- van Vlijmen Elizabeth F. W., Veeger Nic J. G. M., Middeldorp Saskia, Hamulyák Karly, Prins Martin H., Büller Harry R., Meijer Karina Thrombotic risk during oral contraceptive use and pregnancy in women with factor V Leiden or prothrombin mutation: a rational approach to contraception Blood 2011;118 (8):2055-61; quiz 2375 [PubMed]
- Eerenberg Elise S., Kamphuisen Pieter W., Sijpkens Meertien K., Meijers Joost C., Buller Harry R., Levi Marcel Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects Circulation 2011;124 (14):1573-1579 [PubMed]
- Buller Harry R., Lensing Anthonie W. A., Prins Martin H. Oral Rivaroxaban for Symptomatic Venous Thromboembolism REPLY New England journal of medicine 2011;364 (12):1178
- Connolly Stuart J., Milling Truman J., Eikelboom John W., Gibson C. Michael, Curnutte John T., Gold Alex, Bronson Michele D., Lu Genmin, Conley Pamela B., Verhamme Peter, Schmidt Jeannot, Middeldorp Saskia, Cohen Alexander T., Beyer-Westendorf Jan, Albaladejo Pierre, Lopez-Sendon Jose, Goodman Shelly, Leeds Janet, Wiens Brian L., Siegal Deborah M., Zotova Elena, Meeks Brandi, Nakamya Juliet, Lim W. Ting, Crowther Mark, Connolly S. C., Crowther M., Eikelboom J., Gibson M., Milling T. J., Albaladejo P., Cohen A., Lopez-Sendon J., Schmidt J., Verhamme P., Beyer-Westendorf J., Wyse D. G., Garcia D., Prins M. [=Martin H.], Nakamya J., Büller H. R., Mahaffey K., Alexander J., Demchuk A., Raskob G., Schulman S., Meeks B., Zotova E., Holadyk-Gris I., Coppens M. Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors New England journal of medicine 2016;375 (12):1131-1141 [PubMed]
- Raskob G. E., Angchaisuksiri P., Blanco A. N., Buller H., Gallus A., Hunt B. J., Hylek E. M., Kakkar A., Konstantinides S. V., McCumber M., Ozaki Y., Wendelboe A., Weitz J. I. Thrombosis: a major contributor to global disease burden Arteriosclerosis, thrombosis, and vascular biology 2014;34 (11):2363-2371 [PubMed]
Prof. PhD H.R. Buller (Venous and arterial thromboembolic diseases)
In the area of diagnosis and treatment of venous thrombosis and pulmonary embolism there are still some major challenges. The use of simple clinical prediction rules and bedside blood tests that can be safely used in the family care setting is an important research focus of dr. Büller at the present time. In collaboration with colleagues from the Universities of Utrecht and Maastricht two large clinical outcome studies are underway. He has played a crucial role in the design and execution of these projects.
Other diagnostic studies under his supervision focus on improving both the use of ultra sonography and spiral CT, with particular emphasis on further simplifying the algorithms and improving the quality of life of patients. With respect to treatment dr. Büller currently leads as chairman of the steering committee at least five international clinical studies with new simple oral or subcutaneous antithrombotic agents in patients with venous thromboembolism or arterial fibrillation.
Theme: Cardiovascular Diseases
Faculty
Prof. MD PhD S. Middeldorp