Mouse Morphology, Function & Genetics - online (AMC PhD Program; OOA)

Information about the course Mouse Morphology, Function & Genetics.


This course aims to provide a practical understanding of the anatomy, histology and pathology of what is currently the most frequently used experimental animal, the house mouse. A better insight in their (ever changing) genetic make-up can improve the quality of experiments substantially. Additionally, the students will be introduced to modern imaging and genetic modification techniques to enable active participation in the planning of studies. Finally, we want to familiarize the students with some well-known pitfalls of extrapolating findings from mice to man.

After finishing this course students:

  • Can describe and demonstrate the anatomy and histology of major organs of the mouse.
  • Are able to choose mouse strains suitable for their research.
  • Can interpret histological and imaging data.
  • Can judge behavior and deduce wellbeing of experimental animals.
  • Can design mouse experiments that are better suited for translation to humans.


    This course is organized and coordinated by the Tytgat Institute for Liver & Intestinal Research and the Department of Medical Biology, in collaboration with the Oncology Graduate School of Amsterdam (OOA, Onderzoekschool Oncologie Amsterdam). The course is incorporated in the course program of the AMC Graduate School for Medical Sciences. Location: AMC.


      The subjects covered are:

      1. Anatomy (dissection) of adult male and female mice.
      2. Microscopic and pathological anatomy of rodent tissues and organs.
      3. Dealing with pathologically changed animals.
      4. Developmental anatomy; comparison of rodent and human anatomy.
      5. Imaging the mouse (MRI).
      6. Gene targeting, transgenic strategies, and generation of mouse models-1.
      7. Gene targeting, transgenic strategies, and generation of mouse models-2.
      8. Mouse breeding and querying the Jax phenotype database.
      9. Rodent behavior and experimental outcomes.

      Scheduled dates:

      November 22-26 2021

      Target audience:

      PhD candidates, postdocs and technicians are also welcome.


        The course is given in English.

        Study load:

        40 hours, which is comparable to 1.5 ECTS points.

        Number of participants:

        Maximum 28 per course.


        Free of charge.

        Course coordinators:


        Via the Tytgat Institute; Ms Francisca van Leeuwen-Hilbers / Tytgat Institute for Liver and Intestinal Research / / tel. +31 (0)20 - 566 2835.

        More information:

        Ms Francisca van Leeuwen-Hilbers:


        AMC Graduate School
        Tel: +31 (0)20 - 566 3108