- Vermaat Joost S., Pals Steven T., Younes Anas, Dreyling Martin, Federico Massimo, Aurer Igor, Radford John, Kersten Marie José Precision medicine in diffuse large B-cell lymphoma: hitting the target Haematologica 2015;100 (8):989-993 [PubMed]
- Kersten M. J., Kraan W., Doorduijn J., Bromberg J., Lam K., Kluin P. M., van der Holt B. J., Spaargaren M., Pals S. T. Diffuse large B cell lymphomas relapsing in the CNS lack oncogenic MYD88 and CD79B mutations Blood cancer journal 2014;4:e266 [PubMed]
- Mank Arno P. M., Schoonenberg Charlot, Bleeker Kim, Heijmenberg Susanne, Heer Koen de, van Oers Marinus H. J., Kersten Marie José Early discharge after high dose chemotherapy is safe and feasible: a prospective evaluation of 6 years of home care Leukemia & lymphoma 2015;56 (7):2098-2104 [PubMed]
- Hommes Daniel W., Duijvestein Marjolijn, Zelinkova Zuzana, Stokkers Pieter C. F., Ley Maartje Holsbergen-de, Stoker Jaap, Voermans Carlijn, van Oers Marinus H. J., Kersten Marie José Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease Journal of Crohn s & colitis 2011;5 (6):543-549 [PubMed]
- Thijssen R., ter Burg J., van Bochove G. G. W., de Rooij M. F. M., Kuil A., Jansen M. H., Kuijpers T. W., Baars J. W., Virone-Oddos A., Spaargaren M., Egile C., van Oers M. H. J., Eldering E., Kersten M. J., Kater A. P. The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells Leukemia 2016;30 (2):337-345 [PubMed]
Prof. MD PhD M.J. Kersten (Biology and treatment of lymphoma)
Lymphoma is a malignancy of the immune system, resulting from genetic alterations in the lymphoma cells and supported by signals originating from the microenvironment (in the lymph node or bone marrow). With immunochemotherapy, approximately 50% of patients can be cured. Better understanding the biology of lymphoma has resulted in several new treatment options, such as specific kinase inhibitors, antibody drug conjugates and chimeric antigen receptor T cells. The major aims of the research of MJ Kersten are 1. To investigate novel treatments. To this aim a national phase I/II consortium has been established, leading to the availability of novel therapeutic treatment options for lymphoma patients in the Netherlands. MJ Kersten is the principal investigator for several international phase I/II trials (in Hodgkin lymphoma, follicular lymphoma and Waldenstrom's macroglobulinemia). Linked to these clinical studies is a translational research program aiming to better understand response and resistance to these novel agents. Furthermore, she has established a biobank for samples of patients with WM. 2. To better understand the biology underlying tumor growth, progression and treatment resistance (in lymphoma, Waldenstrom's macroglobulinemia and multiple myeloma). This research is done in collaboration with the pathology department at the AMC (Pals/Spaargaren).
PhD Students
W.S. Stevens
Prof. PhD M.H.J. van Oers (Pathogenesis and Immunotherapy of B cell malignancies)
- Acerta Pharma B.V.
- Bureau Stichting Cancer Center Amsterdam
- Celgene Corporation
- Covance CAPS Ltd.
- Covance International Holdings B.V.
- Crediteurenadm. VUmc, p/a Profource Service Center
- Europese Unie
- Kite Pharma, Inc.
- Millennium Pharmaceuticals, Inc.
- N.K.I.
- Novartis Pharma BV
- PAREXEL International (IRL) Limited
- Pharm-Olam International CRA
- Rigel Pharmaceuticals Inc.
- Sanquin Blood Supply Foundation
- Stichting AMC Foundation
- Stichting AMC Foundation (Vrijgesteld)
- Stichting Hematologisch Oncologische Wetenschap
- Stichting Hovon Amsterdam, p/a VUmc
- UMCG
- VUmc Research B.V.