Prof. W.J. de Jonge PhD

Prof. PhD W.J. de Jonge

Position

Full Professor

Main activities

Education, Research

Specialisation

Mucosal Immunology, Neurogastroenterology

Focus of research

The group of Wouter de Jonge studies mechanisms of functional and inflammatory gastro-intestinal disease.

-Preclinical research models for gastrointestinal Disease (IBD, irritable bowel syndrome (IBS), and motility disorders)

-Preclinical and Clinical research in surgical complications, wound healing and anastomotic healing

-Specialized medical nutrition to improve gut epithelial barriers and immunity - in alliance with industrial partners

-Epigenetic aspects of cell differentiation in the gut in health and disease

link to our group website:

http://gut-research.com

Amsterdam UMC Research Institutes

AMC departments

Key publications

van de Pavert Serge A., Olivier Brenda J., Goverse Gera, Vondenhoff Mark F., Greuter Mascha, Beke Patrick, Kusser Kim, Höpken Uta E., Lipp Martin, Niederreither Karen, Blomhoff Rune, Sitnik Kasia, Agace William W., Randall Troy D., de Jonge Wouter J., Mebius Reina E. Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation Nature immunology 2009;10 (11):1193-1199 [PubMed]
van der Zanden Esmerij P., Snoek Susanne A., Heinsbroek Sigrid E., Stanisor Oana I., Verseijden Caroline, Boeckxstaens Guy E., Peppelenbosch Maikel P., Greaves David R., Gordon Siamon, de Jonge Wouter J. Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2 Gastroenterology 2009;137 (3):1029-1039, 1039.e1-4 [PubMed]
de Jonge Wouter J., van der Zanden Esmerij P., The Frans O., Bijlsma Maarten F., van Westerloo David J., Bennink Roelof J., Berthoud Hans-Rudolf, Uematsu Satoshi, Akira Shizuo, van den Wijngaard Rene M., Boeckxstaens Guy E. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway Nature immunology 2005;6 (8):844-851 [PubMed]
Bernink Jochem H., Spits Hergen, de Jonge Wouter J. A new edge to immune surveillance by the neural system Cell research 2016;26 (11):1178-1179 [PubMed]
Willemze Rose A., Luyer Misha D., Buurman Wim A., de Jonge Wouter J. Neural reflex pathways in intestinal inflammation: hypotheses to viable therapy Nature reviews. Gastroenterology & hepatology 2015;12 (6):353-362 [PubMed]

All Publications

Curriculum Vitae

Personal: Wouter J de Jonge, PhD (Eindhoven, Netherlands)

Education:

MSc: 1994, Molecular Biology, University Utrecht
Internships:Research Institute for Toxicology, Utrecht; prof A Oppenhuizen
Hubrecht Laboratory, Utrecht; prof AJ Durston
Wageningen University, Wageningen; Dr MC Lans
Doctorate: 2001 Faculty of Medicine, University of Amsterdam

Positions:

1994-1995 Research Fellow, Department of Human Nutrition, Columbia University, New York, USA.
1995-2000, Doctorate: Implications of arginine deficiency for organ development, Univ of Amsterdam, faculty of Medicine, profs. W.H. Lamers, Univ. Amsterdam; P.B. Soeters, Dep. Surgery, Univ. of Maastricht.
2000-2002 Post doc, Dep. of Gastroenterology, Academic Medical Center, Amsterdam
2002-2006 Assistant Professor, Dep Gastroenterology and Hepatology, Amsterdam
2006-2008 Post Doc, Siamon Gordon laboratory, Sr Dunn School of Pathology, Oxford University, Oxford, UK
2008-2011 Assistant Professor-Principle Investigator, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam

2012-2013 Associate Professor Tytgat Institute and Dept of Gastroenterology and Hepatology, AMC Amsterdam

2013-present-Professor Experimental Neurogastroenterology, AMC Amsterdam

2018-present-Professor of Neurogastroenterology, Department of Surgery, Bonn, Germany

Other positions:

-member of the scientific advisory board MLDS

-Coordinator Horizon 2020 program EID EpiMac 2015-2019

-Scientific Coordinator Horizon 2020 EID GROWTH 2019-2023

-Consultant to Gut Research BV, Amsterdam 2019-present

Selected Grants/Awards:

2015 Project grant Bioelectronics in inflammatory disease

2015 Horizon 2020 ITN grant "EpiMac" (coordinator)

2012 Research grant Kinases in IBD (GlaxoSmithKline UK)

2010 ASNEMGE Rising Star of Gastroenterology-Award 2010
2008 Dutch Organization for Scientific Research; VIDI-Award “The vagus nerve as a regulator of immune tolerance in the intestinal mucosa"
2008 AMC grant; "epigenetic mechanisms in innate immunity"
2006 -EU Marie Curie, Intra-european Fellowship, "Nervous modulation of macrophage activity and inflammation"
2006 -FEBS Long term fellowship award
2007 -Top Institute Pharma, Neuromodulation of innate immune responses,
2005 -“Maag-Lever-Darm Stichting (05-49):”nicotinic agonists for the treatment of ulcerative colitis”.
2003-5 -NWO/STW grant ‘Identifying novel targets in gastrointestinal motility disorders.

Research programmes

Prof. PhD W.J. de Jonge (Gastro-Intestinal diseases)

The research team focusses on homeostasis of the mucosal immune system of the large and small bowel, and the relation to intestinal barrier function and intestinal microflora.

We also have a special interest in functional bowel motility disturbances due to inflammatory disease.

Our clinical interests focuss on the pathogenesis of post-operative ileus, IBS, and IBD

Faculty
PhD J.E. Seppen
PhD A.A. te Velde
PhD R.M.J.G.J. van den Wijngaard

Postdocs
PhD T.B.M. Hakvoort
PhD S.E.M. Heinsbroek
PhD B. Sovran

PhD Students
M.A.J. Becker
MD D.J. Brinkman
MD H.J. Chen
N. Deianova
MD M. de Krijger
MD L.C.S. de Vries
L.D. Eeftinck Schattenkerk
MD A.M.I.M. Elfiky
MSc M. Ghiboub
BSc M. Graute
MD MSc I.L. Hageman
V.W. Joustra
N. Koopman
BSc MSc I.A.M. Kreulen
MSc A.Y.F. Li Yim
R. Luque Martin
MSc P.I. Metselaar
MD E.G. Peters
BSc MSc G. Pitotti
S. Rahman
MD A.S. ten Hove
MD C.P.M. van Helsdingen
MSc I.A.M. van Thiel
PhD N.V. Wieser