1. Latest articles

One-year transplant-free survival following hospital discharge after ICU Admission for ACLF in the Netherlands

This study investigates the long-term outcomes of ICU patients with acute decompensated liver cirrhosis or acute-on-chronic liver failure (ACLF). In total, 47% of 3035 patients survived hospitalization, and the overall probability of 1-year transplant-free survival after hospital discharge was 0.61. The ACLF severity at ICU admission did not independently influence post-discharge survival. Click here for more information.

Jubi de Haan, Fabian Temorshuizen et al. DOI: 10.1016/j.jhep.2024.03.004

    Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the consecutive stages of the COVID-19 pandemic in the Netherlands, an update

    This study reports mortality rates among patients with COVID-19 during the first wave and compared these rates with the following waves. Using COVID-19 patient data from Dutch Intensive Care Units (ICUs), collected by Stichting Nice, between May 2020 and January 2023,  the mortality risks in the initial upsurge of the third wave was similar to the first wave, but mortality rates decreased in later periods. Curious? Click here for more information.

    Fabian Termorshuizen et al. DOI: 10.1186/s13613-023-01238-2

    The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial

    In nine Dutch intensive care units, this study assessed the impact of tailoring potential drug-drug interaction (DDI) alerts to the ICU setting. Using a cluster randomised stepped-wedge trial, a customized clinical decision support system (CDSS) only providing alerts for potential DDIs considered as high risk was implemented and evaluated. The study found a 12% decrease in the number of administered high-risk drug combinations, indicating that tailoring alerts to the ICU setting improves CDSS effectiveness and patient safety. Click here for more information.

    Tinka Bakker, Joanna Klopotowska et al. DOI: 10.1016/S0140-6736(23)02465-0

    Strain on Scarce Intensive Care Beds Drives Reduced Patient Volumes, Patient Selection, and Worse Outcome: A National Cohort Study

    This study analyzed the impact of Intensive Care Unit (ICU) resource allocation during the COVID-19 pandemic on a non-COVID-19 cohort (120.393 patients) in Dutch ICUs. Compared to the prepandemic period cohort (164.737 patients), the pandemic cohort had lower number of non-COVID patients (27% lower), fewer medical patients (3% lower), fewer comorbidities (4% lower), more vasoactive medication (6% higher), and a slightly higher case-mix adjusted hospital mortality (odds 1.08). Click here for more information.

    Sylvia Brinkman, Nicolette de Keizer et al. DOI: 10.1097/CCM.0000000000006156

    Predicting 30-day mortality in intensive care unit patients with ischaemic stroke or intracerebral haemorrhage

    This study developed and validated two predictive models to estimate the 30-day mortality for patients with a stroke admitted to intensive care units (ICUs): one model for patients with ischaemic (N=8 422) and one model for patients with haemorrhagic stroke (N=5 881). The 30-day mortality was 27% in the first group and 41% in the second group. Both models showed high discrimination (AUC of 0.85) and good calibration. Click here for more information.

    Fabian Termorshuizen et al. DOI: 10.1097/EJA.0000000000001920

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          2. PhD theses

          The latest PhD theses of our department.

          3. Research in the spotlight

          Making medical terms patient-friendly

          Interview with Hugo van Mens researcher on Reusable Health Data

          4. Broodje MedInfo (Sandwich MedInfo)

          🍞 Are you interested in or working on a data-driven (research) project in healthcare? And would you like to know more about best practices for your project? Then broodje MedInfo is for you!

          This online event includes research results, tips for your own data project and time for questions.

          Edition 1 | 10 April 2024

          Ronald Cornet presented in the first edition, in Dutch, the importance of the FAIR (Findable, Accessible, Interoperable, Reusable) Principles and how you can apply them in projects. Look here for the tips from the Q&A.

          Slides: https://purl.org/ronco/20240410BMI

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