- Nagasawa Maho, Germar Kristine, Blom Bianca, Spits Hergen Human CD5(+) Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34(+) Progenitor Cells Is Regulated by Id2 Frontiers in immunology 2017;8:1047 [PubMed]
- Karrich Julien J., Jachimowski Loes C. M., Libouban Marion, Iyer Anand, Brandwijk Kim, Taanman-Kueter Esther W., Nagasawa Maho, de Jong Esther C., Uittenbogaart Christel H., Blom Bianca MicroRNA-146a regulates survival and maturation of human plasmacytoid dendritic cells Blood 2013;122 (17):3001-3009 [PubMed]
- Karrich Julien J., Jachimowski Loes C. M., Nagasawa Maho, Kamp Angela, Balzarolo Melania, Wolkers Monika C., Uittenbogaart Christel H., van Ham S. Marieke, Blom Bianca IL-21-stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation Blood 2013;121 (16):3103-3111 [PubMed]
- Karrich Julien J., Balzarolo Melania, Schmidlin Heike, Libouban Marion, Nagasawa Maho, Gentek Rebecca, Kamihira Shimeru, Maeda Takahiro, Amsen Derk, Wolkers Monika C., Blom Bianca The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1 Blood 2012;119 (22):5191-5200 [PubMed]
- Karrich Julien J., Jachimowski Loes C. M., Uittenbogaart Christel H., Blom Bianca The plasmacytoid dendritic cell as the Swiss army knife of the immune system: molecular regulation of its multifaceted functions Journal of immunology (Baltimore, Md. 2014;193 (12):5772-5778 [PubMed]
Positions and Employment:
1993-1997: PhD student, Netherlands Cancer Institute, Amsterdam
1997-2000: Postdoctoral fellow, Schering at DNAX (owned by Schering Plough, now Merck), Palo Alto, CA USA
2000-2003: Senior Postdoc, Netherlands Cancer Institute, Amsterdam
2003-2006: Assistant Professor, Amsterdam Medical Center/University of Amsterdam, Amsterdam
2006-present: Associate Professor, Amsterdam Medical Center/University of Amsterdam, Amsterdam
2010-present: Principal Investigator, Amsterdam Medical Center/University of Amsterdam, Amsterdam
2015-present: Principal Educator, Amsterdam Medical Center/University of Amsterdam, Amsterdam
2016-present: Head of the HIS mouse facility, Amsterdam Medical Center/University of Amsterdam, Amsterdam
PhD B. Blom (Development and function of human lymphocytes)
Our immune system develops from hematopoietic stem cells, which through sequential steps commit into mature effector cells. These processes are tightly orchestrated by cytokines and transcription factors that enforce lineage decisions. Our main objective focusses on the development and function of the lymphoid compartment, including T, B, Natural Killer (NK), innate lymphoid cells (ILCs)and plasmacytoid dendritic cells (pDC) (Blom & Spits, Annu Rev Immunol. 2006). The cytokines that we consider of interest in this context include IL-7, TSLP, FLT3L, IL-15, and IL-21. The families of transcription factors that we, in close collaboration with Prof. dr. Hergen Spits, study include members of the (basic)-helix-loop-helix, Notch, GATA, and Ets families (Nagasawa et al. Front Immunol. 2017, Shikhagaie et al. Cell Rep. 2017, Karrich et al. J Immunol. 2014, Karrich et al. Blood 2013a, Karrich et al. Blood 2013b, Karrich et al. Blood 2012, Dontje et al. Blood 2006, Schmidlin et al. Blood 2006, Colantonio et al. Plos One 2011, Schotte et al. J Exp Med 2004).
Patients that suffer from hematological malignancies may be cured by an allogeneic hematopoietic stem cell transplantation resulting from the graft versus leukemia/lymphoma (GvL) effect. This therapeutic intervention, however, is frequently complicated by graft-versus-host-disease (GvHD) and opportunistic infections causing high morbidity and mortality. As ILCs, in particular the subgroup ILC3, have been forwarded as guardians of the mucosal barriers by the production of IL-22 that restores epithelial linings, we in close collaboration with dr. Mette Hazenberg aim to investigate the role of ILCs in patients that suffer from GvHD.
Theme: Infection and Immunity
Others
K.I.M. Brandwijk-Paarlberg
MD PhD M.D. Hazenberg (Innate and adaptive immunity following allogeneic hematopoietic stem cell transplantation)