P.J. Nederkoorn MD PhD

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MD PhD P.J. Nederkoorn

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
Stroke
Focus of research

The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovascular disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.

The Cerebrovascular Research Group focuses on the acute diagnostic and treatment options in both hemorrhagic and ischemic stroke, including aneurysmal subarachnoid hemorrhage and cerebral venous sinus thrombosis. Solving burning clinical questions is the starting point of the group, but where needed fundamental research is used to understand pathophysiology and develop new treatment strategies – from bed to bench and vice versa. To do so, the group has a strong clinical research infrastructure which runs large cohort studies and (international) multicenter randomized controlled trials which focus on the surveillance, testing and implementation of both new pharmacological and medical devices treatment options in acute stroke. Translational studies are focusing on early diagnostics of stroke subtypes, penumbral salvage/neuroprotection and reperfusion injury. The group is working together with all other major cerebrovascular research groups within the MR Clean and CONTRAST collaborations and is embedded in the cerebrovascular program of Amsterdam Neuroscience Center and is part of the Amsterdam Cardiovascular Sciences group.

 

Amsterdam UMC Research Institutes
AMC departments
Key publications
  • Westendorp Willeke F., Vermeij Jan-Dirk, Zock Elles, Hooijenga Imke J., Kruyt Nyika D., Bosboom Hans J. L. W., Kwa Vincent I. H., Weisfelt Martijn, Remmers Michel J. M., ten Houten Robert, Schreuder A. H. C. M. Tobien, Vermeer Sarah E., van Dijk Ewout J., Dippel Diederik W. J., Dijkgraaf Marcel G. W., Spanjaard Lodewijk, Vermeulen Marinus, van der Poll Tom, Prins Jan M., Vermeij Frederique H., Roos Yvo B. W. E. M., Kleyweg Ruud P., Kerkhoff Henk, Brouwer Matthijs C., Zwinderman Aeilko H., van de Beek Diederik, Nederkoorn Paul J., Vermeij J.-D., Kerkhoff H., Bosboom J. L. W., Kwa V. I. H., Weisfelt M., Remmers M. J. M., van Dijk E. J., Vermeij F., Schreuder A., Vermeer S. E., ten Houten R., Dippel D. W. J., Kappelle L. J., van der Worp H. B., Merkies I. S. J., de Bruijn S. F. T. M., de Laat K. F., Haag Den, Jellema K., Keizer K., de Rijk M. C., Vermeij A. J., de Gans K. The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial Lancet 2015;385 (9977):1519-1526 [PubMed]
  • Bonati Leo H., Nederkoorn Paul J. Clinical Perspective of Carotid Plaque Imaging Neuroimaging clinics of North America 2016;26 (1):175-182 [PubMed]
  • Liem Madieke I., Schreuder Floris H. B. M., van Dijk Anouk C., de Rotte Alexandra A. J., Truijman Martine T. B., Daemen Mat J. A. P., van der Steen Anton F. W., Hendrikse Jeroen, Nederveen Aart J., van der Lugt Aad, Kooi M. Eline, Nederkoorn Paul J. Use of Antiplatelet Agents Is Associated With Intraplaque Hemorrhage on Carotid Magnetic Resonance Imaging: The Plaque at Risk Study Stroke; a journal of cerebral circulation 2015;46 (12):3411-3415 [PubMed]
  • Kloppenborg Raoul P., Geerlings Mirjam I., Visseren Frank L., Mali Willem P. T. M., Vermeulen M., van der Graaf Yolanda, Nederkoorn Paul J. Homocysteine and progression of generalized small-vessel disease The SMART-MR Study Neurology 2014;82 (9):777-783 [PubMed]
  • Zinkstok Sanne M., Engelter Stefan T., Gensicke Henrik, Lyrer Philippe A., Ringleb Peter A., Artto Ville, Putaala Jukka, Haapaniemi Elena, Tatlisumak Turgut, Chen Yaohua, Leys Didier, Sarikaya Hakan, Michel P., Odier Céline, Berrouschot Jörg, Arnold Marcel, Heldner Mirjam R., Zini Andrea, Fioravanti Valentina, Padjen Visnja, Beslac-Bumbasirevic Ljiljana, Pezzini Alessandro, Roos Yvo B., Nederkoorn Paul J. Safety of Thrombolysis in Stroke Mimics Results From a Multicenter Cohort Study Stroke; a journal of cerebral circulation 2013;44 (4):1080-U234 [PubMed]
All Publications
Curriculum Vitae

Curriculum Vitae
Paul J Nederkoorn, 3-2-1969, Neurologist, Clinical Epidemiologist
1997 Medicine, MD, Erasmus University of Rotterdam
2002 Doctorate (PhD), Utrecht University
2005 Master of Science Clinical Epidemiology (MSc), Utrecht University
2007 Board certification Neurology, AMC Amsterdam
 
Positions and Employment
- Staff member Department of Neurology, Academic Medical Center (AMC) Amsterdam
- Position as Principal Investigator at the AMC Amsterdam
- Principle Investigator ‘Preventive Antibiotics in Stroke Study (PASS)’
- Member Steering Committee and nationwide PI ‘Second European Carotid Surgery Trial (ECST-2)’
- Co-chair Thrombolysis in ischemic stroke patients (TriSP) collaboration
- Board member Dutch Neurovascular Society (Nederlandse Neurovasculaire Werkgroep)
- Board member Neurovascular Intervention Center Amsterdam (NICA)
- Fellow European Stroke Organisation (ESO)
- Member Medical Ethical Committee AMC

Other Experience and Professional Memberships
- Associate editor Stroke-group Cochrane Collaboration
- Member editorial board journal Neurovascular Imaging (NVI)
- Member Dutch guideline-committee ‘minor head injury’ (CBO)
- Chair committee quality measures Dutch association of Neurology
- Chair Clinical Audit Board CVA-benchmark Dutch Institute for Clinical Auditing (DICA) and Dutch Society for Neurology (NVN).

Honours and awards
- Dr. J. Meerwaldt Award, Dutch Society of Neurology: best thesis in neuroscience 2002
- Philips Award, Dutch Society of Radiology: best thesis in diagnostic imaging 2003

Research Support
Multicentre Randomized trial of Acute Stroke treatment in the Ambulance with a nitroglycerine Patch (MrASAP)
Netherlands Heart Foundation/ CardioVasculair Onderzoek Nederland (CVON): 1.4 million euro (co-PI). This RCT is part of Consortium for New Treatments of Acute Stroke (CONTRAST), awarded with 6 million euro

Dutch CVA Benchmark research project
DICA Dutch Institute for Clinical Auditing: 150.000 euro (PI)

Thombolysis and Uncontrolled Hypertension Study (Thruth)
Fonds NUTS-OHRA: 165.000 euro (co-PI)

Preventive antibiotics in stroke study (PASS)
Netherlands Organisation of Scientific Research (ZonMW): 500.000 euro (applicant and PI)
Netherlands Heart Foundation (NHS): 250.000 euro (applicant and PI)

‘Parelsnoer initiatief (PSI)’ stroke study
NFU (Dutch Federation of Universities): 280.000 (local PI, local grant AMC)

‘Plaque At RISK (PARISK)’ – study
CTMM project co-funded by NHF; 150.000 (local PI clinical cohort study)

 

Research programmes

MD PhD P.J. Nederkoorn (Stroke)

In general, as a stroke neurologist and clinical epidemiologist my expertise is to perform patient-oriented stroke research and we try to answer ‘clinical burning questions’ in pragmatic, clinical studies.

 

Carotid artery disease

Nation-wide leader, co-investigator of the Second European Carotid Surgery Trial (ECST-2). This is a novel RCT of this European consortium after the International Carotid Stenting Study (ICSS) was completed (Lancet 2010). Recently obtained funding for Dutch population in this RCT (ZonMW) 2017): Carotid endarterectomy or optimized medical therapy in patients with symptomatic carotid artery stenosis: a cost effectiveness analysis.

 

Acute stroke treatments

A Dutch landmark trial, MrCLEAN, was finished in 2015 of which I was co-investigator: ‘A randomized trial of intra-arterial treatment for acute ischemic stroke’ (NEJM 2015). This has led to formation of the ‘Dutch Consortium for new treatments in acute stroke (CONTRAST)’. In this consortium I am co-PI of the Multicentre Randomized trial of Acute Stroke treatment in the Ambulance with a nitroglycerine Patch (MrASAP) study which will start during 2017. Furthermore, I am also co-PI of the ongoing Thombolysis and Uncontrolled Hypertension (TRUTH) Study, a nationwide cohort study in IVT stroke patients.

 

Post-stroke infections

Co-PI of the ‘Preventive Antibiotics and Stroke Study (PASS)’, a large stroke RCT funded by the Netherlands Heart Foundation and ZonMW. Between 2010 and 2015, in 30 Dutch centres 2550 acute stroke patients were enrolled. Results were presented at the World Stroke Conference 2015 (Istanbul) and subsequently published (Lancet 2015).

 

Research into effect of benchmarking

The Dutch Institute for Clinical Auditing (DICA) facilitates clinical audits among which the CVA Benchmark (CVAB). In the CVAB (chair) stroke patients are included and indicators concerning acute stroke treatment are registered. By analysing this big data, quality of stroke care can be determined and changes can be implemented to improve stroke care.

Faculty
MD PhD J. Coutinho

Postdocs
MD PhD S.M. Zinkstok

Prof. PhD Y.B.W.E.M. Roos (Stroke)

Current PhD Candidates
Current research funding
  • Dutch Institute for Clinical Auditing
  • HRB Stroke Clinical Trials Network, UCD CRC
  • Nederlandse Hartstichting
  • UMC Maastricht
  • ZonMw