S. Huveneers PhD

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PhD S. Huveneers

Positions
Associate Professor, Research Associate
Main activities
Research
Specialisation
Vascular Microenvironment & Integrity
Focus of research

www.huveneerslab.eu

Endothelial mechanotransduction in inflammation and vascular disease

  • Investigating vascular integrity in inflammation and cardiovascular disease.
  • Elucidating cytoskeletal-mediated cell-cell junction regulation.
  • Understanding how mechanical forces control endothelial adhesions.
Amsterdam UMC Research Institutes
AMC departments
Key publications
  • van der Stoel Miesje, Schimmel Lilian, Nawaz Kalim, van Stalborch Anne-Marieke, de Haan Annett, Klaus-Bergmann Alexandra, Valent Erik T., Koenis Duco S., van Nieuw Amerongen Geerten P., de Vries Carlie J., de Waard Vivian, Gloerich Martijn, van Buul Jaap D., Huveneers Stephan DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis Journal of cell science 2020;133 (3) [PubMed]
  • Malinova Tsveta S., Huveneers Stephan Sensing of Cytoskeletal Forces by Asymmetric Adherens Junctions Trends in cell biology 2018;28 (4):328-341 [PubMed]
  • Dorland Yvonne L., Huveneers Stephan Cell-cell junctional mechanotransduction in endothelial remodeling Cellular and molecular life sciences 2017;74 (2):279-292 [PubMed]
  • Dorland Yvonne L., Malinova Tsveta S., van Stalborch Anne-Marieke D., Grieve Adam G., van Geemen Daphne, Jansen Nicolette S., de Kreuk Bart-Jan, Nawaz Kalim, Kole Jeroen, Geerts Dirk, Musters René J. P., de Rooij Johan, Hordijk Peter L., Huveneers Stephan The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions Nature communications 2016;7:12210 [PubMed]
  • van Geemen Daphne, Smeets Michel W. J., van Stalborch Anne-Marieke D., Woerdeman Leonie A. E., Daemen Mat J. A. P., Hordijk Peter L., Huveneers Stephan F-actin-anchored focal adhesions distinguish endothelial phenotypes of human arteries and veins Arteriosclerosis, thrombosis, and vascular biology 2014;34 (9):2059-2067 [PubMed]
All Publications
Curriculum Vitae

2016-now Groupleader at the Academic Medical Center

2016-now Vice-chair of the association of researchers in the talent scheme of NWO (VVViO) 

2015 NWO-VIDI fellowship

2012-2016 Group leader at Sanquin Research

2010 NWO-VENI fellowship

2010-now Board member of the Dutch Endothelial Biology Society 

2008-2012 Postdoc at the Hubrecht Institute

2003-2008 PhD student at the Netherlands Cancer Institute & at Leiden University

 

Research programmes

PhD S. Huveneers (Vascular Microenvironment and Integrity)

The group is expertised in vascular cell biology and advanced real-time imaging. Current research lines are aimed at:

  • Investigating vascular integrity in inflammation and cardiovascular disease.
  • Establishing the importance of asymmetric junctions for collective cell behaviour in angiogenesis.
  • Understanding how mechanical forces control endothelial adhesions.
  • Elucidating the role of endothelial Gaq signaling in Sturge-Weber syndrome

To achieve these goals we are determining the physiological importance of endothelial junctional events, such as Pacsin2 and Vinculin recruitment, combining high resolution microscopy of live cell junction dynamics with visualizing endothelial interactions in vivo.
 

Postdocs
PhD A. Angulo Urarte

PhD Students
MSc A. Hooglugt
MSc V. Meyn

Others
BEng A.J. de Haan

Prof. PhD C.J.M. de Vries (Regulation of Vascular Homeostasis and Metabolism)

Prof. PhD P.L. Hordijk (Landsteiner Laboratory)

Current PhD Candidates
Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • NWO