Prof. S. Repping PhD

Prof. PhD S. Repping

Position

Full Professor

Main activities

Patient care, Research

Specialisation

Human Reproductive Biology

Focus of research

Mission Statement
We aim to perform translational research in the field of Reproduction and Development.

Goals & Ambition
It is our ambition to be at the international front of Reproductive Biology research. Although both clinical evaluation studies and fundamental research are carried out within the department, are focus lies in bringing scientific developments to clinical application. The integration of patient care and research within our department provides the proper framework for the realization of this goal and ambition. Within the lines of research in our department we have the following goals:

Spermatogenesis & Stem Cells (dr. Ans van Pelt): We aim to unravel the mechanism of spermatogonial stem cell renewal and differentiation and to determine which genetic aberrations can lead to spermatogenic failure. We aim to develop a clinical application of human SSCs as a way to preserve reproductive potential in young boys diagnosed with cancer. In addition, we are interested in studying the plasticity of spermatogonial stem cells and their ability to form pluripotent cells that are of potential use for Regenerative Medicine.

Preimplantation Embryology (dr. Sebastiaan Mastenbroek): We aim to understand the development of human preimplantation embryos focusing on chromosomal status and developmental competence and to determine the optimal in vitro conditions for preimplantation embryos by conducting laboratory oriented evaluation studies (RCTs). More precisely, we aim to understand the origin and fate of mosaic embryos, i.e. embryos that contain both euploid and aneuploid cells.

Genomic stability of reproductive cells (dr. Geert Hamer): We aim to understand the genomic stability of both male and female gametes as well as the early embryo. Genomic instability can lead to infertilty as well as to developmental disorders and congenital malformations.

Pregnancy disorders (dr. Gijs Afink): We aim to understand the patho-physiology of preeclampsia and premature labour using mouse models and clinical samples.

Amsterdam UMC Research Institutes

AMC departments

Center for Reproductive Medicine

Key publications

Sadri-Ardekani Hooman, Akhondi Mohammad A., van der Veen Fulco, Repping Sjoerd, van Pelt Ans M. M. In Vitro Propagation of Human Prepubertal Spermatogonial Stem Cells JAMA 2011;305 (23):2416-2418 [PubMed]
Sadri-Ardekani Hooman, Mizrak Sefika C., van Daalen Saskia K. M., Korver Cindy M., Roepers-Gajadien Hermien L., Koruji Morteza, Hovingh Suzanne, de Reijke Theo M., de La Rosette Jean J. M. C. H., van der Veen Fulco, de Rooij Dirk G., Repping Sjoerd, van Pelt Ans M. M. Propagation of Human Spermatogonial Stem Cells In Vitro JAMA 2009;302 (19):2127-2134 [PubMed]
Mastenbroek Sebastiaan, Twisk Moniek, van Echten-Arends Jannie, Sikkema-Raddatz Birgit, Korevaar Johanna C., Verhoeve Harold R., Vogel Niels E. A., Arts Eus G. J. M., de Vries Jan W. A., Bossuyt Patrick M., Buys Charles H. C. M., Heineman Maas Jan, Repping Sjoerd, van der Veen Fulco In vitro fertilization with preimplantation genetic screening New England journal of medicine 2007;357 (1):9-17 [PubMed]
van Echten-Arends Jannie, Mastenbroek Sebastiaan, Sikkema-Raddatz Birgit, Korevaar Johanna C., Heineman Maas Jan, van der Veen Fulco, Repping Sjoerd Chromosomal mosaicism in human preimplantation embryos: a systematic review Human reproduction update 2011;17 (5):620-627 [PubMed]
Hughes Jennifer F., Skaletsky Helen, Pyntikova Tatyana, Graves Tina A., van Daalen Saskia K. M., Minx Patrick J., Fulton Robert S., McGrath Sean D., Locke Devin P., Friedman Cynthia, Trask Barbara J., Mardis Elaine R., Warren Wesley C., Repping Sjoerd, Rozen Steve, Wilson Richard K., Page David C. Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content Nature 2010;463 (7280):536-539 [PubMed]

All Publications

Curriculum Vitae

Personal details
Name: Sjoerd Repping, PhD
Title: Professor Human Reproductive Biology
Sex: Male
Date of birth: 19 November 1974
Place of birth: Nijmegen
Nationality: Dutch
Marital status: married, 3 children

A. Positions and Honors:
I. Positions and Employment
2016 – Program Director, Research Theme Reproduction & Development, AMC/VUmc
2013 - Head of the Center for Reprouctive Medicine, AMC, University of Amsterdam
2009 – Professor of Human Reproductive Biology, AMC, University of Amsterdam.
2007 – Principal Investigator, Department of Obstetrics and Gynecology, AMC, University of Amsterdam.
2005 – 2013 Director of the Fertility Laboratory, Center for Reproductive Medicine, AMC, UvA.
2004 – 2009 Visiting scientist, Page Lab, Whitehead Institute, Cambridge, U.S.A.
2005 – 2009 Associate professor, clinical embryologist, Center for Reproductive Medicine, AMC, UvA.
2003 – 2005 Assistant professor, clinical embryologist, Center for Reproductive Medicine, AMC, UvA.
2002 – 2003 Clinical embryologist, research scientist, Center for Reproductive Medicine, AMC, UvA.
2001 – 2001 Visiting graduate student, Page Lab, Whitehead Institute, Cambridge, U.S.A.
1998 – 2002 Clinical embryologist in training, Center for Reproductive Medicine, AMC, UvA.

II. Other Experience and Professional Memberships
2015 -           Advisory committee member for the National Health Council on biotechnological developments
2013 -           Chair of the AMC Environmental Advisory Platform
2013 –          Member of the Central Committee on Research Involving Human Subjects (CCMO)
2012             Member of the ESHRE expert group on Epigenetic and Health effects of ART
2010 –          Chair of the Dutch Society for Clinical Embryology (KLEM)
2010 –          Board member, Dutch Society for Reproductive Medicine
2012 – 2014 Associate Editor Molecular Human Reproduction
2009 – 2011 National Representative of ESHRE for the Netherlands
2009 – 2011 Deputy of the SIG Reproductive Genetics of ESHRE
2009 – 2010 Chair of the workgroup semenanalysis
2009             Member of the local organizing committee of ESHRE Amsterdam
2007 – 2011 Member of the ESHRE PGS Task force
2007 – 2008 Chair of the workgroup on PGS of the ESHRE PGD Consortium
2007             Chair of the advisory board on vitrification
2007             Member of the advisory board on in vitro maturation
2006 – 2011 Chair of the science committee of the KLEM
2005 – 2006 Member of the advisory committee of the board of the AMC on science policy
2005 –           Member of the Research Counsel of the Department of Obstetrics and Gynecology (AMC)
2004 – 2008 Member of the Steering Committee of the ESHRE PGD Consortium
2004 –          Chair of the workgroup on Reproductive Genetics
2003              Member of the organizing committee of the Reinier de Graaff symposium
2001 –           Member of the American Society of Human Genetics (ASHG)
2001 –           Member of the American Society for Reproductive Medicine
1998 –           Member of the European Society of Human Reproduction and Embryology (ESHRE)

III. Honors and Awards
2013 Elected member of The Young Academy of The Royal Netherlands Academy of Arts and Sciences
2011 Tom Voute Award for outstanding research in childhood cancer (Kika)
2009 One of the ten most promising Dutch individuals for the years 2010-2020 (NRC Handelsblad)
2008 VIDI grant for established young researchers
2004 VENI grant for talented young researchers
2004 AMC Young Investigator Publication Award
2003 Cotterman award of the American Society of Human Genetics
2003 Jan Swammerdam prize
2003 Research Institute Gene-expression Endocrinology Metabolism and Oncology (GEMO) prize
2001 Society of Male Reproduction and Urology prize-paper, American Society for Reproductive Medicine
2000 Vereniging voor Fertiliteits Studie (VFS) prize

B. Selection of peer-reviewed publications and patents:
I. Your ten most contributing (most significant) publications
- Sadri-Ardekani, H., Akhondi, M.A., van der Veen, F., Repping, S., van Pelt, A.M. (2011) JAMA 305(23):2416-8
- Hughes, J.F., Skaletsky, H., Pyntikova, T., Graves, T.A., van Daalen, S.K., Minx, P.J., Fulton, R.S., McGrath, S.D., Locke, D.P., Friedman, C., Trask, B.J., Mardis, E.R., Warren, W.C., Repping, S., Rozen, S., Wilson, R.K., Page, D.C. (2010) Nature. 463(7280):539-9
- Sadri-Ardekani, H., Mizrak, S.C., van Daalen, S.K., Korver, C.M., Roepers-Gajadien, H.L., Koruji, M., Hovingh, S., de Reijke, T.M., de la Rosette, J.J., van der Veen, F., de Rooij, D.G., Repping, S., van Pelt, A.M. (2009) JAMA 302(19):2127-34.
- Lange, J., Skaletsky, H., van Daalen, S.K.M., Embry, S.L., Korver, C.M., Brown, L.G., Oates, R.D., Silber, S., Repping, S., Page D.C. (2009) Cell. 138(5):855-69.
- Mastenbroek, S., Twisk, M., van Echten-Arends, J., Sikkema-Raddatz, B., Korevaar, J.C., Verhoeve, H.R., Vogel, N.E., Arts, E.G., de Vries, J.W., Bossuyt, P.M., Buys, C.H., Heineman, M.J., Repping, S., van der Veen, F. (2007) N Engl J Med. 357(1):9-17.
- van Leeuwen, E., Prins, J.M., Jurriaans, S., Boer, K., Reiss, P., Repping, S., van der Veen, F. (2007) Hum Reprod Update. 13(2):197-206.
- Repping, S., van Daalen, S.K., Brown, L.G., Korver, C.M., Lange, J., Marszalek, J.D., Pyntikova, T., van der Veen, F., Skaletsky, H., Page, D.C., Rozen, S. (2006) Nat Genet, 38(4):463-467.
- Repping, S., Skaletsky, H., Brown, L.G., van Daalen, S.K., Korver, C.M., Pyntikova, T., Kuroda-Kawaguchi, T., de Vries, J.W., Oates, R.D., Silber, S., van der Veen, F., Page, D.C. and Rozen, S. (2003) Nat.Genet., 35(3): 247-251.
- Skaletsky, H., Kuroda-Kawaguchi, T., Minx, P. J., Cordum, H. S., Hillier, L., Brown, L. G., Repping, S., Pyntikova, T., Johar, A., Delehaunty, K. et al. (2003) Nature, 423(6942):825-837.
- Repping, S., Skaletsky, H., Lange, J., Silber, S., van der Veen, F., Oates, R. D., Page, D. C., and Rozen, S. (2002) Am.J.Hum.Genet., 71(4):906-922.

II. Median impact factor of your publications
I have (co-)authored 153 papers as listed in the Web of Science with an average of 22.12 citations per item.

III. Median impact factors for your own field(s)
OBSTETRICS & GYNECOLOGY Median Impact Factor 1.804, REPRODUCTIVE BIOLOGY Median Impact Factor 2.385

IV. The top 3 leading Journals in my field are
Human Reproduction Update, Human Reproduction, Fertility & Sterility

V. Patents
United States Patent Application 20090087855, Markers of alterations in the Y chromosome and uses therefor
INV-00463, Leydig Progenitor Cells, 2013

C. Research support
Ongoing research support
- ZonMw Translational Adult Stem Cell Research Grant, 01/01/2014 – 01/01/2022, Role: PI, Amount: 1645 k€
- ZonMw E&K (AID study), 01/01/2014 – 01/01/2017, Role: Co-PI, Amount: 300 k€
- The CoSy trial: Internet based Sex counseling and changes on natural conception in couples in couples with Idiopathic Subfertility (ZonMw, 2015-2018, co-applicant, 250 k)
- Intrauterine insemination in unexplained or mild male subfertility (ZonMw, 2016-2019, co-applicant, 370 k)
- IVF for unexplained or mild male factor subfertility in women between 38 and 43 years of age (ZonMw 2014-2017, co-applicant, 370k)
- Kwaliteit van zorg binnen de NVOG (ZonMw, 2015-2016, PI, 150 k)
- Ontwikkeling van Behandelingskeuzehulpen om de Nederlandse fertiliteitszorg patiëntgerichter en betaalbaarder te maken door overbehandeling tegen te gaan
(Innovatiefonds ZN, 2015-2016, co-applicant, 50k)
- Publieke opinie over de aanvaardbaarheid van artificiële gameten (KNAW, 2015-2016, PI, 8k)

Completed Research Support

- AMC fellowship grant to Geert Hamer, 01/01/2011 – 01/01/2016, Role: Host Laboratory, Amount: 700 k€
- AMC PhD scholarship to Kai Mee Wong, 06/01/2011 – 06/01/2015, Role: Host Laboratory, Amount: 210 k€
- VEMI grant (ZonMw, ENDORECEPT), 04/01/2011 – 04/01/2015, Role: PI, Amount: 125 k€
- VIDI grant (NWO), 04/01/2009 – 04/01/2015, Role: PI, Amount: 600 k€
- KiKa grant, 10/01/2011 – 10/01/2013, Role: co-PI, Amount: 585 k€
- AMC PhD grant to Eleni Mantikou, 06/01/2009 – 06/01/2013, Role: PI, Amount: 210 k€
- KiKa grant, Repping (PI), 09/01/2007 – 09/01/2011, Role: PI, Amount: 630 k€
- AIDS-fund (HIV-ICSI), Repping (PI), 07/01/2007 – 07/01/2009, Role: PI, Amount: 148 k€
- Wim Schellekens grant, 01/01/2004 – 01/01/2006, Role: Co-PI, Amount: 10 k€
- VENI grant (NWO), 01/01/2005 – 01/01/2009, Role: PI, Amount: 200 k€
- NIH/NHGRI/HG00257, 03/01/2003 – 02/28/2006, Role: Co-PI, Amount: 50 k€
- ZonMw grant (Follow-up), 01/01/2003 – 01/01/2008, Role: Co-PI, Amount: 100 k€
- ZonMw grant (PGS), 01/04/2002 – 01/04/2007, Role: Co-PI, Amount: 810 k€
- AIDS-fund (semen), 01/01/2002 – 01/01/2006, Role: Co-PI, Amount: 140 k€
- AMC guideline fund, 07/01/2002 – 07/01/2004, Role: Co-PI, Amount: 20 k€

Supervised PhD students
Completed
Bruce Shapiro defense 20081120 Co-promotor
Henrike Westerveld defense 20081211 Co-promotor
Liesbeth van Leeuwen defense 20090415 Co-promotor
Gianfranco Carlomagno defense 2011011 Promotor
Sebastiaan Mastenbroek 20111026 Promotor
Moniek Twisk 20111026 Co-promotor
Hooman Sadri Ardekani 20111222 Promotor
Anna Musters 20120111 Promotor
Janne-Meije van Weert 20120314 Co-promotor
Michiel Noordam 20120512 Promotor
Julia Chikhovskaya 20131113 Promotor
Laura van Loendersloot 20131203 Co-promotor
Eleni Mantikou 20131203 Promotor
Liesbeth Visser 20141119 Promotor
Bita Nick Kholgh 20150612 Promotor
Emma Verver 20151001 Promotor

Ongoing
Sabrina Jan (2017)
Kai Mee Wong ((2017)
Maartje Cissen (2017)
Saskia Hendriks (2017)
Femke Kop (2017)
Callista Mulder (2017)
Martina Pontesilli (2018)
Robin Struijk (2017)
Majid Tarahomi (2017)
Marja Visser (2017)
Yi Zheng (2017)
Joanna Diogo Portela (2018)
Ieva Masliukaite (2018)
Jitske Eliveld (2018)
Vera Manders (2018)
Robbert Berkhout (2018)
Noor Danhof (2019)