- Chang Gin-Wen, Hsiao Cheng-Chih, Peng Yen-Ming, Vieira Braga Felipe A., Kragten Natasja A. M., Remmerswaal Ester B. M., van de Garde Martijn D. B., Straussberg Rachel, König Gabriele M., Kostenis Evi, Knäuper Vera, Meyaard Linde, van Lier René A. W., van Gisbergen Klaas P. J. M., Lin Hsi-Hsien, Hamann Jörg The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells Cell reports 2016;15 (8):1757-1770 [PubMed]
- Hamann Jörg, Aust Gabriela, Araç Demet, Engel Felix B., Formstone Caroline, Fredriksson Robert, Hall Randy A., Harty Breanne L., Kirchhoff Christiane, Knapp Barbara, Krishnan Arunkumar, Liebscher Ines, Lin Hsi-Hsien, Martinelli David C., Monk Kelly R., Peeters Miriam C., Piao Xianhua, Prömel Simone, Schöneberg Torsten, Schwartz Thue W., Singer Kathleen, Stacey Martin, Ushkaryov Yuri A., Vallon Mario, Wolfrum Uwe, Wright Mathew W., Xu Lei, Langenhan Tobias, Schiöth Helgi B. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors Pharmacological reviews 2015;67 (2):338-367 [PubMed]
- Smolders Joost, Remmerswaal Ester B. M., Schuurman Karianne G., Melief Jeroen, van Eden Corbert G., van Lier René A. W., Huitinga Inge, Hamann Jörg Characteristics of differentiated CD8(+) and CD4 (+) T cells present in the human brain Acta neuropathologica 2013;126 (4):525-535 [PubMed]
- Langenhan Tobias, Aust Gabriela, Hamann Jörg Sticky signaling--adhesion class G protein-coupled receptors take the stage Science signaling 2013;6 (276):re3 [PubMed]
PhD J. Hamann (Immunity (inflammation))
As AMC biobank and research ICT coordinator and head of AMC Biobank, I’m responsible for important parts of research support in the AMC, which are developed together with other university medical centers in the Netherlands. I represent the AMC within the main biobank infrastructures in the Netherlands – the Parelsnoer Institute and BBMRI. The ultimate goal for the coming years is the development of a national research infrastructure for disease prevention and personalized medicine: Health-RI.
In addition, I perform research in the field of immunology.
The role of adhesion G protein-coupled receptors in immunity
Since having cloned and deorphanized CD97 in the mid 90th, we are studying the biology of adhesion GPCRs:
• We discussed that their hybrid architecture is key to understanding the function and signaling of adhesion GPCRs (Sci Signal 2013)
• We confirmed the interaction of CD97 with its ligand CD55 in vivo obtained and obtained evidence for a role of mechanoperception in adhesion-GPCR biology (J Immunol 2013)
• Invited by the International Union of Basic and Clinical Pharmacology (IUPHAR), we developed a unified nomenclature for adhesion GPCRs (Pharm Rev 2015)
• We found that GPR56 expression is triggered by the transcriptional repressor Hobit, is downregulated upon cellular activation, and inhibits immediate effector functions in human NK cells (Cell Reports 2016)
The role of tissue-resident immune cells in inflammation
Aberrant immune activation is at the basis of various inflammatory diseases. We are investigating cellular programs in tissue-resident T cells and macrophages:
• We revealed that the human brain is populated by specialized tissue-resident memory T (TRM) cells with restricted cytotoxic capacity, possibly controlled by PD-1 (Acta Neuropathol 2013 and manuscript in preparation)
• We showed that chronic exposure to glucocorticoids shapes gene expression and modulates innate and adaptive activation pathways in macrophages with distinct changes in leukocyte attraction (J Immunol 2014)
• Studying gene expression in chronic active and inactive multiple sclerosis (MS) lesions, we identified genes that might be involved in the onset or regulation of demyelination, including scavenger receptors (manuscript in preparation)
• We developed a method for the immediate isolation and characterization of human microglia and obtained evidence that they persist in an active-prone state in MS (Glia 2012 & 2013 and Acta Neuropathol Commun 2017)
Postdocs
PhD C. Hsiao
- AMC
- Deutsche Forschungsgemeinschaft