Prof. N. Zelcer PhD

Prof. PhD N. Zelcer

Positions

Assistant Professor, Full Professor

Main activities

Research

Specialisation

Transcriptional regulation of metabolism

Focus of research

* Contribution of the LXR-IDOL-LDLR axis to cholesterol metabolism

* Identification of novel metabolic genes

* Studying the contribution of the UPS system to metabolism

Amsterdam UMC Research Institutes

AMC departments

Medical Biochemistry

Key publications

Sorrentino Vincenzo, Fouchier Sigrid W., Motazacker Mohammad M., Nelson Jessica K., Defesche Joep C., Dallinga-Thie Geesje M., Kastelein John J. P., Kees Hovingh G., Zelcer Noam Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein European heart journal 2013;34 (17):1292-1297 [PubMed]
Nelson Jessica Kristine, Sorrentino Vincenzo, Avagliano Trezza Rossella, Heride Claire, Urbe Sylvie, Distel Ben, Zelcer Noam The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL Circulation research 2016;118 (3):410-419 [PubMed]
Lu Xifeng, Meima Marcel E., Nelson Jessica K., Sorrentino Vincenzo, Loregger Anke, Scheij Saskia, Dekkers Dick H. W., Mulder Monique T., Demmers Jeroen A. A., M-Dallinga-Thie Geesje, Zelcer Noam, Danser A. H. Jan Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism Circulation research 2016;118 (2):222-229 [PubMed]
Zelcer Noam, Sharpe Laura J., Loregger Anke, Kristiana Ika, Cook Emma C. L., Phan Lisa, Stevenson Julian, Brown Andrew J. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway Molecular and cellular biology 2014;34 (7):1262-1270 [PubMed]
Zelcer Noam, Hong Cynthia, Boyadjian Rima, Tontonoz Peter LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor Science 2009;325 (5936):100-104 [PubMed]