Prof. A. Kalsbeek PhD

All Publications

2001 - Recipient of a 1-year research grant from the Hersenstichting Nederland (DFL 48.000,=) on the “Hypothalamic control mechanisms for the activity anticipating peak of glucocorticoids in a day active species” (Principal Investigator)

 

2003 - A 2 month invited professorship at the Universite Louis Pasteur, Strasbourg, France

 

2003 - Recipient of a 1-year research grant from the Hersenstichting Nederland (EURO 24.000,=) on the “Hypothalamic control mechanisms for hormonal rhythms in a day-active rodent” (Principal Investigator)

 

2004 - Recipient of a 4-year research grant from the Dutch Diabetes Foundation (EURO 250.000,=) on the “Control of hepatic insulin resistance by the central nervous system. A study in human brain tissue and experimental animals” (Principal Investigator)

 

2005 - A 2 month invited professorship at the Universite Louis Pasteur, Strasbourg, France

 

2007 - Recipient of a 1-year research grant from the Hersenstichting Nederland (EURO 25.000,=) on the “Dopaminergic disfunction in schizophrenia and the development of hepatic insulin resistance”. (Principal Investigator)

 

2007 - Recipient of a research grant from the KNAW China exchange program (EURO 82.060,=) on the “Hippocampal-hypothalamic connections and the control of the autonomic balance. Challenges to the conventional thinking about mind and body”. (Principal Investigator)

 

2007 - A 2 month invited professorship at the Université Louis Pasteur, Strasbourg, France

 

2008 - Recipient of a TIPharma grant “Drug-Induced weight alterations” (EURO 600.000) (Co-investigator)

 

2008 - Recipient of a TOP research grant from ZON-MW (EURO 675.000) on the project “The Brain - Adipose Tissue axis”. (Principal Investigator)

 

2011 - Recipient of a STW “Perspective” program grant (EURO 6.375.000) on the project “On Time: how to fix a broken (biological) clock”. (co-applicant)

 

2012 - Recipient of a Metavention grant (EURO 110.000) entitled “The autonomic Nervous System and hepatic glucose metabolism” (Principal investigator)

 

2012 - Recipient of an Erasmus Mundus grant (EURO 720.000) entitled “NeuroTime”, total 6 PhD’s. (co-applicant)

 

2014 - Recipient of a NVWA grant “Light-Induced alterations in glucose metabolism” (EURO 330.000) (Principal investigator)

 

2015 - Recipient of a TOP research grant from ZON-MW (EURO 675.000) on the project “Circadian Rhythm of Muscle Mitochondrial Metabolism”. (Principal Investigator)

 

POSITIONS HELD

December 1984 ‑ November 1988

Ph.D Research Associate at the Netherlands Institute for Brain Research, Division of Neuroanatomy (Prefrontal Cortex & Development)

 

April 1989 -  March 1990

Research Associate at the Netherlands Institute for Brain Research, Division of Immunocytochemistry (Hypothalamus & Physiology)

 

April 1990 - August 1992

Research Associate at Université Louis Pasteur, Laboratoire de Zoologie, CNRS URA 1332 Neurobiologie des Fonctions Rythmiques et Saisonnieres

 

September 1992 - August 1996

Research Associate at the Netherlands Institute for Brain

Research, Division of Hypothalamic Integration Mechanisms

 

September 1996 – December 2004

Senior scientist at the Netherlands Institute for Brain Research, Division of Hypothalamic Integration Mechanisms

 

January 2005 – April 2008

Team leader of the Hypothalamic Integration Mechanisms workgroup at the Netherlands Institute for Neuroscience

 

April 2008 –

AMC Principal Investigator at the Department of Endocrinology and Metabolism at the Academic Medical Center of the University of Amsterdam (0.8 fte)

 

April 2008 –

Team leader of the Hypothalamic Integration Mechanisms workgroup at the Netherlands Institute for Neuroscience (0.2 fte)

 

March 2012 –

Professor of Experimental Neuroendocrinology at the Academic Medical Center (AMC).

 

 

TEACHING

Co-promotor of theses:

R.Teclemariam-Mesbah 1991 - 1996.  "Rhythmic Control of Autonomic Functions. Anatomical basis for conveying timing information to the pineal and adrenal glands in rodents" (Faculty of Life Sciences, University of Strasbourg), 10 May 1996

 

S. Barassin 1997 - 2000. “Circadian control of melatonin release” (Faculty of Life Sciences, University of Strasbourg; Netherlands Institute for Brain Research), 11 July 2000

 

I. Palm 1995 - 2001. "Circadian Control of the Hypothalamo-Pituitary-Gonadal Axis", (Netherlands Institute for Brain Research), 13 March 2001

 

S. la Fleur 1997 – 2001. “Circadian control of basal and stimulated insulin release involves SCN projections to the autonomic nervous system”, (Netherlands Institute for Brain Research), 14 June 2001

 

S. Perreau 1999 - 2004. “Hypothalamic GABA release from SCN terminals and its control of circadian rhythms through the autonomic nervous system” (Faculty of Life Sciences, University of Strasbourg; Netherlands Institute for Brain Research), 9 June 2004

 

M. Ruiter 2000 - 2005. “The biological clock and its control of glucose homeostasis. Central and peripheral mechanisms involving glucose counterregulation and insulin resistance”, (Netherlands Institute for Brain Research), 19 April 2005

 

C. Cailotto 2001 – 2006. “The suprachiasmatic nucleus organizes daily physiology. An analysis of the role of the autonomic nervous system and peripheral clock genes”, (Faculty of Life Sciences, University of Strasbourg; Netherlands Institute for Brain Research), 3 November 2006

 

L. Klieverik 2004 – 2008. “The contribution of the central nervous system to metabolic effects of hyperthyroidism in liver and white adipose tissue”, (Netherlands Institute for Brain Research & Academic Medical Centre), 17 September 2009

 

C.X. Yi 2005 – 2010. “Control of hepatic insulin resistance by the central nervous system. A study in human brain tissue and experimental animals”, (Netherlands Institute for Brain Research), 28 January 2010

 

J. Siljee 2007 – 2011. “MC4R mutations; cellular toxicity in neurons and whole body regulation”, (Academic Medical Centre), Stopped

 

J. Liu 2008-2013. “The role of estrogen in hypothalamic regulation of hypothalamus-pituitary-adrenal axis activity, energy homeostasis and bone metabolism”, (Academic Medical Center), 4 June 2013

 

E. Bruinstroop 2008-2013. “Neural control of hepatic lipid metabolism. A pathophysiological perspective”, (Academic medical Center), 12 September 2013

 

E. Girault 2008-2013. “The role of hypothalamic pathways in the metabolic side effects of Olanzapine”, (Netherlands Institute for Neuroscience & Academic Medical Center), 6 December 2013

 

J.K. van den Heuvel 2009-2014. “Neural pathways controlling homeostatic and hedonic feeding in rats on free-choice diets”, (Academic Medical Center), 30 September 2014

 

E.M. de Vries 2010-2014. “Thyroid hormone metabolism during inflammation and fasting”, (Academic Medical Center), 9 April 2015

 

Eliane Lucassen 2011 – 2015 “Circadian timekeeping: from basic clock functioning to clinical implications for health” (Leiden University Medical Center), 31 March 2016

 

Pawan Kumar Jha 2012–2016. “Sleep deprivation and its impact on circadian rhythms and glucose metabolism”, (Academic Medical Center & Université Louis Pasteur), 6 July 2016

 

Yan Su 2011-2015.  “Hypothalamic control of liver and white adipose tissue metabolism”, (Netherlands Institute for Neuroscience & Academic Medical Center), 8 November 2016

 

Zhi Zhang 2012-2016. “Hypothalamic regulation of metabolism: role of thyroid hormone and estrogen”, (Academic Medical Center), 19 January 2017

 

D. Herrera Moro 2011-2015. “Glycosphingolipids and the central regulation of metabolism: sugar analogues as research toles”, (Academic Medical Center), 28 February 2017

 

Dirk Jan Stenvers 2011-2015.  “Light, the circadian timing system, and type 2 diabetes”, (Academic Medical Center), 18 April 2017

 

C. Diepenbroek 2009-2013. “Glucose metabolism, diet composition, and the brain”, (Academic Medical Center), 28 April 2017

 

J.E. Oosterman 2011-2015.  “The rhythm of feeding. Effects of nutrients on metabolism and the molecular clock”, (Academic Medical Center), 23 November 2017

 

Merel Rijnsburger 2012-2016.  “Central regulation of glucose metabolism. Effects of nutrients, serotonin and dopamine”, (Academic Medical Center), 21 February 2018

 

Anneloes Opperhuizen 2012-2016. “Effect of feeding time and light on energy metabolism in rats”, (Academic Medical Center), 9 March 2018

 

Hannah Eggink 2012-2016. “Popping the soap bubble. Bile acids as postprandial signal”, (Academic Medical Center), 21 March 2018

 

Michele Colombo 2013-2018. “Insomnia disorder and endogenous neurophysiological dynamics”, (Netherlands Institute for Neuroscience), 10 April 2018

Aurea Susane Blancas Velazquez 2013-2018. “Palatable food, clock genes and the reward circuitry”, (Academic Medical Center & Université Louis Pasteur), 5 July 2018

 

Satish Sen 2013–2018. “Role of the nuclear receptor Rev-erbalpha in the central control of energy metabolism”, (Academic Medical Center & Université Louis Pasteur), 9 July 2018

 

Wisse van der Meijden (2012-2018). “Left in the Dark. Wavelength-dependent post-illumination effects on human physiology and behaviour”, (Netherlands Institute for Neuroscience & Université Louis Pasteur), 19 September 2018

 

Jacob Itzhacki (2014-2018). “Reward effects of Light”, (Netherlands Institute for Neuroscience & Université Louis Pasteur), 13 September 2018

 

Frederik Buijs 2011 – 2018. “Neuronal feedback to the SCN balances the day night physiology”, (Academic Medical Center (AMC), Amsterdam), 17 January 2019.

 

Evangelia Belegri 2013 – 2019. “Diet-induced hypothalamic inflammation, cellular stress and the acute phase response”, (Department of Endocrinology and Metabolism, Academic Medical Center (AMC), Amsterdam), 3 July 2019.

 

Paul de Goede 2015–2019. “Daily rhythms in muscle mitochondria: effects of time-restricted feeding and exercise”, (Department of Endocrinology and Metabolism, Academic Medical Center (AMC), Amsterdam), 4 October 2019.

 

Muzeyyen Ugur 2015-2019. “Opioids, palatable feeding and exercise”, (Academic Medical Center & Université Louis Pasteur), 8 October 2019

 

Fernando Cázarez Márquez 2014–2018. “Interactions of reproduction and energy metabolism: a round way trip via RF-amide peptides”, (Academic Medical Center & Université Louis Pasteur).

 

R. v/d Spek 2009-2013. “The Brain - Adipose Tissue axis: new connections to stay in control”, (Academic Medical Center).

 

Anayanci Masis Vargas 2015–2019. “Effects of acute and chronic light exposure on hedonic eating behaviour: molecular and neurobiological mechanisms”, (Academic Medical Center & Université Louis Pasteur).

 

Lamis Saad 2015-2019. “Role of cyclical DNA methylation in genes controlled by drugs of abuse and natural reinforcers: implications in behavior and metabolism”, (Academic Medical Center & Université Louis Pasteur).

 

Eleni Angelopoulou 2016-2020. “Kisspeptin and the rhythm of energy balance in reproduction”, (Academic Medical Center & Université Louis Pasteur).

 

Xiao-Lan Wang 2016-2020. “Cleanup at the right time: a common mechanism underlines the molecular clock of microglia and neuronal activity in metabolic and memory control”, (Academic Medical Center & Université Louis Pasteur).

 

 

Member of thesis committee :

N. Jacob “Integration of photoperiodic information by the suprachiasmatic nuclei. Role of melatonin and the intergeniculate leaflet” (Faculty of Life Sciences, University of Strasbourg), January 1999.

 

F. Gauer “Régulations physiologiques d’un message endocrine donneur de temps: la sécrétion de melatonine” (Habilitation; Faculty of Life Sciences, University of Strasbourg), December 2000.

 

B. Zandieh-Doulabi “Expression of thyroid hormone receptor isoforms in rodents” (Dept Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam), June 2003.

 

A. van den Hoek “Insulin sensitivity. Modulation by neuropeptides and hormones” (Dept Endocrinology and Metabolism, Leiden University Medical Centre), April 2006

 

G. Tiesjema “Understanding obesity by local overexpression of neuropeptides: a viral vector based approach” (Rudolf Magnus Instituut voor Neurowetenschappen, Afdeling Farmacologie en Anatomie), March 2007.

 

Anniek Koolman “The role of the endocannabinoid system in the regulation of energy balance” (University Medical Center Groningen, Department of Pediatrics), June 2010.

 

Joram Mul “Rat models in obesity research: functions for PMCH and LPIN1 in energy homeostasis regulation” (University Medical Center Utrecht, Hubrecht Institute), June 2010.

 

Edwin T. Parlevliet “Gut hormones – Novel tools in the treatment of insulin resistance” (Dept Endocrinology and Metabolism, Leiden University Medical Center), October 2010.

 

Esther M van der Zwaal “Olanzapine-induced weight gain. Lessons learned from developing rat models” (Rudolf Magnus Instituut voor Neurowetenschappen, Afdeling Farmacologie en Anatomie), June 2011.

 

Jorge Mendoza “Metabolic and reward feeding synchronizes the rhythmic brain” (Département  Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Intégratives, Universite Louis Pasteur, Strasbourg, France), September 2011.

 

Lu Xu “The non-preganglionic Edinger-Westphal nucleus: an integration center for energy balance and stress adaptation” (Dept Cellular Animal Physiology, Radbout University Nijmegen), December 2011.

 

Reina Paulien Barf “Metabolic consequences of sleep restriction in rats” (Department of Neuroendocrinology, Center for Behavior and Neurosciences, University of Groningen, Groningen), May 2012.

 

Claudia P Coomans “Insulin sensitivity – Modulation by the brain” (Department of Endocrinology and Metabolic Disorders, Leiden University Medical Center, Leiden), June 2012.

 

Anke J.F. Borgers “Hypothalamic functions in patients with pituitary insufficiency” (Department of Endocrinology and Metabolism, Academic Medical Center (AMC), Amsterdam), May 2012.

 

Cathalijn H Leenaars “Sleep deprivation in rats: effects on learning and flexibility” (Netherlands Institute for Neuroscience, Free University Amsterdam), June 2013.

 

Janine Geerling “Central nervous system control of triglyceride metabolism” (Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden), October 2013.

 

Dirk-Jan Saaltink “Doublecortin-like knockdown in the adult mouse brain. Implications for neurogenesis, neuroplasticity and behavior” (Leiden University Medical Center, Leiden), October 2014.

 

Sarah Burke “Gender identity, sex hormones & the developing brain” (Free University Amsterdam), June 2014.

 

Wieteke Beerling “Interpreting the consequences of acute sleep deprivation: Stress physiology as mediator” (Department of Neuroendocrinology, Center for Behavior and Neurosciences, University of Groningen, Groningen), September 2014

 

Karin Koopmans “Central serotonin and dopamine transporters in overeating, obesity and insulin resistance”, (Department of Endocrinology and Metabolism, Academic Medical Center (AMC), Amsterdam), November 2014

 

Leonie van Houten “The role of ovarian factors in the regulation of metabolism”, Department of Internal Medicine, Erasmus MC, Rotterdam), November 2014

 

Arjen Boender “Functional characterization of obesogenic neural circuitries” (University Medical Center Utrecht, Brain Center Rudolf Magnus), January 2015

 

Simon Sjors Evers “The a-typical effects of Olanzapine on body weight regulation and the possible counter effects of Topiramate”, (Department of Neuroendocrinology, Center for Behavior and Neurosciences, University of Groningen, Groningen), February 2015

 

Sander Kooijman “Neural control of lipid metabolism and inflammation; implications for atherosclerosis”, (Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden), November 2015.

 

Rajae Talbi “Seasonal regulation and role of neuropeptides Kisspeptin and RFRP-3 in energy homeostasis in the jerboa (Jaculus orientalis)”, (Laboratory of Neuroendocrinology and Nutritional and Climatic Environment, Faculty of Sciences, ATLAS-Fes, Morocco & Department of Neurobiology of Rhythms, Institut des Neurosciences Cellulaires et Integratives, CNRS-UPR 3212, University of Strasbourg, Strasbourg, France), September 2016.

 

Laura Kervezee “Mind the Time: 24-hour rhythms in drug exposure and effect”, (Leiden University Medical Center, Leiden Academic Center for Drug Research, Centre for Human Drug Research, Leiden), January 2017.

 

Shobhit Dhawan “Neural regulation of innate and adaptive immunity in the gut”, (Tytgat Institute, Academic Medical Center (AMC), Amsterdam), January 2017.

 

Ruth Versteeg “Brain, Nutrition and Metabolism. Studies in lean, obese and insulin resistant humans”, (Department of Endocrinology and Metabolism, Academic Medical Center (AMC), Amsterdam), April 2017.

 

Maria Joao Guimaraes da Lomba Ferraz “Glycospingolipidoses. Enzymes and their lipids”, (Department of Biochemistry, Academic Medical Center (AMC), Amsterdam), June 2017.

 

Jan Hansen “Mind your clocks, the role of the biological clock in human metabolic health”, (Department of Human Biology and Movement Science, Maastricht University), November 2017.

 

Anne van der Spek “The role of intacellular thyroid hormone metabolism in innate immune cells”, (Department of Endocrinology and Metabolism, Academic Medical Center (AMC), Amsterdam), June 2018.

 

Charlotte Heinen “Genetic causes and neonatal diagnosis of congenital isolated central hypothyroidism”, (Department of Endocrinology and Metabolism, Academic Medical Center (AMC), Amsterdam), October 2018.

 

Kathy de Git “Novel insights into concepts related to leptin, the hypothalamus and energy balance”, (University Medical Center Utrecht, Brain Center Rudolf Magnus), October 2018

 

Simone Marie Ota “Chronic social stress and the circadian system: effects on the central clock and peripheral oscillator”, (Chronobiology group, University of Groningen, Groningen), May 2019.

 

Anneleen Segers “Interplay between short-chain fatty acids and the circadian clock in the rhythmicity of contractility and hormone release in the gut”, (Department of Chronic Diseases, Metabolism and Ageing, Faculty of Medicine, KU Leuven, Leuven), December 2019.

 

Myrtille Gumbs “Brain circuitries in control of feeding behaviors: focus on Neuropeptide Y”, (Department of Endocrinology and Metabolism, Amsterdam UMC, Location AMC, Amsterdam), February 2020.

 

Maaike Schilperoort “It’s about time – circadian rhythm and metabolism”, (Dept. Medicine, Div. Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden), April 2020

 

Nemanja Milicevic “Circadian regulation of the retinal pigment epithelium – photoreceptor complex”, (Department of Clinical Genetics, Amsterdam UMC, location AMC), March 2020

 

Elja Louer “Shedding light on RPE physiology. The retinal pigment epithelium in health and disease”, (Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud UMC, Nijmegen), April 2020

 

Kasiphak Kaikaew “Sex differences in the control of adipose tissue functions”, (Department of Internal Medicine, Erasmus University Rotterdam), March/April 2020

 

 

Supervisor of student research :

‑ C. Binneveld (psychology student, University of Utrecht): The immunocytochemical study of the development of GABA con­tai­ning neurons in the rat prefrontal cortex, 1987‑1988.

 

‑ A.J. Voogel (medicine student, University of Amsterdam): Acute and sub‑acute effects of postnatal MPP application in rats, 1987‑­1988.

 

- R. Teclemariah (biology student, University of Paris): Examination of the efferent projections of the suprachiasmatic nucleus in the golden hamster using a combination of immunocy­tochemical and tracer techniques, 1990-1991.

 

- R. Cutrera (biology student, University of Buenos Aires): Functional significance of the serotonergic projection from the raphe nuclei to the suprachiasmatic nuclei in the golden hamster, 1991-1992.

 

- M. Hartwich (medicine student, University of Freiburg): Origin of the substance-P containing fibers in the suprachias­matic nuclei of the golden hamster and the laboratory rat, 1992.

 

- J. Van Der Vliet (Laboratory School, Utrecht): Infusion of SCN-transmitter, via microdialysis, in the SCN target areas, 1993-1994.

 

- E. Daalman (Laboratory School, Utrecht): Development of the transpineal microdialysis technique, 1994.

 

- P. Leunissen (Faculty of Biology, Free University, Amsterdam): The role of the paraventricular nucleus of the thalamus in integrating circadian input and controlling general activity, 1994.

 

- I. Dijkgraaf (Laboratory School, Utrecht): Rhytmic release of Vasopressin within the SCN as measured by microdialysis, 1995.

 

- M. Noordermeer (Laboratory School, Utrecht): Microinfusion of VIP in the MPOA of female rats and its effects on LH and corticosterone release, 1998.

 

- S. Mulder (Laboratory School, Utrecht): Microdialysis of GABA- and VP -(ant)agonists in the MPOA and its effects on body temperature and locomotor activity, 1998.

 

- A. Franke (Faculty of Biology, University of Utrecht): Importance of the vasopressinergic innervation of the PVN for the daily TSH rhythm, 1998.

 

- T. Van Vliet (Faculty of Biology, University of Amsterdam): SCN-lesions and its effects on hormonal parameters of cold-exposure, 1999.

 

- N. Van Druten (Faculty of Biology, University of Amsterdam): Daily changes in the prolactin releasing capacity of the SCN as revealed by timed Domperidone injections, 2000.

 

- V. Baartmans (Laboratory School, Utrecht): Day-Night difference in the hypoglycemia induced counterregulatory growth-hormone response, 2001.

 

- L. van Schaik (Laboratory School, Utrecht): Development of an animal model for the continuous release of corticosterone in the periphery or the central nervous system, 2003.

 

- J. van Ooij (Laboratory School, Leiden): Comparing the effects of PVN or ICV vasopressin administration on the release of corticosterone, 2003.

 

- M. Mulder (Laboratory School, Leiden): Development of corticosterone measurements by microdialysis in the CRY knock-out mice, 2003.

 

- I. Schalij (Laboratory School, Utrecht): PVN control of gluconeogenesis and peripheral glucose uptake in the rat, 2004.

 

- E. Foppen (Laboratory School, Utrecht): Hypothalamic control of the hormonal response induced by the administration of LPS, 2004.

 

- M.B. Bizino (Faculty of Medicine, University of Leiden): Neuronal tracing and immunohistochemical staining for the estrogen receptor α-subtype in rats. A first step in unraveling the mechanism of estrogen-induced modulation of fat distribution, 2005.

 

- L. Timmermans (Faculty of Biology, University of Wageningen): Circadian control of the hormonal response induced by the administration of LPS, 2005.

 

- R. van der Loo (Laboratory School, Leiden): Circadian control of feeding-induced insulin responses during a 4-meal-a-day schedule, 2005.

 

- N. Saderi (Department of Cytomorphology, Cagliari, Italy): Connectivity of VGF-containing hypothalamic neurons, 2007.

 

- R. Ellenbroek (LUMC, Leiden): β-cell mass: is vagal innervation a stimulatory factor? 2007.

 

- M. Harakalova (University of Kosice, Slovak Republic) NPY staining in post mortem human PVN and arcuate nucleus of type 2 diabetic patients. 2007.

 

- P. Enthoven (RUG, Groningen) Is the hypothalamic dopaminergic system involved in the control of hepatic glucose production? 2007.

 

- S. Janssen (RUU, Utrecht) T3 microdialysis in the hypothalamus: effects on feeding behaviour and endogenous glucose production. 2007

 

- T. Richter (UVA, Amsterdam) Glucose microdialysis in the hypothalamus: effects on feeding behaviour and endogenous glucose production. 2008

 

- H.M. Eggink (UVA, Amsterdam) Measuring gluconeogenesis and glycogenolysis in rats. 2008

 

- A. van Riel (UVA, Amsterdam) T3 microdialysis in the hypothalamus and glucose metabolism: effects of the autonomic input to the liver. 2008

 

- M. Schop (UVA, Amsterdam) Hypothalamic control of peripheral glucose homeostasis. 2008

 

- A. Brouwer (VU, Amsterdam) Dopaminergic control of hepatic glucose production. 2009

 

- D. de Jong (UVA, Amsterdam) Effects of centrally administered thyroid hormone on neuronal activity. 2009

 

- R. van der Doelen (Nijmegen) Effects of centrally administered thyrotropin releasing hormone (TRH) on hypothalamic c-fos expression and glucose metabolism. 2009

 

- A. Dobbs (UVA, Amsterdam) Effects of centrally administered neuropeptide Y (NPY) on hypothalamic c-fos expression and hepatic lipid metabolism. 2009

 

- H. Boswijk (Wageningen University) The effect of chronic Olanzapine administration on the insulin cascade. 2010

 

- Urszula Kedzierska (University of Warsaw, Poland) – Effects of food-deprivation and ICV NPY on hypothalamic NPY and c-fos immunoreactivity. 2010

 

- Floortje Haest (Laboratory School, Utrecht) – Effects of retro-dialyzed orexin in different hypothalamic nuclei on lipolysis as measured with stable isotopes. 2010

 

- Elisa Gritsch (Universität für Bodenkultur, Wien) Relation between circadian rhythms in white adipose tissue and obesity, 2011.

 

- Sander Bosker (Free University, Amsterdam) Hepatice triglyceride production in Zucker rats: effects of sympathetic denervation, 2011.

 

- Jitske Eliveld (University of Amsterdam, Amsterdam) Effects of ICV Kisspeptin on glucose metabolism, 2012.

 

- Aldijana Alijagic-Boers (University of Wageningen, Wageningen) Effects of PACAP and the autonomic nervous system on hepatic triglyceride secretion, 2012.

 

- Violeta Castela (Free University Amsterdam) Effects of PACAP and hepatic denervation on hepatic triglyceride secretion, 2013.

 

- Remi Jansen (Laboratory School, Utrecht) – Effects of nocturnal light on glucose tolerance, 2013

 

- Anna Lien Bouhuis (University of Amsterdam) – Direct effects of light manipulation on locomotor activity, energy metabolism and brains of rats, 2014

 

- Awiesha Razab Sekh (Laboratory School Utrecht) – The role of the biological clock in the circadian rhythmicity of hepatic secretion of triglycerides, 2014

 

- Rick van Dorp (University of Amsterdam) – Effects of nocturnal dimlight on daily rhythms in food intake, glucose tolerance and gene expression, 2015

 

- Laura Koekoek (University of Amsterdam) – The effects of fat and sugar given during the dark or light period on body weight, adiposity and clock genes, 2015

 

- Be Gerrevink (Laboratory School Utrecht) – Daily rhythms in lipid metabolism in the rat, 2015

 

- Janneke de Vries (University of Amsterdam) – Time restricted feeding results in circadian desynchronization, 2016

 

- Nikita Korpel (Laboratory School Leiden) – Light at night affects metabolism and activity in rats, 2017

 

- Maja Meskovic (Laboratory School Utrecht) – The role of thyroptropin-releasing hormone (TRH) in the hypothalamic paraventricular nucleus (PVN) in thermoregulation and cold, 2017

 

- Eva van Sambeek (Laboratory School Utrecht) – The effects of nocturnal blue light exposure on energy metabolism and c-fos expression in rats, 2018

 

- Nicole Plomp (Laboratory School Utrecht) – The effects of extension of nocturnal light exposure and fasting on glucose tolerance in rats, 2018

 

- Rick Hogenboom – Vasopressin expression in the suprachiasmatic nucleus of patients with Type 2 diabetes, 2018

 

- Anne Kappert – Effect of time-restricted feeding on sleep, metabolism, activity and heat production in Wistar rats, 2018.

 

- Lizette Hogenberg – The lateral habenula: how blue light influences our lives, 2018.

 

- Tom Hellings – Time restricted food consumption for four weeks as a model for shift work has long lasting effects on the behavior and molecular clock, 2019.

 

- Tom Coopmans – Long term after effects following circadian desynchronization affect gene expression and metabolism differently, 2019.

 

- Esther Bührman – Altered c-fos protein expression in melanopsin projection areas in mice exposed to light at night: new insights in the underlying mechanisms of disruptions in metabolism, 2019.

 

- Deena Gründeling – Light at night and hepatic glucose production, 2019.

 

 

 

INTERNATIONAL CONFERENCES ORGANIZED

 

1995    19th International Summer School of Brain Research “Hypothalamic Integration of Circadian Rhythms”, 28-31 August 1995, Amsterdam.

 

2005    24^th International Summer School of Brain Research “Hypothalamic Integration of Energy Metabolism”, 29 August – 1 October, Amsterdam.

 

2005    X. Congress of the European Pineal and Biological Rhythm Society, 1-5 September 2005, Frankfurt/Main, Germany (International Scientific Committee).

 

2009    Academy Colloquium “Nutrition, Metabolism and the Brain”, 11-14 May 2009, Amsterdam, The Netherlands (Main organizer).

 

2009    XI. Congress of the European Pineal and Biological Rhythm Society, 1-5 September 2009, Strasbourg, France (International Scientific Committee).

 

2011    3^rd Colloquim on “Nutrition, Metabolism and the Brain”, 26-28 April 2011, Groningen, The Netherlands (Co-organizer).

 

2013    4^th Colloquim on “Nutrition, Metabolism and the Brain”, 24-26 April 2013, Amsterdam, The Netherlands (Main organizer).

 

2014    ESE Basic Endocrinology Course on “Neuroendocrinology”, 15-17 January 2014, Amsterdam, The Netherlands (co-organizer).

 

2014    3^rd Annual NeuroTime Meeting, 4 – 6 February 2014, Amsterdam, The Netherlands (Main organizer).

 

2014    25^th Anniversary Symposium of the Netherlands Association for the Study of Obesity, 3-4 April 2014, Oosterbeek, The Netherlands (co-organizer).

 

2017    XV. Congress of the European Biological Rhythm Society (EBRS), 30 July - 3 August 2017, Amsterdam, The Netherlands

 

2019    5^th “Nutrition, Metabolism and Brain” Colloquim on “Muscle Clocks and Diabetes”, 12-14 May 2019, Amsterdam, The Netherlands (Main organizer).

 

 

MISCELLANEOUS

 

- Topic editor Circadian Rhythms and Metabolism for “Molecular Metabolism”

 

- Member of the Dutch Endocrinology Society (NVE)

 

- Member of the International Brain Research Organization (IBRO)

 

- Member of the Society for Research on Biological Rhythms (SRBR)

 

- Treasurer of the European Biological Rhythm Society (EBRS)

 

- Member of the European Neuroendocrine Society (ENEA)

 

- Member of the Society for Neuroscience (SFN)

 

- Treasurer of the Netherlands Association for the Study of Obesity (NASO)

 

 

 

PUBLICATIONS                                                              H-factor = 62 (since February 2020)

 

(a) Key publications

BUIJS, R.M. and A. KALSBEEK – Hypothalamic integration of central and peripheral clocks. Nature Neurosci Rev 2(2001)521-526. IF = 25.9

 

STENVERS DJ, SCHEER FAJL, SCHRAUWEN P, LA FLEUR SE & KALSBEEK A – Circadian clocks and insulin resistance. Nat Rev Endocrinol 15(2019)75-89. IF = 24.6

 

MARTÍNEZ DE MORENTIN PB, LAGE R, FERNÁNDEZ-MALLO D, RUÍZ-PINO F, LIU J, GONZÁLEZ-GARCÍA I, MORGAN DA, PINILLA L, GALLEGO R, SAHA AK, KALSBEEK A, FLIERS E, DIÉGUEZ C, BISSCHOP PH, NOGUEIRAS R, RAHMOUNI K, TENA-SEMPERE M & LÓPEZ M. - Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab 20(2014)41-53. IF = 16.7

 

KREIER,F. E.FLIERS, P.J. VOSHOL, C.G. VAN EDEN, L.M. HAVEKES, A. KALSBEEK, C. VAN HEIJNINGEN, A.A. SLUITER, T.C. METTENLEITER, J.A. ROMIJN, H.P.SAUERWEIN and R.M. BUIJS - Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. J Clin Invest 110(2002)1243-1250. IF = 16.6

 

Klieverik L.P., S. Janssen, E. Foppen, P.H. Bisschop, M. Serlie, A. Boelen, m.t. Ackermans, h.p. Sauerwein, E. Fliers & a. Kalsbeek – Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. PNAS 106(2009)5966-5971. IF = 9.4

 

 

(b) Papers >100 citations

1. VOORN, P., A. KALSBEEK, B. JORRITSMA‑BYHAM, R.M. BUIJS and H.J. GROE­NEWEGEN ‑ The pre‑ and postnatal development of the dopaminer­gic innervation in the striatum of the rat. Neuroscience, 25(1­98­8)857‑887

400

 

2. KALSBEEK, A., P. VOORN, R.M. BUIJS and H.B.M. UYLINGS ‑ Development of the dopaminergic innervation in the prefrontal cortex of the rat. J. Comp. Neurol., 269(1988)58‑72.

354

 

3. BUIJS, R.M. and A. KALSBEEK - The day-night balance of everyday life: Central and peripheral clocks interacting in the hypothalamus. Nature Neurosci. Rev. 2(2001)521-526.

353

 

4. BUIJS, R.M., J. WORTEL, J.J. VAN HEERIKHUIZE, M.G.P. FEENSTRA, G.J. TER HORST, H.J. ROMIJN and A. KALSBEEK - Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway. Eur. J. Neurosci. 11(1999)1535-1544.

303

 

5. KREIER,F., E.FLIERS, P.J. VOSHOL, C.G. VAN EDEN, L.M. HAVEKES, A. KALSBEEK, C. VAN HEIJNINGEN, A.A. SLUITER, T.C. METTENLEITER, J.A. ROMIJN, H.P.SAUERWEIN and R.M. BUIJS - Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. J. Clin. Invest. 110(2002)1243-1250.

276

 

6. Kalsbeek, A., I.F. Palm, S.E. La Fleur, F.A.J.L. Scheer, S. Perreau-Lenz, M. Ruiter, F. Kreier, C. Cailotto and  R.M. BUIJS – SCN outputs and the hypothalamic balance of life. J Biol Rhythms 21(2006)458-469.

236

 

7. BUIJS, R.M., C.G. VAN EDEN, V.D. GONCHARUK, and A. KALSBEEK – The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system. J. Endocrinol. 177(2003)17-26.

229

 

8. BUIJS, R.M., S.E.LA FLEUR, C. VAN HEIJNINGEN, J. WORTEL, L. ZUIDDAM, T.C. METTENLEITER, K. NAGAI, A. KALSBEEK and A. NIIJIMA - The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons. J. Comp. Neurol. 464(2003)36-48.

223

 

9. La FLEUR, S.E., A. KALSBEEK, J. WORTEL, M. FEKKES and R.M. BUIJS - A daily rhythm in glucose tolerance. A role for the suprachiasmatic nucleus. Diabetes 50(2001)1237-1243.

200

 

10. KALSBEEK, A., VAN HEERIKHUIZE,J.J., VAN DER WOUDE,T.P., WORTEL,J. and R.M.BUIJS - A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V₁-antagonist. J. Neuroscience 16(1996) 5555-5565.

198

 

11. KALSBEEK,A., E. FLIERS, J.A. ROMIJN, S.E. LA FLEUR, J. WORTEL, E. ENDERT and R.M. BUIJS - The suprachiasmatic nucleus directly generates the diurnal changes in plasma leptin levels. Endocrinology 142(2001)2677-2685.

183

 

12. MARTÍNEZ DE MORENTIN PB, LAGE R, FERNÁNDEZ-MALLO D, RUÍZ-PINO F, LIU J, GONZÁLEZ-GARCÍA I, MORGAN DA, PINILLA L, GALLEGO R, SAHA AK, KALSBEEK A, FLIERS E, DIÉGUEZ C, BISSCHOP PH, NOGUEIRAS R, RAHMOUNI K, TENA-SEMPERE M & LÓPEZ M. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab 20(2014)41-53.

177

 

13. KALSBEEK, A., VAN DER SPEK, R., LEI, J., ENDERT, E., BUIJS, R.M., FLIERS, E. – Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis. Mol Cell Endocrinol 349(2012)20-29.

175

 

15. KALSBEEK, A., TECLEMARIAM-MESBAH, R. and PÉVET, P. - Efferent projections of the suprachiasmatic nuclei in the golden ham­ster (Mesocricetus auratus). J. Comp. Neurol., 332(1993)293-314.

168

 

15. KALSBEEK, A. and R.M. BUIJS - Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting. Cell Tissue Res. 309(2002)109-118.

165

 

16. KALSBEEK, A., BUIJS, R.M., VAN HEERIKHUIZE,J.J.,ARTS,M. and VAN DER WOUDE T.P. - Vasopressin containing neurons of the suprachiasmatic nuclei inhibit corticosterone release.  Brain Res., 580(1992)62-67

165

 

17. FLEUR, la S.E., A. KALSBEEK, J. WORTEL and R.M. BUIJS - A suprachiasmatic nucleus generated rhythm in basal glucose concentrations. J. Neuroendocrinol. 11(1999)643-652.

157

 

18. KALSBEEK, A., S.E. LA FLEUR, C. VAN HEIJNINGEN and R.M. BUIJS – Suprachiasmatic GABAergic inputs to the PVN control plasma glucose concentrations in the rat via sympathetic innervation of the liver. J Neurosci 24(2004)7604-7613.

138

 

19. PERREAU, S., A. KALSBEEK, M.L. GARIDOU, J. WORTEL, J. VAN DER VLIET, C. VAN HEIJNINGEN, V. SIMONNEAUX, P. PEVET and R.M. BUIJS - Suprachiasmatic control of melatonin synthesis in the rat: inhibitory and stimulatory clock outputs. Eur. J. Neurosci. 17(2003)221-228.

121

 

20. KREIER, F., KAP, Y.S., METTENLEITER, T.C., VAN HEIJNINGEN, C., VAN DER VLIET, J.,KALSBEEK, A., SAUERWEIN, H.P., FLIERS, E., ROMIJN, J.A. and R.M. BUIJS – Tracing from fat tissue, liver and pancreas: A neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology 147(2006)1140-1147.

119

 

21. BUIJS, R.M.,KALSBEEK,A.,VAN DER WOUDE,T.P. and VAN HEERIKHUI­ZE,J. - Suprachiasmatic nucleus lesion increases corticostero­ne secretion. Am. J. Physiol., 264(1993)R1186-R1192.

114

 

22. CAILOTTO, C., S.E. La FLEUR, C. VAN HEIJNINGEN, A. KALSBEEK, M. FEENSTRA, P. PEVET and R.M. BUIJS – The suprachiasmatic nucleus controls the daily variation of plasma glucose via its autonomic output to the liver: Are the clock genes involved? Eur J Neurosci 22(2005)2531-2540.

114

 

23. KALSBEEK, A.,M.L. GARIDOU, I.F. PALM, J. VAN DER VLIET, V. SIMONNEAUX, P. PEVET and R.M. BUIJS - Melatonin sees the light: Blocking GABA-ergic transmission in the paraventricular nucleus induces daytime secretion of melatonin. Eur. J. Neurosci. 12(2000)3146-3154.

113

 

24. KALSBEEK, A. VAN DER VLIET, J. and BUIJS, R.M. - Decrease of endogenous vasopressin release necessary for expression of the circadian rise in plasma corticosterone: A reverse microdialysis study. J. Neuroendocrinol. 8(1996)299-307.

107

 

26. WU, Y.H., FISCHER, D.F., KALSBEEK, A., GARIDOU-BOOF, M.L., VAN DER VLIET, J., VAN HEIJNINGEN, C., LIU, R.Y., ZHOU, J.N. and D.F.SWAAB – Pineal molecular clock oscillation is disturbed in Alzheimer disease, due to functional disconnectivity with the “master clock”. Faseb J 20(2006)1874-1876.

106

 

25. PALM, I.F., E.M. VAN DER BEEK, V.M. WIEGANT, R.M. BUIJS AND A. KALSBEEK - Vasopressin induces an LH surge in ovariectomized, estradiol-treated rats with lesions of the suprachiasmatic nucleus. Neuroscience 93(1999)659-666.

105

 

26. KALSBEEK A, LA FLEUR SE and FLIERS E. Circadian control of glucose metabolism. Mol Metab 3(2014)372-383.

102

 

27. BUIJS, R.M., F.A. SCHEER, F. KREIER, C. YI, N. BOS, V. GONCHARUK and A. KALSBEEK       - Organization of circadian functions: interaction with the body. In: A. Kalsbeek, E. Fliers, M.A. Hofman, D.F. Swaab, E.J.W. Van Someren and R.M. Buijs (Eds): Hypothalamic Integration of Energy Metabolism, Progress in Brain Research, Vol. 153, Amsterdam, Elsevier, pp. 345-363, 2006

101

 

 

(c) Full papers

1. KALSBEEK, A., R.M.BUIJS, M.A.HOFMAN, M.A.H.MATTHIJSSEN, C.W. POOL and H.B.M.UYLINGS ‑ Effects of neonatal thermal lesioning of the mesocortical dopaminergic projection on the development of the rat prefrontal cortex. Devel. Brain Res., 32(1987)123‑132.

 

2. KALSBEEK, A., P.VOORN, R.M.BUIJS and H.B.M.UYLINGS ‑ Development of the dopaminergic innervation in the prefrontal cortex of the rat. J. Comp. Neurol., 269(1988)58‑72.

 

3. KALSBEEK, A., J.P.C.DE BRUIN, M.G.P.FEENSTRA and H.B.M.UYLINGS ‑ Neonatal thermal lesions of the mesolimbocortical dopaminergic projection decrease food‑hoarding behavior. Brain Res., 475(19­88)80‑90.

 

4. VOORN, P., A.KALSBEEK, B.JORRITSMA‑BYHAM, R.M.BUIJS and H.J.GROE­NEWEGEN ‑ The pre‑ and postnatal development of the dopaminer­gic innervation in the striatum of the rat. Neuroscience, 25(1­98­8)857‑887

 

5. KALSBEEK, A., J.P.C.DE BRUIN, M.A.H.MATTHIJSSEN and H.B.M.UYLINGS ‑ Ontogeny of open field activity in rats after neonatal lesio­ning of the mesocortical dopaminergic projection, Be­hav. Brain Res., 32(1989)115-127.

 

6. KALSBEEK, A., M.G.P.FEENSTRA, H.VAN GALEN and H.B.M.UYLINGS ‑ Monoamine and metabolite levels in the prefrontal cortex and the mesolimbic forebrain following neonatal lesions of the ventral tegmental area. Brain Res., 479(1989)339‑343.

 

7. KALSBEEK, A., M.A.H.MATTHIJSSEN and H.B.M.UYLINGS - Morphometric analysis of prefrontal cortical development following neonatal lesioning of the dopaminergic mesocortical projection. Exp. Br­ain Res., 78(1989)279-289.

 

8. STAM, C.J., J.P.C. DE BRUIN, A.M. VAN HAELST, J.J. VAN DEN GUGTEN and A.KALSBEEK ‑ The influence of the mesocortical dopaminer­gic system on activity, food hoarding, aggression and spatial delayed alternation in male rats. Behav. Neurosci., 103(­1989)24-35.

 

9. MATTHIJSSEN, M.A.H., A.KALSBEEK and F.H. DE JONGE - Sparing of male and female sexual behaviour after neonatal depletion of the dopaminergic mesocortical projection. Neurosci. Res. Comm., 6(199­0)95-103.

 

10. FEENSTRA, M.G.P., VOOGEL, A.J., KALSBEEK, A and ROLLEMA, H. - Insensitivity of early postnatal rat brain dopaminergic sys­tems to 1-methyl-4-phenylpyridinium ion (MPP⁺). Biog. Amin­es, 7(1990)425-434.

 

11. KALSBEEK, A., BUIJS, R.M., VAN HEERIKHUIZE, J.J., ARTS, M. and VAN DER WOUDE T.P. - Vasopressin containing neurons of the suprachiasmatic nuclei inhibit corticosterone release.  Brain Res., 580(1992)62-67

 

12. LAKHDAR-GHAZAL, N., KALSBEEK, A. and PÉVET, P. - Sexual dimorphism and seasonal variation in vasoactive intestinal peptide immu­noreactivity in the suprachiasmatic nucleus of Jerboa (Jaculus orientalis). Neurosci. Lett., 144(1992)29-33

 

13. FEENSTRA, M.G.P., KALSBEEK, A. and VAN GALEN, H. - Neonatal lesi­ons of the ventral tegmental area affect monoaminergic respon­ses to stress in the medial prefrontal cortex and other dopa­mine projection areas in adulthood. Brain Res., 596(1992)169-182

 

14. CUTRERA, R., KALSBEEK, A. and PÉVET, P. - No Triazolam induced c-fos expression in the raphe nuclei of the golden hamster. Brain Res., 602(1993)14-20.

 

15. KALSBEEK, A., TECLEMARIAM-MESBAH, R. and PÉVET, P. - Efferent projections of the suprachiasmatic nuclei in the golden ham­ster (Mesocricetus auratus). J. Comp. Neurol., 332(1993)293-314.

 

16. BUIJS, R.M.,KALSBEEK,A.,VAN DER WOUDE,T.P. and VAN HEERIKHUI­ZE,J. - Suprachiasmatic nucleus lesion increases corticostero­ne secretion. Am. J. Physiol., 264(1993)R1186-R1192.

 

17. KALSBEEK, A., RIKKERS, M., VIVIEN-ROELS, B. and PÉVET, P. - Vasopressin and Vasoactive Intestinal Peptide infused in the paraventricular nucleus of the hypothalamus elevate plasma melatonin levels. J. Pineal Res., 15(1993)46-52.

 

18. HERMES, M.L.H.J., KALSBEEK, A., BUIJS, R.M., KIRSCH, R. and PÉVET,P. - Induction of arousal in hibernating European hamsters (Cricetus cricetus) by vasopressin infusion in the lateral septum. Brain Res., 631(1993)313-316.

 

19. CUTRERA, R.A., KALSBEEK, A. and PÉVET, P. - Specific destruction of the serotonergic innervation in the suprachiasmatic nuclei prevents Triazolam induced phase advances of hamster activity rhythms. Behav. Brain Res. 62(1994)21-28.

 

20. MASSON-PÉVET, M., GEORGE, D., KALSBEEK, A., SABOUREAU, M., LAKHDAR-GHAZAL, N. and PÉVET, P. - An attempt to correlate brain areas containing melatonin-binding sites with rhythmic functions: A study in five hibernators species. Cell Tiss. Res. 278(1994)97-106.

 

21. HARTWICH, M., KALSBEEK, A., PEVÉT, P. and NÜRNBERGER, F. - Effects of illumination and enucleation on Substance P-immunoreactive structures in subcortical visual centers of the Golden Hamster and the Wistar rat. Cell Tiss. Res. 277(1994)351-361.

 

22. KALSBEEK, A., BUIJS, R.M., ENGELMANN, M., WOTJAK, C.T. and LANDGRAF, R. - In vivo measurement of a diurnal variation in vasopressin release in the rat suprachiasmatic nucleus. Brain Res. 682(1995)75-82.

 

23. KALSBEEK, A., DRIJFHOUT, W.J., WESTERINK, B.H.C., VAN HEERIKHUIZE, J.J., VAN DER WOUDE, T.P., VAN DER VLIET, J. and BUIS, R.M. - GABA receptors in the region of the dorsomedial hypothalamus of rats are implicated in the control of melatonin and corticosterone release. Neuroendocrinology 63(1996)69-78.

 

24. KALSBEEK, A. VAN DER VLIET, J. and BUIJS, R.M. - Decrease of endogenous vasopressin release necessary for expression of the circadian rise in plasma corticosterone: A reverse microdialysis study. J. Neuroendocrinol. 8(1996)299-307.

 

25. KALSBEEK, A., VAN HEERIKHUIZE,J.J., VAN DER WOUDE,T.P., WORTEL,J. and R.M.BUIJS - A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V₁-antagonist. J. Neuroscience 16(1996) 5555-5565.

 

26. TECLEMARIAM-MESBAH,R., KALSBEEK,A., PEVET,P. and BUIJS,R.M. - Direct vasoactive intestinal polypeptide-containing projection from the suprachiasmatic nucleus to spinal cord projecting hypothalamic paraventricular neurons. Brain Res. 748(1997)71-76.

 

27. TECLEMARIAM-MESBAH, R., KALSBEEK, A., BUIJS, R.M. and PEVET, P. - Oxytocin innervation of spinal preganglionic neurons projecting to the superior cervical ganglion in the rat. Cell Tiss. Res. 287(1997)481-486.

 

28. BUIJS, R.M., J. WORTEL, J.J. VAN HEERIKHUIZE and A. KALSBEEK - Novel environment induced inhibition of corticosterone secretion: physiological evidence for a suprachiasmatic nucleus mediated neuronal hypothalamo-adrenal cortex pathway. Brain Res. 758(1997)229-236.

 

29. KALSBEEK, A. and J.H. STRUBBE - Circadian control of insulin secretion and glucose homeostasis is independent of the temporal distribution of feeding. Physiol. Behav. 63(1998)553-560.

 

30. KALSBEEK, A., VAN HEERIKHUIZE, J.J., WORTEL, J. and R.M. BUIJS - Restricted daytime feeding modifies suprachiasmatic nucleus vasopressin release in rats. J. Biol. Rhythms 13(1998)18-29.

 

31. BUIJS, R.M., J. WORTEL, J.J. VAN HEERIKHUIZE, M.G.P. FEENSTRA, G.J. TER HORST, H.J. ROMIJN and A. KALSBEEK - Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway. Eur. J. Neurosci. 11(1999)1535-1544.

 

32. KALSBEEK, A., R.A. CUTRERA, J.J. VAN HEERIKHUIZE, J. VAN DER VLIET and R.M. BUIJS - GABA release from SCN terminals is necessary for the light-induced inhibition of nocturnal melatonin release in the rat. Neuroscience 91(1999)453-461.

 

33. PALM, I.F., E.M. VAN DER BEEK, V.M. WIEGANT, R.M. BUIJS AND A. KALSBEEK - Vasopressin induces an LH surge in ovariectomized, estradiol-treated rats with lesions of the suprachiasmatic nucleus. Neuroscience 93(1999)659-666.

 

34. BARASSIN, S., M. SABOUREAU, A. KALSBEEK, B. BOTHOREL, B. VIVIEN-ROELS, A. MALAN, R.M. BUIJS, B. GUARDIOLA-LEMAITRE and P. PEVET - Interindividual differences in the pattern of melatonin secretion of the Wistar rat. J. Pineal Res. 27(1999)193-201.

 

35. FLEUR, la S.E., A. KALSBEEK, J. WORTEL and R.M. BUIJS - A suprachiasmatic nucleus generated rhythm in basal glucose concentrations. J. Neuroendocrinol. 11(1999)643-652.

 

36. BARASSIN, S., A. KALSBEEK, M. SABOUREAU, B. BOTHOREL, B. VIVIEN-ROELS, A. MALAN, R.M. BUIJS and P. PEVET - Potentiation effect of vasopressin on melatonin secretion as determined by transpineal microdialysis in the rat. J. Neuroendocrinol. 12(2000)61-68.

 

37. KALSBEEK, A., S. BARASSIN, J.J. VAN HEERIKHUIZE, J. VAN DER VLIET & R.M. BUIJS - Restricted daytime feeding attenuates reentrainment of the circadian melatonin rhythm after an 8-h phase advance of the light-dark cycle. J. Biol. Rhythms 15(2000)57-66.

 

38. KALSBEEK, A.,M.L. GARIDOU, I.F. PALM, J. VAN DER VLIET, V. SIMONNEAUX, P. PEVET and R.M. BUIJS - Melatonin sees the light: Blocking GABA-ergic transmission in the paraventricular nucleus induces daytime secretion of melatonin. Eur. J. Neurosci. 12(2000)3146-3154.

 

39. KALSBEEK, A., E. FLIERS, A.N. FRANKE and R.M. BUIJS - Functional connections between the suprachiasmatic nucleus and the thyroid gland as revealed by lesioning and viral tracing techniques in the rat. Endocrinology 141(2000)3832-3841.

 

40. FLEUR, la S.E., A. KALSBEEK, J. WORTEL and R.M. BUIJS - Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver. Brain Res. 871(2000)50-56.

 

41. PALM, I.F., E.M. VAN DER BEEK, V.M. WIEGANT, R.M. BUIJS and A. KALSBEEK - The stimulatory effect of vasopressin on the luteinizing hormone surge in ovariectomized, estradiol-treated rats is time dependent. Brain Res. 901(2001)109-116.

 

42. PALM, I.F., E.M. VAN DER BEEK, J.J.M. SWARTS, J. VAN DER VLIET, V.M. WIEGANT, R.M. BUIJS and A. KALSBEEK - Control of the estradiol-induced prolactin surge by the suprachiasmatic nucleus. Endocrinology 142(2001)2296-2302.

 

43. KALSBEEK, A., E. FLIERS, J.A. ROMIJN, S.E. LA FLEUR, J. WORTEL, E. ENDERT and R.M. BUIJS - The suprachiasmatic nucleus directly generates the diurnal changes in plasma leptin levels. Endocrinology 142(2001)2677-2685.

 

44. La FLEUR, S.E., A. KALSBEEK, J. WORTEL, M. FEKKES and R.M. BUIJS - A daily rhythm in glucose tolerance. A role for the suprachiasmatic nucleus. Diabetes 50(2001)1237-1243.

 

45. BUIJS, R.M. and A. KALSBEEK – Hypothalamic integration of central and peripheral clocks. Nature Neuroscience Reviews 2(2001)521-526.

 

46. La FLEUR, S.E., A. KALSBEEK, J. WORTEL, J. VAN DER VLIET and R.M. BUIJS - Role for the pineal and melatonin in glucose homeostasis: pinealectomy increases night time glucose concentrations. J. Neuroendocrinol. 13(2001)1025-1032.

 

47. KALSBEEK, A. and R.M. BUIJS - Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting. Cell Tissue Res. 309(2002)109-118.

 

48. KREIER,F. E.FLIERS, P.J. VOSHOL, C.G. VAN EDEN, L.M. HAVEKES, A. KALSBEEK, C. VAN HEIJNINGEN, A.A. SLUITER, T.C. METTENLEITER, J.A. ROMIJN, H.P.SAUERWEIN and R.M. BUIJS - Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. J. Clin. Invest. 110(2002)1243-1250.

 

49. FLIERS, E., J.A. ROMIJN, H.P. SAUERWEIN, A. KALSBEEK and R.M. BUIJS - Vet als geïnnerveerde klier. Ned. T. v. Gen. 146(2002)1976-1979.

 

50. PERREAU, S., A. KALSBEEK, M.L. GARIDOU, J. WORTEL, J. VAN DER VLIET, C. VAN HEIJNINGEN, V. SIMONNEAUX, P. PEVET and R.M. BUIJS - Suprachiasmatic control of melatonin synthesis in the rat: inhibitory and stimulatory clock outputs. Eur. J. Neurosci. 17(2003)221-228.

 

51. BUIJS, R.M., C.G. VAN EDEN, V.D. GONCHARUK, and A. KALSBEEK – The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system. J. Endocrinol. 177(2003)17-26.

 

52. SCHEER, F.A.J.L, A. KALSBEEK and R.M. BUIJS – Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat. Biol. Chem. 384(2003)697-709.

 

53. BUIJS, R.M., S.E.LA FLEUR, C. VAN HEIJNINGEN, J. WORTEL, L. ZUIDDAM, T.C. METTENLEITER, K. NAGAI, A. KALSBEEK and A. NIIJIMA - The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons. J. Comp. Neurol. 464(2003)36-48.

 

54. RUITER, M., S.E. LA FLEUR, C. VAN HEIJNINGEN, A. KALSBEEK and R.M. BUIJS - The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behaviour. Diabetes 52(2003)1709-1715.

 

55. Fliers, E., F.Kreier, P.J. Voshol, L.M. Havekes, H.P. Sauerwein, A. Kalsbeek, R.M. Buijs, J.A. Romijn. White adipose tissue: getting nervous. J. Neuroendocrinol. 15(2003)1005-1010.

 

56. KREIER, F., A. YILMAZ, A. KALSBEEK, E. FLIERS, J.A. ROMIJN, H. SAUERWEIN and R.M. BUIJS – Hypothesis: Shifting the equilibrium from activity to food leads to autonomic unbalance and the metabolic syndrome. Diabetes 52(2003)2652-2656.

 

57. Fliers, E., H.P. Sauerwein, J.A. Romijn, P. Reiss, M. Van der Valk, A. Kalsbeek, F. Kreier, R.M. Buijs. HIV-associated adipose redistribution syndrome is a selective neuropathy. Lancet 362(2003)1758-1760.

 

58. KALSBEEK, A., M. RUITER, S.E. LA FLEUR, C. VAN HEIJNINGEN and R.M. BUIJS – The diurnal modulation of hormonal responses in the rat varies with stimuli. J. Neuroendocrinol. 15(2003)1144-1155.

 

59. KREIER, F., A. KALSBEEK, M. RUITER, A. YILMAZ, J.A. ROMIJN, H.P. SAUERWEIN, E. FLIERS, And R.M. BUIJS – Central nervous determination of food storage – A daily switch from conservation to expenditure. Implications for the metabolic syndrome. Eur. J. Pharmacol. 480(2003)51-65.

 

60. PERREAU-LENZ, S., P. PEVET, R.M. BUIJS and A. KALSBEEK – The biological clock: A bodyguard of temporal homeostasis. Chronobiol. Int. 21(2004)1-25.

 

61. VERHAGEN, L.A.W., P. PEVET, M. SABOUREAU, B. SICARD, B. NESME, B. CLAUSTRAT, R.M. BUIJS and A. KALSBEEK – Temporal organization of the 24-h corticosterone rhythm in the diurnal murid rodent Arvicanthis ansorgei Thomas 1910. Brain Res. 995(2004)197-204.

 

62. PERREAU-LENZ, S., A. KALSBEEK, P. PEVET and R.M. BUIJS – Glutamatergic clock output stimulates melatonin synthesis at night. Eur. J. Neurosci., 19(2004)318-324.

 

63. ZANDIEH-DOULABI, B., M. PLATVOET-TER SCHIPHORST, A. KALSBEEK, E. FLIERS, O. BAKKER and M. WIERSINGA – Diurnal variation in rat liver TRά mRNA is dependent on the biological clock in the suprachiasmatic nucleus (SCN), while that of  TRβ1 mRNA is modified by food. Endocrinology 145(2004)1284-1289.

 

64. ZANDIEH-DOULABI, B., M. PLATVOET-TER SCHIPHORST, A. KALSBEEK, O. BAKKER and M. WIERSINGA - Hyper- and hypothyroidism change the expression and diurnal variation of thyroid hormone receptor isoforms in rat liver without major changes in their zonal distribution. Mol. Cell. Endocrinol. 219(2004)69-75.

 

65. KALSBEEK, A., S.E. LA FLEUR, C. VAN HEIJNINGEN and R.M. BUIJS – Suprachiasmatic GABAergic inputs to the PVN control plasma glucose concentrations in the rat via sympathetic innervation of the liver. J. Neurosci. 24(2004)7604-7613.

 

66. PERREAU-LENZ, S., A. KALSBEEK, J. VAN DER VLIET, P. PEVET and R.M. BUIJS – In vivo evidemce for clock controlled offset of melatonin synthesis. Neuroscience 130(2005)797-803.

 

67. KALSBEEK, A., R.M. BUIJS, T.J. VISSER and E. FLIERS – Daily variations in type II 5’iodothyronine deiodinase activity in the rat brain as controlled by the biological clock. Endocrinology 146(2005)1418-1427.

 

68. CAILOTTO, C., S.E. La FLEUR, C. VAN HEIJNINGEN, A. KALSBEEK, M. FEENSTRA, P. PEVET and R.M. BUIJS – The suprachiasmatic nucleus controls the daily variation of plasma glucose via its autonomic output to the liver: Are the clock genes involved? Eur J Neurosci 22(2005)2531-2540.

 

69. KLIEVERIK, L., KALSBEEK, A. and E. FLIERS – Autonomic innervation of the thyroid gland and its functional implications. Hot Thyroidology 2005, 1.

 

70. KREIER, F., KAP, Y.S., METTENLEITER, T.C., VAN HEIJNINGEN, C., VAN DER VLIET, J.,KALSBEEK, A., SAUERWEIN, H.P., FLIERS, E., ROMIJN, J.A. and R.M. BUIJS – Tracing from fat tissue, liver and pancreas: A neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology 147(2006)1140-1147.

 

71. RUITER, M., R.M. BUIJS and A. KALSBEEK –Hormones and the autonomic nervous system are involved in suprachiasmatic nucleus modulation of glucose homeostasis. Current Diabetes Reviews 2(2006)213-226.

 

72. KALSBEEK, A., S. PERREAU-LENZ and R.M. BUIJS – A network of (autonomic) clock outputs. Chronobiol Int 23(2006)210-215.

 

73. WU, Y.H., FISCHER, D.F., KALSBEEK, A., GARIDOU-BOOF, M.L., VAN DER VLIET, J., VAN HEIJNINGEN, C., LIU, R.Y., ZHOU, J.N. and D.F.SWAAB – Pineal molecular clock oscillation is disturbed in Alzheimer disease, due to functional disconnectivity with the “master clock”. Faseb J 20(2006)1874-1876.

 

74. Kalsbeek, A., I.F. Palm, S.E. La Fleur, F.A.J.L. Scheer, S. Perreau-Lenz, M. Ruiter, F. Kreier, C. Cailotto and  R.M. BUIJS – SCN outputs and the hypothalamic balance of life. J Biol Rhythms 21(2006)458-469.

 

75. BOLK, N., VISSER, T.J., KALSBEEK, A., VAN DOMBURG, R.T., and BERGHOUT, A. – Effects of evening versus morning thyroxine ingestion on serum thyroid hormone profiles in hypothyroid patients. Clin Endocrinol 66(2007)43-48.

 

76. KREIER, F., KALSBEEK, A., SAUERWEIN, H.P., FLIERS, E., ROMIJN, J.A. and R.M. BUIJS – “Diabetes of the elderly” and type 2 diabetes in younger patients: possible role of the biological clock. Exp Gerontol 42(2007)22-27.

 

77. KALSBEEK, A., F. KREIER, E. FLIERS, H.P. SAUERWEIN, J.A. ROMIJN and R.M. BUIJS – Minireview: Circadian control of metabolism by the SCN. Endocrinology 148(2007)5635-5639.

 

78. TIESJEMA, B., S.E. LA FLEUR, C.M.C. LUIJENDIJK, A. KALSBEEK and R.A.H. ADAN – Differential effects of  rAAV-mediated NPY overexpression in the PVN an LH on energy balance. J Neurosci 27(2007)14139-14146.

 

79. CAILOTTO, C., S.E. La FLEUR, C. VAN HEIJNINGEN, A. KALSBEEK, M. FEENSTRA, P. PEVET and R.M. BUIJS – Daily rhythms in metabolic liver enzymes and plasma glucose require a balance in the autonomic output to the liver. Endocrinology 149(2008)1914-1925.

 

80. KALSBEEK, A., VERHAGEN, L.A.W., SCHALIJ, I., FOPPEN, E., SABOUREAU, M., BOTHOREL, B., BUIJS, R.M. & P. PEVET – Opposite actions of hypothalamic vasopressin in circadian corticosterone rhythm in nocturnal versus diurnal species. Eur J Neurosci 27(2008)818-827.

 

81. Klieverik L.P., h.p. Sauerwein, m.t. Ackermans, E. Fliers & a. Kalsbeek - Effects of Thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. Am J Physiol 294(2008)E513-520.

 

82. ACKERMANS, M.T., KLIEVERIK, L.P., ENDERT, E., SAUERWEIN, H.P., KALSBEEK, A. and E. FLIERS – Plasma insulin concentrations during a hyperglycaemic clamp: what do we measure? Ann Clin Biochem 45(2008)430-431.

 

83. YI, C.X., E. CHALLET, P. PEVET, A. KALSBEEK, C. ESCOBAR and R.M. BUIJS – Circulating ghrelin mimetic attenuates phase-shifts and light-induced fos expression in the suprachiasmatic nucleus. Eur J Neurosci  27(2008)1965-1972.

 

84. VAN DEN HOEK AM, C VAN HEIJNINGEN, JP SCHRODER-VAN DER ELST, DM OUWENS, HAVEKES LM, ROMIJN JA, PIJL, H. and A. KALSBEEK - Intracerebroventricular administration of NPY hampers insulin action to suppress endogenous glucose production via the sympathetic nervous system. Diabetes 57(2008)2304-2310.

 

85. KALSBEEK, A., E. FOPPEN, I. SCHALIJ, C. VAN HEIJNINGEN, J. VAN DER VLIET, E. FLIERS and R.M. BUIJS – Circadian control of the daily plasma glucose rhythm: interplay of GABAergic and glutamatergic (clock) outputs. PloS One 3(2008)e3194.

 

86. Klieverik L.P., S. Janssen, E. Foppen, P.H. Bisschop, M. Serlie, A. Boelen, m.t. Ackermans, h.p. Sauerwein, E. Fliers & a. Kalsbeek – Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. PNAS 106(2009)5966-5971.

 

87. KLIEVERIK L.P., E. FOPPEN, M.T. ACKERMANS, M.J. SERLIE, H.P. SAUERWEIN, T.S. SCANLAN, D.K.GRANDY, A. KALSBEEK & E. FLIERS – Central effects of thyronamines on glucose metabolism in the rat. J Endocrinol 201(2009)377-386.

 

88. MISTLBERGER, R.E., R.M. BUIJS, E. CHALLET, C. ESCOBAR, G.J. LANDRY, A. KALSBEEK, P. PEVET and S. SHIBATA – Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice. J Circadian Rhythms 7(2009)3.

 

89. CAILOTTO, C., LEI, J., J. VAN DER VLIET, C. VAN HEIJNINGEN, C. VAN EDEN, A. KALSBEEK, P. PEVET and R.M. BUIJS – Light, time-dependently, affects the functionality of organs via the autonomic nervous system. PLoS One 4(2009)e5650.

 

90. YI, C.X.,  M.J. SERLIE, M.T.  ACKERMANS, E. FOPPEN, R.M. BUIJS, H.P. SAUERWEIN, E FLIERS and A. KALSBEEK - A major role for perifornical orexin neurons in the control of glucose metabolism.  Diabetes 58(2009)1998-2005.

 

91. Mistlberger, R.E., Buijs, R.M., Challet, E., Escobar, C., Landry, G.J., Kalsbeek, A., Pevet, P., Shibata, S. - Food anticipation in Bmal1-/- and AAV-Bmal1 rescued mice: a reply to Fuller et al. J Circadian Rhythms 7(2009)11.

 

92. Klieverik, L.P., Coomans, C.P., Endert, E., Sauerwein, H.P., Havekes, L.M., Voshol, P.J., Rensen, P.C., Romijn, J.A., Kalsbeek, A., Fliers, E. - Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo. Endocrinology 150(2009)5639-48.

 

93. Mul, J.D., YI, C.-X., VAN DEN BERG, S.A., RUITER, M., Toonen, P.W., van der Elst, M.C.J., VOSHOL, P.J., Ellenbroek, B.A., Kalsbeek, A., la Fleur, S.E. and CUPPEN, E. - Pmch expression during early development is critical for normal energy homeostasis. Am J Physiol 298(2010)E477-E488.

 

94. FLIERS, E., KLIEVERIK, L.P AND KALSBEEK, A. – Novel neural pathways for metabolic effects of thyroid hormone. Tr Endocrinol Metab 21(2010)230-236.

 

95. YI, C.-X., LA FLEUR, S.E., FLIERS, E. AND KALSBEEK A. – The role of the autonomic nervous liver innervation in the control of energy metabolism. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802(2010)416-431.

 

96. Yi, C.-X., Sun, N., Ackermans, M.T., Foppen, E., Shi, J., Buijs, R.M., Serlie, M.J., Fliers, E. and Kalsbeek, A. - Pituitary adenylate cyclase-activating polypeptide stimulates glucose production through glycogenolysis and via the hepatic sympathetic innervation in rats. Diabetes 59(2010)1591-1600.

 

97. KALSBEEK, A., YI, C.-X., LA FLEUR, S.E. and FLIERS, E. – The hypothalamic clock and its control of glucose homeostasis. Tr Endocrinology Metab 21(2010)402-410.

 

98. KALSBEEK, A., FLIERS, E., HOFMAN, M.A., SWAAB, D.F. and BUIJS, R.M. – Vasopressin and the output of the biological clock. J Neuroendocrinol 22(2010)362-372.

 

99. LA FLEUR, S.E., C.M.C. LUIJENDIJK, A.J. VAN ROZEN, A. KALSBEEK and R.A.H. ADAN – A free-choice high-fat high-sugar induces glucose intolerance and insulin unresponsiveness to a glucose load not explained by obesity. Int J Obesity 35(2011)595-604.

 

100. ACKERMANS, M.T., KLIEVERIK, L.P., RINGELING, P., ENDERT, E., KALSBEEK, A., FLIERS, E. - An online solid-phase extraction-liquid chromatography-tandem mass spectrometry method to study the presence of thyronamines in plasma and tissue and their putative conversion from 13C6-thyroxine. J Endocrinol 206(2010)327-34.

 

101. KALSBEEK, A.,BRUINSTROOP, E., YI, C.-X., KLIEVERIK, L.P., LA FLEUR, S.E.,  FLIERS, E. – Hypothalamic control of energy metabolism via the autonomic nervous system.  Ann NY Acad Sci 1212(2010)114-129.

 

102. KALSBEEK, A., YI, C.-X., LA FLEUR, S.E., BUIJS, R.M., FLIERS, E. – Suprachiasmatic nucleus and autonomic nervous system influences on awaking from sleep. Int Rev Neurobiol 93(2010)91-107.

 

103. YI, C.-X., KALSBEEK, A., TSCHÖP, M. – Autonomic MC sets the metabolic tone. Cell Metab 13(2011)121-123.

 

104. KALSBEEK, A., LA FLEUR, S.E., SCHEER, F.A., PERREAU-LENZ, S., YI, C.-X., FLIERS, E. & BUIJS, R.M. -  SCN control of energy metabolism during circadian disruption.  FEBS Lett 585(2011)1412-1426.

 

105. ALKEMADE, A., FRIESEMA, E.C.H., KALSBEEK, A., SWAAB, D.F., VISSER, J., FLIERS, E. – Expression of thyroid hormone transporters in the human hypothalamus. J Clin Endocrinol Metab 96(2011)E967-971.

 

106. Liu, J., Qi, X.R., Hu, P., Meng, F.T, KALSBEEK, A., Zhou, J.N. – Acute restraint stress increases intrahypothalamic estradiol concentrations in conjunction with increased hypothalamic oestrogen receptor β and aromatase mRNA expression in female rats.  J Neuroendocrinol 23(2011)435-434.

 

107. KALSBEEK, A., YI, C.-X., CAILOTTO, C., LA FLEUR, S.E., FLIERS, E. and BUIJS, R.M. – Mammalian clock output mechanisms. Essays in Biochemistry, 49(2011)137-151.

 

108. KALSBEEK, A., VAN DER SPEK, R., LEI, J., ENDERT, E., BUIJS, R.M., FLIERS, E. – Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis. Mol Cell Endocrinol 349(2012)20-29.

 

109. KLIEVERIK, L.P., KALSBEEK, A., ACKERMANS, M.T., SAUERWEIN, H.P., WIERSINGA, W.M. & FLIERS, E. - Energy homeostasis and body weight before and after cessation of block and replacement therapy in euthyroid patients with Graves disease. Int J Endocrinol 2011(2011)715370.

 

110. KALSBEEK, A., YI, C.-X., LA FLEUR, S.E., & FLIERS, E. – De rol van de biologische klok en het autonome zenuwstelsel bij wakker worden. Neuropraxis 6(2011)159-171.

 

111. BOELEN, A., VAN BEEREN, M., VOS, X., SUROVTSEVA, O., BELEGRI, E., SAALTINK, D.J., VREUGDENHIL, E., KALSBEEK, A., KWAKKEL, J. and FLIERS, E. - Leptin administration restores the fasting induced increase of hepatic type 3 deiodinase expression in mice. Thyroid 22(2012)192-199.

 

112. YI, C.-X, FOPPEN, E., ABPLANALP, W., GAO, Y., ALKEMADE, A., SERLIE, M.J.,  FLIERS, E., BUIJS, R.M., TSCHOP, M.H. & KALSBEEK, A. - Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes 61(2012)339-345.

 

113. LEENAARS, C.H.C., KALSBEEK, A., HANEGRAAF, M.A.J., FOPPEN, E., JOOSTEN, R.N.J.M.A., POST, G., DEMATTEIS, M., FEENSTRA, M.G.P., AND VAN SOMEREN, E.J.W. - Unaltered instrumental learning and attenuated body weight gain during non-rotating shift-work in rats. Chronobiol Int 29(2012)344-355.

 

114. DONJACOUR, C.E.H.M., KALSBEEK, A., OVEREEM, S., LAMMERS, G.J., PEVET, P., BOTHOREL, B., PIJL, H. and AZIZ, N.A. – Altered circadian rhythm of melatonin concentrations in hypocretin deficient men. Chronobiol Int. 29(2012)356-362.

 

115. BRUINSTROOP, E., PEI, L., ACKERMANS, M., FLIERS, E., KALSBEEK, A. – Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL triglyceride secretion via the sympathetic nervous system. Diabetes 61(2012)1043-1050.

 

116. ALKEMADE, A., C.X. YI, L. PEI, M. HARAKALOVA, D.F. SWAAB, S.E. LA FLEUR, E. FLIERS and A. KALSBEEK – AgRP and NPY expression in the hypothalamic infundibular nucleus correlate with body mass index, whereas changes in aMSH are related to type 2 diabetes. J Clin Endocrinol Metab 97(2012)E925-E933.

 

117. Alkemade, A, Unmehopa, U.A., Hessel, E.V.S., Swaab, D.F., Kalsbeek, A., Fliers, E. - Suppressor of cytokine signaling 3 in the human hypothalamus. Peptides 35(2012)139-142.

 

118. LIU, J., BISSCHOP, P., EGGELS, L., FOPPEN, E., FLIERS, E., ZHOU, J.N., KALSBEEK, A. – Intrahypothalamic estrogen rapidly modulates HPA-axis activity in female rats. Endocrinology 153(2012)3337-3344.

 

119. KALSBEEK, A., J. LIU, J. LEI, L. TIMMERMANS, E. FOPPEN, C. CAILOTTO, E. FLIERS - Differential involvement of the suprachiasmatic nuclei in LPS-induced plasma glucose and corticosterone responses. Chronobiol Int 29(2012)835-849.

 

120. FRIESEMA, E.C.H., T.J. VISSER, A.J. BORGERS, A. KALSBEEK, D.F. SWAAB, E. FLIERS, A. ALKEMADE - Thyroid hormone transporters and deiodinases in the developing human hypothalamus. Eur J Endocrinol 167(2012)379-386.

 

121. Girault, E.M., A. Alkemade, E. Foppen, M.T. Ackermans, E. Fliers, A. Kalsbeek -  Acute peripheral but not central administration of the antipsychotic drug Olanzapine induces hyperglycemia associated with hepatic insulin resistance in male rats. Plos One 7(2012)43244.

 

122. YI, C.X., GERICKE, M., KRUGER, M., ALKEMADE, A., KABRA, D.G., HANSKE, S., FILOSA, J.,  PFLUGER, P., BINGHAM, N., WOODS, S.C., HERMAN, J., KALSBEEK, A., BAUMANN, M., LANG, R., STERN, J.E., BECHMANN, I. & TSCHOP, M.H. – High caloric diet triggers hypothalamic  angiopathy. Mol Metab 1(2012)95-100.

 

123. LIU, J., P.H. BISSCHOP, L. EGGELS, E. FOPPEN, .M.T. ACKERMANS, J.N. ZHOU, E. FLIERS and A. KALSBEEK – Intrahypothalamic estradiol regulates glucose metabolism via the sympathetic nervous system in female rats. Diabetes 62(2013)435-443.

 

124. COOMANS, C.P., S.A.A. VAN DEN BERG, E.A. LUCASSEN, T. HOUBEN, A.C.M. PRONK, R. VAN DER SPEK, A. KALSBEEK, N.R. BIERMASZ, K.W. VAN DIJK, J.A. ROMIJN and J.H. MEIJER – The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity. Diabetes 62(2013)1102-1108.

 

125. SILJEE-WONG, J., U.A. UNMEHOPA, A. KALSBEEK, D.F. SWAAB, E. FLIERS, A. ALKEMADE - Melanocortin-4 Receptor distribution in the human hypothalamus. Eur J Endocrinol 168(2013)361-369.

 

126. BRUINSTROOP, E., LA FLEUR, S.E., ACKERMANS, M., FOPPEN, E., WORTEL, J., KOOIJMAN, S., BERBEE, J.F., RENSEN, P.C., FLIERS, E., KALSBEEK, A. – The autonomic nervous system regulates postprandial liver lipid metabolism. Am J Physiol 304(2013)E1089-E1096.

 

127. Girault, E.M., Toonen, P.W., Eggels, L., Foppen, E., Ackermans, M.T., la Fleur, S.E., Fliers, E., Kalsbeek, A. - Olanzapine-induced changes in glucose metabolism are independent of the melanin-concentrating hormone system. Psychoneuroendocrinology 38(2013)2640-2646.

 

128. Girault, E.M., Foppen, E., Ackermans, M.T., Fliers, E., Kalsbeek, A.  - Central administration of an orexin receptor 1 antagonist prevents the stimulatory effect of Olanzapine on endogenous glucose production. Brain Res 1527(2013)238-245.

 

129. DIEPENBROEK, C., SERLIE, M.J., FLIERS, E., KALSBEEK, A., LA FLEUR, S.E. – Brain areas and pathways in the regulation of glucose metabolism. Biofactors 39(2013)505-513.

 

130. Girault, E.M., B. Guigas, A. Alkemade, E. Foppen, M.T. Ackermans, E. Fliers, A. Kalsbeek -   Olanzapine-induced adiposity resulting from a fuel substrate switch is independent of acute glucoregulatory effects. Naunyn Schmiedeberg’s Archives of Pharmacology 387(2014)185-195.

 

131. Diepenbroek, C., G. van der Plasse, L. Eggels, M. Rijnsburger, M. Feenstra, A. Kalsbeek, D. Denys, E. Fliers, M.J. Serlie, S.E. la Fleur - Alterations in glucose metabolism during deep brain stimulation in the shell region of the nucleus accumbens in rats. Frontiers in Neuroscience 7(2013)226.

 

132. Van den Heuvel JK, L. Eggels, E. Fliers, A. Kalsbeek, R.A.H. Adan, S.E. la Fleur – Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high fat high-sugar diet. Plos One 9(2014)e87729.

 

133. van den Heuvel JK, Eggels L, van Rozen AJ, Luijendijk MCM, Fliers E, Kalsbeek A, Adan RAH, la Fleur SE. Neuropeptide Y and leptin sensitivity is dependent on diet composition. J Neuroendocrinology 26(2014)377-385.

 

134. DE VRIES EM, J. KWAKKEL, L. EGGELS, A. KALSBEEK, P. BARRETT, E. FLIERS and A. BOELEN - NFκB is essential for the lipopolysaccharide-induced increase of type 2 deiodinase in tanycytes. Endocrinology 155(2014)2000-2008.

 

135. KALSBEEK A, LA FLEUR SE and FLIERS E. Circadian control of glucose metabolism. Mol Metab 3(2014)372-383.

 

136. MARTÍNEZ DE MORENTIN PB, LAGE R, FERNÁNDEZ-MALLO D, RUÍZ-PINO F, LIU J, GONZÁLEZ-GARCÍA I, MORGAN DA, PINILLA L, GALLEGO R, SAHA AK, KALSBEEK A, FLIERS E, DIÉGUEZ C, BISSCHOP PH, NOGUEIRAS R, RAHMOUNI K, TENA-SEMPERE M & LÓPEZ M. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab 20(2014)41-53.

 

137. van den Heuvel JK, FURMAN K, GUMBS MCR, Eggels L, OPLAND DM, LAND BB, KOLK SM, NARAYANAN N, Fliers E, Kalsbeek A, DILEONE RJ, la Fleur SE. Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. Biol Psychiatry 77(2015)633-641.

 

138. STENVERS, D.J., SCHOUTEN, L.J., JURGENS, J., ENDERT, E., KALSBEEK, A., FLIERS, E., BISSCHOP, P.H. – Breakfast replacement with a low glycemic response liquid formula in type 2 diabetes: A randomized clinical trial. Brit J Nutr 112(2014)504-512.

 

139. DONJACOUR, C.E.H.M., AZIZ, N.A., OVEREEM, S., KALSBEEK, A., PIJL, H., LAMMERS, G.J. – Glucose and fat metabolism in narcolepsy and the effect of Sodium Oxybate: a hyperinsulinemic clamp study. Sleep 37(2014)795-801.

 

140. FLIERS, E., KALSBEEK, A. BOELEN, A. – Regulation of the hypothalamus-pituitary-thyroid axis: beyond the fixed setpoint. Eur J Endocrinology 171(2014)R197-208.

 

141. SU, Y., VAN DER SPEK, R., FOPPEN, E., KWAKKEL, J., FLIERS, E., KALSBEEK, A. – Effect of adrenalectomy on daily gene expression rhythms in the rat suprachiasmatic and paraventricular hypothalamic nuclei and in white adipose tissue. Chronobiol Int. 32(2015)211-224.

 

142. DE VRIES E.M., L. EGGELS, H.C. VAN BEEREN, M.T. ACKERMANS, A. KALSBEEK, E. FLIERS and A. BOELEN – Fasting induced changes in hepatic thyroid hormone metabolism are independent of autonomic nervous input to the liver. Endocrinology 155(2014)5033-5041.

 

143. OOSTERMAN, J.E., FOPPEN, E., VAN DER SPEK, R., FLIERS, E., LA FLEUR, S.E. and KALSBEEK, A. – Timing of fat and liquid sugar intake alters substrate oxidation and food efficiency in male Wistar rats. Chronobiol Int 32(2015)289-298.

 

144. DE VRIES E.M., L. EGGELS, H.C. VAN BEEREN, M.T. ACKERMANS, A. KALSBEEK, E. FLIERS and A. BOELEN – Differential effects of fasting versus food restriction on hepatic thyroid hormone metabolism. J Endocrinology 224(2014)25-35.

 

145. OOSTERMAN, J.E., A. KALSBEEK, S.E. LA FLEUR, D. BELSHAM – Impact of nutrients on circadian rhythmicity. Am J Physiol 308(2015)R337-350.

 

146. JENNIFER M. ROJAS, EVELINE BRUINSTROOP, RICHARD L. PRINTZ, ALDIJANA ALIJAGIC-BOERS; EWOUT FOPPEN, MAXINE K. TURNEY, LEENA GEORGE ANNETTE G. BECK-SICKINGER, ANDRIES KALSBEEK,  KEVIN D. NISWENDER - Central nervous system neuropeptide Y regulates mediators of hepatic phospholipid remodeling and very low density lipoprotein secretion via sympathetic innervation. Mol Metab 4(2015)210-221.

 

147. KUMAR JHA, P., CHALLET, E., KALSBEEK, A. – Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal animals. Mol Cell Endocrinol 418(2015)74-88.

 

148. OPPERHUIZEN, A.L., VAN KERKHOF L.W., PROPER, K.L., RODENBURG W., KALSBEEK, A. – Rodent models to study the metabolic effects of shiftwork in humans. Front Pharmacol 6(2015)50.

 

149. LEENAARS, C.H.C., KLINKENBERG, I.P.M., AUSSEMS, A., BORGER, N., FAATZ, V., HAK, A., HOUBEN, E., RAMACKERS, J., SNACKERS, J. and A. KALSBEEK – Sleep and food choice in a Dutch student population. J Circ Rhythms 13(2015)1-6.

 

150. VERSTEEG, R.I., SERLIE, M.J., KALSBEEK, A., LA FLEUR, S.E. – Serotonin: a possible intermediate between disturbed circadian rhythms and metabolic disease. Neuroscience 301(2015)155-167.

 

151. BRUINSTROOP, E., ELIVELD, J., FOPPEN, E., BUSKER, S., ACKERMANS, M., HOUTEN, S., FLIERS, E., KALSBEEK, A. – Sympathetic and parasympathetic hepatic denervation modulate dyslipidemia in obese Zucker (fa/fa) rats.  Int J Obes 39(2015)1655-1658.

 

152. KUMAR JHA, P., FOPPEN, E., CHALLET, E. & KALSBEEK, A. – Effects of central gastrin-releasing peptide on glucose metabolism. Brain Res 1625(2015)135-141.

 

153. HERRERA MORO CHAO, D., KALLEMIJN, W.W., MARQUES, A.R.A., ORRE, M., OTTENHOFF, R., VAN ROOMEN, C., FOPPEN, E., RENNER, M.C., MOETON, M., VAN EIJK, M., BOOT, R.G., KAMPHUIS, W., HOL, E..M., ATEN, J., OVERKLEEFT, H.S., KALSBEEK, A. & AERTS, J.M.F.G. – Visualization of active glucocerebrosidase in rodent brain with high spatial resolution following in situ labeling with fluorescent activity based probes. Plos One 10(2015)e0138107.

 

154. LEENAARS CH, ZANT JC, AUSSEMS A, FAATZ V, SNACKERS D, KALSBEEK A. - The Leeds food preference questionnaire after mild sleep restriction - A small feasibility study. Physiol Behav. 154(2016)28-33.

 

155. SU, Y., FOPPEN, E., ZHANG, Z., FLIERS, E., KALSBEEK, A. – Effects of a 6-meals-a-day feeding schedule and a 6-meals-a-day feeding schedule combined with adrenalectomy on daily gene expression rhythms in male rat epididymal white adipose tissue. Genes to Cells 21(2016)6-24.

 

156. SU Y, CAILOTTO C, FOPPEN E, JANSEN R, ZHANG Z, BUIJS R, FLIERS E, KALSBEEK A. - The role of feeding rhythm, adrenal hormones and neuronal inputs in synchronizing daily clock gene rhythms in the liver. Mol Cell Endocrinol. 422(2016)125-31.

 

157. VAN DEN HEUVEL, J.K., EGGELS, L., VAN ROZEN, A.J., FLIERS, E., KALSBEEK, A., ADAN, R.A.H. & LA FLEUR, S.E. – Inhibitory effect of the melanocortin receptor agonist Melanotan-II (MTII) on feeding depends on dietart fat content and not on obesity in rats on free-choice diets. Front Behav Neurosci 9(2015)358.

 

158. ZHANG Z, BISSCHOP P, FOPPEN E, VAN BEEREN HC, KALSBEEK A, BOELEN A, FLIERS E. - A model for chronic, intrahypothalamic thyroid hormone administration in the rat. J Endocrinol. 229(2016)37-45.

 

159. FOPPEN E, TAN AA, ACKERMANS MT, FLIERS E, KALSBEEK A. - Suprachiasmatic nucleus neuropeptides and their control of endogenous glucose production. J Neuroendocrinol. 28(2016)1-12.

 

160. BOTSCHUIJVER, S., YU, Z., WELTING, O., CAILOTTO, C., KALSBEEK, A. and VAN DEN WIJNGAARD, R. – Absence of diurnal variation in visceromotor response to colorectal distention in normal Long Evans rats. F1000 Research 5(2016)98

 

161. VAN DER MEIJDEN, W.P., VAN SOMEREN, J.L., TE LINDERT, B.H.W., BRUIJEL, J., VAN OOSTERHOUT, F., COPPENS, J.E., KALSBEEK, A., CAJOCHEN, C., BOURGIN, P. and VAN SOMEREN, E.J.W. - Individual differences in sleep timing relate to melanopsin-based phototransduction in healthy adolescents and young adults. Sleep 39(2016)1305-1310.

 

162. JHA, P.K., FOPPEN, E., KALSBEEK, A. and CHALLET, E. – Acute sleep restriction severely impairs glucose tolerance in rats. Physiological Reports 4(2016)e12839.

 

163. SU Y, FOPPEN E, FLIERS E, KALSBEEK A. – Effects of intracerebroventricular administration of neuropeptide Y on metabolic gene expression and energy metabolism in male rats.  Endocrinology 157(2016)3070-3085.

 

164. HERRERA MORO CHAO, D., ARGMANN, C., VAN EIJK, M., BOOT, R.G., OTTENHOFF, R., VAN ROOMEN, C., FOPPEN, E., SILJEE, J.E., UNMEHOPA, U.A., KALSBEEK, A. and AERTS, J.M.F.G. - Impact of obesity on taste receptor expression in non-gustatory tissues: emphasis on hypothalamus and brainstem. Sci Reports 6(2016)29094.

 

165. OPPERHUIZEN, A.L., WANG, D., FOPPEN, E., JANSEN, R., BOUDZOVITCH-SUROVTSEVA, O., DE VRIES, J., FLIES, E. and KALSBEEK, A., - Internal desynchronization in rat hypothalamus, liver and muscle as a consequence of feeding during the light phase. Eur J Neurosci 44(2016)2795-2806.

 

166. ZHANG Z, FOPPEN E, SU Y, BISSCHOP PH, KALSBEEK A, FLIERS E and BOELEN A. – Metabolic effects of chronic T3 administration in the hypothalamic paraventricular and ventromedial nucleus in male rats. Endocrinology 157(2016)4076-4085.

 

167. VERSTEEG, R.I., STENVERS, D.J., KALSBEEK, A., BISSCHOP, P.H., SERLIE, M.J. and LA FLEUR, S.E. – Nutrition in the spotlight: metabolic effects of environmental light. Proc Nutr Soc 75(2016)451-463.

 

168. SEN, S., RAINGARD, H., DUMONT, S., KALSBEEK, A., VUILLEZ, P. and CHALLET, E. - Ultradian feeding in mice not only affects the peripheral clock in the liver, but also the master clock in the brain. Chronobiol Int 34(2017)17-36.

 

169. STENVERS, D.J., VAN DORP, R., FOPPEN, E., MENDOZA, J., OPPERHUIZEN, A.L., FLIERS, E., BISSCHOP, P.H., MEIJER, J., KALSBEEK, A., DEBOER, T. - Dim light at night disturbs the daily sleep-wake cycle in the rat. Sci Reports 6(2016)35662.

 

170. DIEPENBROEK, C., EGGELS, L., ACKERMANS, M.T., FLIERS, E., KALSBEEK, A., SERLIE, M.J., LA FLEUR, S.E. - Differential effects of hyper caloric choice diets on insulin sensitivity in rats, J Endocrinol 232(2017)49-57.

 

171. DIEPENBROEK C, RIJNSBURGER M, EGGELS L, VAN MEGEN KM, ACKERMANS MT, FLIERS E, KALSBEEK A, SERLIE MJ, LA FLEUR SE. - Infusion of fluoxetine, a serotonin reuptake inhibitor, in the shell region of the nucleus accumbens increases blood glucose concentrations in rats. Neurosci Lett 637(2017)85-90.

 

172. ZHANG Z, LIU J, VELDHUIS-VLUG AG, SU Y, FOPPEN E, VAN DER EERDEN BC, KOEDAM M, BRAVENBOER N, KALSBEEK A, BOELEN A, FLIERS E, BISSCHOP PH. - Effects of Chronic Estrogen Administration in the Ventromedial Nucleus of the Hypothalamus (VMH) on Fat and Bone Metabolism in Ovariectomized Rats. Endocrinology 157(2016)4930-4942.

 

173. VERSTEEG, R.I., STENVERS, D.J., VISINTAINER, D., LINNENBANK, A., TANCK, M., ZWANENBURG, G., SMILDE, A.K., FLIERS, E., KALSBEEK, A., SERLIE, M.J., LA FLEUR, S.E. and BISSCHOP, P.H. - Acute effects of ambient light on plasma glucose and triglycerides in healthy humans and obese patients with type 2 diabetes. J Biol Rhythms 32(2017)130-142.

 

174. ZHANG, Z., A. BOELEN, P.H. BISSCHOP, A. KALSBEEK and E. FLIERS - Hypothalamic effects of thyroid hormone. Mol Cell Endocrinology 458(2017)143-148.

 

175. JHA P, BOUÂOUDA H, GOURMELEN S, DUMONT S, FUCHS F, GOUMON Y, BOURGIN P, KALSBEEK A AND CHALLET E - Sleep deprivation and caffeine treatment potentiate photic resetting of the master circadian clock in a diurnal rodent. J Neurosci 37(2017)4343-4358.

 

176. OPPERHUIZEN AL, STENVERS DJ, JANSEN RD, FOPPEN E, FLIERS E and KALSBEEK A. - Light at night acutely impairs glucose tolerance in a time-, intensity- and wavelength-dependent manner in rats. Diabetologia 60(2017)1333-1343

 

177. BUIJS, F.N., GUZMÁN-RUIZ, M., LEÓN-MERCADO, L., BASUALDO, M.C., ESCOBAR, C., KALSBEEK, A. and BUIJS, R.M. - Suprachiasmatic nucleus interaction with the arcuate nucleus is essential for organizing physiological function. eNeuro (2017)4(2).

 

178. GAO Y, BIELOHUBY M, FLEMING T, GRABNER GF, FOPPEN E, BERNHARD W, GUZMÁN-RUIZ M, LAYRITZ C, LEGUTKO B, ZINSER E, GARCÍA-CÁCERES C, BUIJS RM, WOODS SC, KALSBEEK A, SEELEY RJ, NAWROTH PP, BIDLINGMAIER M, TSCHÖP MH and YI CX - Dietary sugars, not lipids, drive hypothalamic inflammation. Molecular Metabolism 6(2017)897-908.

 

179. EGGINK, H.M., VAN NIEROP, F.S., SCHOONEMAN, M.G., BOELEN, A., KALSBEEK, A., KOEHORST, M., TEN HAVE, G.A.M., NIEUWDORP, M., GROEN, A.K., ROMIJN, J.A., DEUTZ, N.E.P. and SOETERS, M.R. – Transhepatic bile acid kinetics in pigs and humans. Clin Nutrition 37(2018)1406-1414.

 

180. EGGINK, H.M., OOSTERMAN, J.E., DE GOEDE, P., KOEHORST, M., GROEN, A.K., BOELEN, A., ROMIJN, J.A., SOETERS, M.R., LA FLEUR, S.E. and KALSBEEK, A. – Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats. Chronobiol Int 34(2017)1339-1353.

 

181. WANG D, OPPERHUIZEN AL, REZNICK J, TURNER N, SU Y, COONEY GJ and KALSBEEK A. - Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus. Brain Res. 1671(2017)93-101.

 

182. GAO Y, VIDAL-ITRIAGO A, KALSBEEK MJ, LAYRITZ C, GARCÍA-CÁCERES C, TOM RZ, EICHMANN TO, VAZ FM, HOUTKOOPER RH, VAN DER WEL N, VERHOEVEN AJ, YAN J, KALSBEEK A, ECKEL RH, HOFMANN SM, YI CX. - Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity. Cell Rep 20(2017):3034-3042.

 

183. DE VRIES, E.M., J.E. OOSTERMAN, H.M. EGGINK, P. DE GOEDE, E. FOPPEN, O. BOUDZOVITCH-SUROVTSEVA, A. BOELEN, S.E. LAFLEUR, A. KALSBEEK and J.A. ROMIJN - Effects of meal composition and meal timing on expression of genes involved in hepatic drug metabolism. Plos One 12(2017)e0185520.

 

184. DE GOEDE, P., SEN, S., OOSTERMAN, J.E., SU, Y., FOPPEN, E., JANSEN, R., LA FLEUR, S.E., CHALLET, E. & A. KALSBEEK - Differential effects of diet composition and timing of feeding behavior on rat Brown adipose tissue and Skeletal muscle peripheral clocks. Neurobiology of Sleep and Circadian Rhythms 4(2018)24-33.

 

185. DE GOEDE, P., WEFERS, J., BROMBACHER, E., SCHRAUWEN, P. & A. KALSBEEK - Circadian rhythms in mitochondrial respiration. J Mol Endocrinol 60(2018)R115-R130.

 

186. MERTENS, K.L., KALSBEEK, A., SOETERS, M.R. & H.M. EGGINK - Bile acid signaling pathways from the enterohepatic circulation to the central nervous system. Frontiers in Neuroendocrinology 11(2017)617.

 

187. SEN, S., DUMONT, S., SAGE-CIOCCA, D., REIBEL, S., DE GOEDE, P., KALSBEEK, A. & E. CHALLET - Expression of the clock gene Rev-erbα in the brain controls the circadian organization of food intake and sleep, but not daily variations of energy metabolism. J Neuroendocrinol 30(2018)e12557.

 

188. GAO Y, VIDAL-ITRIAGO A, MILANOVA I, KORPEL NL, KALSBEEK MJ, TOM RZ, KALSBEEK A, HOFMANN SM & YI CX. - Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase. Mol Metab. 2017: S2212-8

 

189. EGGINK HM, TAMBYRAJAH LL, VAN DEN BERG R, MOL I, VAN DEN HEUVEL JK, KOEHORST M, GROEN AK, BOELEN A, KALSBEEK A, ROMIJN JA, RENSEN PCN, KOOIJMAN S & SOETERS MR – Chronic infusion of taurolithocholate into the brain increases fat oxidation in mice. J Endocrinol 236(2018)85-97.

 

190. SU, Y., FOPPEN, E., MACHADO F.S., FLIERS, E. and KALSBEEK, A. - The role of the daily feeding rhythm in the regulation of the day/night rhythm in triglyceride secretion in rats. Chronobiol Int 35(2018)885-895.

 

191. HEINEN CA, ZHANG Z, KLIEVERIK LP, DE WIT TC, BOELEN A, KALSBEEK A, BISSCHOP PHLT, VAN TROTSENBURG ASP, VERBERNE HJ, BOOIJ J & E. FLIERS - Effects of Intravenous Thyrotropin Releasing Hormone on 18F-Fluordeoxyglucose Uptake in Human Brown Adipose Tissue: A Randomized Controlled Trial. Eur J Endocrinol 179(2018)31-38.

 

192. BLANCAS-VELAZQUEZ AS, UNMEHOPA U, EGGELS L, KOEKKOEK L, KALSBEEK A, MENDOZA J, LA FLEUR SE - A free-choice high-fat high-sugar diet alters day-night Per2 gene expression in reward-related brain areas in rats. Front Endocrinology 9(2018)154.

 

193. MACHADO FSM, ZHANG Z, SU Y, DE GOEDE P, JANSEN R, FOPPEN E, COIMBRA CC & KALSBEEK A – Time-of-day effects on metabolic and clock-related adjustments to cold. Front Endocrinol 9(2018)199.

 

194. VAN DER SPEK R, FLIERS E, LA FLEUR SE & A KALSBEEK – Daily gene expression rhythms in rat white adipose tissue do not differ between subcutaneous and intra-abdominal depots. Front Endocrinol 9(2018)206.

 

195. YILMAZ A, KALSBEEK A & BUIJS RM – Circadian behavioral changes in the etiology of spontaneous hypertension but not after the induction of hypertension. Chronobiol Int 35(2018)1221-1235.

 

196. WEFERS J, VAN MOORSEL D, HANSEN J, CONNELL N, HAVEKES B, HOEKS J, VAN MARKEN LICHTENBELT W, DUEZ H, PHIELIX E, KALSBEEK A, BOEKSCHOTEN M, HOOIVELD G, HESSELINK M, KERSTEN S, STAELS B, SCHEER F & SCHRAUWEN P - Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. PNAS 115(2018)7789-7794.

 

197. ZHANG Z, MACHADO F, ZHAO L, HEINEN CA, FOPPEN E, ACKERMANS MT, ZHOU JN, BISSCHOP PH, BOELEN A, FLIERS E and KALSBEEK A. – Administration of thyrotropin-releasing hormone (TRH) in the hypothalamic paraventricular nucleus (PVN) of male rats mimics the metabolic cold defense response. Neuroendocrinology 107(2018)267-279.

 

198. DE GOEDE, P., SEN, S., SU, Y., FOPPEN, E., POIREL, V.J., CHALLET, E. & A. KALSBEEK – An ultradian feeding schedule in rats affects metabolic gene expression in liver, brown adipose tissue and skeletal muscle with only mild effects circadian clocks. Int J Mol Sci 19(2018)E3171.

 

199. STENVERS DJ, SCHEER FAJL, SCHRAUWEN P, LA FLEUR SE & KALSBEEK A – Circadian clocks and insulin resistance. Nat Rev Endocrinol 15(2019)75-89.

 

200. ZHANG Z, MACHADO F, ZHAO L, HEINEN CA, FOPPEN E, ACKERMANS MT, ZHOU JN, BISSCHOP PH, BOELEN A, FLIERS E and KALSBEEK A. – Administration of thyrotropin-releasing hormone (TRH) in the hypothalamic paraventricular nucleus (PVN) of male rats mimics the metabolic cold defense response. Eur Thyroid J 7(2018)279-288.

 

201. SAAD L, SARTORI M, BODETTO SP, ROMIEU R, KALSBEEk A, ZWILLER J & ANGLARD P - Regulation of brain DNA methylation factors and of the orexinergic system by cocaine and food self-administration. Mol Neurobiol 56(2019)5315-5331.

 

202. STENVERS DJ, JONGEJAN A, ATIQI S, VREIJLING JP, LIMONARD EJ, ENDERT E, BAAS F, MOERLAND P, FLIERS E, KALSBEEK A & PH BISSCHOP – The diurnal rhythm of adipose tissue gene expression is reduced in obese patients with type 2 diabetes. Diabetologia 62(2019)704-716.

 

203. PARKAR, S.G., KALSBEEK, A. AND CHEESEMAN, J.F. - Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health. Microorganisms 7(2019)e41

 

204. CAZAREZ MÁRQUEZ F, MILESI S, LARAN-CHICH MP, KLOSEN P, KALSBEEK A, SIMONNEAUX V - Kisspeptin and RFRP3 modulate body mass in the Phodopus Sungorus via two different
hypothalamic pathways. J Neuroendocrinol 31(2019)e12710.

 

205. YILMAZ A, KALSBEEK A and BUIJS RM - Neuropeptide Changes in the Suprachiasmatic Nucleus are associated with hypertension. Chronobiol Int 36(2019)1072-1087.

 

206. MILANOVA, I.V., KALSBEEK, M.J.T., WANG, X.L., KORPEL, N.L., STENVERS, D.J., WOLFF, S.E.C., DE GOEDE, P., HEIJBOER, A.C., FLIERS, E.F., LA FLEUR, S.E., KALSBEEK, A. and YI, C.-X - Diet-induced obesity disturbs microglial immunometabolism in a time-of-day manner. Front Endocrinol 10(2019)424.

 

207. HOGENBOOM, R., KALSBEEK, M.J., KORPEL, N.L., DE GOEDE, P., KOENEN, M., BUIJS, R.M.,  ROMIJN, J.A., SWAAB, D.F., KALSBEEK, A. and YI, C.X. - Loss of arginine-vasopressin neurons and glial cells in the suprachiasmatic nuclei of type 2 diabetes patients. Diabetologia 62(2019)2088-2093.

 

208. OPPERHUIZEN, A.L., FOPPEN, E., JONKER, M., WACKERS, P., VAN FAASSEN, M., VAN WEEGHEL, M., VAN KERKHOF, L., FLIERS, E. and KALSBEEK, A. - Effects of light-at-night on the rat liver – a role for the autonomic nervous system. Front Neurosci 13(2019)647.

 

209. BRUINSTROOP, E., FLIERS, E. and KALSBEEK, A. – Restoring the autonomic balance to reduce liver steatosis. J Physiol 597(2019)4683-4684.

 

210. DE GOEDE, P., FOPPEN, E., RITSEMA, W.I.G.R., KORPEL, N.L., YI, C.X. and KALSBEEK, A. - Time-restricted feeding enhances the day/night difference in glucose tolerance in rats, but only when in line with the circadian timing system. Front Endocrinol 10(2019)554.

 

211. MASIS-VARGAS, A., HICKS, D., KALSBEEK, A. MENDOZA, J. – Exposure to blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sex-dependent manner. Physiol Reports 7(2019)e14257.

 

212. HERRERA MORO CHAO, D., WANG, Y., FOPPEN, E., OTTENHOFF, R., VAN ROOMEN, C., PARLEVLIET, E.T., VAN EIJK, M., VERHOEK, M., BOOT, R., MARQUES, A.R., SCHEIJ, S., MIRZAIAN, M., KOOIJMAN, S., JANSEN, K., WANG, D., MERGEN, C., SEELEY, R.J., TSCHÖP, M.H., OVERKLEEFT, H., RENSEN, P.C.N., KALSBEEK, A., AERTS, J.M.F.G., YI, C. - The iminosugar AMP-DNM improves satiety and activates brown adipose tissue through GLP1. Diabetes 68(2019)2223-2234.

 

213. HOLLANDERS, J.J., VAN DER VOORN, B., DE GOEDE, P., TOOROP, A., DIJKSTRA, L.R., HONIG, A., ROTTEVEEL, J., DOLMAN, K.M., KALSBEEK, A., FINKEN, M.J.J. - Biphasic glucocorticoid rhythm in one month old infants: reflection of a developing HPA-axis? J Clin Endocrinol Metab (In press).

 

214. MUILWIJK, M., STENVERS, D.J., NICOLAOU, M., KALSBEEK, A., VAN VALKENGOED, I.G.M. -  Behavioral circadian timing system disruptors and incident type 2 diabetes in a non-shift working multi-ethnic population. Obesity (In press).

 

FLEURY, G., MASIS VARGAS, A., KALSBEEK, A. - Metabolic implications of exposure to light at night: A compilation of animal and human evidence. Submitted.

 

MASÍS-VARGAS, A., RITSEMA, W.I.G.R., MENDOZA, J., KALSBEEK, A. - Metabolic effects of light at night are time- and wavelength-dependent in rats. Submitted.

 

DE GOEDE, P., HELLINGS, T.P., COOPMANS, T.V., RITSEMA, W.I.G.R., KALSBEEK, A. - After-effects of time-restricted feeding (TRF) on whole body metabolism and gene expression in four different peripheral tissues. Submitted.

 

OOSTERMAN, J.E., KOEKKOEK, L.L., FOPPEN, E., UNMEHOPA, U.A., EGGELS, L., VERHEIJ, J., FLIERS, E., LA FLEUR, S.E., KALSBEEK, A. - Synergistic effect of feeding time and diet on hepatic steatosis and gene expression in male Wistar rats. Submitted.

 

KALSBEEK, M.J.T., WOLFF, S.E.C., KORPEL, N.L., LA FLEUR, S.E., ROMIJN, J.A., FLIERS, E., KALSBEEK, A., SWAAB, D.F., HUITINGA, I., HOL, E.M., YI, C.-X. - Expression of hypothalamic neuropeptides and microglial markers differ between type 2 diabetes patients with different anti-diabetic treatments. Submitted.

 

WANG, X.L., GAO, Y., TZEPLAEFF, L., COSQUER, B., MILANOVA, I., KORPEL, N.L., KALSBEEK, A., BOUTILLIER, A.L., YI, C.-X. -  Bmal1 deletion in microglia facilitates mice to cope with cognitive and metabolic challenges. Submitted.

 

CÁZAREZ-MÁRQUEZ, F., LARAN-CHICH, M.P., KLOSEN, P., KALSBEEK, A., SIMONNEAUX, V. – RFRP3 increases food intake in a sex dependent manner in the seasonal hamster phodopus sungorus. Submitted.

 

VAN DER SPEK, R., FLIERS, E., LA FLEUR, S.E., KALSBEEK, A. - Complete thermal lesions of the SCN do not abolish all rhythms in rat sWAT and eWAT, NAMPT remains rhythmic. Submitted.

 

VAN DER MEIJDEN, W.P., STENVERS, D.J., VAN KERKHOF, L.W.M., VAN NIEROP, L.E., WISSE, A., BISSCHOP, P.H.L.T., VAN SOMEREN, E.J.W. and KALSBEEK, A. - The effects of evening screen use and blue light exposure on sleep and sleepiness in adolescents: a multi-design approach including a randomized controlled trial. Submitted.

 

STENVERS, D.J., VAN NIEROP, F.S., VAZ, F.M., ROMIJN, J.A., FLIERS, E., KALSBEEK, A., BISSCHOP, P.H. & SOETERS, M.R. - Diurnal patterns of postprandial plasma bile acid excursions in obese patients with type 2 2 diabetes and healthy control subjects. Submitted.

 

KUMAR JHA, P., BOUÂOUDA, H., KALSBEEK, A., CHALLET, E. - Feedback action of behavioural arousal to the master circadian clock in nocturnal and diurnal mammals. Submitted.

 

PALM, I.F., J. KASTELIJN, T.H. HORVATH, A. KALSBEEK and E.M. VAN DER BEEK – The input of vasopressin-containing fibers onto gonadotropin –releasing hormone neurons is sex-specific and originates in the suprachiasmatic nucleus. Submitted.

 

 

 

(d) Book chapters

1. UYLINGS, H.B.M., VAN EDEN,C.G.,PARNAVELAS,J.G. and KALSBEEK,A. - The prenatal and postnatal development of rat cerebral cortex. In: B.Kolb and R.C.Tees (Eds.): The Cerebral Cortex of the Rat, M.I.T. Press, Cambridge, pp. 35-76, 1990.

 

2. KALSBEEK,A.,DE BRUIN,J.P.C.,FEENSTRA,M.P.C. and UYLINGS,H.B.M. - Age-dependent effects of lesioning the mesocortical dopamine system upon prefrontal cortex morphometry and PFC-related behaviors. In: H.B.M.Uylings, C.G. Van Eden, J.P.C. De Bruin, M.A.Corner and M.G.P.Feenstra (Eds.): Function, Plasticity and Pathology of the Prefrontal Cortical Systems in Human and Animal Nervous System, Progress in Brain Research., Vol.85, pp. 257-283, 1991.

 

3. BUIJS,R.M.,HERMES,M.L.H.J.,KALSBEEK,A.,VAN DER WOU­DE,T.P. and VAN HEERIKHUIZE,J.J. - Vasopressin: distribution, origin and functions in the central nervous system, In: S.Jard and R.Jam­ison (Eds.): Vasopressin. John Libbey Eurotext/INSERM, Paris, pp. 149-158, 1991.

 

4. KALSBEEK, A. and BUIJS, R.M. - Peptidergic transmitters of the suprachiasmatic nuclei and the control of circadian rhythmici­ty, In: J.Joosse, R.M.Buijs and F.J.H.Tilders (Eds.): The Peptidergic Neuron, Progress in Brain Research, Vol.92, pp. 321-334, 1992.

 

5. KALSBEEK, A., VOORN, P. and BUIJS, R.M. Development of dopamine-containing systems in the CNS. In: A.Björklund, T.Hökfelt and M.Tohyama (Eds.): Ontogeny of Transmitters and Peptides in the Central Nervous System, Handbook of Chemical Neuroa­natomy, Vol.10, Am­sterdam, Elsevier, pp. 63-112, 1992

 

6. TECLEMARIAM-MESBAH, R., KALSBEEK, A. and PÉVET, P. Efferent projections of the suprachiasmatic nucleus and the transmission of photoperiodic information to the pineal gland. In: Y.Touitou, J.Arendt and P.Pévet (Eds.): Melatonin and the pineal gland - From basic science to clinical application, Amsterdam, Excerpta Medica, pp. 159-162, 1993

 

7. BUIJS, R.M. and KALSBEEK, A. Vasopressin neurotransmission: Involvement in temperature regulation and stress response. In: P.Gross, D.Richter, G.L.Robertson (Eds.): Vasopressin. John Libbey Eurotext, Berlin, pp. 233-242, 1993.

 

8. TECLEMARIAM-MESBAH, R., KALSBEEK, A. and PÉVET, P. Afferent projections on preganglionic neurons projecting to the superior cervical ganglion: implication on transmission of photoperiodic information from the SCN to the pineal. In: M.Moller and P.Pévet (Eds.): Advances in Pineal Research, Vol.8, Amsterdam, Excerpta Medica, pp. 51-55, 1994

 

9. BUIJS, R.M. and KALSBEEK, A. Anatomy and Physiology of vasopressin pathways: from temperature regulation to corticotrophin-inhibiting neurotransmission. In: T. Saito, K. Kurokawa & S. Yoshida (Eds.): Neurohypophysis: Recent Progress of Vasopressin and Oxytocin Research, Amstedam, Elsevier Science B.V., 1995.

 

10. KALSBEEK, A. and R.M.BUIJS Rhythms of inhibitory and excitatory output from the circadian timing system as revealed by in vivo micr odialysis. In: R.M.Buijs, A.Kalsbeek, M.Mirmiran, C.M.A. Pennartz, H.J.Romijn (Eds.): Hypothalamic Integration of Circadian Rhythms, Progress in Brain Research, Vol.111, Amsterdam, Elsevier, pp.273-293, 1996.

 

11. KALSBEEK, A., J.H.STRUBBE and R.M.BUIJS Circadian control of corticosterone, melatonin and insulin release: important roles for suprachiasmatic nucleus efferents and the autonomic nervous system. In: Y. Touitou (Ed.), International Congress on Chronobiology, Amsterdam, Elsevier, pp.411-414, 1998.

 

12. BUIJS, R.M., M.H.L.J. HERMES and A. KALSBEEK - The suprachiasmatic nucleus - paraventricular nucleus interactions. A bridge to the neuroendocrine and autonomic nervous system. In: I.J.A Urban, J.P.H. Burbach and D. De Wied (Eds.), Advances in Brain Vasopressin, Progress in Brain Research, Vol.119, Amsterdam, Elsevier, pp.365-382, 1998.

 

13. KALSBEEK, A., I.F. PALM, S.E. la FLEUR and R.M.BUIJS - Circadian control of hormonal rhythms: important roles for suprachiasmatic nucleus efferents and the autonomic nervous system. In: A.L. Van Bemmel, D.G.M. Beersma, H. Folgering, W.F. Hofman and G.S.F. Ruigt (Eds.), Sleep-Wake Research in the Netherlands, Vol.10, Dutch Society for Sleep-Wake Research, Maastricht, pp.25-36, 1999.

 

14. BUIJS, R.M., M.L.H.J. HERMES, J.P. DAI, F. SCHEER and A. KALSBEEK - Circadian organization of the autonomic nervous system. In: G.J. ter Horst (Ed.), The Nervous System and the Heart, Humana Press Inc., pp.117-157, 2000.

 

15. KALSBEEK, A. and R.M. BUIJS - Neurochemistry of the daily melatonin rhythm as controlled by the suprachiasmatic nucleus. In: C. Haldar, S.K. Maitra and M. Singaravel (Eds.), Treatise on Pineal Gland and Melatonin, Science Publishers Inc, Plymouth, pp. 395-405, 2002.

 

16. KALSBEEK, A., I.F.PALM and R.M.BUIJS - Central vasopressin systems and steroid hormones. In D. Poulain, S. Oliet and D. Theodosis (Eds.). Vasopressin and Oxytocin: From Genes to Clinical Applications. Progress in Brain Research, Vol.139, Amsterdam, Elesevier, pp. 57-73, 2002.

 

17. RUITER, M., R.M. BUIJS, A. KALSBEEK – Biological clock control of glucose metabolism – Timing metabolic homeostasis. In Pandi et al. (Eds) Neuroendocrine correlates of sleep/wakefulness. Kluwer, pp 87-117, 2005

 

18. KALSBEEK, A., RUITER, M., LA FLEUR, S.E., CAILOTTO, C., KREIER, F. and R.M. BUIJS         - The hypothalamic clock and its control of glucose homeostasis. In: A. Kalsbeek, E. Fliers, M.A. Hofman, D.F. Swaab, E.J.W. Van Someren and R.M. Buijs (Eds): Hypothalamic Integration of Energy Metabolism, Progress in Brain Research, Vol. 153, Amsterdam, Elsevier, 287-312, 2006.

 

19. BUIJS, R.M., F.A. SCHEER, F. KREIER, C. YI, N. BOS, V. GONCHARUK and A. KALSBEEK       - Organization of circadian functions: interaction with the body. In: A. Kalsbeek, E. Fliers, M.A. Hofman, D.F. Swaab, E.J.W. Van Someren and R.M. Buijs (Eds): Hypothalamic Integration of Energy Metabolism, Progress in Brain Research, Vol. 153, Amsterdam, Elsevier, pp. 345-363, 2006

 

20. BUIJS, R.M. and KALSBEEK, A. – Neuroendocrine regulation and the autonomic nervous system. In: Encyclopedia of Neuroscience, Amsterdam, Elsevier, 2008.

 

21. BUIS, R.M., C. ESCOBAR and A. KALSBEEK – Circadian metabolic rhythms regulated by the suprachiasmatic nucleus. In: The New Encyclopedia of Neuroscience, Amsterdam, Elsevier, pp. 915-923, 2009.

 

22. GIRAULT, E.M., YI, C.X., FLIERS, E. and KALSBEEK, A. – Orexins, feeding, and energy balance. In: A. Shekhar (Ed): Orexin/Hypocretin System, Progress in Brain Research, Vol. 198, Amsterdam, Elsevier, pp. 47-64, 2012.

 

23. STENVERS, D.J., C.F. JONKERS, E. FLIERS, P.H.L.T. BISSCHOP and A. KALSBEEK – Nutrition and the circadian timing system. In: A. Kalsbeek, M. Merrow, T. Roenneberg and R. Foster (Eds): The Neurobiology of Circadian Timing, Progress in Brain Research, Vol. 199, pp. 359-376, Amsterdam, Elsevier, 2012.

 

24. VAN DER SPEK, R., F. KREIER, E. FLIERS and A. KALSBEEK – Circadian rhythms in white adipose tissue. In: A. Kalsbeek, M. Merrow, T. Roenneberg and R. Foster (Eds): The Neurobiology of Circadian Timing, Progress in Brain Research, Vol. 199, pp. 183-201, Amsterdam, Elsevier, 2012.

 

25. KALSBEEK, A. and E. FLIERS – Hypothalamus. In: D.W. Pfaff (Ed): Neuroscience in the 21^st Century, Berlin, Springer Science, 2012.

 

26. KALSBEEK, A. and M.A. HOFMAN – Hypothalamus and Circadian Rhythms. In: B. Dudas (Ed): The Human Hypothalamus: Anatomy, Functions and Disorders, pp. 283-309, NOVA Science Publishers, 2013.

 

27. KALSBEEK, A. and E. FLIERS – Daily regulation of hormone profiles. In: A. Kramer and M. Merrow (Eds): Circadian Clocks, Handbook of Experimental Pharmacology, Vol. 217, pp. 185-226, Springer-Verlag Berlin Heidelberg, 2013.

 

28. LA FLEUR, S.E. and A. KALSBEEK – Increased risk of diabetes due to obesity: does chronodisruption play a role? In: M. Garaulet & J.M. Ordovás (Eds.): Chronobiology and Obesity, Springer Science, New York, pp. 111-131, 2013.

 

29. LA FLEUR, S.E., E. FLIERS and A. KALSBEEK – Neuroscience of glucose homeostasis (Chp.24). In: D.W. Zochodne & R.A. Malik (Eds.), Handbook of Clinical Neurology, Vol.126: Diabetes and the Nervous System, Section: Fundamental Studies of Diabetic Neuroscience, Elsevier, pp. 341-351, 2014

 

30. KALSBEEK, A., E. BRUINSTROOP, C.X. YI, L. KLIEVERIK, J. LIU and E. FLIERS – Hormonal control of metabolism by the hypothalamus – autonomic nervous system – liver axis. In: A.J. van der Lely & P. Delhanty (Eds.): Frontiers in Hormone Research - How the Gut and Brain Control Energy Metabolism, Karger, Basel, Vol.42, pp. 1-28, 2014.

 

31. BRUINSTROOP, E., A. KALSBEEK, A., and E. FLIERS – Hypothalamic control of hepatic lipid metabolism via the autonomic nervous system. In: E. Fliers & A. Kalsbeek (Eds.): Best practice & Research in Clinical Endocrinology & Metabolism, Elsevier, London, Vol.28, pp. 673-684, 2014.

 

32. BISSCHOP, P.H., E. FLIERS and A. KALSBEEK – Autonomic regulation of hepatic glucose metabolism. In: Comprehensive Physiology, John Wiley & Sons, New York. 5(2015)147-165.

 

33. KALSBEEK, A., Y. SU, E. FLIERS and S.E. LA FLEUR – The hypothalamo-pituitary-adrenal axis: circadian dysregulation and obesity. In: J.A. Russell & M.A. Shipston (Eds.): International Neuroendocrine Federation (INF) Masterclass Series: Stress Neuroendocrinology, John Wiley & Sons, Ltd., West Sussex, Chapter 10, pp. 219-243, 2015.

 

34. ROELFSEMA F, BOELEN A, KALSBEEK A & FLIERS E – Regulatory aspects of the human hypothalamus-pituitary-thyroid axis. In: A. Kalsbeek & E. Fliers (Eds.): Best practice & Research in Clinical Endocrinology & Metabolism, Elsevier, London, Vol.31, pp. 487-503, 2017.

 

 

 

 

 

 

 

(e) Books edited

Buijs, R.M., Kalsbeek,A., Mirmiran,M., Pennartz,C.M.A., Romijn,H.J. - Progress in Brain Research, Vol.108 Hypothalamic Integration of Circadian Rhythms, Elsevier Science Publishers, Amsterdam, 1996.

 

A. Kalsbeek, E. Fliers, M.A. Hofman, D.F. Swaab, E.J.W. Van Someren and R.M. Buijs - Progress in Brain Research, Vol. 153 Hypothalamic Integration of Energy Metabolism, Elsevier Science Publishers, Amsterdam, 2006.

 

A. Kalsbeek, M. Merrow, T. Roenneberg and R. Foster – Progress in Brain Research, Vol. 199 The Neurobiology of Circadian Timing, Elsevier Science Publishers, Amsterdam, 2012.

 

E. Fliers and A. Kalsbeek – Hypothalamic Control of Metabolism, Best Practice & Research in Clinical Endocrinology & Metabolism, Elsevier, London, 2014.

 

E. Challet and A. Kalsbeek – Circadian Rhythms and Metabolism, Frontiers in Endocrinology, 2017

 

A. Kalsbeek & E. Fliers – Circadian and Endocrine Rhythms, Best Practice & Research in Clinical Endocrinology & Metabolism, Part 1 & 2, Elsevier, London, 2017.

 

 

 

 

 

 

(f) Invited papers read at an International Congress

1. Neonatal depletion of the mesocortical dopamine system. Beha­vioural, biochemical and morphological consequen­ces, ISPN meeting, Groningen, The Netherlands, August 1988.

 

2. Age-dependent effects of lesioning the mesocor­tical dopami­ne system upon prefrontal cortex morpho­metry and PFC-rela­ted behaviour, 16th Int. Summer School of Brain Re­search, Amster­dam, The Netherlands, August 1989.

 

3. Peptidergic Transmitters of the Suprachiasmatic Nuclei in the Control of Circadian Rhythmicity, 11th Interna­tional Symposium on Neuro­secretion "The Peptidergic Neuron", Amsterdam, The Netherlands, June 1991.

 

4. Circadian Control of Hormonal Rhythms, 19th Int. Summer School of Brain Re­search, Amster­dam, The Netherlands, August 1995

 

5. Circadian rhythms in hormonal release and the importance of SCN transmitters and the autonomic system, Int. Conference on Circadian Light Reception and Regulation, Lyon, France, May 1996.

 

6. Circadian control of corticosterone, melatonin and insulin release: important roles for suprachiasmatic nucleus efferences and the autonomic nervous system, Endocrine Rhythms: Roles of the Sleep-Wake Cycle, the Circadian Clock and the Environment. Diagnostic and Therapeatic Implications, Paris, France, May 1997.

 

7. SCN-control of feeding-induced corticosterone and insulin release, International Congress on Chronobiology, Paris, France, September 1997.

 

8. SCN control of neuroendocrine rhythms, 1998 Workshop on Steroid Hormones and Brain Functions, Breckenridge, Colorado, USA, March 1998.

 

9. SCN control of neuroendocrine systems, 4th International Congress of Neuroendocrinology, Kitakyushu, Japan, October 1998.

 

10. SCN-morphology, physiology and pathology, First Joint Scientific Meeting of the Belgian and Dutch Sleep Societies BASS and NSWO, Heeze, The Netherlands, November 1998.

 

11. Circadian Rhythmicity and the Control of Food Intake and Metabolism. Central Pathways, 19th European Winterconference on Brain Research, Plagne Lauze, France, March 1999

 

12. GABA release from SCN projections to hypothalamic target areas and its implication in the melatonin rhythm, 8th Meeting of the European Pineal Society, Tours, France, June 1999.

 

13. Nervous Pathways and Neurotransmitters involved in the SCN - Driven Daily Rythm of Melatonin, International Congress on Chronobiology, Washington, USA, September 1999.

 

14. Control and regulation of circadian outputs, Society for Research on Biological Rhythms, Amelia Island, USA, May 2000.

 

15. SCN control of hormonal rhythms: an important role for the autonomic nervous system, School of Biological Sciences, University of Surrey, Guilford, United Kingdom, June 2000

 

16. The central pacemaker: coding circadian time for remote areas, FENS2000, Brighton, United Kingdom, June, 2000.

 

17. Control and regulation of circadian outputs, Erasmus Summer School, University of Strasbourg, France, July 2000

 

18. Hormonal control of bio-rhythms, 14th International Congress of Comparative Endocrinology, Napoli, Italy, May, 2001.

 

19. Vasopressin and Steroid Hormones, World Congress on Neurohypophysial Hormones (WCNH), Bordeaux, France, September, 2001.

 

20. Output mechansisms of the mammalian biological clock, 21st Concgress of European Comparative Endocrinologists, Bonn, Germany, August, 2002.

 

21. SCN transmitters and the timing of hormonal rhythms, 55 Mosbacher Kolloquium “The rhythm of life: molecular mechanisms of circadian clocks”, Mosbach, Germany, March, 2003.

 

22. Integration of central clock outputs into peripheral hormonal rhythms, Annual Meeting of the Britisch Society for Neuroendocrinology, Manchester, United Kingdom, September 2003.

 

23. Neural pathways employed by the central pacemaker to transmit its rhythmic output, CIE expert symposiun on the “Non-visual effects of Light”, Vienna, Austria, October 2004.

 

24. Outputs of the biological clock and its control of the daily corticosterone and melatonin rhythms, African Neuroscience School on “Hormones and the Brain”, Rabat, Morocco, March 2005.

 

25. The hypothalamic clock and its control of glucose homeostasis, 24^th International Summer School of Brain Research on “Hypothalamic Integration of Energy Metabolism”, Amsterdam, The Netherlands, August 2005

 

26. The network of (autonomic) clock outputs, Xth EPBRS congress on “A multidisciplinary Biological Rhythms Congress”, Frankfurt/Main, Germany, September 2005

 

27. Circadian rhythms, Amsterdam-China Symposium, Amsterdam, The Netherlands, October, 2005.

 

28. Neuroregulation of daily rhythms in lipid and glucose metabolism, 50.Symposion der Deutschen Gesellschaft für Endokrinologie, Essen, Germany, March 2006

 

29. The hypothalamic clock and its control of glucose and lipid metabolism, 26^th European Winter Conference on Brain Research, Villars sur Ollon, Switzerland, March 2006.

 

30. Circadian control of metabolism by the SCN, VI International Congress of Neuroendocrinology, Pittsburgh, USA, June 2006

 

31. Sympathetic system in the multi-oscillatory mammalian circadian world, 2^nd Mediterranean Collogue of Neuroscience, Marrakech, Morocco, December 2006.

 

32. Circadian and autonomic control of autonomic neurons in the PVN, NEUREX Symposium on Circadian Clocks and Metabolism, Strasbourg, France, February 2007.

 

33. Hypothalamic control of hormone rhythms and the autonomic nervous system, Huazhong University of Science and Technology, Wuhan, China, March 2007.

 

34. Hypothalamic integration of circadian rhythms and energy metabolism, University of Science and Technology of China, Hefei, China, March 2007.

 

35. Circadian and autonomic control of autonomic neurons in the PVN, Nutrition, Metabolism, and the Brain, Satellite meeting of the European Congress on Obesity, Budapest, Hungary, April 2007.

 

36. The mammalian circadian clock: output pathway, 2^nd World Congress of Chronobiology, Tokyo, Japan, November 2007.

 

37. Rhythms in the periphery – The role of melatonin, 10^th Gordon Research Conference on Pineal Cell Biology, Il Ciocco, Italy, April 2008.

 

38. Visualizing feeding pathways in the brain, 13^th Congress of the International Federation of Societies for Histochemistry and Cytochemistry, Gdansk, Poland, August 2008.

 

39. Site specific signaling in the rat hypothalamus as a determinant of endogenous glucose production, 13^th Meeting of the European Neuroendocrine Association, Antalya, Turkey, October 2008.

 

40. Autonomic clocks and circadian rhythms, 19^th International Symposium on the Autonomic Nervous System, Hawai, USA, October 2008.

 

41. Thyroid hormone modulates hepatic glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver, 11^th European Congress of Endocrinology, Istanbul, Turkey, April 2009.

 

42. SCN neuronal outputs as mediators of peripheral circadian structures, XIth Congress of the European Biological Rhythms Society, Strasbourg, France, August 2009

 

43. Vasopressin and the output of the biological clock, 8^th World Congress on Neurohypophysial Hormones, Kitakyushu, Japan, September 2009.

 

44. Hypothalamic control of hepatic glucose metabolism, Neuroscience Seminar Series, Faculty of Life Sciences, University of Manchester,  February, 2010

 

45. Tracking dawn and dusk, Assembling a multi-cellular circadian pacemaker, Lorenz Center, Leiden, August, 2010.

 

46. Hypothalamic control of hepatic glucose metabolism, Metabolic Diseases Institute, University of Cincinnati, November, 2010

 

47. Communication between brain and liver – What is the message? German Metabolic Society, Fulda, March 2011.

 

48. Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL triglyceride secretion in rats via the sympathetic nervous system, Benjamin Franklin Lafayette Seminar, Frejus (France), June 2011.

 

49. The hypothalamic clock and its control of glucose homeostasis, Bregenz School on Endocrinology, Bregenz, Austria, July 2011.

 

50. Clocks, Sleep and Metabolism, XIIth Congress of the European Biological Rhythms Society, Oxford, August 2011.

 

51. Invloed van de biologische klok op obesitas en diabetes, Voedings- en gezondheidscongres, Brussel, November, 2011.

 

52. The hypothalamus and the temporal control of energy metabolism, Neurex Workshop on the Neural Processing of Time, Strasbourg, France, January 2012.

 

53. Metabolic rhythms and the interplay of hypothalamic, autonomic and peripheral clocks, Gordon Research Conference on Pineal Cell Biology: Links to Circadian Clocks, Sleep and Metabolism, Galveston, Texas, January 2012.

 

54. Circadian regulation of glucose and lipid metabolism: neural and endocrine mechanisms, Annual Meeting of the Associated Professional Sleep Societies (APSS), Boston, USA, June 2012.

 

55. A central role for thyroid hormones in glucose metabolism, British Society for Neuroendocrinology, Aberdeen,
Scotland, July 2012.

 

56. Autonomic clocks and sleep, 21^st Congress of the European Sleep Research Society, Versailles, France, September 2012.

 

57. The sympathetic system as an output of the central clock. It’s role in metabolic rhythms, 4^th Conference of the Mediterranean Neuroscience Society, Istanbul, Turkey, October 2012.

 

58. The sympathetic system as an output of the central clock. It’s role in metabolic rhythms, University of Santiago de Compostela - Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain, March 2013.  

 

59. Hypothalamic control of glucose metabolism as revealed by microdialysis, Zhejiang University School of Medicine, Hangzhou, China, April 2013.

 

60. Hypothalamic and clock control of energy metabolism via the autonomic nervous system, 11^th Society of Neuroscientists of Africa (SONA) International Conference, Rabat, Morocco, June 2013.

 

61. Nutrition and the circadian timing system, Lorentz Conference on “Clinical Relevance of Circadian Rhythms”, Leiden, The Netherlands, August 2013.

 

62. Circadian rhythms, autonomic nervous system, HPA-axis activity and metabolic control, Symposium on Stress Hormones and control of Metabolism at the ISPNE, Leiden, August 2013.

 

63. Outputs of the clock and diurnality: the control of corticosterone secretion and glucose homeostasis, International Conference on the “Understanding the Neural Basis of Diurnality”, Strasbourg, France, November 2013.

 

64. Hypothalamic control of circadian rhythms and energy metabolism, Turkish Conference on Circadian Rhythms, Istanbul, March 2014.

 

65. Neural regulation of hepato-gastric functions, 4^th Versailles International Neurosciences in Intensive Care Symposium (VINCS) on The Neurobiological Control of Response to Stress in Critical Illness, Versailles, France, June 2014.

 

66. The circadian clock sets that daily tone for metabolism, 1^st PanAmerican Congress of Physiological Sciences, Iguassu Falls, Brazil, August 2014.

 

67. Rhythms, autonomic outflow and insulin resistance, SFN minisymposium “Obesity and brain control of sympathetic outflow: Impacts on multiple systems”, Society for Neuroscience (SFN), Washington, USA, November 2014.

 

68. Brain areas and pathways in the regulation of glucose metabolism, 5^th Mediterranean Neuroscience Society, Cagliari, Sardinia, Italy, June 2015.

 

69. Effect of nocturnal light on glucose metabolism in humans and experimental animals, Lorentz Conference on “Human Circadian Rhythms: developing a multi-oscillator framework”, Leiden, The Netherlands, August 2015.

 

70. How the SCN synchronizes daily rhythms in peripheral tissues, XIVth European Biological Rhythms Society (EBRS) meeting, Manchester, United Kingdom, August 2015.

 

71. Vasopressin neurons in the suprachiasmatic nucleus (SCN): critical signaling inside and outside the biological clock, 11^th World Congress on Neurohypophysial Hormones (WCNH), Queenstown, New Zealand, August 2015. Plenary Lecture

 

72. Circadian control of glucose metabolism, NEUREX Meeting Circadian clocks and metabolic health. From basic science to clinical implications, Strasbourg, France, June 2016.

 

73. The role of vasopressin in the control of diurnal rhythms, Föhr Colloquium – The Vasopressin Receptors in Health and Disease, Föhr, Germany, September 2016.

 

74. Shining light on diabetes, Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, México, February 2017.

 

75. Glucose regulation: A regulatory feedback network of periphery and brain, 6^th Mediterranean Neuroscience Society (MNS), Malta, June 2017.

 

76. Metabolic clocks. Fundamental and clinical aspects, Summer School on Basic and Clinical Aspects of Neurobiology of Rhythms, Neurex, Strasbourg, France, August 2017.

 

77. Glucose Metabolism, Hypothalamic Mechanisms and the Biological Clock, 2^nd Indonesian Medical Education and Research Institute International Conference, Jakarta, Indonesia, November 2017.

 

78. Glucose Metabolism, Hypothalamic Mechanisms and the Biological Clock, 29^th Conference of European Comparative Endocrinologists, Glasgow, United Kingdom, August 2018.

 

79. Shining light on glucose metabolism, Annual meeting of the French Society of Neuroendocrinology, Paris, France, September 2018.

 

80. Shining light on glucose metabolism, Chrononutrition: from epidemiology to molecular mechanisms, The Physiological Society, London, United Kingdom, November 2018.

 

81. Shining light on glucose metabolism, German Clock Club, Lubeck, Germany, 13 March 2019

 

82. Clocks in conflict: how time of feeding matters, Adipocyte-Brain-Crosstalk Symposium, Lübeck, Germany, 14-15 March 2019.

 

83. Timing of food intake and circadian rhythms, 37^th International Symposium on Diabetes and Nutrition, Maastricht, The Netherlands, 12-15 June 2019.

 

84. Shining light on glucose metabolism: studies in mice, rats and humans, 31^st Annual meeting of the Society for Light Treatment and Biological Rhythms (SLTBR), Chicago, USA, 20-22 June 2019.

 

85. Daily rhythms in energy metabolism: how to time best light, food and activity, 30^th Conference of the International Society for Chronobiology, Warsaw, Poland, 2-5 July 2019

 

86. Metabolic effects of shift work: time-dependent effects of feeding, fasting and exercise, CARE Chronobiology Conference – LMU Munich, Munich, Germany, 18 November 2019

 

87. Metabolic effects of shift work: time-dependent effects of feeding, fasting and exercise, UK Clock Club, Bristol, United Kingdom, 20 March 2020

 

88. Circadian homeostasis: peptide of the central clock, 23nd International Symposium on Regulatory Peptides, Acapulco, Mexico, 18-22 September 2020

 

 

 

General Public

 

1. VPRO televisie, Labyrint “Nieuw Licht op de Biologische Klok”, 10 October 2012

 

2. Wetenschapsrubriek Radio Noord-Holland, 16 October 2012

 

3. Publieksmiddag “Wijzer of DNA: de klok bepaalt”, 4 November 2012, Leiden

 

4. Omnium Omrop Fryslan, 6 December 2012

 

5. Voeding & Visie, “Eten en de Biologische Klok”, 25(1)9-11, 2012

 

6. Esta, “Weg met de Wekker”, 8/13, 12-17, 2013

 

7. Zin, “Leven als onze voorouders. Waarom we het voorbeeld van de oermens moeten volgen”, 101:114-118, 2013

 

8. Intermediair, “Baas over je bioritme”, 01 / 08 / 2013

 

9. Telegraaf, “Onze klok loopt vast”, 14 September 2013

 

10. Omrop Fryslan, Interview, 22 September 2013

 

11. Publieksdag Hersenstichting Nederland, “Voeding, Brein en Ritme”, 11 October 2013

 

12. GezondNU, Zoek het licht. “Waarom daglicht de beste slaappil is”, November 2013

 

13. 7^de Jaarsymposium Endocrinologie, “De Hypothalamus: Nog belangrijker voor de endocrinologie

dan u denkt”, 14 Januari 2014

 

14. CoRaad UvA “Think Different”, De Biologische Klok, 16 Januari 2013

 

15. Endocrinologie, “Gevoelige Endogene Klokken”, Maart 2014

 

16. Herman Wesselink College, “De Biologische Klok”, Amstelveen, 13 Maart

 

17. De Standaard Weekblad, “Wake-up Call”, 26 April 2014

 

18. Darmgezondheid.nl “De Biologische Klok”, Juli 2014

 

19. NVDO Highlights, “’Broken clock’ verhoogt risico op diabetes type 2”, December 2014

 

20. GezondNU “Daarom slaap je korter door blauw licht”, Februari 2015

 

21. Interdisciplinair Congres Amsterdam “Klokje Rond” over biologische ritmes en slaap, CREA, 13 April 2015

 

22. ITS-Academy Netwerkbijeenkomst Hersenen en Leren, ”De chemie van onze hersenklok”, Spinoza Lyceum, Amsterdam, 23 April 2015

 

23. Santé “Verminder een Jetlag”, September 2015

 

24. KNAW symposium “De Biologische Klok”, “Nieuw licht op ons ontbijt”, Trippenhuis, Amsterdam, 26 October 2015

 

25. 2^de JNVE meeting, “Circadian control of hormone rhythms”, Leiden, 29 – 30 October 2015

 

26. Kenniscafé Rijkswaterstaat “Voeding en de biologische klok”, Utrecht, 30 juni 2016

 

27. Algemeen Dagblad, “Zonlicht als slaaphulp”, 24 juni 2017

 

28. Volkskrant “Nobel geneeskunde voor biologische klok”, 3 oktober 2017

 

29. Werkgroep Artsen en Advocaten (WAA) “Onze Biologische Klok”, 7 februari 2018

 

30. Telegraaf “Wintertijd: Zo heb je er het minste last van”, 27 oktober 2018

 

31. BioNieuws “Insuline stuurt circadiane ritmes”, 4 mei 2019

 

32. Volkskrant “Nee, het blauwe licht van schermpjes is niet wat u wakker houdt”, 10 mei 2019

 

33. New Scientist “Om beter te slapen moet je alle vormen van blauw licht filteren”, juni 2019

 

34. New Scientist “Huid en lever weten zonder hulp van je brein hoe laat het is”, juni 2019

 

35. Fit.nl “Is het ongezond om ’s avonds laat te eten?”, Podcast december 2019

 

36. Leven-Lang-Leren “Een diermodel voor ploegendienst?”, NIN, maart 2020

 

 

Prof. PhD A. Kalsbeek (Hypothalamic Integration Mechanisms)

This research group participates in the Amsterdam Center for Metabolism

PhD Students
E. Angelopoulou
S. Kavraal
S. Loyola
A. Masis Vargas
O. Ozyildirim
S. Sen
MSc X.L. Wang

Others
E. Foppen
E. Frankin
R.D. Jansen

• F. Cazarez Marquez
• S. Kavraal
• L.L. Koekkoek
• S.E. Loyola Arroyo
• I.V. Milanova
• L. Saad
• X. Wang
• Y. Wei

• AMC