D.M. de Bruin BSc MSc PhD

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BSc MSc PhD D.M. de Bruin

Positions
Research Associate, MD-PhD
Main activities
Research
Specialisation
optics, photonics, imaging, focal therapy, clinical translation
Focus of research

1) Digital pathology, funded by ITEA

2) quantitative analysis of data using i.e. a convolutional neural networks (CNN), funded by ITEA.

3) Imaging using contrast enhanced endoscopy, optical coherence tomography (OCT) and con-focal laser endomicroscopy (CLE) during interventions, funded by ZonMW and cure for cancer (CFC).

4) Functional (in vivo) optical imaging of malignant and benign disease, funded by ZonMW and cure for cancer (CFC).

5) Design and development of new minimally invasive optical devices for in vivo use, funded by STW.

6) Focal therapy of malignancies using transcutaneous laser ablation, funded by CFC and NWO-TTW.

7) Clinical Translation and intergration of novel technology.

Amsterdam UMC Research Institutes
AMC departments
Key publications
  • Cauberg Evelyne C. C., de Bruin Daniël M., Faber Dirk J., van Leeuwen Ton G., de La Rosette Jean J. M. C. H., de Reijke Theo M. A new generation of optical diagnostics for bladder cancer: technology, diagnostic accuracy, and future applications European urology 2009;56 (2):287-296 [PubMed]
  • Wijmans Lizzy, de Bruin Daniel M., Meijer Sybren L., Annema Jouke T. Real-Time Optical Biopsy of Lung Cancer American journal of respiratory and critical care medicine 2016;194 (8):e10-e11 [PubMed]
  • Bus M. T. J., de Bruin D. M., Faber D. J., Kamphuis G. M., Zondervan P. J., Laguna-Pes M. P., van Leeuwen T. G., de Reijke Th M., de la Rosette J. J. M. C. H. Optical Coherence Tomography as a Tool for In Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study of Diagnostic Accuracy Journal of urology 2016;196 (6):1749-1755 [PubMed]
  • Baard Joyce, de Bruin Daniel M., Zondervan Patricia J., Kamphuis Guido, de la Rosette Jean, Laguna M. Pilar Diagnostic dilemmas in patients with upper tract urothelial carcinoma Nature reviews. Urology 2017;14 (3):181-191 [PubMed]
  • de Bruin Daniel M., Broekgaarden Mans, van Gemert Martin J. C., Heger Michal, de la Rosette Jean J., van Leeuwen Ton G., Faber Dirk J. Assesment of apoptosis induced changes in scattering using optical coherence tomography Journal of biophotonics 2016;9 (9):913-923 [PubMed]
All Publications
Curriculum Vitae

I’m a group leader and staff member, performing translational technology research at both the department of Urology and the department of Biomedical Engineering & Physics of the AUMC respectively. My task is to guide PhD students and initiate new research that will ultimately result in minimal invasive optical technology that allows diagnosis and focal treatment of disease. 

I studied photonics and laser-optics at Technical College Ede. After graduation, he studied molecular biology (BSc) at the University of Applied Sciences Utrecht which was finished with a full year research internship at the Wellman Center for Photomedicine, Harvard Medical School. Subsequently, I received his Master degree (MSc) in medical biochemistry from the University of Amsterdam. While obtaining his Masters, Martijn finished his doctorate (PhD) at the department of biomedical engineering & physics (BMEP) at the Academic Medical Center (AMC).

My projects revolve around a) digital pathology using AI as computer aided diagnosis for pathologists and b) optical coherence tomography (OCT) and con-focal laser endomicroscopy (CLE) which are both novel light based imaging techniques that enables real-time minimal invasive optical biopsy. The ultimate goal of these novel modalities is to create, in combination with all available clinical patient data, a diagnostic support system for physicians to differentiate oncological disease and predict disease recurrence and progression. 

Additionally, our group develops novel needle based transcutaneous laser ablation technology (TCLA) as a novel interventional treatment for cancer. We put emphasis on the development of treatment dosimetry/planning in order to predict the ablated volume, which is paramount in oncological treatment. Combining knowledge of light-tissue interaction with thermodynamics of tissue and the development of novel steerable needles will lead to a predictable minimal invasive ablation of tumor.

Besides physical understanding and engineering the basic technologies involved, the department of Biomedical Engineering & Physics leaps the gap that exists between new optical clinical technologies and the everyday clinical reality. This resulted in successful collaborations between the department of BMEP and departments such as Urology, Cardiology, Surgery, Radiology and Radiotherapy within the AUMC. Moreover, other hospitals such as the Dutch Cancer Institute (NKI), the Free University medical center (VUmc), Delft University and international hospitals are involved in their projects as well.

Research programmes

Prof. MSc PhD A.G.J.M. van Leeuwen (Biomedical photonics for functional and molecular imaging)

BSc MSc PhD D.M. de Bruin (Optical diagnostics and minimal invasive focal treatment of urological disease)

Current PhD Candidates
Current research funding
  • Elesta S.r.L.
  • Personeelsproject - Industrie
  • Stichting Cure for Cancer