survey on Magnitude, Drivers, Consequences and Potential Solutions PLoS ONE 2012;7 (9):e43404 [PubMed]
Kremer Andreas E., van Dijk Remco, Leckie Pamela, Schaap Frank G., Kuiper Edith M. M., Mettang Thomas, Reiners Katrin S., Raap Ulrike, van Buuren Henk R., van Erpecum Karel J., Davies Nathan A., Rust Christian, Engert Andreas, Jalan Rajiv, Oude Elferink Ronald P. J., Beuers Ulrich Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions Hepatology (Baltimore, Md.) 2012;56 (4):1391-1400 [PubMed]
Beuers Ulrich, Maroni Luca, Elferink Ronald O. The biliary HCO3- umbrella: experimental evidence revisited Current opinion in gastroenterology 2012;28 (3):253-257 [PubMed]
Bolier A. R., Peri S., Oude Elferink R. P. J., Beuers U. The challenge of cholestatic pruritus Acta gastro-enterologica Belgica 2012;75 (4):399-404 [PubMed]
Hoekstra Ruurdtje, Nibourg Geert A. A., van der Hoeven Tessa V., Ackermans Mariëtte T., Hakvoort Theodorus B. M., van Gulik Thomas M., Oude Elferink Ronald P., Chamuleau Robert A. F. M. The effect of rat acute-liver-failure plasma on HepaRG cells International journal of artificial organs 2012;35 (11):1006-1014 [PubMed]

2011

Oude Elferink Ronald P. J., Paulusma C. C. ABCG5/8 and its Role in Sterol Homeostasisin: Kenneth J. Linton, B. Holland, editors. The ABC Transportersof Human Physiology and Disease. Singapore: World Scientific; 2011. p. 375-397, ISBN 3978981428006
van Geer Michael A. Adenovirus targeting for gene therapy of pancreatic cancer 2011. 173p. ISBN 9789490371623. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
de Waart Dirk Rudi Basolateral and apical ABC transporters in liver and intestineAmsterdam: Ipskamp; 2011. 200p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink Ronald P. J.; Co-supervisor: Paulusma C. C.)
Hohenester Simon, Maillette de Buy Wenniger Lucas, Jefferson Douglas M., Oude Elferink Ronald P., Beuers Ulrich Biliary bicarbonate secretion constitutes a protective mechanism against bile acid-induced injury in man Digestive diseases (Basel, Switzerland) 2011;29 (1):62-65 [PubMed]
Groen Annemiek, Romero Marta Rodriguez, Kunne Cindy, Hoosdally Sarah J., Dixon Peter H., Wooding Carol, Williamson Catherine, Seppen Jurgen, van den Oever Karin, Mok Kam S., Paulusma Coen C., Linton Kenneth J., Oude Elferink Ronald P. J. Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity Gastroenterology 2011;141 (5):1927-37.e1-4 [PubMed]
Nur Erfan, Verwijs Mirjam, de Waart Dirk R., Schnog John-John B., Otten Hans-Martin, Brandjes Dees P., Biemond Bart J., Elferink Ronald P. J. Oude Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2011;1812 (11):1412-1417 [PubMed]
Oude Elferink Ronald Pj, Kremer Andreas E., Beuers Ulrich Mediators of pruritus during cholestasis Current opinion in gastroenterology 2011;27 (3):289-293 [PubMed]
Kremer Andreas E., Oude Elferink Ronald P. J., Beuers Ulrich Pathophysiology and current management of pruritus in liver disease Clinics and research in hepatology and gastroenterology 2011;35 (2):89-97 [PubMed]
Kremer Andreas E., Maillette de Buy Wenniger Lucas, Oude Elferink Ronald P. J., Beuers Ulrich Pruritus bij leverziekten. Pathogenese en behandeling Nederlands tijdschrift voor geneeskunde 2011;155 (52):A4045 [PubMed]
Oude Elferink Ronald Pj, Beuers Ulrich Targeting the ABCB4 gene to control cholesterol homeostasis Expert opinion on therapeutic targets 2011;15 (10):1173-1182 [PubMed]
Hoekstra Ruurdtje, Nibourg Geert A. A., van der Hoeven Tessa V., Ackermans Mariëtte T., Hakvoort Theodorus B. M., van Gulik Thomas M., Lamers Wouter H., Elferink Ronald P. Oude, Chamuleau Robert A. F. M. The HepaRG cell line is suitable for bioartificial liver application international journal of biochemistry & cell biology 2011;43 (10):1483-1489 [PubMed]
Oude Elferink Ronald P. J., Kremer Andreas E., Martens Job J. W. W., Beuers Ulrich H. The molecular mechanism of cholestatic pruritus Digestive diseases (Basel, Switzerland) 2011;29 (1):66-71 [PubMed]

2010

Cruchten S. T. J. van, de Waart D. R., Kunne C., Hooiveld G. J. E. J., Boekschoten M. V., Katan M. B., Elferink R. P. J. Oude, Witkamp R. F. Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice Drug metabolism and disposition: the biological fate of chemicals 2010;38 (4):635-640 [PubMed]
van Geer Michael A., Brevoord Daniel, Kuhlmann Koert F. D., Bakker Conny T., Mizuguchi Hiroyuki, Wesseling John G., ten Kate Fibo J., Gouma Dirk J., Oude Elferink Ronald P. J., Bosma Piter J. A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer International journal of oncology 2010;36 (1):233-244 [PubMed]
Uriarte Iker, Banales Jesús M., Sáez Elena, Arenas Fabián, Oude Elferink Ronald P. J., Prieto Jesús, Medina Juan F. Bicarbonate Secretion of Mouse Cholangiocytes Involves Na+-HCO3- Cotransport in Addition to Na+-Independent Cl-/HCO3- Exchange Hepatology (Baltimore, Md.) 2010;51 (3):891-902 [PubMed]
Triantis Vassilis, Saeland Eirikur, Bijl Nora, Oude-Elferink Ronald P., Jansen Peter L. M. Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1 Hepatology (Baltimore, Md.) 2010;52 (2):656-666 [PubMed]
Van Hooft Jeanin, Elferink Ronald Oude, Seppen Jurgen Gulzigheid en boete: Laxatiekuren en 'leverstenen' Nederlands tijdschrift voor geneeskunde 2010;154 (51-52):2391-2393
van Hooft J., Oude Elferink R., Seppen J. Gulzigheid en Boete Nederlands tijdschrift voor geneeskunde 2010;154 (51-52):A2645 [PubMed]
de Waart Dirk R., Hausler Stephanie, Vlaming Maria L., Kunne Cindy, Hanggi Emanuel, Gruss Hans-Jurgen, Oude Elferink R. P. J., Stieger Bruno Hepatic Transport Mechanisms of Cholyl-L-Lysyl-Fluorescein Journal of pharmacology and experimental therapeutics 2010;334 (1):78-86 [PubMed]
Sokolovic Aleksandar, Sokolovic Milka, Boers Willem, Oude Elferink Ronald P. J., Bosma Piter J. Insulin-like growth factor binding protein 5 enhances survival of LX2 human hepatic stellate cells Fibrogenesis & tissue repair 2010;3 (3):1-13 [PubMed]
Kremer Andreas E., Martens Job J. W. W., Kulik Wim, Ruëff Franziska, Kuiper Edith M. M., van Buuren Henk R., van Erpecum Karel J., Kondrackiene Jurate, Prieto Jesus, Rust Christian, Geenes Victoria L., Williamson Catherine, Moolenaar Wouter H., Beuers Ulrich, Elferink Ronald P. J. Oude Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus Gastroenterology 2010;139 (3):1008-U399 [PubMed]
van de Steeg Evita, Wagenaar Els, van der Kruijssen Cornelia M. M., Burggraaff Johanna E. C., de Waart Dirk R., Elferink Ronald P. J. Oude, Kenworthy Kathryn E., Schinkel Alfred H. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs Journal of clinical investigation 2010;120 (8):2942-2952 [PubMed]
Paulusma Coen C., Oude Elferink Ronald P. J. P4 ATPases - The physiological relevance of lipid flipping transporters FEBS letters 2010;584 (13):2708-2716 [PubMed]
Paulusma Coen C., Oude Elferink Ronald P. J., Jansen Peter L. M. Progressive Familial Intrahepatic Cholestasis Type 1 Seminars in liver disease 2010;30 (2):117-124 [PubMed]
Kremer Andreas E., Oude-Elferink Ronald P.J., Beuers Ulrich Pruritus in patients with hepatobiliary diseasesin: Pruritus. Springer London; 2010. p. 177-187, ISBN 9781848823211
Shah Sohela, Sanford Ukina R., Vargas Julie C., Xu Hongmei, Groen Annamiek, Paulusma Coen C., Grenert James P., Pawlikowska Ludmila, Sen Saunak, Elferink Ronald P. J. Oude, Bull Laura N. Strain background modifies phenotypes in the ATP8B1-deficient mouse PLoS ONE 2010;5 (2):e8984 [PubMed]
Beuers Ulrich, Hohenester Simon, de Buy Wenniger Lucas J. Maillette, Kremer Andreas E., Jansen Peter L. M., Oude Elferink Ronald P. J. The biliary HCO(3) (-) umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies Hepatology (Baltimore, Md.) 2010;52 (4):1489-1496 [PubMed]

2009

Paulusma Coen C., Dewaart D. Rudi, Kunne Cindy, Mok Kam S., Oude Elferink Ronald P. J. Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content Journal of biological chemistry 2009;284 (15):9947-9954 [PubMed]
Jansen Ineke D. C., Mardones Pablo, Lecanda Fernando, de Vries Teun J., Recalde Sergio, Hoeben Kees A., Schoenmaker Ton, Ravesloot Jan-Hindrik, van Borren Marcel M. G. J., van Eijden Theo M., Bronckers Antonius L. J. J., Kellokumpu Sakari, Medina Juan F., Everts Vincent, Oude Elferink Ronald P. J. Ae2(a,b)-Deficient mice exhibit osteopetrosis of long bones but not of calvaria FASEB journal 2009;23 (10):3470-3481 [PubMed]
Oude Elferink Ronald, Beuers Ulrich Are pigs more human than mice? Journal of hepatology 2009;50 (4):838-841 [PubMed]
Stapelbroek Janneke M., Peters Theo A., van Beurden Denis H. A., Curfs Jo H. A. J., Joosten Anneke, Beynon Andy J., van Leeuwen Bibian M., van der Velden Lieke M., Bull Laura, Oude Elferink Ronald P., van Zanten Bert A., Klomp Leo W. J., Houwen Roderick H. J. ATP8B1 is essential for maintaining normal hearing Proceedings of the National Academy of Sciences of the United States of America 2009;106 (24):9709-9714 [PubMed]
De Waart Dirk R., Oude Elferink Ronald P.J. Bile Canalicular Transportersin: Transporters as Drug Carriers. Wiley-VCH Verlag; 2009. p. 299-324, ISBN 9783527316618
de Waart Dirk R., Vlaming Maria L. H., Kunne Cindy, Schinkel Alfred H., Oude Elferink Ronald P. J. Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2 Drug metabolism and disposition: the biological fate of chemicals 2009;37 (8):1698-1702 [PubMed]
Folmer Dineke E., van der Mark Vincent A., Ho-Mok Kam S., Oude Elferink Ronald P. J., Paulusma Coen C. Differential Effects of Progressive Familial Intrahepatic Cholestasis Type 1 and Benign Recurrent Intrahepatic Cholestasis Type 1 Mutations on Canalicular Localization of ATP8B1 Hepatology (Baltimore, Md.) 2009;50 (5):1597-1605 [PubMed]
van Geer Michael A., Bakker Conny T., Koizumi Naoya, Mizuguchi Hiroyuki, Wesseling John G., Oude Elferink Ronald P. J., Bosma Piter J. Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo World journal of gastroenterology 2009;15 (22):2754-2762 [PubMed]
Fisher Craig D., Lickteig Andrew J., Augustine Lisa M., Oude Elferink Ronald P. J., Besselsen David G., Erickson Robert P., Cherrington Nathan J. Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats European journal of pharmacology 2009;613 (1-3):119-127 [PubMed]
van Geer Michael A., Kuhlmann Koert F. D., Bakker Conny T., ten Kate Fibo J. W., Oude Elferink Ronald P. J., Bosma Piter J. Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices World journal of gastroenterology 2009;15 (11):1359-1366 [PubMed]
Kuhlmann K. F. D., van Geer M. A., Bakker C. T., Dekker J. E. M., Havenga M. J. E., Elferink R. P. J. Oude, Gouma D. J., Bosma P. J., Wesseling J. G. Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma Cancer gene therapy 2009;16 (7):585-597 [PubMed]
Vlaming Maria L. H., Pala Zeliha, van Esch Anita, Wagenaar Els, de Waart Dirk R., van de Wetering Koen, van der Kruijssen Cornelia M. M., Oude Elferink Ronald P. J., van Tellingen Olaf, Schinkel Alfred H. Functionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo Clinical cancer research 2009;15 (9):3084-3093 [PubMed]
Hardikar Winita, Kansal Shivani, Oude Elferink Ronald P. J., Angus Peter Intrahepatic cholestasis of pregnancy: When should you look further? World journal of gastroenterology 2009;15 (9):1126-1129 [PubMed]
Bronckers Antonius L. J. J., Lyaruu Donacian M., Jansen Ineke D. C., Medina Juan F., Kellokumpu Sakari, Hoeben Kees A., Gawenis Lara R., Oude-Elferink Ronald P. J., Everts Vincent Localization and Function of the Anion Exchanger Ae2 in Developing Teeth and Orofacial Bone in Rodents Journal of experimental zoology. Part B. Molecular and developmental evolution 2009;312B (4):375-387 [PubMed]
Deurholt Tanja, van Til Niek P., Chhatta Aniska A., ten Bloemendaal Lysbeth, Schwartlander Ruth, Payne Catherine, Plevris John N., Sauer Igor M., Chamuleau Robert A. F. M., Oude Elferink Ronald P. J., Seppen Jurgen, Hoekstra Ruurdtje Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes BMC biotechnology 2009;9 (1):89 [PubMed]
van der Velde Astrid E. Novel insights in cholesterol excretion 2009. 151p. ISBN 9789064643248. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Oude Elferink R. P. J., Groen A. K.)
Folmer Dineke E., Elferink Ronald P. J. Oude, Paulusma Coen C. P4 ATPases - lipid flippases and their role in disease BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2009;1791 (7):628-635 [PubMed]
Vrins Carlos L. J., van der Velde Astrid E., van den Oever Karin, Levels Johannes H. M., Huet Stephane, Oude Elferink Ronald P. J., Kuipers Folkert, Groen Albert K. Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux Journal of lipid research 2009;50 (10):2046-2054 [PubMed]
Hohenester Simon, Oude-Elferink Ronald P. J., Beuers Ulrich Primary biliary cirrhosis Seminars in immunopathology 2009;31 (3):283-307 [PubMed]
Markusic David M., van Til Niek P., Hiralall Johan K., Elferink Ronald P. J. Oude, Seppen Jurgen Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain BMC biotechnology 2009;9 (1):85 [PubMed]
Wiersma Harmen, Gatti Alberto, Nijstad Niels, Oude Elferink Ronald P. J., Kuipers Folkert, Tietge Uwe J. F. Scavenger Receptor Class B Type I Mediates Biliary Cholesterol Secretion Independent of ATP-Binding Cassette Transporter g5/g8 in Mice Hepatology (Baltimore, Md.) 2009;50 (4):1263-1272 [PubMed]
Seppen Jurgen, El Filali Ebtisam, Oude Elferink Ronald Small animal models of hepatocyte transplantation Methods in molecular biology (Clifton, N.J.) 2009;481:1-8 [PubMed]
Elferink Ronald P.J.Oude, Paulusma Coen C. The Function of the Canalicular Membrane in Bile Formation and Secretionin: The Liver. John Wiley & Sons, Ltd.; 2009. p. 339-348, ISBN 9780470723135
Groen Annemiek The molecular mechanis of Atp8b1 - deficiency 2009. 158p. ISBN 9789090239651. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Paulusma C. C.)
Elferink R. O., De Waart R., Kunne C., Paulusma C. The role of ABC transporters in drug absorption and enterohepatic circulation Journal of Veterinary Pharmacology and Therapeutics 2009;32 (SUPPL. 1):56

2008

Groen Annemiek, Kunne Cindy, Jongsma Geartsje, van den Oever Karin, Mok Kam S., Petruzzelli Michele, Vrins Carlos L. J., Bull Laura, Paulusma Coen C., Oude Elferink Ronald P. J. Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice Gastroenterology 2008;134 (7):2091-2100 [PubMed]
Mardones Pablo, Medina Juan F., Elferink Ronald P. J. Oude Activation of cyclic AMP Signaling in Ae2-deficient mouse fibroblasts Journal of biological chemistry 2008;283 (18):12146-12153 [PubMed]
Salas January T., Banales Jesús M., Sarvide Sarai, Recalde Sergio, Ferrer Alex, Uriarte Iker, Oude Elferink Ronald P. J., Prieto Jesús, Medina Juan F. Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis Gastroenterology 2008;134 (5):1482-1493 [PubMed]
van Til Niek P., Heutinck Kirstin M., van der Rijt Roos, Paulusma Coen C., van Wijland Michel, Markusic David M., Elferink Ronald P. J. Oude, Seppen Jurgen Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity Retrovirology 2008;5:14 [PubMed]
Paulusma Coen C., Folmer Dineke E., Ho-Mok Kam S., de Waart D. Rudi, Hilarius Petra M., Verhoeven Arthur J., Oude Elferink Ronald P. J. ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity Hepatology (Baltimore, Md.) 2008;47 (1):268-278 [PubMed]
Poyck Paul P. C., van Wijk Albert C. W. A., van der Hoeven Tessa V., de Waart Dirk R., Chamuleau Robert A. F. M., van Gulik Thomas M., Oude Elferink Ronald P. J., Hoekstra Ruurdtje Evaluation of a new immortalized human fetal liver cell line (cBAL111) for application in bioartificial liver Journal of hepatology 2008;48 (2):266-275 [PubMed]
Correa Paulo Renato A.V., Nathanson Michael H., Wolkoff Allan W., Novikoff Phyllis M., Thevananther Sundararajah, Karpen Saul J., Elferink Ronald P.J.Oude, Püschel Gerhard P., Stieger Bruno Functions of the Liverin: Textbook of Hepatology. Wiley-Blackwell Publishing Ltd; 2008. p. 89-128, ISBN 9781405127417
Vlaming Maria L. H., Pala Zeliha, van Esch Anita, Wagenaar Els, van Tellingen Olaf, de Waart Dirk R., Oude Elferink Ronald P. J., van de Wetering Koen, Schinkel Alfred H. Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate Clinical cancer research 2008;14 (24):8152-8160 [PubMed]
Beuers Ulrich, Oude-Elferink Ronald P. J. New light on anion exchangers in primary biliary cirrhosis Journal of hepatology 2008;49 (6):881-883 [PubMed]
Kremer Andreas E., Beuers Ulrich, Oude-Elferink Ronald P. J., Pusl Thomas Pathogenesis and Treatment of Pruritus in Cholestasis Drugs 2008;68 (15):2163-2182 [PubMed]
van der Velde Astrid E., Vrins Carlos L. J., van den Oever Karin, Seemann Ingar, Oude Elferink Ronald P. J., van Eck Miranda, Kuipers Folkert, Groen Albert K. Regulation of direct transintestinal cholesterol excretion in mice American journal of physiology. Gastrointestinal and liver physiology 2008;295 (1):G203-G208 [PubMed]
Lyaruu D. M., Bronckers A. L. J. J., Mulder L., Mardones P., Medina J. F., Kellokumpu S., Oude Elferink R. P. J., Everts V. The anion exchanger Ae2 is required for enamel maturation in mouse teeth Matrix biology 2008;27 (2):119-127 [PubMed]

2007

Deurholt Tanja Development of an immortalised human hepatocyte cell line for the AMC bio-artificial liver 2007. 141p. ISBN 9789090225098. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink Ronald P. J.; Co-supervisors: Chamuleau Robert A. F. M., Hoekstra R.)
van der Velde Astrid E., Vrins Carlos L. J., van den Oever Karin, Kunne Cindy, Elferink Ronald P. J. Oude, Kljipers Folkert, Groen Albert K. Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice Gastroenterology 2007;133 (3):967-975 [PubMed]
Oude Elferink Ronald P. J., Paulusma Coen C. Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein) Pflugers Archiv 2007;453 (5):601-610 [PubMed]
Oude Elferink R. P. J. Genetic cholestatic diseasesin: Juan Rodes, J. P. Benhamou, A. T. Blei, J. Reichen, M. Rizetto, editors. Textbook of Hepatology. S.l.: Blackwell Publishing; 2007. p. 1383-1390
Pietrangelo Antonello, Oude Elferink Ronald, Prieto Jesus, Bacon Bruce R. Genetics in liver diseases Journal of hepatology 2007;46 (6):1143-1148 [PubMed]
Oude Elferink R. P. J. Hepatic transport processesin: Juan Rodes, J. P. Benhamou, A. T. Blei, J. Reichen, M. Rizetto, editors. Textbook of Hepatology. S.l.: Blackwell Publishing; 2007. p. 109-113
Groen Annemiek, Kunne Cindy, Paulusma Coen C., Kramer Werner, Agellon Luis B., Bull Laura N., Elferink Ronald P. J. Oude Intestinal bile salt absorption in Atp8b1 deficient mice Journal of hepatology 2007;47 (1):114-122 [PubMed]
van Til N. P. Lentiviral gene therapy for the treatment of inherited liver disease 2007. 132p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink Ronald P. J.; Co-supervisor: Seppen Jurgen)
Markusic David M. Lentiviral vectors for regulated and liver directed gene therapy 2007. 117p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink Ronald P. J.; Co-supervisor: Seppen Jurgen)
Lyaruu D. M., Bronckers A. L.J.J., Mulder L., Mardones P., Medina J. F., Kellokumpu S., Oude Elferink R. P.J., Everts V. Localization and function of the anionic exchanger AE2 in developing rodent teeth European cells & materials 2007;14 (SUPPL.2):42
Hafkamp Anja M., Nelisse-Haak Rineke, Sinaasappel Maarten, Oude Elferink Ronald P. J., Verkade Henkjan J. Orlistat treatment of unconjugated hyperbilirubinemia in Crigler-Najjar disease: a randomized controlled trial Pediatric research 2007;62 (6):725-730 [PubMed]
Markusic David M., Kanitz Alexander, Oude-Elferink Ronald P. J., Seppen Jurgen Preferential gene transfer of lentiviral vectors to liver-derived cells, using a hepatitis B peptide displayed on GP64 Human gene therapy 2007;18 (7):673-679 [PubMed]
Elferink R. P. J. Oude, de Waart R. Transporters in the intestine limiting drug and toxin absorption Journal of physiology and biochemistry 2007;63 (1):75-81 [PubMed]

2006

Hoekstra Ruurdtje, Deurholt Tanja, ten Bloemendaal Lysbeth, Desille Mireille, van Wijk Albert C. W. A., Clement Bruno, Oude Elferink Ronald P. J., van Gulik Thomas M., Chamuleaut Robert A. F. M. Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives Cell transplantation 2006;15 (5):423-433 [PubMed]
Paulusma Coen C., Groen Annemiek, Kunne Cindy, Ho-Mok Kam S., Spijkerboer Astrid L., Rudi de Waart D., Hoek Frans J., Vreeling Heleen, Hoeben Kees A., van Marle Jan, Pawlikowska Ludmila, Bull Laura N., Hofmann Alan F., Knisely A. S., Oude Elferink Ronald P. J. Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport Hepatology (Baltimore, Md.) 2006;44 (1):195-204 [PubMed]
Vlaming M. L. H., Mohrmann K., Wagenaar E., de Waart D. R., Elferink R. P. J. Oude, Lagas J. S., van Tellingen O., Vainchtein L. D., Rosing H., Beijnen J. H., Schellens J. H. M., Schinkel A. H. Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice Journal of pharmacology and experimental therapeutics 2006;318 (1):319-327 [PubMed]
Paulusma Coen C., Oude Elferink Ronald P. J. Diseases of intramembranous lipid transport FEBS letters 2006;580 (23):5500-5509 [PubMed]
Oude Elferink Ronald P. J., Paulusma Coen C., Groen Albert K. Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases Gastroenterology 2006;130 (3):908-925 [PubMed]
Seppen J., van Til N. P., van der Rijt R., Hiralall J. K., Kunne C., Oude Elferink R. P. J. Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats Gene therapy 2006;13 (8):672-677 [PubMed]
Groen Annemiek, Kunne Cindy, Oude Elferink Ronald P. J. Increased serum concentrations of secondary bile salts during cholate feeding are due to coprophagy. A study with wild-type and Atp8b1-deficient mice Molecular pharmaceutics 2006;3 (6):756-761 [PubMed]
Recalde Sergio, Muruzábal Francisco, Looije Norbert, Kunne Cindy, Burrell María A., Sáez Elena, Martínez-Ansó Eduardo, Salas January T., Mardones Pablo, Prieto Jesús, Medina Juan F., Elferink Ronald P. J. Oude Inefficient chronic activation of parietal cells in Ae2a,b(-/-) mice American journal of pathology 2006;169 (1):165-176 [PubMed]
Deurholt Tanja, ten Bloemendaal Lysbeth, Chhatta Aniska A., van Wijk Albert C. W. A., Weijer Kees, Seppen Jurgen, Elferink Ronald P. J. Oude, Chamuleau Robert A. F. M., Hoekstra Ruurdtje In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions Cell transplantation 2006;15 (8-9):811-822 [PubMed]
Zelcer Noam, van de Wetering Koen, de Waart Rudi, Scheffer George L., Marschall Hanns-Ulrich, Wielinga Peter R., Kuil Annemieke, Kunne Cindy, Smith Alexander, van der Valk Martin, Wijnholds Jan, Elferink Ronald Oude, Borst Piet Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides Journal of hepatology 2006;44 (4):768-775 [PubMed]
de Waart Dirk R., Paulusma Coen C., Kunne Cindy, Oude Elferink Ronald P. J. Multidrug resistance associated protein 2 mediates transport of prostaglandin E2 Liver international 2006;26 (3):362-368 [PubMed]
Oude Elferink Ronald "Return to sender, address unknown...." Are variant addressins involved in PSC? Journal of hepatology 2006;45 (5):633-635 [PubMed]
Kosters Astrid, Kunne Cindy, Looije Norbert, Patel Shailendra B., Oude Elferink Ronald P. J., Groen Albert K. The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice Journal of lipid research 2006;47 (9):1959-1966 [PubMed]
Boers Willem, Aarrass Saida, Linthorst Chris, Pinzani Massimo, Elferink Ronald Oude, Bosma Piter Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins Journal of biological chemistry 2006;281 (24):16289-16295 [PubMed]

2005

Manautou José E., de Waart Dirk R., Kunne Cindy, Zelcer Noam, Goedken Michael, Borst Piet, Elferink Ronald Oude Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene Hepatology (Baltimore, Md.) 2005;42 (5):1091-1098 [PubMed]
Kosters A. Biliary cholesterol secretion in mice 2005. 171p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Groen A. K.)
Markusic David, Oude-Elferink Ronald, Das Atze T., Berkhout Ben, Seppen Jurgen Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter Nucleic acids research 2005;33 (6):e63 [PubMed]
Lie-A-Ling M. Gene therapy for cholangiocarcinoma 2005. 152p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
van Til Niek P., Markusic David M., van der Rijt Roos, Kunne Cindy, Hiralall Johan K., Vreeling Heleen, Frederiks Wilma M., Oude-Elferink Ronald P. J., Seppen Jurgen Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes Molecular therapy 2005;11 (1):26-34 [PubMed]
Oude Elferink Ronald P. J. Manipulation of biliary lipids by gene therapy: potential consequences for patients with progressive familial intrahepatic cholestasis Current drug targets 2005;5 (2):199-202 [PubMed]
Paulusma C. C., Oude Elferink R. P. J. The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2005;1741 (1-2):11-24 [PubMed]
Groen Albert K., Oude Elferink Ronald P. J. Treatment modalities for hepatocellular carcinoma Current cancer drug targets 2005;5 (2):131-138 [PubMed]

2004

Pawlikowska Ludmila, Groen Annemiek, Eppens Elaine F., Kunne Cindy, Ottenhoff Roelof, Looije Norbert, Knisely A. S., Killeen Nigel P., Bull Laura N., Elferink Ronald P. J. Oude, Freimer Nelson B. A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion Human molecular genetics 2004;13 (8):881-892 [PubMed]
Klett Eric L., Lu Kangmo, Kosters Astrid, Vink Edwin, Lee Mi-Hye, Altenburg Michael, Shefer Sarah, Batta Ashok K., Yu Hongwei, Chen Jianliang, Klein Richard, Looije Norbert, Oude-Elferink Ronald, Groen Albert K., Maeda Nobuyo, Salen Gerald, Patel Shailendra B. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol BMC medicine 2004;2 (1):5 [PubMed]
Dietrich Christoph G., Geier Andreas, Salein Nina, Lammert Frank, Roeb Elke, Oude Elferink Ronald P. J., Matern Siegfried, Gartung Carsten Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2 Gastroenterology 2004;126 (4):1044-1053 [PubMed]
Koshy Abraham, Bosma Piter J., Oude-Elferink Ronald P. J. Crigler-Najjar syndrome type 1 associated with combined 1070A-->G, Q357R and (TA)7 mutation in Kuwaiti Bedouin families indicate a founder effect in Arabs Journal of clinical gastroenterology 2004;38 (5):465-467 [PubMed]
Dietrich C. G., Geier A., Wasmuth H. E., Matern S., Gartung C., de Waart D. R., Elferink R. P. J. O. Influence of biliary cirrhosis on the detoxification and elimination of a food derived carcinogen Gut 2004;53 (12):1850-1855 [PubMed]
Elferink Ronald P. J. Oude, Ottenhoff Roelof, Fricker Gert, Seward David J., Ballatori Nazzareno, Boyer James Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters American journal of physiology. Gastrointestinal and liver physiology 2004;286 (5):G762-G768 [PubMed]
Oude Elferink R. P. J., van Aalderen W. M. C., Hoekstra J. B. L., Stouthard M. E. A. Researchcode AMC:Onafhankelijk in wetenschapS.l.: s.n.; 2004.
Groen Albert K., Oude Elferink Ronald P. J., Verkade Henkian J., Kuipers Folkert The ins and outs of reverse cholesterol transport Annals of medicine 2004;36 (2):135-145 [PubMed]
Oude Elferink Ronald The start of a new era in bile physiology Journal of hepatology 2004;41 (6):902-904 [PubMed]
Elferink Ronald Oude Yin Zhi Huang and other plant-derived preparations: where herbal and molecular medicine meet Journal of hepatology 2004;41 (4):691-693 [PubMed]

2003

Dietrich C. G., Geier A., Oude Elferink R. P. J. ABC of oral bioavailability: transporters as gatekeepers in the gut Gut 2003;52 (12):1788-1795 [PubMed]
Medina Juan F., Recalde Sergio, Prieto Jesús, Lecanda Jon, Saez Elena, Funk Colin D., Vecino Paola, van Roon Marian A., Ottenhoff Roelof, Bosma Piter J., Bakker Conny T., Elferink Ronald P. J. Oude Anion exchanger 2 is essential for spermiogenesis in mice Proceedings of the National Academy of Sciences of the United States of America 2003;100 (26):15847-15852 [PubMed]
Elferink R. Oude Cholestasis Gut 2003;52 (Suppl. 2):II42-II48 [PubMed]
Dietrich C. G., Geier A., Oude Elferink R. P. J., Matern S. Defense barriers in the body: contribution of multidrug resistance-associated protein 2 Comments on modern biology: B. Comments on toxicology 2003;9:201-214
Oude Elferink Ronald Elucidation of the biliary secretion machinery Current gastroenterology reports 2003;5 (6):439-440 [PubMed]
Borst P., van Meer G. F. B. P., Oude Elferink R. P. J. Lipid transport by ABC-transportersin: B. Holland, S. Cole, K. Kuchler, C. Higgins, editors. From bacteria to man. S.l.: Academic Press; 2003. p. 461-478
Seppen Jurgen, van der Rijt Roos, Looije Norbert, van Til Niek P., Lamers Wouter H., Oude Elferink Ronald P. J. Long-term correction of bilirubin UDPglucuronyltransferase deficiency in rats by in utero lentiviral gene transfer Molecular therapy 2003;8 (4):593-599 [PubMed]
Dietrich C. G. MRP2 and the defence against drugs and toxins 2003. 102p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Gartung C.)
Oude Elferink Ronald One step further towards real high-throughput functional genomics Trends in biotechnology 2003;21 (4):146-147 [PubMed]

2002

Fouassier Laura, Kinnman Nils, Lefèvre Guillaume, Lasnier Elisabeth, Rey Colette, Poupon Raoul, Elferink Ronald P. J. Oude, Housset Chantal Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan Journal of hepatology 2002;37 (2):184-191 [PubMed]
Elferink R. O., Groen A. K. Genetic defects in hepatobiliary transport BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2002;1586 (2):129-145 [PubMed]
Seppen Jurgen, Rijnberg Martijn, Cooreman Michel P., Oude Elferink Ronald P. J. Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes Journal of hepatology 2002;36 (4):459-465 [PubMed]
Elferink Ronald Oude Lipids and ABC transporters Kidney international 2002;62 (5):1516
Borst P., Elferink R. Oude Mammalian ABC transporters in health and disease Annual review of biochemistry 2002;71:537-592 [PubMed]
Jonker Johan W., Buitelaar Marije, Wagenaar Els, van der Valk Martin A., Scheffer George L., Scheper Rik J., Plosch Torsten, Kuipers Folkert, Elferink Ronald P. J. Oude, Rosing Hilde, Beijnen Jos H., Schinkel Alfred H. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria Proceedings of the National Academy of Sciences of the United States of America 2002;99 (24):15649-15654 [PubMed]
Scheffer George L., Kool Marcel, de Haas Marcel, de Vree J. Marleen L., Pijnenborg Adriana C. L. M., Bosman Diederik K., Elferink Ronald P. J. Oude, van der Valk Paul, Borst Piet, Scheper Rik J. Tissue distribution and induction of human multidrug resistant protein 3 Laboratory investigation; a journal of technical methods and pathology 2002;82 (2):193-201 [PubMed]
Elferink Ronald P. J. Oude Understanding and controlling hepatobiliary function Best practice & research. Clinical gastroenterology 2002;16 (6):1025-1034 [PubMed]

2001

Voshol P. J., Koopen N. R., de Vree J. M., Havinga R., Princen H. M., Elferink R. P., Groen A. K., Kuipers F. Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice Journal of hepatology 2001;34 (2):202-209 [PubMed]
Eppens E. F., van Mil S. W., de Vree J. M., Mok K. S., Juijn J. A., Oude Elferink R. P., Berger R., Houwen R. H., Klomp L. W. FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte Journal of hepatology 2001;35 (4):436-443 [PubMed]
Dietrich C. G., de Waart D. R., Ottenhoff R., Schoots I. G., Elferink R. P. Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats Molecular pharmacology 2001;59 (5):974-980 [PubMed]
Dietrich C. G., Ottenhoff R., de Waart D. R., Oude-Elferink R. P. Lack of UGT1 isoforms in Gunn rats changes metabolic ratio and facilitates excretion of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo Toxicology and applied pharmacology 2001;170 (2):137-143 [PubMed]
Oude Elferink R. P., Zadina J. MDR1 P-glycoprotein transports endogenous opioid peptides Peptides 2001;22 (12):2015-2020 [PubMed]
Dietrich C. G., de Waart D. R., Ottenhoff R., Bootsma A. H., van Gennip A. H., Elferink R. P. Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo Carcinogenesis 2001;22 (5):805-811 [PubMed]
Wymenga L. F., Groenier K., Schuurman J., Boomsma J. H., Elferink R. O., Mensink H. J. Pretreatment levels of urinary deoxypyridinoline as a potential marker in patients with prostate cancer with or without bone metastasis BJU international 2001;88 (3):231-235 [PubMed]
Dietrich C. G., Ottenhoff R., de Waart D. R., Oude Elferink R. P. Role of MRP2 and GSH in intrahepatic cycling of toxins Toxicology 2001;167 (1):73-81 [PubMed]
Jacquemin E., de Vree J. M., Cresteil D., Sokal E. M., Sturm E., Dumont M., Scheffer G. L., Paul M., Burdelski M., Bosma P. J., Bernard O., Hadchouel M., Elferink R. P. The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood Gastroenterology 2001;120 (6):1448-1458 [PubMed]

2000

de Vree J. M., Ottenhoff R., Bosma P. J., Smith A. J., Aten J., Oude Elferink R. P. Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis Gastroenterology 2000;119 (6):1720-1730 [PubMed]
Sewnath M. E., Levels H. H., Oude Elferink R., van Noorden C. J., ten Kate F. J., van Deventer S. J., Gouma D. J. Endotoxin-induced mortality in bile duct-ligated rats after administration of reconstituted high-density lipoprotein Hepatology (Baltimore, Md.) 2000;32 (6):1289-1299 [PubMed]
Oude Elferink R. P., Groen A. K. Mechanisms of biliary lipid secretion and their role in lipid homeostasis Seminars in liver disease 2000;20 (3):293-305 [PubMed]
Voshol P. J., Minich D. M., Havinga R., Elferink R. P., Verkade H. J., Groen A. K., Kuipers F. Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice Gastroenterology 2000;118 (1):173-182 [PubMed]
Frijters C. M. G. Regulation of biliary lipid secretion 2000. 156p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Tytgat G. N. J., Borst P.; Co-supervisors: Oude Elferink R. P. J., Groen A. K.)
Scheffer G. L., Kool M., Heijn M., de Haas M., Pijnenborg A. C., Wijnholds J., van Helvoort A., de Jong M. C., Hooijberg J. H., Mol C. A., van der Linden M., de Vree J. M., van der Valk P., Elferink R. P., Borst P., Scheper R. J. Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies Cancer research 2000;60 (18):5269-5277 [PubMed]
Elferink Ronald Oude, De Vree Marleen, Frijters Charles, Groen Albert The role of phospholipids in bile formation: What can we learn from animals and human disease? Journal of Hepatology, Supplement 2000;32 (2):3-4
Paulusma C. C., Kothe M. J., Bakker C. T., Bosma P. J., van Bokhoven I., van Marle J., Bolder U., Tytgat G. N., Oude Elferink R. P. Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver Hepatology (Baltimore, Md.) 2000;31 (3):684-693 [PubMed]

1999

Paulusma C. C., van Geer M. A., Evers R., Heijn M., Ottenhoff R., Borst P., Oude Elferink R. P. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione Biochemical journal 1999;338 ( Pt 2):393-401 [PubMed]
Marsman Willem A., Oude-Elferink Ronald P.J., Jones E. Anthony Jeuk en leverziekten: Krabben is te meten; jeuk niet Pharmaceutisch Weekblad 1999;134 (9):324-328
de Vree J. M., Romijn J. A., Mok K. S., Mathus-Vliegen L. M., Stoutenbeek C. P., Ostrow J. D., Tytgat G. N., Sauerwein H. P., Oude Elferink R. P., Groen A. K. Lack of enteral nutrition during critical illness is associated with profound decrements in biliary lipid concentrations American journal of clinical nutrition 1999;70 (1):70-77 [PubMed]
Smith A. J., Oude Elferink R. P. Liver gene disruptions: winners by KO? Journal of hepatology 1999;31 (4):752-759 [PubMed]
van Helvoort A., de Brouwer A., Ottenhoff R., Brouwers J. F., Wijnholds J., Beijnen J. H., Rijneveld A., van der Poll T., van der Valk M. A., Majoor D., Voorhout W., Wirtz K. W., Elferink R. P., Borst P. Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces Proceedings of the National Academy of Sciences of the United States of America 1999;96 (20):11501-11506 [PubMed]
Kool M., van der Linden M., de Haas M., Scheffer G. L., de Vree J. M., Smith A. J., Jansen G., Peters G. J., Ponne N., Scheper R. J., Elferink R. P., Baas F., Borst P. MRP3, an organic anion transporter able to transport anti-cancer drugs Proceedings of the National Academy of Sciences of the United States of America 1999;96 (12):6914-6919 [PubMed]
Bolder U., Trang N. V., Hagey L. R., Schteingart C. D., Ton-Nu H. T., Cerrè C., Elferink R. P., Hofmann A. F. Sulindac is excreted into bile by a canalicular bile salt pump and undergoes a cholehepatic circulation in rats Gastroenterology 1999;117 (4):962-971 [PubMed]
Elferink R. P., Groen A. K. The mechanism of biliary lipid secretion and its defects Gastroenterology clinics of North America 1999;28 (1):59-74, vi [PubMed]
Frijters C. M., Tuijn C. J., Ottenhoff R., Zegers B. N., Groen A. K., Elferink R. P. The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids Journal of lipid research 1999;40 (11):1950-1958 [PubMed]

1998

Sewnath M. E., Levels J. H.M., Kimmings A. N., Van Deventer S. J.H., Maas M. A.W., Oude Elferink R. P.J., Gouma D. J. A shift in lipoprotein bound endotoxin distribution in bile duct ligated rats European journal of gastroenterology & hepatology 1998;10 (12):A12
Elferink R. P., Ottenhoff R., van Marle J., Frijters C. M., Smith A. J., Groen A. K. Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse Journal of clinical investigation 1998;102 (9):1749-1757 [PubMed]
Oude Elferink R. P., van Berge Henegouwen G. P. Cracking the genetic code for benign recurrent and progressive familial intrahepatic cholestasis Journal of hepatology 1998;29 (2):317-320 [PubMed]
Evers R., Kool M., van Deemter L., Janssen H., Calafat J., Oomen L. C., Paulusma C. C., Oude Elferink R. P., Baas F., Schinkel A. H., Borst P. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA Journal of clinical investigation 1998;101 (7):1310-1319 [PubMed]
Smith A. J., de Vree J. M., Ottenhoff R., Oude Elferink R. P., Schinkel A. H., Borst P. Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice Hepatology (Baltimore, Md.) 1998;28 (2):530-536 [PubMed]
de Vree J. M., Jacquemin E., Sturm E., Cresteil D., Bosma P. J., Aten J., Deleuze J. F., Desrochers M., Burdelski M., Bernard O., Oude Elferink R. P., Hadchouel M. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis Proceedings of the National Academy of Sciences of the United States of America 1998;95 (1):282-287 [PubMed]
Voshol P. J., Havinga R., Wolters H., Ottenhoff R., Princen H. M., Oude Elferink R. P., Groen A. K., Kuipers F. Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice Gastroenterology 1998;114 (5):1024-1034 [PubMed]
Frijters C. M., Tuijn C. J., Hoek F. J., Groen A. K., Oude Elferink R. P., Zegers B. N. Reversed-phase liquid chromatographic method for the determination of 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labelled lipid analogues Journal of chromatography. B, Biomedical sciences and applications 1998;710 (1-2):9-16 [PubMed]
Seitz S., Kretz-Rommel A., Oude Elferink R. P., Boelsterli U. A. Selective protein adduct formation of diclofenac glucuronide is critically dependent on the rat canalicular conjugate export pump (Mrp2) Chemical research in toxicology 1998;11 (5):513-519 [PubMed]

1997

Paulusma C. C., Kool M., Bosma P. J., Scheffer G. L., ter Borg F., Scheper R. J., Tytgat G. N., Borst P., Baas F., Oude Elferink R. P. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome Hepatology (Baltimore, Md.) 1997;25 (6):1539-1542 [PubMed]
Elferink R. P., Tytgat G. N., Groen A. K. Hepatic canalicular membrane 1: The role of mdr2 P-glycoprotein in hepatobiliary lipid transport FASEB journal 1997;11 (1):19-28 [PubMed]
Crawford A. R., Smith A. J., Hatch V. C., Oude Elferink R. P., Borst P., Crawford J. M. Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy Journal of clinical investigation 1997;100 (10):2562-2567 [PubMed]
Kotal P., van der Veere C. N., Sinaasappel M., Elferink R. O., Vítek L., Brodanová M., Jansen P. L., Fevery J. Intestinal excretion of unconjugated bilirubin in man and rats with inherited unconjugated hyperbilirubinemia Pediatric research 1997;42 (2):195-200 [PubMed]
Frijters C. M. G., Groen A. K., Elferink R. P. J. O. MDR2 P-glycoprotein-mediated lipid secretion and its relevance to biliary drug transport Advanced drug delivery reviews 1997;25 (2-3):201-215
Kuipers F., Oude Elferink R. P., Verkade H. J., Groen A. K. Mechanisms and (patho)physiological significance of biliary cholesterol secretion Sub-cellular biochemistry 1997;28 (10):295-318 [PubMed]
van der Veere C. N., Jansen P. L., Sinaasappel M., van der Meer R., van der Sijs H., Rammeloo J. A., Goyens P., van Nieuwkerk C. M., Oude Elferink R. P. Oral calcium phosphate: a new therapy for Crigler-Najjar disease? Gastroenterology 1997;112 (2):455-462 [PubMed]
Frijters C. M., Ottenhoff R., van Wijland M. J., van Nieuwkerk C. M., Groen A. K., Oude Elferink R. P. Regulation of mdr2 P-glycoprotein expression by bile salts Biochemical journal 1997;321 (2):389-395 [PubMed]
Paulusma C. C., Oude Elferink R. P. The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man Journal of molecular medicine (Berlin, Germany) 1997;75 (6):420-428 [PubMed]
van Nieuwerk C. M., Groen A. K., Ottenhoff R., van Wijland M., van den Bergh Weerman M. A., Tytgat G. N., Offerhaus Johan J. A., Oude Elferink R. P. The role of bile salt composition in liver pathology of mdr2 (-/-) mice: differences between males and females Journal of hepatology 1997;26 (1):138-145 [PubMed]
Seppen J., Tada K., Ottenhoff R., Sengupta K., Chowdhury N. R., Chowdhury J. R., Bosma P. J., Oude Elferink R. P. Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation Human gene therapy 1997;8 (1):27-36 [PubMed]

1996

Seppen J., Steenken E., Lindhout D., Bosma P. J., Elferink R. P. A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II FEBS letters 1996;390 (3):294-298 [PubMed]
Evers R., Zaman G. J., van Deemter L., Jansen H., Calafat J., Oomen L. C., Oude Elferink R. P., Borst P., Schinkel A. H. Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells Journal of clinical investigation 1996;97 (5):1211-1218 [PubMed]
Seppen J., Tada K., Hellwig S., Bakker C. T., Prasad V. R., Roy Chowdhury N., Roy Chowdhury J., Bosma P. J., Oude Elferink R. P. Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase Biochemical journal 1996;314 ( Pt 2):477-483 [PubMed]
Paulusma C. C., Bosma P. J., Zaman G. J., Bakker C. T., Otter M., Scheffer G. L., Scheper R. J., Borst P., Oude Elferink R. P. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene Science 1996;271 (5252):1126-1128 [PubMed]
Groen A. K., Elferink R. P., Tager J. M. Control analysis of biliary lipid secretion Journal of theoretical biology 1996;182 (3):427-436 [PubMed]
van Nieuwkerk C. M., Elferink R. P., Groen A. K., Ottenhoff R., Tytgat G. N., Dingemans K. P., van den Bergh Weerman M. A., Offerhaus G. J. Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene Gastroenterology 1996;111 (1):165-171 [PubMed]
Frijters C. M., Ottenhoff R., van Wijland M. J., van Nieuwkerk C., Groen A. K., Oude Elferink R. P. Influence of bile salts on hepatic mdr2 P-glycoprotein expression Advances in enzyme regulation 1996;36:351-363 [PubMed]
van der Veere C. N., Schoemaker B., Bakker C., van der Meer R., Jansen P. L., Elferink R. P. Influence of dietary calcium phosphate on the disposition of bilirubin in rats with unconjugated hyperbilirubinemia Hepatology (Baltimore, Md.) 1996;24 (3):620-626 [PubMed]
Stouthard J. M., Oude Elferink R. P., Sauerwein H. P. Interleukin-6 enhances glucose transport in 3T3-L1 adipocytes Biochemical and biophysical research communications 1996;220 (2):241-245 [PubMed]
Oude Elferink R. P., Frijters C. M., Paulusma C., Groen A. K. Regulation of canalicular transport activities Journal of hepatology 1996;24 (Suppl. 1):94-99 [PubMed]
Oude Elferink R. P., Ottenhoff R., van Wijland M., Frijters C. M., van Nieuwkerk C., Groen A. K. Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein Journal of lipid research 1996;37 (5):1065-1075 [PubMed]

1995

Oude Elferink R. P., Meijer D. K., Kuipers F., Jansen P. L., Groen A. K., Groothuis G. M. Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON BIOMEMBRANES 1995;1241 (2):215-268 [PubMed]
Seppen J., Jansen P. L., Oude Elferink R. P. Immunoaffinity purification and reconstitution of the human bilirubin/phenol UDP-glucuronosyltransferase family Protein expression and purification 1995;6 (2):149-154 [PubMed]
Roelofsen H., Schoemaker B., Bakker C., Ottenhoff R., Jansen P. L., Elferink R. P. Impaired hepatocanalicular organic anion transport in endotoxemic rats American journal of physiology 1995;269 (3 Part 1):G427-G434 [PubMed]
van der Veere C. N., Schoemaker B., van der Meer R., Groen A. K., Jansen P. L., Oude Elferink R. P. Rapid association of unconjugated bilirubin with amorphous calcium phosphate Journal of lipid research 1995;36 (8):1697-1707 [PubMed]
Roelofsen H., Bakker C. T., Schoemaker B., Heijn M., Jansen P. L., Elferink R. P. Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes Hepatology (Baltimore, Md.) 1995;21 (6):1649-1657 [PubMed]
Oude Elferink R. P., Ottenhoff R., van Wijland M., Smit J. J., Schinkel A. H., Groen A. K. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse Journal of clinical investigation 1995;95 (1):31-38 [PubMed]
Groen A. K., van Wijland M. J., Frederiks W. M., Smit J. J., Schinkel A. H., Oude Elferink R. P. Regulation of protein secretion into bile: studies in mice with a disrupted mdr2 p-glycoprotein gene Gastroenterology 1995;109 (6):1997-2006 [PubMed]
Zaman G. J., Lankelma J., van Tellingen O., Beijnen J., Dekker H., Paulusma C., Oude Elferink R. P., Baas F., Borst P. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein Proceedings of the National Academy of Sciences of the United States of America 1995;92 (17):7690-7694 [PubMed]
Bosma P. J., Chowdhury J. R., Bakker C., Gantla S., de Boer Anita, Oostra B. A., Lindhout D., Tytgat G. N., Jansen P. L., Oude Elferink R. P. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome New England journal of medicine 1995;333 (18):1171-1175 [PubMed]
Oude Elferink R. P., Groen A. K. The role of mdr2 P-glycoprotein in biliary lipid secretion. Cross-talk between cancer research and biliary physiology Journal of hepatology 1995;23 (5):617-625 [PubMed]

1994

Bosma P. J., Seppen J., Goldhoorn B., Bakker C., Oude Elferink R. P., Chowdhury J. R., Chowdhury N. R., Jansen P. L. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man Journal of biological chemistry 1994;269 (27):17960-17964 [PubMed]
Roelofsen H., van der Veere C. N., Ottenhoff R., Schoemaker B., Jansen P. L., Oude Elferink R. P. Decreased bilirubin transport in the perfused liver of endotoxemic rats Gastroenterology 1994;107 (4):1075-1084 [PubMed]
Seppen J., Bosma P. J., Goldhoorn B. G., Bakker C. T., Chowdhury J. R., Chowdhury N. R., Jansen P. L., Oude Elferink R. P. Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase Journal of clinical investigation 1994;94 (6):2385-2391 [PubMed]
Bosma P. J., Seppen J., Goldhoorn B., Bakker C., Elferink R. P.J.O., Chowdhury J. R., Chowdhury N. R., Jansen P. L.M. Erratum: Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man (Journal of Biological Chemistry (1994) 269 (17960-17964)) Journal of biological chemistry 1994;269 (41):25942
van Wijland M. J., Klinkspoor J. H., de Wit L. T., Oude Elferink R. P., Tytgat G. N., Groen A. K. Heterogeneity of human gallbladder mucin in bile Clinical science (London, England 1994;86 (1):67-74 [PubMed]
Mauad T. H., van Nieuwkerk C. M., Dingemans K. P., Smit J. J., Schinkel A. H., Notenboom R. G., van den Bergh Weerman M. A., Verkruisen R. P., Groen A. K., Oude Elferink R. P. Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis American journal of pathology 1994;145 (5):1237-1245 [PubMed]
Oude Elferink R. P., Jansen P. L. The role of the canalicular multispecific organic anion transporter in the disposal of endo- and xenobiotics Pharmacology & therapeutics 1994;64 (1):77-97 [PubMed]

1993

Oude Elferink R. P., Bakker C. T., Roelofsen H., Middelkoop E., Ottenhoff R., Heijn M., Jansen P. L. Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter Hepatology (Baltimore, Md.) 1993;17 (3):434-444 [PubMed]
Bosma P. J., Goldhoorn B., Oude Elferink R. P., Sinaasappel M., Oostra B. A., Jansen P. L. A mutation in bilirubin uridine 5'-diphosphate-glucuronosyltransferase isoform 1 causing Crigler-Najjar syndrome type II Gastroenterology 1993;105 (1):216-220 [PubMed]
van Es H. H., Bout A., Liu J., Anderson L., Duncan A. M., Bosma P., Oude Elferink R., Jansen P. L., Chowdhury J. R., Schurr E. Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37 Cytogenetics and cell genetics 1993;63 (2):114-116 [PubMed]
Muhler Andreas, Oude Elferink Ronald P.J., Weinmann Hanns Joachim Complete elimination of the hepatobiliary mr contrast agent Gd-EOB-DTPA in hepatic dysfunction: An experimental study using transport-deficient, mutant rats Magma (New York, N.Y.) 1993;1 (3-4):134-139
Oude Elferink R. P., Bakker C. T., Jansen P. L. Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells) Biochemical journal 1993;290 ( Pt 3):759-764 [PubMed]
Jansen P. L., Oude Elferink R. P. Hereditary conjugated hyperbilirubinemia in Wistar rats: a model for the study of ATP-dependent hepatocanalicular organic anion transport Advances in veterinary science and comparative medicine 1993;37:175-195 [PubMed]
Smit J. J., Schinkel A. H., Oude Elferink R. P., Groen A. K., Wagenaar E., van Deemter L., Mol C. A., Ottenhoff R., van der Lugt N. M., van Roon M. A. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease Cell 1993;75 (3):451-462 [PubMed]
Jansen P. L., van Klinken J. W., van Gelder M., Ottenhoff R., Elferink R. P. Preserved organic anion transport in mutant TR- rats with a hepatobiliary secretion defect American journal of physiology 1993;265 (3 Part 1):G445-G452 [PubMed]

1992

Heijn M., Oude Elferink R. P., Jansen P. L. ATP-dependent multispecific organic anion transport system in rat erythrocyte membrane vesicles American journal of physiology 1992;262 (1 Part 1):C104-C110 [PubMed]
Bosma P. J., Chowdhury J. R., Huang T. J., Lahiri P., Elferink R. P., van Es H. H., Lederstein M., Whitington P. F., Jansen P. L., Chowdhury N. R. Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I FASEB journal 1992;6 (10):2859-2863 [PubMed]
Bosma P. J., Chowdhury N. R., Goldhoorn B. G., Hofker M. H., Oude Elferink R. P., Jansen P. L., Chowdhury J. R. Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I Hepatology (Baltimore, Md.) 1992;15 (5):941-947 [PubMed]

1991

Klumperman J., Fransen J. A., Boekestijn T. C., Oude Elferink R. P., Matter K., Hauri H. P., Tager J. M., Ginsel L. A. Biosynthesis and transport of lysosomal alpha-glucosidase in the human colon carcinoma cell line Caco-2: secretion from the apical surface Journal of cell science 1991;100 (2):339-347 [PubMed]
Velardi A. L., Groen A. K., Elferink R. P., van der Meer R., Palasciano G., Tytgat G. N. Cell type-dependent effect of phospholipid and cholesterol on bile salt cytotoxicity Gastroenterology 1991;101 (2):457-464 [PubMed]
Roelofsen H., Ottenhoff R., Oude Elferink R. P., Jansen P. L. Hepatocanalicular organic-anion transport is regulated by protein kinase C Biochemical journal 1991;278 ( Pt 3):637-641 [PubMed]
Oude Elferink R. P., Ottenhoff R., Radominska A., Hofmann A. F., Kuipers F., Jansen P. L. Inhibition of glutathione-conjugate secretion from isolated hepatocytes by dipolar bile acids and other organic anions Biochemical journal 1991;274 (1):281-286 [PubMed]

1990

Oude Elferink R. P., Ottenhoff R., Liefting W. G., Schoemaker B., Groen A. K., Jansen P. L. ATP-dependent efflux of GSSG and GS-conjugate from isolated rat hepatocytes American journal of physiology 1990;258 (5 Part 1):G699-G706 [PubMed]
van Es H. H., Goldhoorn B. G., Paul-Abrahamse M., Elferink R. P., Jansen P. L. Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I Journal of clinical investigation 1990;85 (4):1199-1205 [PubMed]

1989

de Vries M. H., Redegeld F. A., Koster A. S., Noordhoek J., de Haan J. G., Oude Elferink R. P., Jansen P. L. Hepatic, intestinal and renal transport of 1-naphthol-beta-D-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia Naunyn-Schmiedeberg s archives of pharmacology 1989;340 (5):588-592 [PubMed]
Elferink R. P., Ottenhoff R., Liefting W., de Haan J., Jansen P. L. Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia Journal of clinical investigation 1989;84 (2):476-483 [PubMed]
Oude Elferink R. P., Fransen J., Klumperman J., Ginsel L. A., Tager J. M. Secretion of a precursor form of lysosomal alpha-glucosidase from the brush border of human kidney proximal tubule cells European journal of cell biology 1989;50 (2):299-303 [PubMed]
Oude Elferink R. P., de Haan J., Lambert K. J., Hagey L. R., Hofmann A. F., Jansen P. L. Selective hepatobiliary transport of nordeoxycholate side chain conjugates in mutant rats with a canalicular transport defect Hepatology (Baltimore, Md.) 1989;9 (6):861-865 [PubMed]

1988

Jansen P. L., Oude Elferink R. P. Hereditary hyperbilirubinemias: a molecular and mechanistic approach Seminars in liver disease 1988;8 (2):168-178 [PubMed]
Fransen J. A., Ginsel L. A., Cambier P. H., Klumperman J., Oude Elferink R. P., Tager J. M. Immunocytochemical demonstration of the lysosomal enzyme alpha-glucosidase in the brush border of human intestinal epithelial cells European journal of cell biology 1988;47 (1):72-80 [PubMed]
Tager J. M., Aerts J. M. F. G., Oude Elferink R. P. J., Groen A. K., Hollemans M., Schram A. W. pH regulation of intracellular membrane flow.in: D. Haussinger, editors. pH homeostatis, mechanisms and control. New York: Academic Press; 1988. p. 123-162, ISBN 9780123330659

1987

Tager J. M., Oude Elferink R. P., Reuser A., Kroos M., Ginsel L. A., Fransen J. A., Klumperman J. alpha-Glucosidase deficiency (Pompe's disease) Enzyme 1987;38 (1-4):280-285 [PubMed]
Weijers R. N., Oude Elferink R. P., Mulder J., Kruijswijk H. Characterization of immunoglobulin A kappa autoantibodies to human lactate dehydrogenase isoenzyme-3 Clinical immunology and immunopathology 1987;42 (1):110-122 [PubMed]

1986

Oude Elferink R. P., van Doorn-van Wakeren J., Hendriks T., Strijland A., Tager J. M. Transport and processing of endocytosed lysosomal alpha-glucosidase in cultured human skin fibroblasts European Journal of Biochemistry / FEBS 1986;158 (2):339-344 [PubMed]

1985

Oude Elferink R. P., van Doorn-van Wakeren J., Strijland A., Reuser A. J., Tager J. M. Biosynthesis and intracellular transport of alpha-glucosidase and cathepsin D in normal and mutant human fibroblasts European Journal of Biochemistry / FEBS 1985;153 (1):55-63 [PubMed]
Reuser A. J., Kroos M., Oude Elferink R. P., Tager J. M. Defects in synthesis, phosphorylation, and maturation of acid alpha-glucosidase in glycogenosis type II Journal of biological chemistry 1985;260 (14):8336-8341 [PubMed]

1984

Oude Elferink Ronald P.J., Hendriks Theo, Strijland Anneke, Brouwer-Kelder Elisabeth M., Damsma Otto, Hilkens John, Hilgers Jo, Tager Joseph M. Differential effects of leupeptin on the maturation of lysosomal α-glucosidase Biochemical Society transactions 1984;12 (6):1028-1029
Oude Elferink R. P., Brouwer-Kelder E. M., Surya I., Strijland A., Kroos M., Reuser A. J., Tager J. M. Isolation and characterization of a precursor form of lysosomal alpha-glucosidase from human urine European Journal of Biochemistry / FEBS 1984;139 (3):489-495 [PubMed]
Tager J. M., Jonsson L. V., Aerts J. M., Elferink R. P., Schram A. W., Erickson A. H., Barranger J. A. Metabolic consequences of genetic defects in lysosomes Biochemical Society transactions 1984;12 (6):902-905 [PubMed]
Oude Elferink R. P., Strijland A., Surya I., Brouwer-Kelder E. M., Kroos M., Hilkens J., Hilgers J., Reuser A. J., Tager J. M. Use of a monoclonal antibody to distinguish between precursor and mature forms of human lysosomal alpha-glucosidase European Journal of Biochemistry / FEBS 1984;139 (3):497-502 [PubMed]

1983

Tager J. M., Elferink R. O., Brouwer-Kelder B., Strijland A., Hilkens J., Reuser A., Kroos M., Surya I., Paape M., Hilgers J. Multiple molecular forms of human acid alpha-glucosidase Isozymes 1983;7:101-112 [PubMed]
Oude Elferink R. P., Harms E., Strijland A., Tager J. M. The intralysosomal pH in cultured human skin fibroblasts in relation to cystine accumulation in patients with cystinosis Biochemical and biophysical research communications 1983;116 (1):154-161 [PubMed]

1982

Steckel F., Gieselmann V., Waheed A., Hasilik A., von Figura K., Oude Elferink R., Kalsbeek R., Tager J. M. Biosynthesis of acid alpha-glucosidase in late-onset forms of glycogenosis type II (Pompe's disease) FEBS letters 1982;150 (1):69-76 [PubMed]

1981

Hollemans M., Oude Elferink Ronald, de Groot P. G., Strijland A., Tager J. M. Accumulation of weak bases in relation to intralysosomal pH in cultured human skin fibroblasts BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1981;643 (1):140-151 [PubMed]
De Groot Philip G., Elferink Ronald Oude, Hollemans Marja, Strijland Anneke, Westerveld Andries, Khan P. Meera, Tager Joseph M. Inactivation by chloroquine of α-galactosidase in cultured human skin fibroblasts Experimental cell research 1981;136 (2):327-333 [PubMed]

1980

Hollemans M., Oude Elferink R., De Groot P. G. The effects of chloroquine on the intra- and extracellular levels of lysosomal enzymes in human skin fibroblasts European journal of cell biology 1980;22 (1):M605

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