M.H. Mochtar MD PhD

foto

MD PhD M.H. Mochtar

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
gynaecologist
Focus of research

Unexplained subfertility

The research programme focuses on the evaluation of therapy of couples with Unexplained subfertility and male factor subfertility. A distinction is made between women younger than 38 years of age and older, since age is a predominate factor in the changes to become pregnant. The research will be performed  in multicenter national setting (Dutch Fertility Consortium) Unexplained subfertility will be investigated with regard to diagnostic strategies and expectant management. The applicant is the principal investigator of a current randomised study comparing different ovarian hyperstimulation medication for the first line treatment of these couples i.e. Intra uterine insemination. In 2015 two more multicentre studies will be started comparing the standard treatment IUI for younger women, IVF for older women to expectant management. Next to efficacy, patients preferences and implementing expectant management will be the focus of these studies.

Male factor subfertility

The second research line focuses on male factor subfertility a distinction is made in mild male factor and severe male factor. In couples in whom the man suffers from azoospermia, surgically removed sperm is used for ICSI treatment. In case this treatment fails, treatment with donor semen can be an alternative. The applicant is principal investigator of a randomised study comparing intra-cervical insemination of donor sperm to intra uterine insemination.

Patient preferences 

Key publications
  • van den Wijngaard L., Rodijk I. C. M., van der Veen F., Gooskens-van Erven M. H. W., Koks C. A. M., Verhoeve H. R., Mol B. W. J., van Wely M., Mochtar M. H. Patient preference for a long-acting recombinant FSH product in ovarian hyperstimulation in IVF: a discrete choice experiment Human reproduction (Oxford, England) 2015;30 (2):331-337 [PubMed]
  • Musters A. M., van Wely M., Mastenbroek S., Kaaijk E. M., Repping S., van der Veen F., Mochtar M. H. The effect of recombinant LH on embryo quality: a randomized controlled trial in women with poor ovarian reserve Human reproduction (Oxford, England) 2012;27 (1):244-250 [PubMed]
  • Mochtar M. H., Custers I. M., Koks C. A. M., Bernardus R. E., Verhoeve H. R., Mol B. W., van Wely M., van der Veen F. Timing oocyte collection in GnRH agonists down-regulated IVF and ICSI cycles: a randomized clinical trial Human reproduction (Oxford, England) 2011;26 (5):1091-1096 [PubMed]
  • Kop P. A. L., van Wely M., Mol B. W., de Melker A. A., Janssens P. M. W., Arends B., Curfs M. H. J. M., Kortman M., Nap A., Rijnders E., Roovers J. P. W. R., Ruis H., Simons A. H. M., Repping S., van der Veen F., Mochtar M. H. Intrauterine insemination or intracervical insemination with cryopreserved donor sperm in the natural cycle: a cohort study Human reproduction (Oxford, England) 2015;30 (3):603-607 [PubMed]
  • Mochtar Monique H., Danhof Nora A., Ayeleke Reuben Olugbenga, van der Veen Fulco, van Wely Madelon Recombinant luteinizing hormone (rLH) and recombinant follicle stimulating hormone (rFSH) for ovarian stimulation in IVF/ICSI cycles Cochrane database of systematic reviews (Online) 2017;2017 (5):CD005070 [PubMed]
All Publications
Research programmes

MD PhD M.H. Mochtar (Promoties)

Prof. PhD S. Repping (Reproduction & Development -- Human Reproduction)

Prof. PhD F. van der Veen (Reproduction and development])

Prof. MD PhD M. Goddijn (Reproductive Medicine)

Current PhD Candidates
  • P.A.L. Kop
  • A.M. Schrijvers
  • L. van den Wijngaard