N.A. Kootstra PhD

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PhD N.A. Kootstra

Position
Associate Professor
Main activities
Research, Other
Specialisation
Immunology; Virology; infectious disease
Focus of research

Host-virus interactions in the natural course of infection and during therapeutic interventions.

Key publications
  • Cobos Jiménez Viviana, Wit Ferdinand W. N. M., Joerink Maaike, Maurer Irma, Harskamp Agnes M., Schouten Judith, Prins Maria, van Leeuwen Ester M. M., Booiman Thijs, Deeks Steven G., Reiss Peter, Kootstra Neeltje A., van der Valk M., Kooij K. W., van Zoest R. A., Elsenga B. C., Prins M., Martens M., Boeser-Nunnink B., Geerlings S. E., Godfried M. H., Goorhuis A., Hovius J. W. R., Nellen F. J. B., van der Meer J. T. M., van der Poll T., Prins J. M., Wiersinga W. J., Postema P. G., Bisschop P. H. L. T., Serlie M. J. M., Dekker E., de Rooij S. E. J. A., Vogt L., Portegies P., Schmand B. A., Geurtsen G. J., van Eck-Smit B. L. F., de Jong M., Richel D. J., Verbraak F. D., Demirkaya N., Ruhé H. G., Nieuwkerk P. T., van Steenwijk R. P., Majoie C. B. L. M., Caan M. W. A., van Lunsen H. W., van den Born B. J. H., Stroes E. S. G. T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment Journal of infectious diseases 2016;214 (2):216-225 [PubMed]
  • van der Ree Meike H., de Vree J. Marleen, Stelma Femke, Willemse Sophie, van der Valk Marc, Rietdijk Svend, Molenkamp Richard, Schinkel Janke, van Nuenen Ad C., Beuers Ulrich, Hadi Salah, Harbers Marten, van der Veer Eva, Liu Kai, Grundy John, Patick Amy K., Pavlicek Adam, Blem Jacqueline, Huang Michael, Grint Paul, Neben Steven, Gibson Neil W., Kootstra Neeltje A., Reesink Hendrik W. Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial Lancet 2017;389 (10070):709-717 [PubMed]
  • Booiman Thijs, Setiawan Laurentia C., Kootstra Neeltje A. Genetic variation in Trex1 affects HIV-1 disease progression AIDS (London, England) 2014;28 (17):2517-2521 [PubMed]
  • Jansen Louis, de Niet Annikki, Stelma Femke, van Iperen Erik P. A., van Dort Karel A., Tempelmans Plat-Sinnige Marjan J., Takkenberg R. Bart, Chin Daniel J., Zwinderman A. H. Koos, Lopatin Uri, Kootstra Neeltje A., Reesink Hendrik W. HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels Journal of hepatology 2014;61 (4):730-737 [PubMed]
  • Gijsbers Esther F., van Nuenen Ad C., de la Peňa Alba Torrents, Bowles Emma J., Stewart-Jones Guillaume B., Schuitemaker Hanneke, Kootstra Neeltje A. Low level of HIV-1 evolution after transmission from mother to child Scientific reports 2014;4:5079 [PubMed]
All Publications
Research programmes

PhD N.A. Kootstra (Host-virus interaction and immune responses in viral infections.)

mainly focuses on virus-host interactions in the natural course of HIV-1 infection and during therapeutic intervention. In particular, we study the role of restriction factors and other newly identified HIV dependency factors in HIV-1 replication and pathogenesis. Furthermore, we study immunological ageing in patients with HIV receiving long-term cART who participate in the prospective ageing cohort study on “Co-morbidity and Ageing with HIV” (AGEhIV) and participate in the COBRA study (EU FP7) on “Co-morbidity in relation to Aids”.

In collaboration with Sanquin and the Department of Gastroenterology at the AMC, the role of viral and host factors in HBV replication and the response to antiviral therapy in chronic hepatitis B patients is investigated.

Our group participates in the Amsterdam Cohort Studies on HIV infection and AIDS (www.amsterdamcohortstudies.org) and the prospective HIV and aging cohort (AgeIV).

Postdocs
PhD T. Booiman

Others
BEng B.D.M. Boeser-Nunnink
BEng A.F. Girigorie
BEng A.M. Harskamp-Holwerda
BEng M.M. Mangas Ruiz
BEng I. Maurer
BEng K.A. van Dort
BEng A.C. van Nuenen

Prof. MD PhD P. Reiss (Complications of HIV and HIV treatment)

Current research funding
  • AMC
  • NWO
  • Nederlandse Vereniging voor Gastro-Enterologie