1. Latest articles

The latest scientific publications of our department with a short summary.

Creation of a gold standard Dutch corpus of clinical notes for adverse drug event detection: the Dutch ADE

A high-quality corpus of Dutch ICU medical notes was created to help computers detect medication side effects, especially those impacting the kidneys. Two medical experts analyzed anonymized notes from 102 adult ICU patients suspected of having drug-related kidney issues. They labeled medications, medical problems, and their relationships using standardized, double-checked guidelines. Over 16,000 labels were added in total, including 614 for drug-related side effects. The resulting dataset will be used to train computer systems to identify side effects in Dutch electronic medical records automatically.

Rachel O'Sullivan-Murphy, et el DOI: 10.1007/s10579-025-09832-5

Identifying a cohort of hospitalized chronic kidney disease patients using electronic health records: lessons learnt and implications for future research and clinical practice guidelines

This study identified a chronic kidney disease (CKD) cohort from Amsterdam UMC using electronic health records based on six logical rules.

Pooling these six logical rules resulted in identifying 17 805 hospitalized CKD patients (16.4%). The proportions identified by each logical rule varied from 2.1% to 8.4%. Our findings highlight the need to formalize the CKD clinical definition into a computer-interpretable one, to avoid inconsistencies in EHR implementation across studies.

 Daniel Fernandez Llaneza, et el DOI: 10.1093/ckj/sfaf073

An Order-Sensitive Hierarchical Neural Model for Early Lung Cancer Detection Using Dutch Primary Care Notes and Structured Data

This study created two AI models to help detect lung cancer early by analyzing doctors’ notes and other health information.

One model was based on these notes alone and the other combined the notes with other health data. Both models worked well in spotting patients at high risk for lung cancer. The model that included both the notes and other data was slightly more accurate.

Iacopo Vagliano, et el DOI: 10.3390/cancers17071151

Implementing Findable, Accessible, Interoperable, Reusable (FAIR) Principles in Child and Adolescent Mental Health Research: Mixed Methods Approach

This study identified barriers to implementing the FAIR (Findable, Accessible, Interoperable, Reusable) principles in child and adolescent mental health research.

A total of 45 barriers were identified, including those related to organizational policies and software. Key recommendations include adding a FAIR data steward to the research team, providing accessible guides, and ensuring sustainable funding to overcome these barriers, ultimately enhancing data reusability.

 Rowdy de Groot, et el DOI: 10.2196/59113

Unmasking the chameleons: A benchmark for out-of-distribution detection in medical tabular data

Machine learning models often struggle to generalize to data distributions that differ from their training dataset, known as "out-of-distribution" (OOD) data. It is important to detect OOD because prediction on such data can be unreliable.

While OOD detection methods have been explored in various fields, their effectiveness for medical data remains unclear. This study aims to evaluate and compare different OOD detection methods in the context of medical tabular data.

 The visual summary and interview with Giovanni Cina explains OOD.

 Mohammad Azizmalayeri, et al DOI:10.1016/j,ijmedinf.2024.105762


2. PhD theses

The latest PhD theses of our department.


3. Research in the spotlight

Researchers of our department in the spotlight! With a visual summary and a short interview. Curious? Click on the figures to find out more.

Digital tools in cancer screening

Interview with Corine Oldhoff-Nuijsink, researcher on Human Factors Engineering.

Federated learning in the healthcare setting

Interview with Sebastian van der Voort, researcher on Quality of care (IT systems), Methods in Medical Informatics and Reusable Health Data

Detecting unreliable predictions of ML models

Interview with Giovanni Cinà, researcher on Methods in Medical Informatics

Making medical terms patient-friendly

Interview with Hugo van Mens, researcher on Reusable Health Data


4. Broodje MedInfo (Sandwich MedInfo)

🍞 Are you interested in or working on a data-driven (research) project in healthcare? And would you like to know more about best practices for your project? Then broodje MedInfo is for you!

This online event includes research results, tips for your own data project and time for questions. Below, you can find the recordings of previous editions on FAIR, LLMs, Audit & Feedback and Usability.

Usable computer systems

In this edition, Linda Dusseljee-Peute spoke about usable computer systems (e.g. apps, decision support systems, and electronic health records), human-computer interaction, design and the currently available evidence.

Slides: Broodje MedInfo Usable computer systems

Quality registrations and Audit & Feedback

Nicolette de Keizer and Ferishta Bakhshi-Raiez presented, in Dutch, results of continuous improvement using a quality registration in specialist medical care and the implications of a new Dutch law.

Slides: Broodje MedInfo Quality registrations


LLMs

Iacer Coimbra Alves Cavalcanti Calixto presented, in English, the opportunities and challenges of Large Language Models in healthcare. Including patient privacy, model interpretability, and reducing administrative burden.

Slides: Broodje MedInfo LLMs

FAIR

Ronald Cornet presented in the first edition, in Dutch, the importance of the FAIR (Findable, Accessible, Interoperable, Reusable) Principles and how you can apply them in projects. Look here for the tips from the Q&A.

Slides: Broodje MedInfo FAIR


5. Podcast Health Informatics (in Dutch)

All podcasts


6. Technical reports

Check here for all our technical reports!