S.I. Bouwman-Gringhuis PhD

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PhD S.I. Bouwman-Gringhuis

Position
Associate Professor
Main activities
Research
Specialisation
Molecular biology, signal transduction, innate immunology
Focus of research

My research focuses on the identification of signaling pathways induced by C-type lectins on dendritic cells and how these signaling pathways lead to pathogen-specific T cell polarization, neutrophil activation as well as anti-viral responses, which could be targeted therapeutically to either enhance immunity or deter aberrant immunity.
 

Amsterdam UMC Research Institutes
AMC departments
Key publications
  • Gringhuis Sonja I., Kaptein Tanja M., Wevers Brigitte A., Theelen Bart, van der Vlist Michiel, Boekhout Teun, Geijtenbeek Teunis B. H. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1 beta via a noncanonical caspase-8 inflammasome Nature immunology 2012;13 (3):246-U63 [PubMed]
  • Geijtenbeek Teunis B. H., Gringhuis Sonja I. C-type lectin receptors in the control of T helper cell differentiation Nature reviews. Immunology 2016;16 (7):433-448 [PubMed]
  • Wevers Brigitte A., Kaptein Tanja M., Zijlstra-Willems Esther M., Theelen Bart, Boekhout Teun, Geijtenbeek Teunis B. H., Gringhuis Sonja I. Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity Cell host & microbe 2014;15 (4):494-505 [PubMed]
  • Mesman Annelies W., Zijlstra-Willems Esther M., Kaptein Tanja M., de Swart Rik L., Davis Meredith E., Ludlow Martin, Duprex W. Paul, Gack Michaela U., Gringhuis Sonja I., Geijtenbeek Teunis B. H. Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases Cell host & microbe 2014;16 (1):31-42 [PubMed]
  • Gringhuis Sonja I., Hertoghs Nina, Kaptein Tanja M., Zijlstra-Willems Esther M., Sarrami-Fooroshani Ramin, Sprokholt Joris K., van Teijlingen Nienke H., Kootstra Neeltje A., Booiman Thijs, van Dort Karel A., Ribeiro Carla M. S., Drewniak Agata, Geijtenbeek Teunis B. H. HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3 Nature immunology 2017;18 (2):225-235 [PubMed]
All Publications
Research programmes

PhD S.I. Bouwman-Gringhuis (C-type lectin signaling in infection and immunity)

Dendritic cells initiate adaptive immune responses to combat infections. C-type lectins are crucial in pathogen recognition and in shaping adaptive immunity. However, little is known about the molecular signaling pathways that are induced by C-type lectins upon pathogen binding. My research focuses on the identification of signaling pathways induced by C-type lectins and how these signaling pathways lead to pathogen-specific T cell polarization. Furthermore, we investigate whether these signaling pathways are involved in the induction of aberrant immune responses as observed during asthma or allergy.

Others
BEng MSc T.M. Kaptein

Prof. PhD T.B.H. Geijtenbeek (Dendritic cells in infection and immunity)

Current PhD Candidates
Current research funding
  • Stichting Aidsfonds/SOA AIDS Nederland