Amsterdam UMC Locatie AMC

PhD H.L. Tan

Position

Associate Professor

Main activities

Patient care, Research

Specialisation

Cardiology, Cardiogenetics

Focus of research

Clinical Research:

Projects:
- Pathophysiology of inherited and acquired cardiac arrhythmias, e.g., Brugada syndrome, Long QT syndrome, drug-induced arrhythmias
- Genetic basis and clinical determinants of inherited heart disease, in particular, primary arrhythmia syndromes, sudden cardiac death, and cardiomyopathies
- Electrophysiological and structural remodeling in right ventricular failure
- Genetic basis of congenital structural heart disease
Methods:
- Noninvasive cardiac electrophysiology: body surface mapping
- Invasive cardiac electrophysiology: electrophysiologic study, epicardial mapping during cardiac surgery
- Imaging: echocardiography

Basic Research:

Projects:
- Molecular basis of right ventricular failure
- Ion channel remodeling in congestive heart failure
- Biophysical characterization of variant ion channels in primary arrhythmia syndromes
- Development of a bio-engineered cardiac pacemaker
Methods:
- Patch-clamp studies of isolated myocytes and transfected cell cultures
- Electrical and optical activation mapping
- Viral transduction of cultured myocytes
- Imaging: echocardiography

Amsterdam UMC Research Institutes

ACS - Heart failure & arrhythmias

AMC departments

Cardiology

Key publications

Bardai Abdennasser, Amin Ahmad S., Blom Marieke T., Bezzina Connie R., Berdowski Jocelyn, Langendijk Pim N. J., Beekman Leander, Klemens Christine A., Souverein Patrick C., Koster Rudolph W., de Boer Anthonius, Tan Hanno L. Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: evidence from bench, bedside, and community European heart journal 2013;34 (20):1506-1516 [PubMed]
Hardziyenka Maxim, Campian Maria E., Verkerk Arie O., Surie Sulaiman, van Ginneken Antoni C. G., Hakim Sara, Linnenbank André C., de Bruin-Bon Rianne H. A. C. M., Beekman Leander, van der Plas Mart N., Remme Carol A., van Veen Toon A. B., Bresser Paul, de Bakker Jacques M. T., Tan Hanno L. Electrophysiologic Remodeling of the Left Ventricle in Pressure Overload-Induced Right Ventricular Failure Journal of the American College of Cardiology 2012;59 (24):2193-2202 [PubMed]
Bardai Abdennasser, Berdowski Jocelyn, van der Werf Christian, Blom Marieke T., Ceelen Manon, van Langen Irene M., Tijssen Jan G. P., Wilde Arthur A. M., Koster Rudolph W., Tan Hanno L. Incidence, Causes, and Outcomes of Out-of-Hospital Cardiac Arrest in Children A Comprehensive, Prospective, Population-Based Study in the Netherlands Journal of the American College of Cardiology 2011;57 (18):1822-1828 [PubMed]
Lamberts Robert J., Blom Marieke T., Wassenaar Merel, Bardai Abdennasser, Leijten Frans S., de Haan Gerrit-Jan, Sander Josemir W., Thijs Roland D., Tan Hanno L. Sudden cardiac arrest in people with epilepsy in the community: Circumstances and risk factors Neurology 2015;85 (3):212-218 [PubMed]
Hardziyenka Maxim, Campian Maria E., Reesink Herre J., Surie Sulaiman, Bouma Berto J., Groenink Maarten, Klemens Christine A., Beekman Leander, Remme Carol A., Bresser Paul, Tan Hanno L. Right ventricular failure following chronic pressure overload is associated with reduction in left ventricular mass: evidence for atrophic remodeling Journal of the American College of Cardiology 2011;57 (8):921-928 [PubMed]

All Publications

Research programmes

PhD H.L. Tan (Sudden cardiac death Applying lessons from monogenic inherited arrhythmia syndromes to develop new gene-oriented treatment strategies)

Applying lessons from monogenic inherited arrhythmia syndromes to develop new gene-oriented treatment strategies

1.Implementation of Biopacemaker Program, aimed at constructing bio-engineered cardiac pacemakers using gene therapy

2.Implementation of ARREST-11 Study, a prospective population-based study into clinical and genetic determinants of sudden cardiac death from noncardiac

Theme: Cardiovascular Diseases

This research group participates in the Heart Failure Research Center

Postdocs
PhD M.T. Blom
PhD G.J.J. Boink

PhD Students
D.A. van Hoeijen

Others
BSc S. Brands
BSc P.C.M. Homma
BSc M. Klerk

Current PhD Candidates